Improving the Fairness of Chest X-ray Classifiers
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Abstract (arXiv)
Deep learning models have reached or surpassed human-level performance in the field of medical imaging, especially in disease diagnosis using chest x-rays. However, prior work has found that such classifiers can exhibit biases in the form of gaps in predictive performance across protected groups. In this paper, we question whether striving to achieve zero disparities in predictive performance (i.e. group fairness) is the appropriate fairness definition in the clinical setting, over minimax fairness, which focuses on maximizing the performance of the worst-case group. We benchmark the performance of nine methods in improving classifier fairness across these two definitions. We find, consistent with prior work on non-clinical data, that methods which strive to achieve better worst-group performance do not outperform simple data balancing. We also find that methods which achieve group fairness do so by worsening performance for all groups. In light of these results, we discuss the utility of fairness definitions in the clinical setting, advocating for an investigation of the bias-inducing mechanisms in the underlying data generating process whenever possible.
Key facts. Cited by 52 papers in the map (data through 7 Oct 2026). Builds on 40 of its 88 references that are in the map. First posted on arXiv 23 Mar 2022.
Builds on
40 of 88 references.
References · 40
- 2016Densely Connected Convolutional Networkscited by 6,691
- 2016Equality of Opportunity in Supervised Learningcited by 2,000
- 2019A Survey on Bias and Fairness in Machine Learningcited by 1,911
- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
- 2019Distributionally Robust Neural Networks for Group Shifts: On the Importance of Regularization for Worst-Case Generalizationcited by 1,232
- 2017Counterfactual Fairnesscited by 802
- 2016Fair prediction with disparate impact: A study of bias in recidivism prediction instrumentscited by 671
- 2018Mitigating Unwanted Biases with Adversarial Learningcited by 663
- 2019MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographscited by 590
- 2016Inherent Trade-Offs in the Fair Determination of Risk Scorescited by 582
- 2021Just Train Twice: Improving Group Robustness without Training Group Informationcited by 522
- 2017CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learningcited by 459
28 more
- 2019Measuring Calibration in Deep Learningcited by 443
- 2017On Fairness and Calibrationcited by 406
- 2017Preventing Fairness Gerrymandering: Auditing and Learning for Subgroup Fairnesscited by 381
- 2018Learning Adversarially Fair and Transferable Representationscited by 353
- 2019Measurement and Fairnesscited by 299
- 2020Fairness without Demographics through Adversarially Reweighted Learningcited by 251
- 2015The Variational Fair Autoencodercited by 223
- 2018Multiaccuracy: Black-Box Post-Processing for Fairness in Classificationcited by 221
- 2015Censoring Representations with an Adversarycited by 191
- 2021Simple data balancing achieves competitive worst-group-accuracycited by 177
- 2021Reading Race: AI Recognises Patient's Racial Identity In Medical Imagescited by 155
- 2020CheXclusion: Fairness gaps in deep chest X-ray classifierscited by 153
- 2020Minimax Pareto Fairness: A Multi Objective Perspectivecited by 152
- 2020Learning from Failure: Training Debiased Classifier from Biased Classifiercited by 133
- 2020Ethical Machine Learning in Health Carecited by 112
- 2018Learning Controllable Fair Representationscited by 83
- 2020Hurtful Words: Quantifying Biases in Clinical Contextual Word Embeddingscited by 79
- 2018Achieving Fairness through Adversarial Learning: an Application to Recidivism Predictioncited by 77
- 2020An Empirical Characterization of Fair Machine Learning For Clinical Risk Predictioncited by 45
- 2019Fair Classification and Social Welfarecited by 40
- 2021RadFusion: Benchmarking Performance and Fairness for Multimodal Pulmonary Embolism Detection from CT and EHRcited by 32
- 2020Does enforcing fairness mitigate biases caused by subpopulation shift?cited by 25
- 2018Creating Fair Models of Atherosclerotic Cardiovascular Disease Riskcited by 23
- 2020CheXpert++: Approximating the CheXpert labeler for Speed,Differentiability, and Probabilistic Outputcited by 23
- 2020FairALM: Augmented Lagrangian Method for Training Fair Models with Little Regretcited by 22
- 2020Review of Mathematical frameworks for Fairness in Machine Learningcited by 21
- 2021Fairness On The Ground: Applying Algorithmic Fairness Approaches to Production Systemscited by 20
- 2021A comparison of approaches to improve worst-case predictive model performance over patient subpopulationscited by 12
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Citing papers per year: 2022: 7; 2023: 14; 2024: 15; 2025: 13; 2026: 3.
52 papers.
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- 2022MEDFAIR: Benchmarking Fairness for Medical Imagingcited by 66
- 2022Detecting Shortcut Learning for Fair Medical AI using Shortcut Testingcited by 52
- 2024FairMedFM: Fairness Benchmarking for Medical Imaging Foundation Modelscited by 47
- 2022The Road to Explainability is Paved with Bias: Measuring the Fairness of Explanationscited by 41
- 2022Fairness in Recommendation: Foundations, Methods and Applicationscited by 27
- 2022Addressing Fairness Issues in Deep Learning-Based Medical Image Analysis: A Systematic Reviewcited by 27
- 2022What Makes a Good Explanation?: A Harmonized View of Properties of Explanationscited by 21
- 2024Fairness and Bias in Multimodal AI: A Surveycited by 19
- 2023FairAdaBN: Mitigating unfairness with adaptive batch normalization and its application to dermatological disease classificationcited by 18
- 2024Advancing human-centric AI for robust X-ray analysis through holistic self-supervised learningcited by 18
- 2023On Fairness of Medical Image Classification with Multiple Sensitive Attributes via Learning Orthogonal Representationscited by 17
- 2023Unlocking Accuracy and Fairness in Differentially Private Image Classificationcited by 16
38 more
- 2024Slicing Through Bias: Explaining Performance Gaps in Medical Image Analysis using Slice Discovery Methodscited by 14
- 2023Are Sex-based Physiological Differences the Cause of Gender Bias for Chest X-ray Diagnosis?cited by 13
- 2023On (assessing) the fairness of risk score modelscited by 12
- 2024Rethinking Fair Representation Learning for Performance-Sensitive Taskscited by 8
- 2023Evaluating the Impact of Social Determinants on Health Prediction in the Intensive Care Unitcited by 7
- 2022Imputation Strategies Under Clinical Presence: Impact on Algorithmic Fairnesscited by 6
- 2023Are demographically invariant models and representations in medical imaging fair?cited by 6
- 2024Multi-Label Continual Learning for the Medical Domain: A Novel Benchmarkcited by 6
- 2023Unveiling Fairness Biases in Deep Learning-Based Brain MRI Reconstructioncited by 5
- 2023(Predictable) Performance Bias in Unsupervised Anomaly Detectioncited by 4
- 2023Towards objective and systematic evaluation of bias in artificial intelligence for medical imagingcited by 4
- 2023The Limits of Fair Medical Imaging AI In The Wildcited by 4
- 2024HIST-AID: Leveraging Historical Patient Reports for Enhanced Multi-Modal Automatic Diagnosiscited by 4
- 2025Preventing Shortcut Learning in Medical Image Analysis through Intermediate Layer Knowledge Distillation from Specialist Teacherscited by 4
- 2024Looking Beyond What You See: An Empirical Analysis on Subgroup Intersectional Fairness for Multi-label Chest X-ray Classification Using Social Determinants of Racial Health Inequitiescited by 3
- 2024FairREAD: Re-fusing Demographic Attributes after Disentanglement for Fair Medical Image Classificationcited by 3
- 2025Fair Foundation Models for Medical Image Analysis: Challenges and Perspectivescited by 3
- 2025Evaluating and Mitigating Bias in AI-Based Medical Text Generationcited by 3
- 2023MLHOps: Machine Learning for Healthcare Operationscited by 2
- 2024APPLE: Adversarial Privacy-aware Perturbations on Latent Embedding for Unfairness Mitigationcited by 2
- 2024Fairness Evolution in Continual Learning for Medical Imagingcited by 2
- 2024The Disparate Benefits of Deep Ensemblescited by 2
- 2025Benchmarking Fairness-aware Graph Neural Networks in Knowledge Graphscited by 2
- 2023Benchmarking bias: Expanding clinical AI model card to incorporate bias reporting of social and non-social factorscited by 1
- 2024Improving Fairness of Automated Chest X-ray Diagnosis by Contrastive Learningcited by 1
- 2025EchoQA: A Large Collection of Instruction Tuning Data for Echocardiogram Reportscited by 1
- 2025Understanding-informed Bias Mitigation for Fair CMR Segmentationcited by 1
- 2025AdFair-CLIP: Adversarial Fair Contrastive Language-Image Pre-training for Chest X-rayscited by 1
- 2025FairSSL: Fair Multimodal Self-Supervised Learningcited by 1
- 2025A Primer on Causal and Statistical Dataset Biases for Fair and Robust Image Analysiscited by 1
- 2025OxEnsemble: Fair Ensembles for Low-Data Classificationcited by 1
- 2026DUCX: Decomposing Unfairness in Tool-Using Chest X-ray Agentscited by 1
- 2023An Investigation Into Race Bias in Random Forest Models Based on Breast DCE-MRI Derived Radiomics Featurescited by 0
- 2024Hidden in Plain Sight: Undetectable Adversarial Bias Attacks on Vulnerable Patient Populationscited by 0
- 2024Dataset Representativeness and Downstream Task Fairnesscited by 0
- 2025SWiFT: Soft-Mask Weight Fine-tuning for Bias Mitigationcited by 0
- 2025The Impact of Skin Tone Label Granularity on the Performance and Fairness of AI Based Dermatology Image Classification Modelscited by 0
- 2025meval: A Statistical Toolbox for Fine-Grained Model Performance Analysiscited by 0
50 most cited of 52 All 52 (JSON)
- 2026Cohort-Anchored Foundation Models for Electronic Health Records: From Risk Scores to Auditable Peer Cohorts20 Jun 2026
- 2026DUCX: Decomposing Unfairness in Tool-Using Chest X-ray Agents28 Feb 2026
- 2026Patient-Conditioned Adaptive Offsets for Reliable Diagnosis across Subgroups19 Jan 2026
- 2025meval: A Statistical Toolbox for Fine-Grained Model Performance Analysis19 Dec 2025
- 2025OxEnsemble: Fair Ensembles for Low-Data Classification10 Dec 2025
- 2025Preventing Shortcut Learning in Medical Image Analysis through Intermediate Layer Knowledge Distillation from Specialist Teachers21 Nov 2025
- 2025Benchmarking Fairness-aware Graph Neural Networks in Knowledge Graphs21 Oct 2025
- 2025The Impact of Skin Tone Label Granularity on the Performance and Fairness of AI Based Dermatology Image Classification Models14 Sep 2025
- 2025A Primer on Causal and Statistical Dataset Biases for Fair and Robust Image Analysis4 Sep 2025
- 2025SWiFT: Soft-Mask Weight Fine-tuning for Bias Mitigation26 Aug 2025
- 2025FairSSL: Fair Multimodal Self-Supervised Learning22 Aug 2025
- 2025AdFair-CLIP: Adversarial Fair Contrastive Language-Image Pre-training for Chest X-rays30 Jun 2025
38 more
- 2025Evaluating and Mitigating Bias in AI-Based Medical Text Generation24 Apr 2025
- 2025Understanding-informed Bias Mitigation for Fair CMR Segmentation21 Mar 2025
- 2025EchoQA: A Large Collection of Instruction Tuning Data for Echocardiogram Reports4 Mar 2025
- 2025Fair Foundation Models for Medical Image Analysis: Challenges and Perspectives24 Feb 2025
- 2024FairREAD: Re-fusing Demographic Attributes after Disentanglement for Fair Medical Image Classification20 Dec 2024
- 2024HIST-AID: Leveraging Historical Patient Reports for Enhanced Multi-Modal Automatic Diagnosis16 Nov 2024
- 2024The Disparate Benefits of Deep Ensembles17 Oct 2024
- 2024Rethinking Fair Representation Learning for Performance-Sensitive Tasks5 Oct 2024
- 2024FairMedFM: Fairness Benchmarking for Medical Imaging Foundation Models1 Jul 2024
- 2024Dataset Representativeness and Downstream Task Fairness28 Jun 2024
- 2024Fairness and Bias in Multimodal AI: A Survey27 Jun 2024
- 2024Slicing Through Bias: Explaining Performance Gaps in Medical Image Analysis using Slice Discovery Methods17 Jun 2024
- 2024Advancing human-centric AI for robust X-ray analysis through holistic self-supervised learning2 May 2024
- 2024Fairness Evolution in Continual Learning for Medical Imaging10 Apr 2024
- 2024Multi-Label Continual Learning for the Medical Domain: A Novel Benchmark10 Apr 2024
- 2024Looking Beyond What You See: An Empirical Analysis on Subgroup Intersectional Fairness for Multi-label Chest X-ray Classification Using Social Determinants of Racial Health Inequities27 Mar 2024
- 2024APPLE: Adversarial Privacy-aware Perturbations on Latent Embedding for Unfairness Mitigation8 Mar 2024
- 2024Hidden in Plain Sight: Undetectable Adversarial Bias Attacks on Vulnerable Patient Populations8 Feb 2024
- 2024Improving Fairness of Automated Chest X-ray Diagnosis by Contrastive Learning25 Jan 2024
- 2023The Limits of Fair Medical Imaging AI In The Wild11 Dec 2023
- 2023Benchmarking bias: Expanding clinical AI model card to incorporate bias reporting of social and non-social factors21 Nov 2023
- 2023Towards objective and systematic evaluation of bias in artificial intelligence for medical imaging3 Nov 2023
- 2023An Investigation Into Race Bias in Random Forest Models Based on Breast DCE-MRI Derived Radiomics Features29 Sep 2023
- 2023Unveiling Fairness Biases in Deep Learning-Based Brain MRI Reconstruction25 Sep 2023
- 2023(Predictable) Performance Bias in Unsupervised Anomaly Detection25 Sep 2023
- 2023Unlocking Accuracy and Fairness in Differentially Private Image Classification21 Aug 2023
- 2023Are Sex-based Physiological Differences the Cause of Gender Bias for Chest X-ray Diagnosis?9 Aug 2023
- 2023Evaluating the Impact of Social Determinants on Health Prediction in the Intensive Care Unit22 May 2023
- 2023MLHOps: Machine Learning for Healthcare Operations4 May 2023
- 2023Are demographically invariant models and representations in medical imaging fair?2 May 2023
- 2023FairAdaBN: Mitigating unfairness with adaptive batch normalization and its application to dermatological disease classification15 Mar 2023
- 2023On (assessing) the fairness of risk score models17 Feb 2023
- 2023On Fairness of Medical Image Classification with Multiple Sensitive Attributes via Learning Orthogonal Representations4 Jan 2023
- 2022What Makes a Good Explanation?: A Harmonized View of Properties of Explanations10 Nov 2022
- 2022MEDFAIR: Benchmarking Fairness for Medical Imaging4 Oct 2022
- 2022Addressing Fairness Issues in Deep Learning-Based Medical Image Analysis: A Systematic Review27 Sep 2022
- 2022Imputation Strategies Under Clinical Presence: Impact on Algorithmic Fairness13 Aug 2022
- 2022Detecting Shortcut Learning for Fair Medical AI using Shortcut Testing21 Jul 2022
50 newest of 52 All 52 (JSON)
- 2024Fairness and Bias in Multimodal AI: A Surveycited by 19
- 2024Fairness and Bias in Multimodal AI: A Survey27 Jun 2024
- 2022MEDFAIR: Benchmarking Fairness for Medical Imagingcited by 66
- 2022Detecting Shortcut Learning for Fair Medical AI using Shortcut Testingcited by 52
- 2024FairMedFM: Fairness Benchmarking for Medical Imaging Foundation Modelscited by 47
- 2022The Road to Explainability is Paved with Bias: Measuring the Fairness of Explanationscited by 41
- 2022Fairness in Recommendation: Foundations, Methods and Applicationscited by 27
- 2022Addressing Fairness Issues in Deep Learning-Based Medical Image Analysis: A Systematic Reviewcited by 27
- 2022What Makes a Good Explanation?: A Harmonized View of Properties of Explanationscited by 21
- 2023FairAdaBN: Mitigating unfairness with adaptive batch normalization and its application to dermatological disease classificationcited by 18
- 2024Advancing human-centric AI for robust X-ray analysis through holistic self-supervised learningcited by 18
- 2023On Fairness of Medical Image Classification with Multiple Sensitive Attributes via Learning Orthogonal Representationscited by 17
- 2023Unlocking Accuracy and Fairness in Differentially Private Image Classificationcited by 16
- 2024Slicing Through Bias: Explaining Performance Gaps in Medical Image Analysis using Slice Discovery Methodscited by 14
12 most cited of 51 All 51 (JSON)
- 2026Cohort-Anchored Foundation Models for Electronic Health Records: From Risk Scores to Auditable Peer Cohorts20 Jun 2026
- 2026DUCX: Decomposing Unfairness in Tool-Using Chest X-ray Agents28 Feb 2026
- 2026Patient-Conditioned Adaptive Offsets for Reliable Diagnosis across Subgroups19 Jan 2026
- 2025meval: A Statistical Toolbox for Fine-Grained Model Performance Analysis19 Dec 2025
- 2025OxEnsemble: Fair Ensembles for Low-Data Classification10 Dec 2025
- 2025Preventing Shortcut Learning in Medical Image Analysis through Intermediate Layer Knowledge Distillation from Specialist Teachers21 Nov 2025
- 2025Benchmarking Fairness-aware Graph Neural Networks in Knowledge Graphs21 Oct 2025
- 2025The Impact of Skin Tone Label Granularity on the Performance and Fairness of AI Based Dermatology Image Classification Models14 Sep 2025
- 2025A Primer on Causal and Statistical Dataset Biases for Fair and Robust Image Analysis4 Sep 2025
- 2025SWiFT: Soft-Mask Weight Fine-tuning for Bias Mitigation26 Aug 2025
- 2025FairSSL: Fair Multimodal Self-Supervised Learning22 Aug 2025
- 2025AdFair-CLIP: Adversarial Fair Contrastive Language-Image Pre-training for Chest X-rays30 Jun 2025
12 newest of 51 All 51 (JSON)