mlsanityData to 7 Oct 2026

Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning

arXiv 2506.07044 ↗First posted 8 Jun 2025cs.CL cs.AI cs.CVcited by 217

On the map: LLM reasoning → Clinical and biomedical applications

also in 1 more
Abstract (arXiv)

Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in understanding common visual elements, largely due to their large-scale datasets and advanced training strategies. However, their effectiveness in medical applications remains limited due to the inherent discrepancies between data and tasks in medical scenarios and those in the general domain. Concretely, existing medical MLLMs face the following critical limitations: (1) limited coverage of medical knowledge beyond imaging, (2) heightened susceptibility to hallucinations due to suboptimal data curation processes, (3) lack of reasoning capabilities tailored for complex medical scenarios. To address these challenges, we first propose a comprehensive data curation procedure that (1) efficiently acquires rich medical knowledge data not only from medical imaging but also from extensive medical texts and general-domain data; and (2) synthesizes accurate medical captions, visual question answering (VQA), and reasoning samples. As a result, we build a multimodal dataset enriched with extensive medical knowledge. Building on the curated data, we introduce our medical-specialized MLLM: Lingshu. Lingshu undergoes multi-stage training to embed medical expertise and enhance its task-solving capabilities progressively. Besides, we preliminarily explore the potential of applying reinforcement learning with verifiable rewards paradigm to enhance Lingshu's medical reasoning ability. Additionally, we develop MedEvalKit, a unified evaluation framework that consolidates leading multimodal and textual medical benchmarks for standardized, fair, and efficient model assessment. We evaluate the performance of Lingshu on three fundamental medical tasks, multimodal QA, text-based QA, and medical report generation. The results show that Lingshu consistently outperforms the existing open-source multimodal models on most tasks ...

Key facts. Cited by 217 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 77 of its 117 references that are in the map. First posted on arXiv 8 Jun 2025.

Builds on

77 of 117 references.

Closest ancestors · 5

Same direction, newest first

  1. 2025MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs1 Apr
  2. 2025MedAgent-Pro: Towards Evidence-based Multi-modal Medical Diagnosis via Reasoning Agentic Workflow21 Mar
  3. 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models18 Mar
  4. 2025MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning26 Feb
  5. 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec

Other references · 72

  1. 2024The Llama 3 Herd of Modelscited by 14,192
  2. 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 8,851
  3. 2020Measuring Massive Multitask Language Understandingcited by 7,768
  4. 2023Efficient Memory Management for Large Language Model Serving with PagedAttentioncited by 5,767
  5. 2025Qwen2.5-VL Technical Reportcited by 5,418
  6. 2023Improved Baselines with Visual Instruction Tuningcited by 4,362
  7. 2023MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGIcited by 2,044
  8. 2014CIDEr: Consensus-based Image Description Evaluationcited by 2,027
  9. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  10. 2025InternVL3: Exploring Advanced Training and Test-Time Recipes for Open-Source Multimodal Modelscited by 1,769
  11. 2024Expanding Performance Boundaries of Open-Source Multimodal Models with Model, Data, and Test-Time Scalingcited by 1,573
  12. 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
38 more
  1. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  2. 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Daycited by 1,287
  3. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  4. 2017ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseasescited by 969
  5. 2025SFT Memorizes, RL Generalizes: A Comparative Study of Foundation Model Post-trainingcited by 655
  6. 2023BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairscited by 506
  7. 2025VideoLLaMA 3: Frontier Multimodal Foundation Models for Image and Video Understandingcited by 502
  8. 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
  9. 2017CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learningcited by 459
  10. 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
  11. 2024VLMEvalKit: An Open-Source Toolkit for Evaluating Large Multi-Modality Modelscited by 443
  12. 2023Med-Flamingo: a Multimodal Medical Few-shot Learnercited by 387
  13. 2025HealthBench: Evaluating Large Language Models Towards Improved Human Healthcited by 385
  14. 2024LMMs-Eval: Reality Check on the Evaluation of Large Multimodal Modelscited by 344
  15. 2023PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answeringcited by 333
  16. 2020CheXbert: Combining Automatic Labelers and Expert Annotations for Accurate Radiology Report Labeling Using BERTcited by 329
  17. 2023ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledgecited by 324
  18. 2025Demystifying Long Chain-of-Thought Reasoning in LLMscited by 323
  19. 2024Molmo and PixMo: Open Weights and Open Data for State-of-the-Art Vision-Language Modelscited by 321
  20. 2025VL-Rethinker: Incentivizing Self-Reflection of Vision-Language Models with Reinforcement Learningcited by 315
  21. 2025MM-Eureka: Exploring the Frontiers of Multimodal Reasoning with Rule-based Reinforcement Learningcited by 294
  22. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 215
  23. 2023PMC-CLIP: Contrastive Language-Image Pre-training using Biomedical Documentscited by 212
  24. 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 212
  25. 2024Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agentscited by 210
  26. 2023BiomedGPT: A Generalist Vision-Language Foundation Model for Diverse Biomedical Taskscited by 201
  27. 2020Can AI help in screening Viral and COVID-19 pneumonia?cited by 200
  28. 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 194
  29. 2023Quilt-1M: One Million Image-Text Pairs for Histopathologycited by 192
  30. 2021Evaluating Deep Neural Networks Trained on Clinical Images in Dermatology with the Fitzpatrick 17k Datasetcited by 184
  31. 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLMcited by 182
  32. 2019A Question-Entailment Approach to Question Answeringcited by 133
  33. 2020PAD-UFES-20: a skin lesion dataset composed of patient data and clinical images collected from smartphonescited by 116
  34. 2020PanNuke Dataset Extension, Insights and Baselinescited by 113
  35. 2025HealthGPT: A Medical Large Vision-Language Model for Unifying Comprehension and Generation via Heterogeneous Knowledge Adaptationcited by 112
  36. 2024BiomedParse: a biomedical foundation model for image parsing of everything everywhere all at oncecited by 107
  37. 2024Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questionscited by 106
  38. 2024CheXpert Plus: Augmenting a Large Chest X-ray Dataset with Text Radiology Reports, Patient Demographics and Additional Image Formatscited by 100

50 most cited of 72 All 72 (JSON)

Built on by

Cited by year (2026 to 7 Oct)

Citing papers per year: 2025: 54; 2026: 163.

217 papers.

Sort:

By area:

  1. 2025Baichuan-M2: Scaling Medical Capability with Large Verifier Systemcited by 55
  2. 2025A Survey of Scientific Large Language Models: From Data Foundations to Agent Frontierscited by 34
  3. 2025ReasonMed: A 370K Multi-Agent Generated Dataset for Advancing Medical Reasoningcited by 26
  4. 2025Pillar-0: A New Frontier for Radiology Foundation Modelscited by 24
  5. 2025Med-CMR: A Fine-Grained Benchmark Integrating Visual Evidence and Clinical Logic for Medical Complex Multimodal Reasoningcited by 14
  6. 2026Entropy-Adaptive Fine-Tuning: Resolving Confident Conflicts to Mitigate Forgettingcited by 14
  7. 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMscited by 12
  8. 2025UniMedVL: Unifying Medical Multimodal Understanding and Generation through Observation-Knowledge-Analysiscited by 12
  9. 2026MedMO: Grounding and Understanding Multimodal Large Language Model for Medical Imagescited by 12
  10. 2025MedReasoner: Reinforcement Learning Drives Reasoning Grounding from Clinical Thought to Pixel-Level Precisioncited by 10
  11. 2025Beyond the Crowd: LLM-Augmented Community Notes for Governing Health Misinformationcited by 10
  12. 2025Fleming-VL: Towards Universal Medical Visual Reasoning with Multimodal LLMscited by 10
38 more
  1. 2025OralGPT-Omni: A Versatile Dental Multimodal Large Language Modelcited by 10
  2. 2025OctoMed: Data Recipes for State-of-the-Art Multimodal Medical Reasoningcited by 10
  3. 2026IBISAgent: Reinforcing Pixel-Level Visual Reasoning in MLLMs for Universal Biomedical Object Referring and Segmentationcited by 10
  4. 2026Baichuan-M3: Modeling Clinical Inquiry for Reliable Medical Decision-Makingcited by 10
  5. 2026OmniCT: Towards a Unified Slice-Volume LVLM for Comprehensive CT Analysiscited by 9
  6. 2025GeoPQA: Bridging the Visual Perception Gap in MLLMs for Geometric Reasoningcited by 8
  7. 2025Citrus-V: Advancing Medical Foundation Models with Unified Medical Image Grounding for Clinical Reasoningcited by 8
  8. 2025SaFeR-VLM: Toward Safety-aware Fine-grained Reasoning in Multimodal Modelscited by 8
  9. 2025Ophiuchus: Incentivizing Tool-augmented "Think with Images" for Joint Medical Segmentation, Understanding and Reasoningcited by 8
  10. 2025CXRAgent: Director-Orchestrated Multi-Stage Reasoning for Chest X-Ray Interpretationcited by 7
  11. 2025OmniBrainBench: A Comprehensive Multimodal Benchmark for Brain Imaging Analysis Across Multi-stage Clinical Taskscited by 7
  12. 2025PET2Rep: Towards Vision-Language Model-Drived Automated Radiology Report Generation for Positron Emission Tomographycited by 6
  13. 2025Bridging the Gap in Ophthalmic AI: MM-Retinal-Reason Dataset and OphthaReason Model toward Dynamic Multimodal Reasoningcited by 6
  14. 2025GGBench: A Geometric Generative Reasoning Benchmark for Unified Multimodal Modelscited by 6
  15. 2025RadImageNet-VQA: A Large-Scale CT and MRI Dataset for Radiologic Visual Question Answeringcited by 6
  16. 2026M3CoTBench: Benchmark Chain-of-Thought of MLLMs in Medical Image Understandingcited by 6
  17. 2026MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learningcited by 6
  18. 2026MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMscited by 6
  19. 2026Photon: Speedup Volume Understanding with Efficient Multimodal Large Language Modelscited by 6
  20. 2025EchoVLM: Dynamic Mixture-of-Experts Vision-Language Model for Universal Ultrasound Intelligencecited by 5
  21. 2025Be My Eyes: Extending Large Language Models to New Modalities Through Multi-Agent Collaborationcited by 5
  22. 2025DentalGPT: Incentivizing Multimodal Complex Reasoning in Dentistrycited by 5
  23. 2026MedGround: Bridging the Evidence Gap in Medical Vision-Language Models with Verified Grounding Datacited by 5
  24. 2026MergePipe: A Budget-Aware Parameter Management System for Scalable LLM Mergingcited by 5
  25. 2026Brain-WM: Brain Glioblastoma World Modelcited by 5
  26. 2026AD-Copilot: A Vision-Language Assistant for Industrial Anomaly Detection via Visual In-context Comparisoncited by 5
  27. 2026MedOpenClaw and MedFlowBench: Auditing Medical Agents in Full-Study Workflowscited by 5
  28. 2026MedVR: Annotation-Free Medical Visual Reasoning via Agentic Reinforcement Learningcited by 5
  29. 2025CCD: Mitigating Hallucinations in Radiology MLLMs via Clinical Contrastive Decodingcited by 4
  30. 2026MEDVISTAGYM: A Scalable Training Environment for Thinking with Medical Images via Tool-Integrated Reinforcement Learningcited by 4
  31. 2026TARSE: Test-Time Adaptation via Retrieval of Skills and Experience for Reasoning Agentscited by 4
  32. 2026Better Eyes, Better Thoughts: Why Vision Chain-of-Thought Fails in Medicinecited by 4
  33. 2026Medical Reasoning with Large Language Models: A Survey and MR-Benchcited by 4
  34. 2026Lost in Volume: The CT-SpatialVQA Benchmark for Evaluating Semantic-Spatial Understanding of 3D Medical Vision-Language Modelscited by 4
  35. 2025Can Generalist Vision Language Models (VLMs) Rival Specialist Medical VLMs? Benchmarking and Strategic Insightscited by 3
  36. 2025How Far Have Medical Vision-Language Models Come? A Comprehensive Benchmarking Studycited by 3
  37. 2025Beyond Classification Accuracy: Neural-MedBench and the Need for Deeper Reasoning Benchmarkscited by 3
  38. 2025RAU: Reference-based Anatomical Understanding with Vision Language Modelscited by 3

50 most cited of 217 All 217 (JSON)

Similar, not cited

Close in wording, no citation either way

  1. 2024PeFoMed: Parameter Efficient Fine-tuning of Multimodal Large Language Models for Medical Imaging
  2. 2025Chiron-o1: Igniting Multimodal Large Language Models towards Generalizable Medical Reasoning via Mentor-Intern Collaborative Search
  3. 2024MedViLaM: A multimodal large language model with advanced generalizability and explainability for medical data understanding and generation
  4. 2025MedMKEB: A Comprehensive Knowledge Editing Benchmark for Medical Multimodal Large Language Models
  5. 2025Scaling Large Vision-Language Models for Enhanced Multimodal Comprehension In Biomedical Image Analysis
  6. 2024LLaVA-Ultra: Large Chinese Language and Vision Assistant for Ultrasound
  7. 2024Parameter-Efficient Fine-Tuning Medical Multimodal Large Language Models for Medical Visual Grounding
  8. 2024MC-CoT: A Modular Collaborative CoT Framework for Zero-shot Medical-VQA with LLM and MLLM Integration