MAPLE: Elevating Medical Reasoning from Statistical Consensus to Process-Led Alignment
On the map: LLM reasoning → Clinical and biomedical applications
also in 1 more
Abstract (arXiv)
Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be unreliable in complex medical scenarios where the most frequent reasoning path is not necessarily the clinically correct one. In this work, we propose a novel and unified training paradigm that integrates medical process reward models with TTRL to bridge the gap between test-time scaling (TTS) and parametric model optimization. Specifically, we advance the TTRL framework by replacing the conventional MV with a fine-grained, expert-aligned supervision paradigm using Med-RPM. This integration ensures that reinforcement learning is guided by medical correctness rather than mere consensus, effectively distilling search-based intelligence into the model's parametric memory. Extensive evaluations on four different benchmarks have demonstrated that our developed method consistently and significantly outperforms current TTRL and standalone PRM selection. Our findings establish that transitioning from stochastic heuristics to structured, step-wise rewards is essential for developing reliable and scalable medical AI systems
Key facts. No citing papers in the map yet (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 18 of its 29 references that are in the map. First posted on arXiv 9 Mar 2026.
Builds on
18 of 29 references.
Closest ancestors · 3
Same direction, newest first
- 2025Med-PRM: Medical Reasoning Models with Stepwise, Guideline-verified Process Rewards13 Jun
- 2025m1: Unleash the Potential of Test-Time Scaling for Medical Reasoning with Large Language Models1 Apr
- 2025Limitations of Large Language Models in Clinical Problem-Solving Arising from Inflexible Reasoning5 Feb
Other references · 15
- 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 8,851
- 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,146
- 2022Self-Consistency Improves Chain of Thought Reasoning in Language Modelscited by 5,601
- 2023Let's Verify Step by Stepcited by 3,598
- 2024Scaling LLM Test-Time Compute Optimally can be More Effective than Scaling Model Parameterscited by 1,928
- 2024Generative Verifiers: Reward Modeling as Next-Token Predictioncited by 465
- 2025TTRL: Test-Time Reinforcement Learningcited by 253
- 2025A Survey on Test-Time Scaling in Large Language Models: What, How, Where, and How Well?cited by 215
- 2024Multi-step Problem Solving Through a Verifier: An Empirical Analysis on Model-induced Process Supervisioncited by 51
- 2025A Survey of Test-Time Compute: From Intuitive Inference to Deliberate Reasoningcited by 40
- 2025A Survey of Process Reward Models: From Outcome Signals to Process Supervisions for Large Language Modelscited by 37
- 2025ETTRL: Balancing Exploration and Exploitation in LLM Test-Time Reinforcement Learning Via Entropy Mechanismcited by 35
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- 2026Scaling Medical Reasoning Verification via Tool-Integrated Reinforcement Learning
- 2025Fleming-R1: Toward Expert-Level Medical Reasoning via Reinforcement Learning
- 2026Eliciting Medical Reasoning with Knowledge-enhanced Data Synthesis: A Semi-Supervised Reinforcement Learning Approach
- 2025MedS3: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision
- 2026Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Models
- 2025Med-U1: Incentivizing Unified Medical Reasoning in LLMs via Large-scale Reinforcement Learning
- 2026Rewarding Reasoning, Not Answers: Fixing and Bounding Test-Time Reinforcement Learning on Medical QA
- 2025Improving Medical Reasoning with Curriculum-Aware Reinforcement Learning