mlsanityData to 14 Oct 2026

On the Robustness of Answer Formats in Medical Reasoning Models

arXiv 2509.20866 ↗First posted 25 Sep 2025cs.CL cs.LGcited by 2

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Medical reasoning models (MRMs) achieve superior performance on medical benchmarks compared to medical LLMs; however, high accuracy alone is insufficient for practical deployment. One of such requirements for real-world application is robustness to varying output constraints. Specifically, posing the same medical question while requesting different answer formats should not affect the underlying correctness of the response. We investigate this phenomenon in this paper, focusing on MRMs. To quantify this behavior, we propose the metric answer-format robustness: the ability to reliably generate correct outputs across varying specified formats. We examine three representative formats: multiple-choice, open-ended question-answering, and ranked lists. Across 15 proprietary and open-weight models, we observe substantial variation in format robustness (35-100%). Furthermore, we conduct controlled fine-tuning experiments on a shared backbone with matched training data to isolate the effects of the fine-tuning paradigm. We find that supervised fine-tuning yields more stable behavior across formats, whereas reinforcement fine-tuning often exhibits higher cross-format brittleness, with the degree of instability strongly dependent on reward design. Overall, answer-format robustness in MRMs is trainable yet brittle and requires careful evaluation for practical medical use.

Key facts. Cited by 2 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 32 of its 71 references that are in the map. First posted on arXiv 25 Sep 2025.

Builds on

32 of 71 references.

Closest ancestors · 4

Same direction, newest first

  1. 2025Med-U1: Incentivizing Unified Medical Reasoning in LLMs via Large-scale Reinforcement Learning14 Jun
  2. 2025Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL23 May
  3. 2025m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models1 Apr
  4. 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec

Other references · 28

  1. 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 9,379
  2. 2025Qwen3 Technical Reportcited by 8,820
  3. 2024Qwen2.5 Technical Reportcited by 4,942
  4. 2025Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilitiescited by 3,796
  5. 2025Gemma 3 Technical Reportcited by 1,824
  6. 2025Understanding R1-Zero-Like Training: A Critical Perspectivecited by 1,345
  7. 2025s1: Simple test-time scalingcited by 1,341
  8. 2019ZeRO: Memory Optimizations Toward Training Trillion Parameter Modelscited by 1,301
  9. 2025Humanity's Last Examcited by 491
  10. 2025Stop Overthinking: A Survey on Efficient Reasoning for Large Language Modelscited by 464
  11. 2025MedGemma Technical Reportcited by 436
  12. 2025HealthBench: Evaluating Large Language Models Towards Improved Human Healthcited by 429
16 more
  1. 20242 OLMo 2 Furiouscited by 340
  2. 2025OpenThoughts: Data Recipes for Reasoning Modelscited by 304
  3. 2025Logic-RL: Unleashing LLM Reasoning with Rule-Based Reinforcement Learningcited by 262
  4. 2024Capabilities of Gemini Models in Medicinecited by 237
  5. 2025A Survey of Reinforcement Learning for Large Reasoning Modelscited by 180
  6. 2025REASONING GYM: Reasoning Environments for Reinforcement Learning with Verifiable Rewardscited by 130
  7. 2024Open-LLM-Leaderboard: From Multi-choice to Open-style Questions for LLMs Evaluation, Benchmark, and Arenacited by 76
  8. 2025Effectively Controlling Reasoning Models through Thinking Interventioncited by 65
  9. 2025Sequential Diagnosis with Language Modelscited by 60
  10. 2025When Thinking Fails: The Pitfalls of Reasoning for Instruction-Following in LLMscited by 53
  11. 2025Scaling Reasoning, Losing Control: Evaluating Instruction Following in Large Reasoning Modelscited by 28
  12. 2025MORQA: Benchmarking Evaluation Metrics for Medical Open-Ended Question Answeringcited by 8
  13. 2025It is Too Many Options: Pitfalls of Multiple-Choice Questions in Generative AI and Medical Educationcited by 7
  14. 2024Reliable and diverse evaluation of LLM medical knowledge masterycited by 6
  15. 2025Reasoning Model is Stubborn: Diagnosing Instruction Overriding in Reasoning Modelscited by 6
  16. 2024Using Large Language Models to Generate Clinical Trial Tables and Figurescited by 3

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Cited by year (2026 to 14 Oct)

Citing papers per year: 2026: 2.

2 papers.

Similar, not cited

Close in wording, no citation either way

  1. 2026When Chain-of-Thought Backfires: Evaluating Prompt Sensitivity in Medical Language Models
  2. 2026Domain Fine-Tuning vs. Retrieval-Augmented Generation for Medical Multiple-Choice Question Answering: A Controlled Comparison at the 4B-Parameter Scale
  3. 2025Limitations of Large Language Models in Clinical Problem-Solving Arising from Inflexible Reasoning
  4. 2026CLEAR: Revealing How Noise and Ambiguity Degrade Reliability in LLMs for Medicine
  5. 2025MedOmni-45deg: A Safety-Performance Benchmark for Reasoning-Oriented LLMs in Medicine
  6. 2025Structured Outputs Enable General-Purpose LLMs to be Medical Experts
  7. 2026Knowing When to Abstain: Medical LLMs Under Clinical Uncertainty
  8. 2026Can Large Language Models Self-Correct in Medical Question Answering? An Exploratory Study