Think Twice to See More: Iterative Visual Reasoning in Medical VLMs
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Medical vision-language models (VLMs) excel at image-text understanding but typically rely on a single-pass reasoning that neglects localized visual cues. In clinical practice, however, human experts iteratively scan, focus, and refine the regions of interest before reaching a final diagnosis. To narrow this machine-human perception gap, we introduce ViTAR, a novel VLM framework that emulates the iterative reasoning process of human experts through a cognitive chain of "think-act-rethink-answer". ViTAR treats medical images as interactive objects, enabling models to engage multi-step visual reasoning. To support this approach, we curate a high-quality instruction dataset comprising 1K interactive examples that encode expert-like diagnostic behaviors. In addition, a 16K visual question answering training data has been curated towards fine-grained visual diagnosis. We introduce a two-stage training strategy that begins with supervised fine-tuning to guide cognitive trajectories, followed by the reinforcement learning to optimize decision-making. Extensive evaluations demonstrate that ViTAR outperforms strong state-of-the-art models. Visual attention analysis reveals that from the "think" to "rethink" rounds, ViTAR increasingly anchors visual grounding to clinically critical regions and maintains high attention allocation to visual tokens during reasoning, providing mechanistic insight into its improved performance. These findings demonstrate that embedding expert-style iterative thinking chains into VLMs enhances both performance and trustworthiness of medical AI.
Key facts. Cited by 12 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 41 of its 49 references that are in the map. First posted on arXiv 11 Oct 2025.
Builds on
41 of 49 references.
Closest ancestors · 5
Same direction, newest first
- 2025Chiron-o1: Igniting Multimodal Large Language Models towards Generalizable Medical Reasoning via Mentor-Intern Collaborative Search20 Jun
- 2025Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning8 Jun
- 2025Improving Medical Reasoning with Curriculum-Aware Reinforcement Learning25 May
- 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models18 Mar
- 2025MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning26 Feb
Other references · 36
- 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 8,851
- 2023Visual Instruction Tuningcited by 7,792
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- 2025Qwen2.5-VL Technical Reportcited by 5,418
- 2024Qwen2.5 Technical Reportcited by 4,713
- 2024GPT-4o System Cardcited by 4,467
- 2025Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilitiescited by 3,655
- 2023FlashAttention-2: Faster Attention with Better Parallelism and Work Partitioningcited by 2,551
- 2023MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGIcited by 2,044
- 2025InternVL3: Exploring Advanced Training and Test-Time Recipes for Open-Source Multimodal Modelscited by 1,769
- 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Daycited by 1,287
- 2023PyTorch FSDP: Experiences on Scaling Fully Sharded Data Parallelcited by 641
24 more
- 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
- 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
- 2017Deep Learning for Medical Image Analysiscited by 399
- 2025DeepEyes: Incentivizing "Thinking with Images" via Reinforcement Learningcited by 398
- 2023Med-Flamingo: a Multimodal Medical Few-shot Learnercited by 387
- 2023PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answeringcited by 333
- 2025Pixel Reasoner: Incentivizing Pixel-Space Reasoning with Curiosity-Driven Reinforcement Learningcited by 267
- 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 212
- 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 194
- 2025Thinking with Images for Multimodal Reasoning: Foundations, Methods, and Future Frontierscited by 193
- 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLMcited by 182
- 2025OpenThinkIMG: Learning to Think with Images via Visual Tool Reinforcement Learningcited by 163
- 2024Does Prompt Formatting Have Any Impact on LLM Performance?cited by 132
- 2024MMedAgent: Learning to Use Medical Tools with Multi-modal Agentcited by 108
- 2025More Thinking, Less Seeing? Assessing Amplified Hallucination in Multimodal Reasoning Modelscited by 84
- 2024MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicinecited by 79
- 2025Traceable Evidence Enhanced Visual Grounded Reasoning: Evaluation and Methodologycited by 67
- 2025Large-scale and Fine-grained Vision-language Pre-training for Enhanced CT Image Understandingcited by 53
- 2024VILA-M3: Enhancing Vision-Language Models with Medical Expert Knowledgecited by 50
- 2025VLM-R3: Region Recognition, Reasoning, and Refinement for Enhanced Multimodal Chain-of-Thoughtcited by 47
- 2024GEMeX: A Large-Scale, Groundable, and Explainable Medical VQA Benchmark for Chest X-ray Diagnosiscited by 28
- 2024Data-Centric Foundation Models in Computational Healthcare: A Surveycited by 27
- 2024R-LLaVA: Improving Med-VQA Understanding through Visual Region of Interestcited by 21
- 2025Roboflow100-VL: A Multi-Domain Object Detection Benchmark for Vision-Language Modelscited by 20
Built on by
Citing papers per year: 2025: 2; 2026: 10.
12 papers.
- 2025Are Video Models Ready as Zero-Shot Reasoners? An Empirical Study with the MME-CoF Benchmarkcited by 41
- 2026MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolutioncited by 12
- 2026MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learningcited by 6
- 2026Better Eyes, Better Thoughts: Why Vision Chain-of-Thought Fails in Medicinecited by 4
- 20256 Fingers, 1 Kidney: Natural Adversarial Medical Images Reveal Critical Weaknesses of Vision-Language Modelscited by 3
- 2026MATRIX: A Multimodal Benchmark and Post-Training Framework for Materials Sciencecited by 3
- 2026MedLVR: Latent Visual Reasoning for Reliable Medical Visual Question Answeringcited by 1
- 2026Grounded 3D-Aware Spatial Vision-Language Modelingcited by 1
- 2026CORTEX: A Structured Reasoning Benchmark for Trustworthy 3D Chest CT MLLMscited by 1
- 2026UltrasoundAgents: Hierarchical Multi-Agent Evidence-Chain Reasoning for Breast Ultrasound Diagnosiscited by 0
- 2026LiteMedCoT-VL: Parameter-Efficient Adaptation for Medical Visual Question Answeringcited by 0
- 2026Token-Sparse Medical Multimodal Reasoning via Dual-Stream Reinforcement Learningcited by 0
- 2026Token-Sparse Medical Multimodal Reasoning via Dual-Stream Reinforcement Learning30 Jun 2026
- 2026CORTEX: A Structured Reasoning Benchmark for Trustworthy 3D Chest CT MLLMs25 Jun 2026
- 2026Grounded 3D-Aware Spatial Vision-Language Modeling28 May 2026
- 2026LiteMedCoT-VL: Parameter-Efficient Adaptation for Medical Visual Question Answering10 May 2026
- 2026MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolution29 Apr 2026
- 2026MedLVR: Latent Visual Reasoning for Reliable Medical Visual Question Answering10 Apr 2026
- 2026UltrasoundAgents: Hierarchical Multi-Agent Evidence-Chain Reasoning for Breast Ultrasound Diagnosis11 Mar 2026
- 2026Better Eyes, Better Thoughts: Why Vision Chain-of-Thought Fails in Medicine2 Mar 2026
- 2026MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learning3 Feb 2026
- 2026MATRIX: A Multimodal Benchmark and Post-Training Framework for Materials Science30 Jan 2026
- 20256 Fingers, 1 Kidney: Natural Adversarial Medical Images Reveal Critical Weaknesses of Vision-Language Models3 Dec 2025
- 2025Are Video Models Ready as Zero-Shot Reasoners? An Empirical Study with the MME-CoF Benchmark30 Oct 2025
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