mlsanityData to 14 Oct 2026

Elicit and Enhance: Advancing Multimodal Reasoning in Medical Scenarios

arXiv 2505.23118 ↗First posted 29 May 2025cs.CL cs.AIcited by 6

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Effective clinical decision-making depends on iterative, multimodal reasoning across diverse sources of evidence. The recent emergence of multimodal reasoning models has significantly transformed the landscape of solving complex tasks. Although such models have achieved notable success in mathematics and science, their application to medical domains remains underexplored. In this work, we propose textitMedE2, a two-stage post-training pipeline that elicits and then enhances multimodal reasoning for medical domains. In Stage-I, we fine-tune models using 2,000 text-only data samples containing precisely orchestrated reasoning demonstrations to elicit reasoning behaviors. In Stage-II, we further enhance the model's reasoning capabilities using 1,500 rigorously curated multimodal medical cases, aligning model reasoning outputs with our proposed multimodal medical reasoning preference. Extensive experiments demonstrate the efficacy and reliability of textitMedE2 in improving the reasoning performance of medical multimodal models. Notably, models trained with textitMedE2 consistently outperform baselines across multiple medical multimodal benchmarks. Additional validation on larger models and under inference-time scaling further confirms the robustness and practical utility of our approach.

Key facts. Cited by 6 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 53 of its 71 references that are in the map. First posted on arXiv 29 May 2025.

Builds on

53 of 71 references.

Closest ancestors · 4

Same direction, newest first

  1. 2025GMAI-VL-R1: Harnessing Reinforcement Learning for Multimodal Medical Reasoning2 Apr
  2. 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models18 Mar
  3. 2025MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning26 Feb
  4. 2025O1 Replication Journey -- Part 3: Inference-time Scaling for Medical Reasoning11 Jan

Other references · 49

  1. 2022Training language models to follow instructions with human feedbackcited by 15,971
  2. 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,459
  3. 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 9,379
  4. 2022ReAct: Synergizing Reasoning and Acting in Language Modelscited by 8,695
  5. 2023Direct Preference Optimization: Your Language Model is Secretly a Reward Modelcited by 8,065
  6. 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,330
  7. 2023Efficient Memory Management for Large Language Model Serving with PagedAttentioncited by 5,944
  8. 2025Qwen2.5-VL Technical Reportcited by 5,587
  9. 2023Reflexion: Language Agents with Verbal Reinforcement Learningcited by 4,276
  10. 2023Let's Verify Step by Stepcited by 3,789
  11. 2023Tree of Thoughts: Deliberate Problem Solving with Large Language Modelscited by 3,211
  12. 2023InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Taskscited by 2,565
37 more
  1. 2019Fine-Tuning Language Models from Human Preferencescited by 2,150
  2. 2023MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGIcited by 2,080
  3. 2023MathVista: Evaluating Mathematical Reasoning of Foundation Models in Visual Contextscited by 1,614
  4. 2024LlamaFactory: Unified Efficient Fine-Tuning of 100+ Language Modelscited by 1,464
  5. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
  6. 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Daycited by 1,305
  7. 2024OlympiadBench: A Challenging Benchmark for Promoting AGI with Olympiad-Level Bilingual Multimodal Scientific Problemscited by 1,136
  8. 2023Math-Shepherd: Verify and Reinforce LLMs Step-by-step without Human Annotationscited by 928
  9. 2017Mastering Chess and Shogi by Self-Play with a General Reinforcement Learning Algorithmcited by 734
  10. 2023OpenFlamingo: An Open-Source Framework for Training Large Autoregressive Vision-Language Modelscited by 565
  11. 2022BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Miningcited by 538
  12. 2024MMMU-Pro: A More Robust Multi-discipline Multimodal Understanding Benchmarkcited by 512
  13. 2025LIMO: Less is More for Reasoningcited by 498
  14. 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 449
  15. 2023Med-Flamingo: a Multimodal Medical Few-shot Learnercited by 392
  16. 2025MM-Eureka: Exploring the Frontiers of Multimodal Reasoning with Rule-based Reinforcement Learningcited by 303
  17. 2023Towards Generalist Biomedical AIcited by 289
  18. 2024Is DPO Superior to PPO for LLM Alignment? A Comprehensive Studycited by 262
  19. 2024Enhancing the Reasoning Ability of Multimodal Large Language Models via Mixed Preference Optimizationcited by 239
  20. 2024Capabilities of Gemini Models in Medicinecited by 237
  21. 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 224
  22. 2023BiomedGPT: A Generalist Vision-Language Foundation Model for Diverse Biomedical Taskscited by 201
  23. 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 200
  24. 2024Sycophancy to Subterfuge: Investigating Reward-Tampering in Large Language Modelscited by 178
  25. 2024Imitate, Explore, and Self-Improve: A Reproduction Report on Slow-thinking Reasoning Systemscited by 164
  26. 2024O1 Replication Journey: A Strategic Progress Report -- Part 1cited by 143
  27. 2018Hybrid Retrieval-Generation Reinforced Agent for Medical Image Report Generationcited by 141
  28. 2025LIMR: Less is More for RL Scalingcited by 139
  29. 2024Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questionscited by 109
  30. 2024O1 Replication Journey -- Part 2: Surpassing O1-preview through Simple Distillation, Big Progress or Bitter Lesson?cited by 92
  31. 2024MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicinecited by 81
  32. 2024o1-Coder: an o1 Replication for Codingcited by 78
  33. 2023Qilin-Med-VL: Towards Chinese Large Vision-Language Model for General Healthcarecited by 62
  34. 2024Learning Planning-based Reasoning by Trajectories Collection and Process Reward Synthesizingcited by 49
  35. 2025Skywork R1V2: Multimodal Hybrid Reinforcement Learning for Reasoningcited by 49
  36. 2023Qilin-Med: Multi-stage Knowledge Injection Advanced Medical Large Language Modelcited by 24
  37. 2024Coarse-to-Fine Highlighting: Reducing Knowledge Hallucination in Large Language Modelscited by 7

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Cited by year (2026 to 14 Oct)

Citing papers per year: 2025: 2; 2026: 4.

6 papers.

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Close in wording, no citation either way

  1. 2024Inquire, Interact, and Integrate: A Proactive Agent Collaborative Framework for Zero-Shot Multimodal Medical Reasoning
  2. 2025Chiron-o1: Igniting Multimodal Large Language Models towards Generalizable Medical Reasoning via Mentor-Intern Collaborative Search
  3. 2025MedVLThinker: Simple Baselines for Multimodal Medical Reasoning
  4. 2025Med-CMR: A Fine-Grained Benchmark Integrating Visual Evidence and Clinical Logic for Medical Complex Multimodal Reasoning
  5. 2026Medical Reasoning with Large Language Models: A Survey and MR-Bench
  6. 2025Automating Expert-Level Medical Reasoning Evaluation of Large Language Models
  7. 2025MedAtlas: Evaluating LLMs for Multi-Round, Multi-Task Medical Reasoning Across Diverse Imaging Modalities and Clinical Text
  8. 2025OctoMed: Data Recipes for State-of-the-Art Multimodal Medical Reasoning