mlsanityData to 7 Oct 2026

CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models

arXiv 2608.26147 ↗First posted 29 Jun 2026cs.CL cs.CVcited by 0

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Large Language Models (LLMs) have shown strong potential for medical reasoning, yet the scarcity and cost of expert-annotated data constrain their progress. While reinforcement learning offers a scalable alternative, standard outcome-based methods in medicine often suffer from autoregressive credit assignment failure and gradient variance explosion. This leads to the "Right Answer, Wrong Reason" trap, where models inadvertently reinforce spurious correlations and dataset shortcuts rather than valid clinical deduction. In this work, we propose Causally-Aligned Reasoning Exploration (CARE), a theoretically grounded framework for intrinsic experience curation. CARE is built upon two rigorous conditions for high-quality training trajectories: Causal Sufficiency, which utilizes an agreement-based self-verification mechanism to mimic do-calculus interventions and effectively debias gradients; and Proximal Learnability, which employs dynamic entropy bounds to select experiences within the model's zone of proximal development for variance-bounded optimization. These rigorously filtered experiences are optimized via a dual-stream objective that combines on-policy group-relative exploration with difficulty-weighted experience replay. Extensive experiments on diverse medical multimodal and text-only benchmarks demonstrate that CARE consistently outperforms other strong competitors, substantially reducing correct-but-inconsistent reasoning and improving training stability.

Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 60 of its 76 references that are in the map. First posted on arXiv 29 Jun 2026.

Builds on

60 of 76 references.

Closest ancestors · 11

Same direction, newest first

  1. 2025Baichuan-M2: Scaling Medical Capability with Large Verifier System2 Sep
  2. 2025CAPO: Reinforcing Consistent Reasoning in Medical Decision-Making15 Jun
  3. 2025Med-PRM: Medical Reasoning Models with Stepwise, Guideline-verified Process Rewards13 Jun
  4. 2025ReasonMed: A 370K Multi-Agent Generated Dataset for Advancing Medical Reasoning11 Jun
  5. 2025Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning8 Jun
  6. 2025RARL: Improving Medical VLM Reasoning and Generalization with Reinforcement Learning and LoRA under Data and Hardware Constraints7 Jun
  7. 2025Improving Medical Reasoning with Curriculum-Aware Reinforcement Learning25 May
  8. 2025GMAI-VL-R1: Harnessing Reinforcement Learning for Multimodal Medical Reasoning2 Apr
  9. 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models18 Mar
  10. 2025MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning26 Feb
  11. 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec

Other references · 49

  1. 2017Proximal Policy Optimization Algorithmscited by 14,441
  2. 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,084
  3. 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 8,851
  4. 2020Measuring Massive Multitask Language Understandingcited by 7,768
  5. 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,146
  6. 2025Qwen2.5-VL Technical Reportcited by 5,418
  7. 2024GPT-4o System Cardcited by 4,467
  8. 2025Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilitiescited by 3,655
  9. 2013Playing Atari with Deep Reinforcement Learningcited by 3,211
  10. 2015Trust Region Policy Optimizationcited by 2,503
  11. 2023A Survey on Large Language Model based Autonomous Agentscited by 2,203
  12. 2023MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGIcited by 2,044
37 more
  1. 2020Offline Reinforcement Learning: Tutorial, Review, and Perspectives on Open Problemscited by 1,873
  2. 2025InternVL3: Exploring Advanced Training and Test-Time Recipes for Open-Source Multimodal Modelscited by 1,769
  3. 2023MetaGPT: Meta Programming for A Multi-Agent Collaborative Frameworkcited by 1,761
  4. 2024MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmarkcited by 1,758
  5. 2024Expanding Performance Boundaries of Open-Source Multimodal Models with Model, Data, and Test-Time Scalingcited by 1,573
  6. 2023CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Societycited by 1,348
  7. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  8. 2023MemGPT: Towards LLMs as Operating Systemscited by 1,295
  9. 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Daycited by 1,287
  10. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  11. 2024OpenAI o1 System Cardcited by 1,220
  12. 2025Janus-Pro: Unified Multimodal Understanding and Generation with Data and Model Scalingcited by 787
  13. 2024DeepSeek-V3 Technical Reportcited by 724
  14. 2025Vision-R1: Incentivizing Reasoning Capability in Multimodal Large Language Modelscited by 653
  15. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 525
  16. 2023Reinforced Self-Training (ReST) for Language Modelingcited by 486
  17. 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
  18. 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
  19. 2025MedGemma Technical Reportcited by 398
  20. 2025RAGEN: Understanding Self-Evolution in LLM Agents via Multi-Turn Reinforcement Learningcited by 357
  21. 2023PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answeringcited by 333
  22. 2025Reinforcement Learning for Reasoning in Large Language Models with One Training Examplecited by 288
  23. 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 212
  24. 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 194
  25. 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLMcited by 182
  26. 2023Zhongjing: Enhancing the Chinese Medical Capabilities of Large Language Model through Expert Feedback and Real-world Multi-turn Dialoguecited by 118
  27. 2025HealthGPT: A Medical Large Vision-Language Model for Unifying Comprehension and Generation via Heterogeneous Knowledge Adaptationcited by 112
  28. 2023BioMedGPT: Open Multimodal Generative Pre-trained Transformer for BioMedicinecited by 99
  29. 2025Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understandingcited by 96
  30. 2024Towards Building Multilingual Language Model for Medicinecited by 91
  31. 2025ExGRPO: Learning to Reason from Experiencecited by 49
  32. 2024BiMediX2: Bio-Medical EXpert LMM for Diverse Medical Modalitiescited by 20
  33. 2026Clinical Cognition Alignment for Gastrointestinal Diagnosis with Multimodal LLMscited by 3
  34. 2026Compatibility-Aware Dynamic Fine-Tuning for Large Language Modelscited by 3
  35. 2025LLM-Powered Virtual Patient Agents for Interactive Clinical Skills Training with Automated Feedbackcited by 2
  36. 2026World Models Meet Language Models: On the Complementarity of Concrete and Abstract Reasoningcited by 2
  37. 2025Advances in Large Language Models for Medicinecited by 1

Built on by

Not cited yet.

Similar, not cited

Close in wording, no citation either way

  1. 2025MedS3: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision
  2. 2026MAPLE: Elevating Medical Reasoning from Statistical Consensus to Process-Led Alignment
  3. 2025Fleming-R1: Toward Expert-Level Medical Reasoning via Reinforcement Learning
  4. 2025CARE: Turning LLMs Into Causal Reasoning Expert
  5. 2026Scaling Medical Reasoning Verification via Tool-Integrated Reinforcement Learning
  6. 2026CURE-Med: Curriculum-Informed Reinforcement Learning for Multilingual Medical Reasoning
  7. 2026When Models Learn to Ask Why: Adaptive Causal Reasoning for Trustworthy Medical Vision-Language Models
  8. 2026Eliciting Medical Reasoning with Knowledge-enhanced Data Synthesis: A Semi-Supervised Reinforcement Learning Approach