Adapting Neural Networks for the Estimation of Treatment Effects
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Abstract (arXiv)
This paper addresses the use of neural networks for the estimation of treatment effects from observational data. Generally, estimation proceeds in two stages. First, we fit models for the expected outcome and the probability of treatment (propensity score) for each unit. Second, we plug these fitted models into a downstream estimator of the effect. Neural networks are a natural choice for the models in the first step. The question we address is: how can we adapt the design and training of the neural networks used in the first step in order to improve the quality of the final estimate of the treatment effect? We propose two adaptations based on insights from the statistical literature on the estimation of treatment effects. The first is a new architecture, the Dragonnet, that exploits the sufficiency of the propensity score for estimation adjustment. The second is a regularization procedure, targeted regularization, that induces a bias towards models that have non-parametrically optimal asymptotic properties `out-of-the-box`. Studies on benchmark datasets for causal inference show these adaptations outperform existing methods. Code is available at github.com/claudiashi57/dragonnet.
Key facts. Cited by 285 papers in the map (data through 7 Oct 2026). First posted on arXiv 5 Jun 2019.
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Citing papers per year: 2021: 28; 2022: 44; 2023: 47; 2024: 63; 2025: 65; 2026: 38.
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- 2021Nonparametric Estimation of Heterogeneous Treatment Effects: From Theory to Learning Algorithmscited by 144
- 2021The Causal-Neural Connection: Expressiveness, Learnability, and Inferencecited by 97
- 2022Diffusion Causal Models for Counterfactual Estimationcited by 87
- 2021On Inductive Biases for Heterogeneous Treatment Effect Estimationcited by 74
- 2024Causal machine learning for predicting treatment outcomescited by 73
- 2021VCNet and Functional Targeted Regularization For Learning Causal Effects of Continuous Treatmentscited by 59
- 2022Neural Causal Models for Counterfactual Identification and Estimationcited by 54
- 2025Do-PFN: In-Context Learning for Causal Effect Estimationcited by 46
- 2025CausalPFN: Amortized Causal Effect Estimation via In-Context Learningcited by 43
- 2021RieszNet and ForestRiesz: Automatic Debiased Machine Learning with Neural Nets and Random Forestscited by 42
- 2021Conditional Distributional Treatment Effect with Kernel Conditional Mean Embeddings and U-Statistic Regressioncited by 40
- 2021Causal Effect Inference for Structured Treatmentscited by 38
38 more
- 2023Measuring axiomatic soundness of counterfactual image modelscited by 34
- 2023Optimal Transport for Treatment Effect Estimationcited by 32
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- 2021A Critical Look at the Consistency of Causal Estimation With Deep Latent Variable Modelscited by 29
- 2022Estimating average causal effects from patient trajectoriescited by 29
- 2021Causal-BALD: Deep Bayesian Active Learning of Outcomes to Infer Treatment-Effects from Observational Datacited by 27
- 2021Estimating Average Treatment Effects via Orthogonal Regularizationcited by 25
- 2021SurvITE: Learning Heterogeneous Treatment Effects from Time-to-Event Datacited by 25
- 2022Exploring Transformer Backbones for Heterogeneous Treatment Effect Estimationcited by 25
- 2022Empirical Analysis of Model Selection for Heterogeneous Causal Effect Estimationcited by 25
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- 2022Scalable Sensitivity and Uncertainty Analysis for Causal-Effect Estimates of Continuous-Valued Interventionscited by 20
- 2024Doubly Robust Causal Effect Estimation under Networked Interference via Targeted Learningcited by 19
- 2021Estimating Categorical Counterfactuals via Deep Twin Networkscited by 18
- 2022TDR-CL: Targeted Doubly Robust Collaborative Learning for Debiased Recommendationscited by 18
- 2022Robust and Agnostic Learning of Conditional Distributional Treatment Effectscited by 18
- 2023Zero-shot causal learningcited by 17
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- 2023A Neural Framework for Generalized Causal Sensitivity Analysiscited by 17
- 2022DESCN: Deep Entire Space Cross Networks for Individual Treatment Effect Estimationcited by 16
- 2024Causal Inference with Generative Artificial Intelligence: Application to Texts as Treatmentscited by 16
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- 2024Rankability-enhanced Revenue Uplift Modeling Framework for Online Marketingcited by 12
- 2022Estimating counterfactual treatment outcomes over time in complex multiagent scenarioscited by 11
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- 2023Dynamic Inter-treatment Information Sharing for Individualized Treatment Effects Estimationcited by 11
- 2024Meta-Learners for Partially-Identified Treatment Effects Across Multiple Environmentscited by 11
- 2025Doubly Robust Alignment for Large Language Modelscited by 11
- 2021Intact-VAE: Estimating Treatment Effects under Unobserved Confoundingcited by 10
- 2021Finding Valid Adjustments under Non-ignorability with Minimal DAG Knowledgecited by 10
- 2022Partial Identification with Noisy Covariates: A Robust Optimization Approachcited by 10
50 most cited of 285 All 285 (JSON)
- 2026MECHVAR: Variance-Guided Mechanism Discrimination for Autonomous Machine Learning Experiment Selection1 Oct 2026
- 2026Should I stay or should I show? Learning to selectively disclose information30 Sep 2026
- 2026What You Observe Determines How You Identify Causal Effects: Evaluating Causal Models across Observational Views29 Sep 2026
- 2026Weighted Spline-Expanded Networks with Distributional Balancing for Continuous Treatment Effects27 Sep 2026
- 2026Splitting the Difference: Interpretable Causal Forests for Treatment Effect Heterogeneity and Bias15 Sep 2026
- 2026Representation Learning for Sample-Efficient CATE Estimation by Leveraging Multiple Outcomes5 Sep 2026
- 2026Transportable Causal Effect Estimation across Networks under Interference19 Aug 2026
- 2026Doubly Robust Estimation of Causal Effect on CVR with Targeted Regularization13 Aug 2026
- 2026From Prediction to Incrementality: Causal Optimization for Large-Scale Targeting and Recommendation10 Aug 2026
- 2026Multi-channel Uplift Policy Learning30 Jul 2026
- 2026Uncertainty-Guided LLM Semantic Augmentation for Heterogeneous Treatment Effect Estimation29 Jul 2026
- 2026TLRNet: Estimating Individual Treatment Effect based on Local Information and Single Learner Structure23 Jul 2026
38 more
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- 2026Outcome-adapted Automatic Debiased Machine Learning3 Jul 2026
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- 2026Cross-Head Attention Uplift Network with Inverse Propensity Score under Unobserved Confounding25 Jun 2026
- 2026Balanced Twins: Causal Inference on Time Series with Hidden Confounding17 Jun 2026
- 2026CausalPOI: Spatio-Temporal Graph-Based Causal Modeling for Cold-Start POI Check-in Forecasting3 Jun 2026
- 2026Using Text-Based Causal Inference to Disentangle Factors Influencing Online Review Ratings2 Jun 2026
- 2026Tailoring Strictly Proper Scoring Rules for Downstream Tasks: An Application to Causal Inference2 Jun 2026
- 2026BuddyBench: A Privacy-Constrained Multi-Task Benchmark for Pediatric Social-Communication Personalization27 May 2026
- 2026Causal Risk Minimization for High-Dimensional Treatments26 May 2026
- 2026Causal Representation Learning for Generalisable Recommendation26 May 2026
- 2026Treatment Effect Estimation with Differentiated Networked Effect on Graph Data23 May 2026
- 2026FML-bench: A Controlled Study of AI Research Agent Strategies from the Perspective of Search Dynamics17 May 2026
- 2026Conditional Attribute Estimation with Autoregressive Sequence Models13 May 2026
- 2026Real vs. Semi-Simulated: Rethinking Evaluation for Treatment Effect Estimation11 May 2026
- 2026RepFlow: Representation Enhanced Flow Matching for Causal Effect Estimation7 May 2026
- 2026Bayesian X-Learner: Calibrated Posterior Inference for Heterogeneous Treatment Effects under Heavy-Tailed Outcomes30 Apr 2026
- 2026Dialysis Risk Prediction and Treatment Effect Estimation for AKI patients using Longitudinal Electronic Health Records27 Apr 2026
- 2026MOCA: A Transformer-based Modular Causal Inference Framework with One-way Cross-attention and Cutting Feedback25 Apr 2026
- 2026Evaluating Uplift Modeling under Structural Biases: Insights into Metric Stability and Model Robustness21 Mar 2026
- 2026Improving RCT-Based Treatment Effect Estimation Under Covariate Mismatch via Calibrated Alignment19 Mar 2026
- 2026Orthogonal Uplift Learning with Permutation-Invariant Representations for Combinatorial Treatments23 Feb 2026
- 2026Decoding ML Decision: An Agentic Reasoning Framework for Large-Scale Ranking System20 Feb 2026
- 2026Estimating Aleatoric Uncertainty in the Causal Treatment Effect9 Feb 2026
- 2026Disentangled Instrumental Variables for Causal Inference with Networked Observational Data8 Feb 2026
- 2026Direct Doubly Robust Estimation of Conditional Quantile Contrasts27 Jan 2026
- 2025PIPCFR: Pseudo-outcome Imputation with Post-treatment Variables for Individual Treatment Effect Estimation21 Dec 2025
- 2025Towards a Relationship-Aware Transformer for Tabular Data8 Dec 2025
- 2025Text Rationalization for Robust Causal Effect Estimation5 Dec 2025
- 2025A Large Scale Heterogeneous Treatment Effect Estimation Framework and Its Applications of Users' Journey at Snap25 Nov 2025
- 2025Learning Subgroups with Maximum Treatment Effects without Causal Heuristics25 Nov 2025
- 2025Reliable Selection of Heterogeneous Treatment Effect Estimators23 Nov 2025
- 2025Multiple Treatments Causal Effects Estimation with Task Embeddings and Balanced Representation Learning12 Nov 2025
- 2025Riesz Regression As Direct Density Ratio Estimation6 Nov 2025
- 2025A Comparative Study of Model Adaptation Strategies for Multi-Treatment Uplift Modeling3 Nov 2025
- 2025Bi-Level Decision-Focused Causal Learning for Large-Scale Marketing Optimization: Bridging Observational and Experimental Data22 Oct 2025
- 2025Improving the Generation and Evaluation of Synthetic Data for Downstream Medical Causal Inference21 Oct 2025
- 2025A Relative Error-Based Evaluation Framework of Heterogeneous Treatment Effect Estimators18 Oct 2025
50 newest of 285 All 285 (JSON)
- 2026FML-bench: A Controlled Study of AI Research Agent Strategies from the Perspective of Search Dynamics17 May 2026
- 2026Decoding ML Decision: An Agentic Reasoning Framework for Large-Scale Ranking System20 Feb 2026
- 2025FML-bench: Benchmarking Machine Learning Agents for Scientific Research12 Oct 2025
- 2025Doubly Robust Alignment for Large Language Modelscited by 11
- 2025Doubly Robust Alignment for Large Language Models1 Jun 2025
- 2021Nonparametric Estimation of Heterogeneous Treatment Effects: From Theory to Learning Algorithmscited by 144
- 2021The Causal-Neural Connection: Expressiveness, Learnability, and Inferencecited by 97
- 2022Diffusion Causal Models for Counterfactual Estimationcited by 87
- 2021On Inductive Biases for Heterogeneous Treatment Effect Estimationcited by 74
- 2024Causal machine learning for predicting treatment outcomescited by 73
- 2021VCNet and Functional Targeted Regularization For Learning Causal Effects of Continuous Treatmentscited by 59
- 2022Neural Causal Models for Counterfactual Identification and Estimationcited by 54
- 2025Do-PFN: In-Context Learning for Causal Effect Estimationcited by 46
- 2025CausalPFN: Amortized Causal Effect Estimation via In-Context Learningcited by 43
- 2021RieszNet and ForestRiesz: Automatic Debiased Machine Learning with Neural Nets and Random Forestscited by 42
- 2021Conditional Distributional Treatment Effect with Kernel Conditional Mean Embeddings and U-Statistic Regressioncited by 40
- 2021Causal Effect Inference for Structured Treatmentscited by 38
12 most cited of 279 All 279 (JSON)
- 2026MECHVAR: Variance-Guided Mechanism Discrimination for Autonomous Machine Learning Experiment Selection1 Oct 2026
- 2026Should I stay or should I show? Learning to selectively disclose information30 Sep 2026
- 2026What You Observe Determines How You Identify Causal Effects: Evaluating Causal Models across Observational Views29 Sep 2026
- 2026Weighted Spline-Expanded Networks with Distributional Balancing for Continuous Treatment Effects27 Sep 2026
- 2026Splitting the Difference: Interpretable Causal Forests for Treatment Effect Heterogeneity and Bias15 Sep 2026
- 2026Representation Learning for Sample-Efficient CATE Estimation by Leveraging Multiple Outcomes5 Sep 2026
- 2026Transportable Causal Effect Estimation across Networks under Interference19 Aug 2026
- 2026Doubly Robust Estimation of Causal Effect on CVR with Targeted Regularization13 Aug 2026
- 2026From Prediction to Incrementality: Causal Optimization for Large-Scale Targeting and Recommendation10 Aug 2026
- 2026Multi-channel Uplift Policy Learning30 Jul 2026
- 2026Uncertainty-Guided LLM Semantic Augmentation for Heterogeneous Treatment Effect Estimation29 Jul 2026
- 2026TLRNet: Estimating Individual Treatment Effect based on Local Information and Single Learner Structure23 Jul 2026
12 newest of 279 All 279 (JSON)