Likelihood Ratios for Out-of-Distribution Detection
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Abstract (arXiv)
Discriminative neural networks offer little or no performance guarantees when deployed on data not generated by the same process as the training distribution. On such out-of-distribution (OOD) inputs, the prediction may not only be erroneous, but confidently so, limiting the safe deployment of classifiers in real-world applications. One such challenging application is bacteria identification based on genomic sequences, which holds the promise of early detection of diseases, but requires a model that can output low confidence predictions on OOD genomic sequences from new bacteria that were not present in the training data. We introduce a genomics dataset for OOD detection that allows other researchers to benchmark progress on this important problem. We investigate deep generative model based approaches for OOD detection and observe that the likelihood score is heavily affected by population level background statistics. We propose a likelihood ratio method for deep generative models which effectively corrects for these confounding background statistics. We benchmark the OOD detection performance of the proposed method against existing approaches on the genomics dataset and show that our method achieves state-of-the-art performance. We demonstrate the generality of the proposed method by showing that it significantly improves OOD detection when applied to deep generative models of images.
Key facts. Cited by 451 papers in the map (data through 7 Oct 2026). First posted on arXiv 7 Jun 2019.
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Citing papers per year: 2021: 112; 2022: 117; 2023: 71; 2024: 64; 2025: 54; 2026: 33.
451 papers.
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- 2021Generalized Out-of-Distribution Detection: A Surveycited by 796
- 2021A Survey of Uncertainty in Deep Neural Networkscited by 675
- 2021CutPaste: Self-Supervised Learning for Anomaly Detection and Localizationcited by 529
- 2021ReAct: Out-of-distribution Detection With Rectified Activationscited by 486
- 2021Towards Out-Of-Distribution Generalization: A Surveycited by 431
- 2021GAN Inversion: A Surveycited by 366
- 2021On the Importance of Gradients for Detecting Distributional Shifts in the Wildcited by 338
- 2021Exploring the Limits of Out-of-Distribution Detectioncited by 283
- 2021SSD: A Unified Framework for Self-Supervised Outlier Detectioncited by 264
- 2021MOS: Towards Scaling Out-of-distribution Detection for Large Semantic Spacecited by 233
- 2022Delving into Out-of-Distribution Detection with Vision-Language Representationscited by 215
- 2021A Simple Fix to Mahalanobis Distance for Improving Near-OOD Detectioncited by 206
38 more
- 2022Out-of-Distribution Detection and Selective Generation for Conditional Language Modelscited by 193
- 2021A Unified Survey on Anomaly, Novelty, Open-Set, and Out-of-Distribution Detection: Solutions and Future Challengescited by 154
- 2022How to Exploit Hyperspherical Embeddings for Out-of-Distribution Detection?cited by 128
- 2022Is Out-of-Distribution Detection Learnable?cited by 109
- 2021Semantically Coherent Out-of-Distribution Detectioncited by 107
- 2023LoCoOp: Few-Shot Out-of-Distribution Detection via Prompt Learningcited by 107
- 2022Catching Both Gray and Black Swans: Open-set Supervised Anomaly Detectioncited by 104
- 2021Model-Based Domain Generalizationcited by 103
- 2022Denoising diffusion models for out-of-distribution detectioncited by 102
- 2021Can multi-label classification networks know what they don't know?cited by 100
- 2021MOOD: Multi-level Out-of-distribution Detectioncited by 94
- 2023A Survey of Safety and Trustworthiness of Large Language Models through the Lens of Verification and Validationcited by 91
- 2021Constraints Penalized Q-learning for Safe Offline Reinforcement Learningcited by 90
- 2021Understanding Failures in Out-of-Distribution Detection with Deep Generative Modelscited by 89
- 2022GMMSeg: Gaussian Mixture based Generative Semantic Segmentation Modelscited by 87
- 2021Types of Out-of-Distribution Texts and How to Detect Themcited by 80
- 2021Provable Guarantees for Understanding Out-of-distribution Detectioncited by 78
- 2022Unknown-Aware Object Detection: Learning What You Don't Know from Videos in the Wildcited by 70
- 2021Does Your Dermatology Classifier Know What It Doesn't Know? Detecting the Long-Tail of Unseen Conditionscited by 68
- 2021On the Impact of Spurious Correlation for Out-of-distribution Detectioncited by 68
- 2021Revisiting Mahalanobis Distance for Transformer-Based Out-of-Domain Detectioncited by 67
- 2022RbA: Segmenting Unknown Regions Rejected by Allcited by 67
- 2023Energy-based Out-of-Distribution Detection for Graph Neural Networkscited by 67
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- 2021What Does Rotation Prediction Tell Us about Classifier Accuracy under Varying Testing Environments?cited by 63
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- 2021Hierarchical VAEs Know What They Don't Knowcited by 58
- 2023Unsupervised Out-of-Distribution Detection with Diffusion Inpaintingcited by 57
- 2022RankFeat: Rank-1 Feature Removal for Out-of-distribution Detectioncited by 52
- 2024Community Forensics: Using Thousands of Generators to Train Fake Image Detectorscited by 50
- 2021Rectangular Flows for Manifold Learningcited by 49
- 2021Densely connected normalizing flowscited by 49
- 2022A Simple Approach to Improve Single-Model Deep Uncertainty via Distance-Awarenesscited by 49
- 2022GOOD-D: On Unsupervised Graph Out-Of-Distribution Detectioncited by 47
- 2024A Closer Look at the Robustness of Contrastive Language-Image Pre-Training (CLIP)cited by 44
- 2022Harnessing Out-Of-Distribution Examples via Augmenting Content and Stylecited by 43
- 2024Learning with Mixture of Prototypes for Out-of-Distribution Detectioncited by 43
- 2021Neural Mean Discrepancy for Efficient Out-of-Distribution Detectioncited by 42
50 most cited of 451 All 451 (JSON)
- 2026Upholding Robustness in Federated Learning: Trends, Emerging Strategies, and Research Opportunities23 Sep 2026
- 2026SAM3-O2D2: Zero-Shot Object Out-of-Distribution Detection by Object Class Prompting of the SAM3-Image Model8 Sep 2026
- 2026FRAGMENT: Factorized Graph Representations for Document Generation and Editing via Entity-Aware Transformations19 Aug 2026
- 2026A Probabilistic Circuit-Induced Pseudo-Metric for Out-of-Distribution Detection10 Aug 2026
- 2026Uncertainty-Aware World Model for Aerial Image-Goal Navigation6 Aug 2026
- 2026Training-Free Out-of-Distribution Detection for Pathology Whole-Slide Images2 Aug 2026
- 2026Hybrid Latent-Structural Fusion (HLSF) for Cyber Anomaly Detection20 Jul 2026
- 2026Local Diagnostics of Continuous Normalizing Flow for Out-of-Distribution Detection30 May 2026
- 2026YoCausal: How Far is Video Generation from World Model? A Causality Perspective28 May 2026
- 2026The Signal in the Noise: OOD Detection Through Goodness-of-Fit Testing in Factorised Latent Spaces21 May 2026
- 2026Early High-Frequency Injection for Geometry-Sensitive OOD Detection20 May 2026
- 2026Surviving the Unseen: Predictive Defense for Novel Multi-Turn Multimodal Attacks18 May 2026
38 more
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- 2026Beyond Penalization: Diffusion-based Out-of-Distribution Detection and Selective Regularization in Offline Reinforcement Learning6 May 2026
- 2026Geometry over Density: Few-Shot Cross-Domain OOD Detection5 May 2026
- 2026Useful Features, Backward Scores: OOD in Language-Model Trajectories30 Apr 2026
- 2026Toward Robust In-Context Learning: Leveraging Out-of-distribution Proxies for Target Inaccessible Demonstration Retrieval13 Apr 2026
- 2026One-Step Score-Based Density Ratio Estimation12 Apr 2026
- 2026Deep Networks Favor Simple Data1 Apr 2026
- 2026Out-of-Distribution Object Detection in Street Scenes via Synthetic Outlier Exposure and Transfer Learning17 Mar 2026
- 2026Preconditioned Test-Time Adaptation for Out-of-Distribution Debiasing in Narrative Generation14 Mar 2026
- 2026Spatial Autoregressive Modeling of DINOv3 Embeddings for Unsupervised Anomaly Detection3 Mar 2026
- 2026Mind the Way You Select Negative Texts: Pursuing the Distance Consistency in OOD Detection with VLMs3 Mar 2026
- 2026The Invisible Gorilla Effect in Out-of-distribution Detection23 Feb 2026
- 2026Vendi Novelty Scores for Out-of-Distribution Detection10 Feb 2026
- 2026Mitigating the Likelihood Paradox in Flow-based OOD Detection via Entropy Manipulation10 Feb 2026
- 2026Don't Break the Boundary: Continual Unlearning for OOD Detection Based on Free Energy Repulsion6 Feb 2026
- 2026Learning with Adaptive Prototype Manifolds for Out-of-Distribution Detection5 Feb 2026
- 2026COMBOOD: A Semiparametric Approach for Detecting Out-of-distribution Data for Image Classification4 Feb 2026
- 2026Trust The Typical4 Feb 2026
- 2026GEPC: Group-Equivariant Posterior Consistency for Out-of-Distribution Detection in Diffusion Models30 Jan 2026
- 2026Vision Also You Need: Navigating Out-of-Distribution Detection with Multimodal Large Language Model20 Jan 2026
- 2025Out-of-Distribution Detection in Molecular Complexes via Diffusion Models for Irregular Graphs20 Dec 2025
- 2025Rethinking Jailbreak Detection of Large Vision Language Models with Representational Contrastive Scoring12 Dec 2025
- 2025PRADA: Probability-Ratio-Based Attribution and Detection of Autoregressive-Generated Images25 Nov 2025
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- 2025Uncertainty-Guided Checkpoint Selection for Reinforcement Finetuning of Large Language Models13 Nov 2025
- 2025Perturbations in the Orthogonal Complement Subspace for Efficient Out-of-Distribution Detection2 Nov 2025
- 2025Out-of-Distribution Detection for Safety Assurance of AI and Autonomous Systems24 Oct 2025
- 2025EigenScore: OOD Detection using Covariance in Diffusion Models8 Oct 2025
- 2025Human Texts Are Outliers: Detecting LLM-generated Texts via Out-of-distribution Detection7 Oct 2025
- 2025POLAR: Automating Cyber Threat Prioritization through LLM-Powered Assessment2 Oct 2025
- 2025SCOPED: Score-Curvature Out-of-distribution Proximity Evaluator for Diffusion1 Oct 2025
- 2025What Did I Learn? Operational Competence Assessment for AI-Based Trajectory Planners1 Oct 2025
- 2025Flow-Induced Diagonal Gaussian Processes21 Sep 2025
- 2025AdaptiveGuard: Towards Adaptive Runtime Safety for LLM-Powered Software21 Sep 2025
- 2025Out of Distribution Detection in Self-adaptive Robots with AI-powered Digital Twins16 Sep 2025
- 2025Pathology-Informed Latent Diffusion Model for Anomaly Detection in Lymph Node Metastasis21 Aug 2025
50 newest of 451 All 451 (JSON)
- 2022Denoising diffusion models for out-of-distribution detectioncited by 102
- 2023Unsupervised Out-of-Distribution Detection with Diffusion Inpaintingcited by 57
- 2024Out-of-Distribution Detection with a Single Unconditional Diffusion Modelcited by 22
- 2023Dual Conditioned Diffusion Models for Out-Of-Distribution Detection: Application to Fetal Ultrasound Videoscited by 12
- 2023Likelihood-based Out-of-Distribution Detection with Denoising Diffusion Probabilistic Modelscited by 10
- 2024Diffusion-based Layer-wise Semantic Reconstruction for Unsupervised Out-of-Distribution Detectioncited by 5
- 2023Investigating the Adversarial Robustness of Density Estimation Using the Probability Flow ODEcited by 4
- 2025EigenScore: OOD Detection using Covariance in Diffusion Modelscited by 4
- 2025SCOPED: Score-Curvature Out-of-distribution Proximity Evaluator for Diffusioncited by 3
- 2024Approximations to the Fisher Information Metric of Deep Generative Models for Out-Of-Distribution Detectioncited by 2
- 2025Zero-Shot Image Anomaly Detection Using Generative Foundation Modelscited by 2
- 2024Unsupervised Detection of Fetal Brain Anomalies using Denoising Diffusion Modelscited by 1
12 most cited of 18 All 18 (JSON)
- 2026GEPC: Group-Equivariant Posterior Consistency for Out-of-Distribution Detection in Diffusion Models30 Jan 2026
- 2025Out-of-Distribution Detection in Molecular Complexes via Diffusion Models for Irregular Graphs20 Dec 2025
- 2025EigenScore: OOD Detection using Covariance in Diffusion Models8 Oct 2025
- 2025SCOPED: Score-Curvature Out-of-distribution Proximity Evaluator for Diffusion1 Oct 2025
- 2025Pathology-Informed Latent Diffusion Model for Anomaly Detection in Lymph Node Metastasis21 Aug 2025
- 2025Time-reversed Flow Matching with Worst Transport in High-dimensional Latent Space for Image Anomaly Detection7 Aug 2025
- 2025Zero-Shot Image Anomaly Detection Using Generative Foundation Models30 Jul 2025
- 2024Diffusion-based Layer-wise Semantic Reconstruction for Unsupervised Out-of-Distribution Detection16 Nov 2024
- 2024Exploring Out-of-distribution Detection for Sparse-view Computed Tomography with Diffusion Models9 Nov 2024
- 2024Supervised Score-Based Modeling by Gradient Boosting2 Nov 2024
- 2024Unsupervised Detection of Fetal Brain Anomalies using Denoising Diffusion Models7 Aug 2024
- 2024Out-of-Distribution Detection with a Single Unconditional Diffusion Model20 May 2024
12 newest of 18 All 18 (JSON)
- 2024Conjugated Semantic Pool Improves OOD Detection with Pre-trained Vision-Language Modelscited by 13
- 2025Knowledge Regularized Negative Feature Tuning of Vision-Language Models for Out-of-Distribution Detectioncited by 4
- 2026Vision Also You Need: Navigating Out-of-Distribution Detection with Multimodal Large Language Modelcited by 0
- 2026Vision Also You Need: Navigating Out-of-Distribution Detection with Multimodal Large Language Model20 Jan 2026
- 2025Knowledge Regularized Negative Feature Tuning of Vision-Language Models for Out-of-Distribution Detection26 Jul 2025
- 2024Conjugated Semantic Pool Improves OOD Detection with Pre-trained Vision-Language Models11 Oct 2024
- 2021Generalized Out-of-Distribution Detection: A Surveycited by 796
- 2021A Survey of Uncertainty in Deep Neural Networkscited by 675
- 2021CutPaste: Self-Supervised Learning for Anomaly Detection and Localizationcited by 529
- 2021ReAct: Out-of-distribution Detection With Rectified Activationscited by 486
- 2021Towards Out-Of-Distribution Generalization: A Surveycited by 431
- 2021GAN Inversion: A Surveycited by 366
- 2021On the Importance of Gradients for Detecting Distributional Shifts in the Wildcited by 338
- 2021Exploring the Limits of Out-of-Distribution Detectioncited by 283
- 2021SSD: A Unified Framework for Self-Supervised Outlier Detectioncited by 264
- 2021MOS: Towards Scaling Out-of-distribution Detection for Large Semantic Spacecited by 233
- 2022Delving into Out-of-Distribution Detection with Vision-Language Representationscited by 215
- 2021A Simple Fix to Mahalanobis Distance for Improving Near-OOD Detectioncited by 206
12 most cited of 417 All 417 (JSON)
- 2026Upholding Robustness in Federated Learning: Trends, Emerging Strategies, and Research Opportunities23 Sep 2026
- 2026SAM3-O2D2: Zero-Shot Object Out-of-Distribution Detection by Object Class Prompting of the SAM3-Image Model8 Sep 2026
- 2026FRAGMENT: Factorized Graph Representations for Document Generation and Editing via Entity-Aware Transformations19 Aug 2026
- 2026A Probabilistic Circuit-Induced Pseudo-Metric for Out-of-Distribution Detection10 Aug 2026
- 2026Training-Free Out-of-Distribution Detection for Pathology Whole-Slide Images2 Aug 2026
- 2026Hybrid Latent-Structural Fusion (HLSF) for Cyber Anomaly Detection20 Jul 2026
- 2026Local Diagnostics of Continuous Normalizing Flow for Out-of-Distribution Detection30 May 2026
- 2026The Signal in the Noise: OOD Detection Through Goodness-of-Fit Testing in Factorised Latent Spaces21 May 2026
- 2026Early High-Frequency Injection for Geometry-Sensitive OOD Detection20 May 2026
- 2026Scaling Pretrained Representations Enables Label-Free Out-of-Distribution Detection Without Fine-Tuning7 May 2026
- 2026Geometry over Density: Few-Shot Cross-Domain OOD Detection5 May 2026
- 2026Useful Features, Backward Scores: OOD in Language-Model Trajectories30 Apr 2026
12 newest of 417 All 417 (JSON)