Medical Large Language Model Benchmarks Should Prioritize Construct Validity
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Abstract (arXiv)
Medical large language models (LLMs) research often makes bold claims, from encoding clinical knowledge to reasoning like a physician. These claims are usually backed by evaluation on competitive benchmarks; a tradition inherited from mainstream machine learning. But how do we separate real progress from a leaderboard flex? Medical LLM benchmarks, much like those in other fields, are arbitrarily constructed using medical licensing exam questions. For these benchmarks to truly measure progress, they must accurately capture the real-world tasks they aim to represent. In this position paper, we argue that medical LLM benchmarks should (and indeed can) be empirically evaluated for their construct validity. In the psychological testing literature, "construct validity" refers to the ability of a test to measure an underlying "construct", that is the actual conceptual target of evaluation. By drawing an analogy between LLM benchmarks and psychological tests, we explain how frameworks from this field can provide empirical foundations for validating benchmarks. To put these ideas into practice, we use real-world clinical data in proof-of-concept experiments to evaluate popular medical LLM benchmarks and report significant gaps in their construct validity. Finally, we outline a vision for a new ecosystem of medical LLM evaluation centered around the creation of valid benchmarks.
Key facts. Cited by 36 papers in the map (data through 7 Oct 2026). Builds on 11 of its 58 references that are in the map. First posted on arXiv 12 Mar 2025.
Builds on
11 of 58 references.
References · 11
- 2021Training Verifiers to Solve Math Word Problemscited by 9,743
- 2014ImageNet Large Scale Visual Recognition Challengecited by 8,441
- 2022Emergent Abilities of Large Language Modelscited by 2,483
- 2022Large Language Models Encode Clinical Knowledgecited by 1,807
- 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
- 2023Large Language Models Can Be Easily Distracted by Irrelevant Contextcited by 820
- 2021AI and the Everything in the Whole Wide World Benchmarkcited by 340
- 2023Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarizationcited by 244
- 2023Towards Accurate Differential Diagnosis with Large Language Modelscited by 115
- 2023Diagnostic Reasoning Prompts Reveal the Potential for Large Language Model Interpretability in Medicinecited by 83
- 2023Does progress on ImageNet transfer to real-world datasets?cited by 35
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Citing papers per year: 2025: 12; 2026: 24.
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- 2025Measuring what Matters: Construct Validity in Large Language Model Benchmarkscited by 102
- 2025ER-Reason: A Benchmark Dataset for LLM Clinical Reasoning in the Emergency Roomcited by 21
- 2025Assessing the Chemical Intelligence of Large Language Modelscited by 14
- 2026Establishing Construct Validity in LLM Capability Benchmarks Requires Nomological Networkscited by 6
- 2026Resolution Diagnostics for Paired LLM Evaluationcited by 6
- 2025On Path to Multimodal Historical Reasoning: HistBench and HistAgentcited by 5
- 2025VERA-MH Concept Papercited by 4
- 2026Expert Evaluation of Clinical AI Tools on Real Point-of-Care Clinical Queriescited by 4
- 2025ReX-MLE: The Autonomous Agent Benchmark for Medical Imaging Challengescited by 3
- 2026The Persona Paradox: Medical Personas as Behavioral Priors in Clinical Language Modelscited by 3
- 2025When the Domain Expert Has No Time and the LLM Developer Has No Clinical Expertise: Real-World Lessons from LLM Co-Design in a Safety-Net Hospitalcited by 2
- 2025Reliable agent engineering should integrate machine-compatible organizational principlescited by 2
24 more
- 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contextscited by 1
- 2025Measurement as Bricolage: Examining How Data Scientists Construct Target Variables for Predictive Modeling Taskscited by 1
- 2025Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarkscited by 1
- 2026Distributional Open-Ended Evaluation of LLM Cultural Value Alignment Based on Value Codebookcited by 1
- 2026ContractBench: Can LLM Agents Preserve Observation Contracts?cited by 1
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
- 2026Do Assessment Instruments Measure the Same Thing for Humans and LLMs? A Latent Structure Analysiscited by 1
- 2026MTDiag: A Multi-Turn Diagnostic Dataset Towards Clinically Meaningful LLM Evaluationcited by 1
- 2025DeepQuestion: Systematic Generation of Real-World Challenges for Evaluating LLMs Performancecited by 0
- 2026Aligning Language Model Benchmarks with Pairwise Preferencescited by 0
- 2026Who Benchmarks the Benchmarks? A Case Study of LLM Evaluation in Icelandiccited by 0
- 2026BenchBrowser: Retrieving Evidence for Evaluating Benchmark Validitycited by 0
- 2026DepthCharge: A Domain-Agnostic Framework for Measuring Depth-Dependent Knowledge in Large Language Modelscited by 0
- 2026VERA-MH: Validation of Ethical and Responsible AI in Mental Healthcited by 0
- 2026Healthcare LLM Benchmarks Are Only as Good as Their Explicit Assumptionscited by 0
- 2026Evaluating the Diagnostic Robustness of Vision-Language Models Under Visual and Textual Perturbationscited by 0
- 2026Position: Reasoning is a Learnable Rule-Based Processcited by 0
- 2026Position: Medical AI Neglects Real Treatment Outcomescited by 0
- 2026Frontier AI Forecasting Has a Measurement Problem: An Audit of Progress Evidencecited by 0
- 2026An Investigation of the NeurIPS and ICML 2025 Position Trackscited by 0
- 2026One Perturbation Is Not Enough: Identifiability and Blind Baselines for Behavioral AI Evaluationcited by 0
- 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmarkcited by 0
- 2026Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Expertscited by 0
- 2026A rubric landscape for evaluating clinical reasoning in large language models: what exists, what is missing, and what needs to be combinedcited by 0
- 2026A rubric landscape for evaluating clinical reasoning in large language models: what exists, what is missing, and what needs to be combined1 Oct 2026
- 2026Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Experts29 Sep 2026
- 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmark24 Sep 2026
- 2026One Perturbation Is Not Enough: Identifiability and Blind Baselines for Behavioral AI Evaluation5 Sep 2026
- 2026MTDiag: A Multi-Turn Diagnostic Dataset Towards Clinically Meaningful LLM Evaluation25 Aug 2026
- 2026Do Assessment Instruments Measure the Same Thing for Humans and LLMs? A Latent Structure Analysis16 Aug 2026
- 2026Frontier AI Forecasting Has a Measurement Problem: An Audit of Progress Evidence14 Aug 2026
- 2026Evaluating the Diagnostic Robustness of Vision-Language Models Under Visual and Textual Perturbations5 Aug 2026
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning8 Jul 2026
- 2026An Investigation of the NeurIPS and ICML 2025 Position Tracks6 Jul 2026
- 2026Position: Medical AI Neglects Real Treatment Outcomes28 Jun 2026
- 2026Expert Evaluation of Clinical AI Tools on Real Point-of-Care Clinical Queries27 Jun 2026
24 more
- 2026Position: Reasoning is a Learnable Rule-Based Process29 May 2026
- 2026Resolution Diagnostics for Paired LLM Evaluation28 May 2026
- 2026Healthcare LLM Benchmarks Are Only as Good as Their Explicit Assumptions21 May 2026
- 2026ContractBench: Can LLM Agents Preserve Observation Contracts?17 May 2026
- 2026VERA-MH: Validation of Ethical and Responsible AI in Mental Health13 May 2026
- 2026Who Benchmarks the Benchmarks? A Case Study of LLM Evaluation in Icelandic17 Mar 2026
- 2026Distributional Open-Ended Evaluation of LLM Cultural Value Alignment Based on Value Codebook16 Mar 2026
- 2026Establishing Construct Validity in LLM Capability Benchmarks Requires Nomological Networks16 Mar 2026
- 2026DepthCharge: A Domain-Agnostic Framework for Measuring Depth-Dependent Knowledge in Large Language Models5 Mar 2026
- 2026BenchBrowser: Retrieving Evidence for Evaluating Benchmark Validity25 Feb 2026
- 2026Aligning Language Model Benchmarks with Pairwise Preferences2 Feb 2026
- 2026The Persona Paradox: Medical Personas as Behavioral Priors in Clinical Language Models8 Jan 2026
- 2025ReX-MLE: The Autonomous Agent Benchmark for Medical Imaging Challenges19 Dec 2025
- 2025Reliable agent engineering should integrate machine-compatible organizational principles8 Dec 2025
- 2025Measuring what Matters: Construct Validity in Large Language Model Benchmarks3 Nov 2025
- 2025VERA-MH Concept Paper17 Oct 2025
- 2025Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarks29 Sep 2025
- 2025When the Domain Expert Has No Time and the LLM Developer Has No Clinical Expertise: Real-World Lessons from LLM Co-Design in a Safety-Net Hospital11 Aug 2025
- 2025Measurement as Bricolage: Examining How Data Scientists Construct Target Variables for Predictive Modeling Tasks3 Jul 2025
- 2025DeepQuestion: Systematic Generation of Real-World Challenges for Evaluating LLMs Performance30 May 2025
- 2025ER-Reason: A Benchmark Dataset for LLM Clinical Reasoning in the Emergency Room28 May 2025
- 2025On Path to Multimodal Historical Reasoning: HistBench and HistAgent26 May 2025
- 2025Assessing the Chemical Intelligence of Large Language Models12 May 2025
- 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contexts5 May 2025
- 2025ER-Reason: A Benchmark Dataset for LLM Clinical Reasoning in the Emergency Roomcited by 21
- 2025Assessing the Chemical Intelligence of Large Language Modelscited by 14
- 2025On Path to Multimodal Historical Reasoning: HistBench and HistAgentcited by 5
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
- 2026A rubric landscape for evaluating clinical reasoning in large language models: what exists, what is missing, and what needs to be combinedcited by 0
- 2026A rubric landscape for evaluating clinical reasoning in large language models: what exists, what is missing, and what needs to be combined1 Oct 2026
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning8 Jul 2026
- 2025ER-Reason: A Benchmark Dataset for LLM Clinical Reasoning in the Emergency Room28 May 2025
- 2025On Path to Multimodal Historical Reasoning: HistBench and HistAgent26 May 2025
- 2025Assessing the Chemical Intelligence of Large Language Models12 May 2025
- 2025Measuring what Matters: Construct Validity in Large Language Model Benchmarkscited by 102
- 2026Establishing Construct Validity in LLM Capability Benchmarks Requires Nomological Networkscited by 6
- 2026Resolution Diagnostics for Paired LLM Evaluationcited by 6
- 2025VERA-MH Concept Papercited by 4
- 2026Expert Evaluation of Clinical AI Tools on Real Point-of-Care Clinical Queriescited by 4
- 2026The Persona Paradox: Medical Personas as Behavioral Priors in Clinical Language Modelscited by 3
- 2025When the Domain Expert Has No Time and the LLM Developer Has No Clinical Expertise: Real-World Lessons from LLM Co-Design in a Safety-Net Hospitalcited by 2
- 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contextscited by 1
- 2025Measurement as Bricolage: Examining How Data Scientists Construct Target Variables for Predictive Modeling Taskscited by 1
- 2025Measuring Competency, Not Performance: Item-Aware Evaluation Across Medical Benchmarkscited by 1
- 2026Distributional Open-Ended Evaluation of LLM Cultural Value Alignment Based on Value Codebookcited by 1
- 2026Do Assessment Instruments Measure the Same Thing for Humans and LLMs? A Latent Structure Analysiscited by 1
12 most cited of 26 All 26 (JSON)
- 2026Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Experts29 Sep 2026
- 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmark24 Sep 2026
- 2026One Perturbation Is Not Enough: Identifiability and Blind Baselines for Behavioral AI Evaluation5 Sep 2026
- 2026MTDiag: A Multi-Turn Diagnostic Dataset Towards Clinically Meaningful LLM Evaluation25 Aug 2026
- 2026Do Assessment Instruments Measure the Same Thing for Humans and LLMs? A Latent Structure Analysis16 Aug 2026
- 2026Frontier AI Forecasting Has a Measurement Problem: An Audit of Progress Evidence14 Aug 2026
- 2026An Investigation of the NeurIPS and ICML 2025 Position Tracks6 Jul 2026
- 2026Position: Medical AI Neglects Real Treatment Outcomes28 Jun 2026
- 2026Expert Evaluation of Clinical AI Tools on Real Point-of-Care Clinical Queries27 Jun 2026
- 2026Position: Reasoning is a Learnable Rule-Based Process29 May 2026
- 2026Resolution Diagnostics for Paired LLM Evaluation28 May 2026
- 2026Healthcare LLM Benchmarks Are Only as Good as Their Explicit Assumptions21 May 2026
12 newest of 26 All 26 (JSON)