mlsanityData to 7 Oct 2026

Medical Large Language Model Benchmarks Should Prioritize Construct Validity

arXiv 2503.10694 ↗First posted 12 Mar 2025cs.CLcited by 36

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Abstract (arXiv)

Medical large language models (LLMs) research often makes bold claims, from encoding clinical knowledge to reasoning like a physician. These claims are usually backed by evaluation on competitive benchmarks; a tradition inherited from mainstream machine learning. But how do we separate real progress from a leaderboard flex? Medical LLM benchmarks, much like those in other fields, are arbitrarily constructed using medical licensing exam questions. For these benchmarks to truly measure progress, they must accurately capture the real-world tasks they aim to represent. In this position paper, we argue that medical LLM benchmarks should (and indeed can) be empirically evaluated for their construct validity. In the psychological testing literature, "construct validity" refers to the ability of a test to measure an underlying "construct", that is the actual conceptual target of evaluation. By drawing an analogy between LLM benchmarks and psychological tests, we explain how frameworks from this field can provide empirical foundations for validating benchmarks. To put these ideas into practice, we use real-world clinical data in proof-of-concept experiments to evaluate popular medical LLM benchmarks and report significant gaps in their construct validity. Finally, we outline a vision for a new ecosystem of medical LLM evaluation centered around the creation of valid benchmarks.

Key facts. Cited by 36 papers in the map (data through 7 Oct 2026). Builds on 11 of its 58 references that are in the map. First posted on arXiv 12 Mar 2025.

Builds on

11 of 58 references.

References · 11

  1. 2021Training Verifiers to Solve Math Word Problemscited by 9,743
  2. 2014ImageNet Large Scale Visual Recognition Challengecited by 8,441
  3. 2022Emergent Abilities of Large Language Modelscited by 2,483
  4. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  5. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  6. 2023Large Language Models Can Be Easily Distracted by Irrelevant Contextcited by 820
  7. 2021AI and the Everything in the Whole Wide World Benchmarkcited by 340
  8. 2023Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarizationcited by 244
  9. 2023Towards Accurate Differential Diagnosis with Large Language Modelscited by 115
  10. 2023Diagnostic Reasoning Prompts Reveal the Potential for Large Language Model Interpretability in Medicinecited by 83
  11. 2023Does progress on ImageNet transfer to real-world datasets?cited by 35

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2025: 12; 2026: 24.

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  1. 2025Measuring what Matters: Construct Validity in Large Language Model Benchmarkscited by 102
  2. 2025ER-Reason: A Benchmark Dataset for LLM Clinical Reasoning in the Emergency Roomcited by 21
  3. 2025Assessing the Chemical Intelligence of Large Language Modelscited by 14
  4. 2026Establishing Construct Validity in LLM Capability Benchmarks Requires Nomological Networkscited by 6
  5. 2026Resolution Diagnostics for Paired LLM Evaluationcited by 6
  6. 2025On Path to Multimodal Historical Reasoning: HistBench and HistAgentcited by 5
  7. 2025VERA-MH Concept Papercited by 4
  8. 2026Expert Evaluation of Clinical AI Tools on Real Point-of-Care Clinical Queriescited by 4
  9. 2025ReX-MLE: The Autonomous Agent Benchmark for Medical Imaging Challengescited by 3
  10. 2026The Persona Paradox: Medical Personas as Behavioral Priors in Clinical Language Modelscited by 3
  11. 2025When the Domain Expert Has No Time and the LLM Developer Has No Clinical Expertise: Real-World Lessons from LLM Co-Design in a Safety-Net Hospitalcited by 2
  12. 2025Reliable agent engineering should integrate machine-compatible organizational principlescited by 2
24 more
  1. 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contextscited by 1
  2. 2025Measurement as Bricolage: Examining How Data Scientists Construct Target Variables for Predictive Modeling Taskscited by 1
  3. 2025Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarkscited by 1
  4. 2026Distributional Open-Ended Evaluation of LLM Cultural Value Alignment Based on Value Codebookcited by 1
  5. 2026ContractBench: Can LLM Agents Preserve Observation Contracts?cited by 1
  6. 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
  7. 2026Do Assessment Instruments Measure the Same Thing for Humans and LLMs? A Latent Structure Analysiscited by 1
  8. 2026MTDiag: A Multi-Turn Diagnostic Dataset Towards Clinically Meaningful LLM Evaluationcited by 1
  9. 2025DeepQuestion: Systematic Generation of Real-World Challenges for Evaluating LLMs Performancecited by 0
  10. 2026Aligning Language Model Benchmarks with Pairwise Preferencescited by 0
  11. 2026Who Benchmarks the Benchmarks? A Case Study of LLM Evaluation in Icelandiccited by 0
  12. 2026BenchBrowser: Retrieving Evidence for Evaluating Benchmark Validitycited by 0
  13. 2026DepthCharge: A Domain-Agnostic Framework for Measuring Depth-Dependent Knowledge in Large Language Modelscited by 0
  14. 2026VERA-MH: Validation of Ethical and Responsible AI in Mental Healthcited by 0
  15. 2026Healthcare LLM Benchmarks Are Only as Good as Their Explicit Assumptionscited by 0
  16. 2026Evaluating the Diagnostic Robustness of Vision-Language Models Under Visual and Textual Perturbationscited by 0
  17. 2026Position: Reasoning is a Learnable Rule-Based Processcited by 0
  18. 2026Position: Medical AI Neglects Real Treatment Outcomescited by 0
  19. 2026Frontier AI Forecasting Has a Measurement Problem: An Audit of Progress Evidencecited by 0
  20. 2026An Investigation of the NeurIPS and ICML 2025 Position Trackscited by 0
  21. 2026One Perturbation Is Not Enough: Identifiability and Blind Baselines for Behavioral AI Evaluationcited by 0
  22. 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmarkcited by 0
  23. 2026Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Expertscited by 0
  24. 2026A rubric landscape for evaluating clinical reasoning in large language models: what exists, what is missing, and what needs to be combinedcited by 0