Graph-Guided Network for Irregularly Sampled Multivariate Time Series
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Abstract (arXiv)
In many domains, including healthcare, biology, and climate science, time series are irregularly sampled with varying time intervals between successive readouts and different subsets of variables (sensors) observed at different time points. Here, we introduce RAINDROP, a graph neural network that embeds irregularly sampled and multivariate time series while also learning the dynamics of sensors purely from observational data. RAINDROP represents every sample as a separate sensor graph and models time-varying dependencies between sensors with a novel message passing operator. It estimates the latent sensor graph structure and leverages the structure together with nearby observations to predict misaligned readouts. This model can be interpreted as a graph neural network that sends messages over graphs that are optimized for capturing time-varying dependencies among sensors. We use RAINDROP to classify time series and interpret temporal dynamics on three healthcare and human activity datasets. RAINDROP outperforms state-of-the-art methods by up to 11.4% (absolute F1-score points), including techniques that deal with irregular sampling using fixed discretization and set functions. RAINDROP shows superiority in diverse setups, including challenging leave-sensor-out settings.
Key facts. Cited by 110 papers in the map (data through 7 Oct 2026). Builds on 41 of its 67 references that are in the map. First posted on arXiv 11 Oct 2021.
Builds on
41 of 67 references.
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Citing papers per year: 2022: 8; 2023: 25; 2024: 32; 2025: 20; 2026: 25.
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- 2022Multimodal learning with graphscited by 54
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- 2026Domain Generalization under Sampling Pattern Shifts in Irregular Time Series27 Sep 2026
- 2026Multimodal Prompt Learning with Irregular EHRs for Robust Monitoring of Critical Care Patients22 Aug 2026
- 2026L'evy Attention: Single-Pass Predictive Uncertainty for Continuous-Time Attention19 Aug 2026
- 2026Beyond MSE: Rethinking the Evaluation Metric and Benchmarking for Irregular Time Series Forecasting18 Aug 2026
- 2026Rethinking Irregular Time Series Forecasting from the Perspective of Basis Functions18 Aug 2026
- 2026GARLIC: Graph Attention-based Relational Learning of Multivariate Time Series in Intensive Care11 Aug 2026
- 2026MissHyper: Restoring Clinical Synchronicity in Missingness-Guided Hypergraph Forecasting24 Jul 2026
- 2026Online Irregular Multivariate Time Series Forecasting via Uncertainty-Driven Dual-Expert Calibration27 May 2026
- 2026QuITE: Query-Based Irregular Time Series Embedding27 May 2026
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