Med-U1: Incentivizing Unified Medical Reasoning in LLMs via Large-scale Reinforcement Learning
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Medical Question-Answering (QA) encompasses a broad spectrum of tasks, including multiple choice questions (MCQ), open-ended text generation, and complex computational reasoning. Despite this variety, a unified framework for delivering high-quality medical QA has yet to emerge. Although recent progress in reasoning-augmented large language models (LLMs) has shown promise, their ability to achieve comprehensive medical understanding is still largely unexplored. In this paper, we present Med-U1, a unified framework for robust reasoning across medical QA tasks with diverse output formats, ranging from MCQs to complex generation and computation tasks. Med-U1 employs pure large-scale reinforcement learning with mixed rule-based binary reward functions, incorporating a length penalty to manage output verbosity. With multi-objective reward optimization, Med-U1 directs LLMs to produce concise and verifiable reasoning chains. Empirical results reveal that Med-U1 significantly improves performance across multiple challenging Med-QA benchmarks, surpassing even larger specialized and proprietary models. Furthermore, Med-U1 demonstrates robust generalization to out-of-distribution (OOD) tasks. Extensive analysis presents insights into training strategies, reasoning chain length control, and reward design for medical LLMs. Our code is available here.
Key facts. Cited by 8 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 21 of its 32 references that are in the map. First posted on arXiv 14 Jun 2025.
Builds on
21 of 32 references.
Closest ancestors · 6
Same direction, newest first
- 2025m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models1 Apr
- 2025Med-RLVR: Emerging Medical Reasoning from a 3B base model via reinforcement Learning27 Feb
- 2025FineMedLM-o1: Enhancing Medical Knowledge Reasoning Ability of LLM from Supervised Fine-Tuning to Test-Time Training16 Jan
- 2025O1 Replication Journey -- Part 3: Inference-time Scaling for Medical Reasoning11 Jan
- 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec
- 2024MedCoT: Medical Chain of Thought via Hierarchical Expert18 Dec
Other references · 15
- 2017Proximal Policy Optimization Algorithmscited by 15,215
- 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 9,379
- 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,330
- 2024Qwen2.5 Technical Reportcited by 4,942
- 2024LlamaFactory: Unified Efficient Fine-Tuning of 100+ Language Modelscited by 1,464
- 2025s1: Simple test-time scalingcited by 1,341
- 2024OpenAI o1 System Cardcited by 1,244
- 2025Kimi k1.5: Scaling Reinforcement Learning with LLMscited by 1,210
- 2025Vision-R1: Incentivizing Reasoning Capability in Multimodal Large Language Modelscited by 665
- 2025L1: Controlling How Long A Reasoning Model Thinks With Reinforcement Learningcited by 384
- 2023A Long Way to Go: Investigating Length Correlations in RLHFcited by 291
- 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 224
3 more
- 2025Phi-4-reasoning Technical Reportcited by 151
- 2024Med-MoE: Mixture of Domain-Specific Experts for Lightweight Medical Vision-Language Modelscited by 46
- 2024Following Length Constraints in Instructionscited by 46
Built on by
Citing papers per year: 2025: 5; 2026: 3.
8 papers.
- 2025A Survey of Reinforcement Learning for Large Reasoning Modelscited by 180
- 2025Med-GLIP: Advancing Medical Language-Image Pre-training with Large-scale Grounded Datasetcited by 7
- 2026Reward Modeling for Reinforcement Learning-Based LLM Reasoning: Design, Challenges, and Evaluationcited by 7
- 2026DEEPMED: Building a Medical DeepResearch Agent via Multi-hop Med-Search Data and Turn-Controlled Agentic Training & Inferencecited by 6
- 2025Toward Clinically Explainable AI for Medical Diagnosis: A Foundation Model with Human-Compatible Reasoning via Reinforcement Learningcited by 5
- 2025On the Robustness of Answer Formats in Medical Reasoning Modelscited by 2
- 2025Scalable Stewardship of an LLM-Assisted Clinical Benchmark with Physician Oversightcited by 2
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning8 Jul 2026
- 2026Reward Modeling for Reinforcement Learning-Based LLM Reasoning: Design, Challenges, and Evaluation10 Feb 2026
- 2026DEEPMED: Building a Medical DeepResearch Agent via Multi-hop Med-Search Data and Turn-Controlled Agentic Training & Inference26 Jan 2026
- 2025Scalable Stewardship of an LLM-Assisted Clinical Benchmark with Physician Oversight22 Dec 2025
- 2025On the Robustness of Answer Formats in Medical Reasoning Models25 Sep 2025
- 2025A Survey of Reinforcement Learning for Large Reasoning Models10 Sep 2025
- 2025Toward Clinically Explainable AI for Medical Diagnosis: A Foundation Model with Human-Compatible Reasoning via Reinforcement Learning4 Sep 2025
- 2025Med-GLIP: Advancing Medical Language-Image Pre-training with Large-scale Grounded Dataset14 Aug 2025
Similar, not cited
Close in wording, no citation either way
- 2026MedRouter: Demystifying Knowledge Differences Across Medical LLMs for Routing-Based Reasoning
- 2025Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL
- 2026Medmarks: A Comprehensive Open-Source LLM Benchmark Suite for Medical Tasks
- 2024LLM-MedQA: Enhancing Medical Question Answering through Case Studies in Large Language Models
- 2025MedVLThinker: Simple Baselines for Multimodal Medical Reasoning
- 2025Med-R3: Enhancing Medical Retrieval-Augmented Reasoning of LLMs via Progressive Reinforcement Learning
- 2025Disentangling Reasoning and Knowledge in Medical Large Language Models
- 2025Reasoning LLMs in the Medical Domain: A Literature Survey