mlsanityData to 14 Oct 2026

m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models

arXiv 2504.00869 ↗First posted 1 Apr 2025cs.CL cs.AIcited by 46

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Test-time scaling has emerged as a powerful technique for enhancing the reasoning capabilities of large language models. However, its effectiveness in medical reasoning remains uncertain, as the medical domain fundamentally differs from mathematical tasks in terms of knowledge representation and decision-making processes. In this paper, we provide the first comprehensive investigation of test-time scaling for medical reasoning and present m1, a simple yet effective approach that increases a model's medical reasoning capability at inference. Our evaluation across diverse medical tasks demonstrates that test-time scaling consistently enhances medical reasoning, enabling lightweight fine-tuned models under 10B parameters to establish new state-of-the-art performance, while our 32B model rivals previous 70B-scale medical LLMs. However, we identify an optimal reasoning token budget of approximately 4K, beyond which performance may degrade due to overthinking. Budget forcing, which extends test-time computation through iterative prompts, helps models double-check answers but does not necessarily improve the overall medical QA performance and, in some cases, even introduces errors into previously correct responses. Our case-by-case analysis identifies insufficient medical knowledge as a key bottleneck that prevents further performance gains through test-time scaling. We find that increasing data scale, improving data quality, and expanding model capacity consistently enhance medical knowledge grounding, enabling continued performance improvements, particularly on challenging medical benchmarks where smaller models reach saturation. These findings underscore fundamental differences between medical and mathematical reasoning in LLMs, highlighting that enriched medical knowledge, other than increased reasoning depth alone, is essential for realizing the benefits of test-time scaling.

Key facts. Cited by 46 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 24 of its 42 references that are in the map. First posted on arXiv 1 Apr 2025.

Builds on

24 of 42 references.

Closest ancestors · 1

Same direction, newest first

  1. 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec

Other references · 23

  1. 2023GPT-4 Technical Reportcited by 18,396
  2. 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,459
  3. 2024Qwen2.5 Technical Reportcited by 4,942
  4. 2024GPT-4o System Cardcited by 4,588
  5. 2023GPQA: A Graduate-Level Google-Proof Q&A Benchmarkcited by 2,879
  6. 2024MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmarkcited by 1,848
  7. 2022Large Language Models Encode Clinical Knowledgecited by 1,830
  8. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
  9. 2025s1: Simple test-time scalingcited by 1,341
  10. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,288
  11. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 543
  12. 2025Open-Reasoner-Zero: An Open Source Approach to Scaling Up Reinforcement Learning on the Base Modelcited by 461
11 more
  1. 2025L1: Controlling How Long A Reasoning Model Thinks With Reinforcement Learningcited by 384
  2. 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 224
  3. 2025Towards Thinking-Optimal Scaling of Test-Time Compute for LLM Reasoningcited by 119
  4. 2024Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questionscited by 109
  5. 2019HEAD-QA: A Healthcare Dataset for Complex Reasoningcited by 101
  6. 2024Towards Building Multilingual Language Model for Medicinecited by 92
  7. 2024Med42-v2: A Suite of Clinical LLMscited by 90
  8. 2024UltraMedical: Building Specialized Generalists in Biomedicinecited by 67
  9. 2024Improving Retrieval-Augmented Generation in Medicine with Iterative Follow-up Questionscited by 54
  10. 2024A Preliminary Study of o1 in Medicine: Are We Closer to an AI Doctor?cited by 33
  11. 2023DeepScaler: Holistic Autoscaling for Microservices Based on Spatiotemporal GNN with Adaptive Graph Learningcited by 7

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Cited by year (2026 to 14 Oct)

Citing papers per year: 2025: 24; 2026: 22.

46 papers.

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  1. 2025Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RLcited by 36
  2. 2025MedFrameQA: A Multi-Image Medical VQA Benchmark for Clinical Reasoningcited by 34
  3. 2025X-Reasoner: Towards Generalizable Reasoning Across Modalities and Domainscited by 31
  4. 2025MedVLThinker: Simple Baselines for Multimodal Medical Reasoningcited by 27
  5. 2025MedAgentGym: A Scalable Agentic Training Environment for Code-Centric Reasoning in Biomedical Data Sciencecited by 23
  6. 2025Disentangling Reasoning and Knowledge in Medical Large Language Modelscited by 18
  7. 2025Beyond Log Likelihood: Probability-Based Objectives for Supervised Fine-Tuning across the Model Capability Continuumcited by 18
  8. 2025Knowledge or Reasoning? A Close Look at How LLMs Think Across Domainscited by 14
  9. 2025InfiMed-ORBIT: Aligning LLMs on Open-Ended Complex Tasks via Rubric-Based Incremental Trainingcited by 12
  10. 2025Medical Reasoning in the Era of LLMs: A Systematic Review of Enhancement Techniques and Applicationscited by 10
  11. 2026Recursive Multi-Agent Systemscited by 10
  12. 2025Revisiting Test-Time Scaling: A Survey and a Diversity-Aware Method for Efficient Reasoningcited by 9
34 more
  1. 2025Med-U1: Incentivizing Unified Medical Reasoning in LLMs via Large-scale Reinforcement Learningcited by 8
  2. 2026Beyond Accuracy: Evaluating Visual Grounding In Multimodal Medical Reasoningcited by 7
  3. 2026How Inference Compute Shapes Frontier LLM Evaluationcited by 7
  4. 2026From Chatbot to Digital Colleague: The Paradigm Shift Toward Persistent Autonomous AIcited by 6
  5. 2026Improving Clinical Diagnosis with Counterfactual Multi-Agent Reasoningcited by 5
  6. 2025SSR: Speculative Parallel Scaling Reasoning in Test-timecited by 4
  7. 2025Learning a Continue-Thinking Token for Enhanced Test-Time Scalingcited by 4
  8. 2025Understanding the Role of Training Data in Test-Time Scalingcited by 4
  9. 2026Medical Reasoning with Large Language Models: A Survey and MR-Benchcited by 4
  10. 2026ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoningcited by 4
  11. 2025Rethinking Test-Time Scaling for Medical AI: Model and Task-Aware Strategies for LLMs and VLMscited by 3
  12. 2025Towards Efficient Medical Reasoning with Minimal Fine-Tuning Datacited by 3
  13. 2026Gradients Must Earn Their Influence: Unifying SFT with Generalized Entropic Objectivescited by 3
  14. 2026Theoretical Perspectives on Data Quality and Synergistic Effects in Pre- and Post-Training Reasoning Modelscited by 3
  15. 2026MedAction: Towards Active Multi-turn Clinical Diagnostic LLMscited by 3
  16. 2025On the Robustness of Answer Formats in Medical Reasoning Modelscited by 2
  17. 2025AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantificationcited by 2
  18. 2025Synthesizing High-Quality Visual Question Answering from Medical Documents with Generator-Verifier LMMscited by 2
  19. 2025Follow the Path: Reasoning over Knowledge Graph Paths to Improve Large Language Model Factualitycited by 1
  20. 2025Pedagogy-R1: Pedagogically-Aligned Reasoning Model with Balanced Educational Benchmarkcited by 1
  21. 2025ClinBench-HPB: A Clinical Benchmark for Evaluating LLMs in Hepato-Pancreato-Biliary Diseasescited by 1
  22. 2026MedVerse: Efficient and Reliable Medical Reasoning via DAG-Structured Parallel Executioncited by 1
  23. 2026Process Reward Agents for Steering Knowledge-Intensive Reasoningcited by 1
  24. 2026Eliciting Medical Reasoning with Knowledge-enhanced Data Synthesis: A Semi-Supervised Reinforcement Learning Approachcited by 1
  25. 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
  26. 2025TimeHC-RL: Temporal-aware Hierarchical Cognitive Reinforcement Learning for Enhancing LLMs' Social Intelligencecited by 0
  27. 2026MAPLE: Elevating Medical Reasoning from Statistical Consensus to Process-Led Alignmentcited by 0
  28. 2026A Unifying Lens on Supervised Fine-Tuning Through Target Distribution Designcited by 0
  29. 2026eCREAM-MedCorpus A Large-Scale Corpus of Clinical Notes for Italiancited by 0
  30. 2026Recovering General Capabilities via Uncertainty-Calibrated Multi-Teacher On-Policy Distillationcited by 0
  31. 2026Fathom-Vaidya: Advancing Medical Reasoning with Rubric-Based Rewardscited by 0
  32. 2026SAGE: Semantic Anchor-Guided Evolution for Grounded Medical QA Data Synthesiscited by 0
  33. 2026Beyond Domain-Routed Supervision: Cross-Teacher Guarding for Multi-Teacher On-Policy Distillationcited by 0
  34. 2026Geometric Calibration of Supervised Fine-Tuningcited by 0

Similar, not cited

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  1. 2025O1 Replication Journey -- Part 3: Inference-time Scaling for Medical Reasoning
  2. 2025Automating Expert-Level Medical Reasoning Evaluation of Large Language Models
  3. 2025MedOmni-45deg: A Safety-Performance Benchmark for Reasoning-Oriented LLMs in Medicine
  4. 2026MedCoG: Maximizing LLM Inference Density in Medical Reasoning via Meta-Cognitive Regulation
  5. 2025Exploring Efficiency Frontiers of Thinking Budget in Medical Reasoning: Scaling Laws between Computational Resources and Reasoning Quality
  6. 2024Critique of Impure Reason: Unveiling the reasoning behaviour of medical Large Language Models
  7. 2026Medmarks: A Comprehensive Open-Source LLM Benchmark Suite for Medical Tasks
  8. 2026Advances in LLM Reasoning Enable Flexibility in Clinical Problem-Solving