mlsanityData to 14 Oct 2026

Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning

arXiv 2607.07761 ↗First posted 8 Jul 2026cs.AIcited by 1

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-view approach that connects clinical practice with computational methods. On the clinical side, we establish a five-level competency scheme following Miller's Pyramid, progressing from knowledge recall to dynamic case management. On the computational side, we link deductive, inductive, and abductive reasoning patterns to common medical goals and tasks. We also introduce a benchmark dataset spanning five levels of medical reasoning capability and report results on 18 state-of-the-art models, revealing that medical specialist models excel in diagnosis-centric tasks while general models lead in decision support and dialogue. We conclude by discussing current progress and open challenges, including data limitations, hallucination, and grounding issues, and outline directions toward safer, more reliable, and workflow-ready systems.

Key facts. Cited by 1 paper in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 71 of its 201 references that are in the map. First posted on arXiv 8 Jul 2026.

Builds on

71 of 201 references.

Closest ancestors · 30

Same direction, newest first

  1. 2025EHR-R1: A Reasoning-Enhanced Foundational Language Model for Electronic Health Record Analysis29 Oct
  2. 2025Toward Clinically Explainable AI for Medical Diagnosis: A Foundation Model with Human-Compatible Reasoning via Reinforcement Learning4 Sep
  3. 2025Tree-of-Reasoning: Towards Complex Medical Diagnosis via Multi-Agent Reasoning with Evidence Tree5 Aug
  4. 2025AURA: A Multi-Modal Medical Agent for Understanding, Reasoning & Annotation22 Jul
  5. 2025MAM: Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis via Role-Specialized Collaboration24 Jun
  6. 2025Med-U1: Incentivizing Unified Medical Reasoning in LLMs via Large-scale Reinforcement Learning14 Jun
  7. 2025Med-REFL: Medical Reasoning Enhancement via Self-Corrected Fine-grained Reflection11 Jun
  8. 2025ReasonMed: A 370K Multi-Agent Generated Dataset for Advancing Medical Reasoning11 Jun
  9. 2025QoQ-Med: Building Multimodal Clinical Foundation Models with Domain-Aware GRPO Training31 May
  10. 2025MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoning31 May
  11. 2025MedOrch: Medical Diagnosis with Tool-Augmented Reasoning Agents for Flexible Extensibility30 May
  12. 2025Elicit and Enhance: Advancing Multimodal Reasoning in Medical Scenarios29 May
18 more
  1. 2025TAGS: A Test-Time Generalist-Specialist Framework with Retrieval-Augmented Reasoning and Verification23 May
  2. 2025Patho-R1: A Multimodal Reinforcement Learning-Based Pathology Expert Reasoner16 May
  3. 2025ChestX-Reasoner: Advancing Radiology Foundation Models with Reasoning through Step-by-Step Verification29 Apr
  4. 2025ClinicalGPT-R1: Pushing reasoning capability of generalist disease diagnosis with large language model13 Apr
  5. 2025The Multi-Round Diagnostic RAG Framework for Emulating Clinical Reasoning10 Apr
  6. 2025GMAI-VL-R1: Harnessing Reinforcement Learning for Multimodal Medical Reasoning2 Apr
  7. 2025MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs1 Apr
  8. 2025m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models1 Apr
  9. 2025MedAgent-Pro: Towards Evidence-based Multi-modal Medical Diagnosis via Reasoning Agentic Workflow21 Mar
  10. 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models18 Mar
  11. 2025TxAgent: An AI Agent for Therapeutic Reasoning Across a Universe of Tools14 Mar
  12. 2025MedicalAgentsBench for Complex Medical Reasoning: Comparing Internalized Reasoning Models versus Externalized Agent-based Frameworks10 Mar
  13. 2025Quantifying the Reasoning Abilities of LLMs on Real-world Clinical Cases6 Mar
  14. 2025MedS3: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision21 Jan
  15. 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec
  16. 2024MedCoT: Medical Chain of Thought via Hierarchical Expert18 Dec
  17. 2024Few shot chain-of-thought driven reasoning to prompt LLMs for open ended medical question answering7 Mar
  18. 2023MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning16 Nov

Other references · 41

  1. 2023GPT-4 Technical Reportcited by 18,396
  2. 2020Measuring Massive Multitask Language Understandingcited by 7,963
  3. 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,330
  4. 2021Finetuned Language Models Are Zero-Shot Learnerscited by 3,780
  5. 2023A Survey of Large Language Modelscited by 2,576
  6. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
  7. 2024OpenAI o1 System Cardcited by 1,244
  8. 2023The Dawn of LMMs: Preliminary Explorations with GPT-4V(ision)cited by 681
  9. 2019ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmissioncited by 493
  10. 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 475
  11. 2025MedGemma Technical Reportcited by 436
  12. 2025HealthBench: Evaluating Large Language Models Towards Improved Human Healthcited by 429
29 more
  1. 2025Towards Reasoning Era: A Survey of Long Chain-of-Thought for Reasoning Large Language Modelscited by 384
  2. 2023PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answeringcited by 338
  3. 2024Capabilities of Gemini Models in Medicinecited by 237
  4. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 231
  5. 2022Large Language Models are Few-Shot Clinical Information Extractorscited by 207
  6. 2024MMedAgent: Learning to Use Medical Tools with Multi-modal Agentcited by 109
  7. 2025Medical Hallucinations in Foundation Models and Their Impact on Healthcarecited by 93
  8. 2023ClinicalGPT: Large Language Models Finetuned with Diverse Medical Data and Comprehensive Evaluationcited by 88
  9. 2025MedRAX: Medical Reasoning Agent for Chest X-raycited by 70
  10. 2025MedHELM: Holistic Evaluation of Large Language Models for Medical Taskscited by 64
  11. 2025Sequential Diagnosis with Language Modelscited by 60
  12. 2025Baichuan-M1: Pushing the Medical Capability of Large Language Modelscited by 43
  13. 2025Medical Large Language Model Benchmarks Should Prioritize Construct Validitycited by 38
  14. 2025Real-World Doctor Agent with Proactive Consultation through Multi-Agent Reinforcement Learningcited by 27
  15. 2025CARES: Comprehensive Evaluation of Safety and Adversarial Robustness in Medical LLMscited by 26
  16. 2024MedHalu: Hallucinations in Responses to Healthcare Queries by Large Language Modelscited by 21
  17. 2024Medical Multimodal Foundation Models in Clinical Diagnosis and Treatment: Applications, Challenges, and Future Directionscited by 18
  18. 2024MedAide: Information Fusion and Anatomy of Medical Intents via LLM-based Agent Collaborationcited by 16
  19. 20253MDBench: Medical Multimodal Multi-agent Dialogue Benchmarkcited by 16
  20. 2025The challenge of uncertainty quantification of large language models in medicinecited by 14
  21. 2025Tree-based RAG-Agent Recommendation System: A Case Study in Medical Test Datacited by 9
  22. 2025AUTOCT: Automating Interpretable Clinical Trial Prediction with LLM Agentscited by 9
  23. 2025Evolving Interactive Diagnostic Agents in a Virtual Clinical Environmentcited by 9
  24. 2024Ensuring Safety and Trust: Analyzing the Risks of Large Language Models in Medicinecited by 7
  25. 2025Open-Medical-R1: How to Choose Data for RLVR Training at Medicine Domaincited by 7
  26. 2025MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generationcited by 5
  27. 2025Mediator-Guided Multi-Agent Collaboration among Open-Source Models for Medical Decision-Makingcited by 5
  28. 2025Learning to Be A Doctor: Searching for Effective Medical Agent Architecturescited by 4
  29. 2023Assessing AI Impact Assessments: A Classroom Studycited by 2

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Citing papers per year: 2026: 1.

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  4. 2025Medical Reasoning in the Era of LLMs: A Systematic Review of Enhancement Techniques and Applications
  5. 2025A Survey of LLM-based Agents in Medicine: How far are we from Baymax?
  6. 2025Automating Expert-Level Medical Reasoning Evaluation of Large Language Models
  7. 2024Critique of Impure Reason: Unveiling the reasoning behaviour of medical Large Language Models
  8. 2025Medical Reasoning in LLMs: An In-Depth Analysis of DeepSeek R1