Open-Medical-R1: How to Choose Data for RLVR Training at Medicine Domain
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Abstract (arXiv)
This paper explores optimal data selection strategies for Reinforcement Learning with Verified Rewards (RLVR) training in the medical domain. While RLVR has shown exceptional potential for enhancing reasoning capabilities in large language models, most prior implementations have focused on mathematics and logical puzzles, with limited exploration of domain-specific applications like medicine. We investigate four distinct data sampling strategies from MedQA-USMLE: random sampling (baseline), and filtering using Phi-4, Gemma-3-27b-it, and Gemma-3-12b-it models. Using Gemma-3-12b-it as our base model and implementing Group Relative Policy Optimization (GRPO), we evaluate performance across multiple benchmarks including MMLU, GSM8K, MMLU-Pro, and CMMLU. Our findings demonstrate that models trained on filtered data generally outperform those trained on randomly selected samples. Notably, training on self-filtered samples (using Gemma-3-12b-it for filtering) achieved superior performance in medical domains but showed reduced robustness across different benchmarks, while filtering with larger models from the same series yielded better overall robustness. These results provide valuable insights into effective data organization strategies for RLVR in specialized domains and highlight the importance of thoughtful data selection in achieving optimal performance. You can access our repository (https://github.com/Qsingle/open-medical-r1) to get the codes.
Key facts. Cited by 7 papers in the map (data through 14 Oct 2026). Builds on 19 of its 25 references that are in the map. First posted on arXiv 16 Apr 2025.
Builds on
19 of 25 references.
References · 19
- 2021Training Verifiers to Solve Math Word Problemscited by 10,109
- 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 9,379
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- 2024Phi-4 Technical Reportcited by 711
7 more
- 2025SimpleRL-Zoo: Investigating and Taming Zero Reinforcement Learning for Open Base Models in the Wildcited by 511
- 2025Open-Reasoner-Zero: An Open Source Approach to Scaling Up Reinforcement Learning on the Base Modelcited by 461
- 2024ReFT: Reasoning with Reinforced Fine-Tuningcited by 239
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- 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Modelscited by 144
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Citing papers per year: 2025: 2; 2026: 5.
7 papers.
- 2025A Survey of Reinforcement Learning for Large Reasoning Modelscited by 180
- 2025Training LLMs for EHR-Based Reasoning Tasks via Reinforcement Learningcited by 14
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
- 2026RexDrug: Reliable Multi-Drug Combination Extraction through Reasoning-Enhanced LLMscited by 0
- 2026HEALing Entropy Collapse: Enhancing Exploration in Few-Shot RLVR via Hybrid-Domain Entropy Dynamics Alignmentcited by 0
- 2026Pen-Strategist: A Reasoning Framework for Penetration Testing Strategy Formation and Analysiscited by 0
- 2026Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Modelscited by 0
- 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning8 Jul 2026
- 2026Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Models3 Jul 2026
- 2026Pen-Strategist: A Reasoning Framework for Penetration Testing Strategy Formation and Analysis6 May 2026
- 2026HEALing Entropy Collapse: Enhancing Exploration in Few-Shot RLVR via Hybrid-Domain Entropy Dynamics Alignment20 Apr 2026
- 2026RexDrug: Reliable Multi-Drug Combination Extraction through Reasoning-Enhanced LLMs9 Mar 2026
- 2025A Survey of Reinforcement Learning for Large Reasoning Models10 Sep 2025
- 2025Training LLMs for EHR-Based Reasoning Tasks via Reinforcement Learning30 May 2025
Similar, not cited
Close in wording, no citation either way
- 2025MedGR2: Breaking the Data Barrier for Medical Reasoning via Generative Reward Learning
- 2025Fleming-R1: Toward Expert-Level Medical Reasoning via Reinforcement Learning
- 2021Model Selection for Offline Reinforcement Learning: Practical Considerations for Healthcare Settings
- 2025Toward Effective Reinforcement Learning Fine-Tuning for Medical VQA in Vision-Language Models
- 2025Clinical-R1: Empowering Large Language Models for Faithful and Comprehensive Reasoning with Clinical Objective Relative Policy Optimization
- 2025Benchmark Success, Clinical Failure: When Reinforcement Learning Optimizes for Benchmarks, Not Patients
- 2026DataFlex-RL: An Evaluation Platform for RLVR Data Policies
- 2025Towards High Data Efficiency in Reinforcement Learning with Verifiable Reward