mlsanityData to 7 Oct 2026

MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoning

arXiv 2506.00555 ↗First posted 31 May 2025cs.LG cs.AI cs.CLcited by 37

On the map: LLM reasoning → Clinical and biomedical applications

also in 2 more
Abstract (arXiv)

Medical Large Vision-Language Models (Med-LVLMs) have shown strong potential in multimodal diagnostic tasks. However, existing single-agent models struggle to generalize across diverse medical specialties, limiting their performance. Recent efforts introduce multi-agent collaboration frameworks inspired by clinical workflows, where general practitioners (GPs) and specialists interact in a fixed sequence. Despite improvements, these static pipelines lack flexibility and adaptability in reasoning. To address this, we propose MMedAgent-RL, a reinforcement learning (RL)-based multi-agent framework that enables dynamic, optimized collaboration among medical agents. Specifically, we train two GP agents based on Qwen2.5-VL via RL: the triage doctor learns to assign patients to appropriate specialties, while the attending physician integrates the judgments from multi-specialists and its own knowledge to make final decisions. To address the inconsistency in specialist outputs, we introduce a curriculum learning (CL)-guided RL strategy with dynamic entropy regulation, progressively teaching the attending physician to balance between imitating specialists and correcting their mistakes. Experiments on five medical VQA benchmarks demonstrate that MMedAgent-RL outperforms both open-source and proprietary Med-LVLMs. Notably, it achieves an average performance gain of 23.6% over strong baselines.

Key facts. Cited by 37 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 62 of its 77 references that are in the map. First posted on arXiv 31 May 2025.

Builds on

62 of 77 references.

Closest ancestors · 4

Same direction, newest first

  1. 2025GMAI-VL-R1: Harnessing Reinforcement Learning for Multimodal Medical Reasoning2 Apr
  2. 2025MedicalAgentsBench for Complex Medical Reasoning: Comparing Internalized Reasoning Models versus Externalized Agent-based Frameworks10 Mar
  3. 2025MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning26 Feb
  4. 2023MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning16 Nov

Other references · 58

  1. 2022Training language models to follow instructions with human feedbackcited by 15,712
  2. 2017Proximal Policy Optimization Algorithmscited by 14,441
  3. 2023Visual Instruction Tuningcited by 7,792
  4. 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,146
  5. 2023Efficient Memory Management for Large Language Model Serving with PagedAttentioncited by 5,767
  6. 2022Self-Consistency Improves Chain of Thought Reasoning in Language Modelscited by 5,601
  7. 2025Qwen2.5-VL Technical Reportcited by 5,418
  8. 2023Improved Baselines with Visual Instruction Tuningcited by 4,362
  9. 2017Deep reinforcement learning from human preferencescited by 3,846
  10. 2023InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Taskscited by 2,534
  11. 2023Qwen-VL: A Versatile Vision-Language Model for Understanding, Localization, Text Reading, and Beyondcited by 2,179
  12. 2019Fine-Tuning Language Models from Human Preferencescited by 2,124
38 more
  1. 2023MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGIcited by 2,044
  2. 2024Scaling LLM Test-Time Compute Optimally can be More Effective than Scaling Model Parameterscited by 1,928
  3. 2023AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversationcited by 1,906
  4. 2023MetaGPT: Meta Programming for A Multi-Agent Collaborative Frameworkcited by 1,761
  5. 2024Expanding Performance Boundaries of Open-Source Multimodal Models with Model, Data, and Test-Time Scalingcited by 1,573
  6. 2023CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Societycited by 1,348
  7. 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Daycited by 1,287
  8. 2025Kimi k1.5: Scaling Reinforcement Learning with LLMscited by 1,193
  9. 2024Yi: Open Foundation Models by 01.AIcited by 706
  10. 2025VLM-R1: A Stable and Generalizable R1-style Large Vision-Language Modelcited by 515
  11. 2025Visual-RFT: Visual Reinforcement Fine-Tuningcited by 501
  12. 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
  13. 2025The Entropy Mechanism of Reinforcement Learning for Reasoning Language Modelscited by 463
  14. 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
  15. 2024Training Language Models to Self-Correct via Reinforcement Learningcited by 405
  16. 2024AFlow: Automating Agentic Workflow Generationcited by 395
  17. 2023Med-Flamingo: a Multimodal Medical Few-shot Learnercited by 387
  18. 2020Curriculum Learning for Reinforcement Learning Domains: A Framework and Surveycited by 350
  19. 2025Demystifying Long Chain-of-Thought Reasoning in LLMscited by 323
  20. 2025VL-Rethinker: Incentivizing Self-Reflection of Vision-Language Models with Reinforcement Learningcited by 315
  21. 2025MM-Eureka: Exploring the Frontiers of Multimodal Reasoning with Rule-based Reinforcement Learningcited by 294
  22. 2023Towards Generalist Biomedical AIcited by 286
  23. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 215
  24. 2024Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agentscited by 210
  25. 2025SFT or RL? An Early Investigation into Training R1-Like Reasoning Large Vision-Language Modelscited by 209
  26. 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 194
  27. 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLMcited by 182
  28. 2023Towards Generalist Foundation Model for Radiology by Leveraging Web-scale 2D&3D Medical Datacited by 176
  29. 2025R1-Zero's "Aha Moment" in Visual Reasoning on a 2B Non-SFT Modelcited by 163
  30. 2024MDAgents: An Adaptive Collaboration of LLMs for Medical Decision-Makingcited by 162
  31. 2024MMedAgent: Learning to Use Medical Tools with Multi-modal Agentcited by 108
  32. 2024AI Hospital: Benchmarking Large Language Models in a Multi-agent Medical Interaction Simulatorcited by 99
  33. 2024MMed-RAG: Versatile Multimodal RAG System for Medical Vision Language Modelscited by 84
  34. 2025Boosting the Generalization and Reasoning of Vision Language Models with Curriculum Reinforcement Learningcited by 71
  35. 2025MDocAgent: A Multi-Modal Multi-Agent Framework for Document Understandingcited by 66
  36. 2014Curriculum Learning of Multiple Taskscited by 65
  37. 2024CARES: A Comprehensive Benchmark of Trustworthiness in Medical Vision Language Modelscited by 64
  38. 2023Qilin-Med-VL: Towards Chinese Large Vision-Language Model for General Healthcarecited by 62

50 most cited of 58 All 58 (JSON)

Built on by

Cited by year (2026 to 7 Oct)

Citing papers per year: 2025: 19; 2026: 18.

37 papers.

Sort:

By area:

  1. 2025The Landscape of Agentic Reinforcement Learning for LLMs: A Surveycited by 195
  2. 2025Thinking with Images for Multimodal Reasoning: Foundations, Methods, and Future Frontierscited by 193
  3. 2025A Survey of Reinforcement Learning for Large Reasoning Modelscited by 175
  4. 2025Agent0: Unleashing Self-Evolving Agents from Zero Data via Tool-Integrated Reasoningcited by 68
  5. 2026When Single-Agent with Skills Replace Multi-Agent Systems and When They Failcited by 34
  6. 2025MedAgentGym: A Scalable Agentic Training Environment for Code-Centric Reasoning in Biomedical Data Sciencecited by 22
  7. 2025PathAgent: Toward Interpretable Analysis of Whole-slide Pathology Images via Large Language Model-based Agentic Reasoningcited by 18
  8. 2025PhysUniBench: A Multi-Modal Physics Reasoning Benchmark at Undergraduate Levelcited by 14
  9. 2025UniShield: An Adaptive Multi-Agent Framework for Unified Forgery Image Detection and Localizationcited by 9
  10. 2025Ophiuchus: Incentivizing Tool-augmented "Think with Images" for Joint Medical Segmentation, Understanding and Reasoningcited by 8
  11. 2025Alignment Tipping Process: How Self-Evolution Pushes LLM Agents Off the Railscited by 7
  12. 2026Thinking with Deltas: Incentivizing Reinforcement Learning via Differential Visual Reasoning Policycited by 6
25 more
  1. 20263DMedAgent: Unified Perception-to-Understanding for 3D Medical Analysiscited by 5
  2. 2025A Survey on AgentOps: Categorization, Challenges, and Future Directionscited by 3
  3. 2025AT-CXR: Uncertainty-Aware Agentic Triage for Chest X-rayscited by 3
  4. 2025CogDoc: Towards Unified thinking in Documentscited by 3
  5. 2026Reasoning over Precedents Alongside Statutes: Case-Augmented Deliberative Alignment for LLM Safetycited by 3
  6. 2026CARE: Towards Clinical Accountability in Multi-Modal Medical Reasoning with an Evidence-Grounded Agentic Frameworkcited by 3
  7. 2026When Does RL Help Medical VLMs? Disentangling Vision, SFT, and RL Gainscited by 2
  8. 2026GLANCE: A Global-Local Coordination Multi-Agent Framework for Music-Grounded Non-Linear Video Editingcited by 2
  9. 2025TeamMedAgents: Pareto-Efficient Multi-Agent Medical Reasoning Through Teamwork Theorycited by 1
  10. 2025MedFact-R1: Towards Factual Medical Reasoning via Pseudo-Label Augmentationcited by 1
  11. 2025UCAgents: Unidirectional Convergence for Visual Evidence Anchored Multi-Agent Medical Decision-Makingcited by 1
  12. 2025MedInsightBench: Evaluating Medical Analytics Agents Through Multi-Step Insight Discovery in Multimodal Medical Datacited by 1
  13. 2026TheraAgent: Multi-Agent Framework with Self-Evolving Memory and Evidence-Calibrated Reasoning for PET Theranosticscited by 1
  14. 2026Beyond English benchmarks: clinical llm evaluation in Brazilian Portuguesecited by 1
  15. 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoningcited by 1
  16. 2026The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomycited by 1
  17. 2025Lessons Learned from Evaluation of LLM based Multi-agents in Safer Therapy Recommendationcited by 0
  18. 2025GRASP: Graph Reasoning Agents for Systems Pharmacology with Human-in-the-Loopcited by 0
  19. 2026MedVerse: Efficient and Reliable Medical Reasoning via DAG-Structured Parallel Executioncited by 0
  20. 2026MedCoRAG: Interpretable Hepatology Diagnosis via Hybrid Evidence Retrieval and Multispecialty Consensuscited by 0
  21. 2026MultiDx: A Multi-Source Knowledge Integration Framework towards Diagnostic Reasoningcited by 0
  22. 2026C-MIG: Multi-view Information Gain-based Retrieval-Augmented Generation for Clinical Diagnosis Reasoningcited by 0
  23. 2026Mathematical methods of reinforcement learningcited by 0
  24. 2026EVADE: Evidence-Verified Agentic Diagnosis with Escapecited by 0
  25. 2026BioMed-Agent-RL: A Meta Learning, All You Need for Biomedical Applicationscited by 0

Similar, not cited

Close in wording, no citation either way

  1. 2026MMedExpert-R1: Strengthening Multimodal Medical Reasoning via Domain-Specific Adaptation and Clinical Guideline Reinforcement
  2. 2024Inquire, Interact, and Integrate: A Proactive Agent Collaborative Framework for Zero-Shot Multimodal Medical Reasoning
  3. 2026MedPrune: Topology-Efficient Multimodal Multi-Agent Communication Evolution for Medical VQA Tasks
  4. 2025Mediator-Guided Multi-Agent Collaboration among Open-Source Models for Medical Decision-Making
  5. 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models
  6. 2026MedMASLab: A Unified Orchestration Framework for Benchmarking Multimodal Medical Multi-Agent Systems
  7. 2025MAM: Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis via Role-Specialized Collaboration
  8. 2026MediX-R1: Open Ended Medical Reinforcement Learning