m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Test-time scaling has emerged as a powerful technique for enhancing the reasoning capabilities of large language models. However, its effectiveness in medical reasoning remains uncertain, as the medical domain fundamentally differs from mathematical tasks in terms of knowledge representation and decision-making processes. In this paper, we provide the first comprehensive investigation of test-time scaling for medical reasoning and present m1, a simple yet effective approach that increases a model's medical reasoning capability at inference. Our evaluation across diverse medical tasks demonstrates that test-time scaling consistently enhances medical reasoning, enabling lightweight fine-tuned models under 10B parameters to establish new state-of-the-art performance, while our 32B model rivals previous 70B-scale medical LLMs. However, we identify an optimal reasoning token budget of approximately 4K, beyond which performance may degrade due to overthinking. Budget forcing, which extends test-time computation through iterative prompts, helps models double-check answers but does not necessarily improve the overall medical QA performance and, in some cases, even introduces errors into previously correct responses. Our case-by-case analysis identifies insufficient medical knowledge as a key bottleneck that prevents further performance gains through test-time scaling. We find that increasing data scale, improving data quality, and expanding model capacity consistently enhance medical knowledge grounding, enabling continued performance improvements, particularly on challenging medical benchmarks where smaller models reach saturation. These findings underscore fundamental differences between medical and mathematical reasoning in LLMs, highlighting that enriched medical knowledge, other than increased reasoning depth alone, is essential for realizing the benefits of test-time scaling.
Key facts. Cited by 46 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 24 of its 42 references that are in the map. First posted on arXiv 1 Apr 2025.
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24 of 42 references.
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Other references · 23
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- 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
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- 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,288
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- 2024Improving Retrieval-Augmented Generation in Medicine with Iterative Follow-up Questionscited by 54
- 2024A Preliminary Study of o1 in Medicine: Are We Closer to an AI Doctor?cited by 33
- 2023DeepScaler: Holistic Autoscaling for Microservices Based on Spatiotemporal GNN with Adaptive Graph Learningcited by 7
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- 2026Theoretical Perspectives on Data Quality and Synergistic Effects in Pre- and Post-Training Reasoning Models1 Mar 2026
- 2026MedVerse: Efficient and Reliable Medical Reasoning via DAG-Structured Parallel Execution7 Feb 2026
- 2025Understanding the Role of Training Data in Test-Time Scaling4 Oct 2025
- 2025AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantification29 Sep 2025
- 2025On the Robustness of Answer Formats in Medical Reasoning Models25 Sep 2025
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- 2026eCREAM-MedCorpus A Large-Scale Corpus of Clinical Notes for Italian10 Jun 2026
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- 2026Beyond Accuracy: Evaluating Visual Grounding In Multimodal Medical Reasoning3 Mar 2026
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