Improving Medical Reasoning with Curriculum-Aware Reinforcement Learning
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Recent advances in reinforcement learning with verifiable, rule-based rewards have greatly enhanced the reasoning capabilities and out-of-distribution generalization of VLMs/LLMs, obviating the need for manually crafted reasoning chains. Despite these promising developments in the general domain, their translation to medical imaging remains limited. Current medical reinforcement fine-tuning (RFT) methods predominantly focus on close-ended VQA, thereby restricting the model's ability to engage in world knowledge retrieval and flexible task adaptation. More critically, these methods fall short of addressing the critical clinical demand for open-ended, reasoning-intensive decision-making. To bridge this gap, we introduce MedCCO, the first multimodal reinforcement learning framework tailored for medical VQA that unifies close-ended and open-ended data within a curriculum-driven RFT paradigm. Specifically, MedCCO is initially fine-tuned on a diverse set of close-ended medical VQA tasks to establish domain-grounded reasoning capabilities, and is then progressively adapted to open-ended tasks to foster deeper knowledge enhancement and clinical interpretability. We validate MedCCO across eight challenging medical VQA benchmarks, spanning both close-ended and open-ended settings. Experimental results show that MedCCO consistently enhances performance and generalization, achieving a 11.4% accuracy gain across three in-domain tasks, and a 5.7% improvement on five out-of-domain benchmarks. These findings highlight the promise of curriculum-guided RL in advancing robust, clinically-relevant reasoning in medical multimodal language models.
Key facts. Cited by 16 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 25 of its 45 references that are in the map. First posted on arXiv 25 May 2025.
Builds on
25 of 45 references.
Closest ancestors · 4
Same direction, newest first
- 2025MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs1 Apr
- 2025Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models18 Mar
- 2025MedVLM-R1: Incentivizing Medical Reasoning Capability of Vision-Language Models (VLMs) via Reinforcement Learning26 Feb
- 2025FineMedLM-o1: Enhancing Medical Knowledge Reasoning Ability of LLM from Supervised Fine-Tuning to Test-Time Training16 Jan
Other references · 21
- 2017Proximal Policy Optimization Algorithmscited by 14,441
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- 2025Qwen2.5-VL Technical Reportcited by 5,418
- 2024HybridFlow: A Flexible and Efficient RLHF Frameworkcited by 1,980
- 2024Expanding Performance Boundaries of Open-Source Multimodal Models with Model, Data, and Test-Time Scalingcited by 1,573
- 2024Yi: Open Foundation Models by 01.AIcited by 706
- 2023Aligning Large Multimodal Models with Factually Augmented RLHFcited by 703
- 2025Vision-R1: Incentivizing Reasoning Capability in Multimodal Large Language Modelscited by 653
- 2025VLM-R1: A Stable and Generalizable R1-style Large Vision-Language Modelcited by 515
- 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
- 2023PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answeringcited by 333
- 2025R1-VL: Learning to Reason with Multimodal Large Language Models via Step-wise Group Relative Policy Optimizationcited by 296
9 more
- 2025Seg-Zero: Reasoning-Chain Guided Segmentation via Cognitive Reinforcementcited by 234
- 2023Beyond Hallucinations: Enhancing LVLMs through Hallucination-Aware Direct Preference Optimizationcited by 223
- 2025MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understandingcited by 212
- 2024Aligning Modalities in Vision Large Language Models via Preference Fine-tuningcited by 197
- 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 194
- 2023Towards Generalist Foundation Model for Radiology by Leveraging Web-scale 2D&3D Medical Datacited by 176
- 2025VisualPRM: An Effective Process Reward Model for Multimodal Reasoningcited by 134
- 2024RLAIF-V: Open-Source AI Feedback Leads to Super GPT-4V Trustworthinesscited by 129
- 2025Virgo: A Preliminary Exploration on Reproducing o1-like MLLMcited by 68
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Citing papers per year: 2025: 8; 2026: 8.
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- 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMscited by 12
- 2025Bridging the Gap in Ophthalmic AI: MM-Retinal-Reason Dataset and OphthaReason Model toward Dynamic Multimodal Reasoningcited by 6
- 2026MedVR: Annotation-Free Medical Visual Reasoning via Agentic Reinforcement Learningcited by 5
- 2025Adaptive Reinforcement for Open-ended Medical Reasoning via Semantic-Guided Reward Collapse Mitigationcited by 4
- 2025Skin-R1: Clinical Knowledge-Guided Dermatological Diagnosis Using Vision-Language Modelscited by 4
- 2025CX-Mind: A Pioneering Multimodal Large Language Model for Interleaved Reasoning in Chest X-ray via Curriculum-Guided Reinforcement Learningcited by 2
- 2025AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantificationcited by 2
- 2025Proactive Reasoning-with-Retrieval Framework for Medical Multimodal Large Language Modelscited by 1
- 2026ReasonAny: Incorporating Reasoning Capability to Any Model via Simple and Effective Model Mergingcited by 1
- 2026Incentivizing Cardiologist-Like Reasoning in MLLMs for Interpretable Echocardiographic Diagnosiscited by 1
- 2025A global log for medical AIcited by 0
- 2026A Vision for Multisensory Intelligence: Sensing, Science, and Synergycited by 0
4 more
- 2026MedLoc-R1: Performance-Aware Curriculum Reward Scheduling for GRPO-Based Medical Visual Groundingcited by 0
- 2026Look-Closer-Then-Diagnose: Confidence-Aware Ultrasound VQA via Active Zoomingcited by 0
- 2026Token-Sparse Medical Multimodal Reasoning via Dual-Stream Reinforcement Learningcited by 0
- 2026CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Modelscited by 0
- 2026Token-Sparse Medical Multimodal Reasoning via Dual-Stream Reinforcement Learning30 Jun 2026
- 2026CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models29 Jun 2026
- 2026Look-Closer-Then-Diagnose: Confidence-Aware Ultrasound VQA via Active Zooming20 May 2026
- 2026MedVR: Annotation-Free Medical Visual Reasoning via Agentic Reinforcement Learning9 Apr 2026
- 2026MedLoc-R1: Performance-Aware Curriculum Reward Scheduling for GRPO-Based Medical Visual Grounding30 Mar 2026
- 2026Incentivizing Cardiologist-Like Reasoning in MLLMs for Interpretable Echocardiographic Diagnosis13 Jan 2026
- 2026ReasonAny: Incorporating Reasoning Capability to Any Model via Simple and Effective Model Merging9 Jan 2026
- 2026A Vision for Multisensory Intelligence: Sensing, Science, and Synergy8 Jan 2026
- 2025Skin-R1: Clinical Knowledge-Guided Dermatological Diagnosis Using Vision-Language Models18 Nov 2025
- 2025Proactive Reasoning-with-Retrieval Framework for Medical Multimodal Large Language Models21 Oct 2025
- 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMs11 Oct 2025
- 2025A global log for medical AI5 Oct 2025
4 more
- 2025AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantification29 Sep 2025
- 2025Bridging the Gap in Ophthalmic AI: MM-Retinal-Reason Dataset and OphthaReason Model toward Dynamic Multimodal Reasoning22 Aug 2025
- 2025Adaptive Reinforcement for Open-ended Medical Reasoning via Semantic-Guided Reward Collapse Mitigation18 Aug 2025
- 2025CX-Mind: A Pioneering Multimodal Large Language Model for Interleaved Reasoning in Chest X-ray via Curriculum-Guided Reinforcement Learning31 Jul 2025
- 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMscited by 12
- 2025Bridging the Gap in Ophthalmic AI: MM-Retinal-Reason Dataset and OphthaReason Model toward Dynamic Multimodal Reasoningcited by 6
- 2026MedVR: Annotation-Free Medical Visual Reasoning via Agentic Reinforcement Learningcited by 5
- 2025Adaptive Reinforcement for Open-ended Medical Reasoning via Semantic-Guided Reward Collapse Mitigationcited by 4
- 2025CX-Mind: A Pioneering Multimodal Large Language Model for Interleaved Reasoning in Chest X-ray via Curriculum-Guided Reinforcement Learningcited by 2
- 2025AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantificationcited by 2
- 2025Proactive Reasoning-with-Retrieval Framework for Medical Multimodal Large Language Modelscited by 1
- 2026ReasonAny: Incorporating Reasoning Capability to Any Model via Simple and Effective Model Mergingcited by 1
- 2026Incentivizing Cardiologist-Like Reasoning in MLLMs for Interpretable Echocardiographic Diagnosiscited by 1
- 2026MedLoc-R1: Performance-Aware Curriculum Reward Scheduling for GRPO-Based Medical Visual Groundingcited by 0
- 2026Token-Sparse Medical Multimodal Reasoning via Dual-Stream Reinforcement Learningcited by 0
- 2026CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Modelscited by 0
- 2026Token-Sparse Medical Multimodal Reasoning via Dual-Stream Reinforcement Learning30 Jun 2026
- 2026CARE: Causally-Aligned Reasoning Exploration for Medical Large Language Models29 Jun 2026
- 2026MedVR: Annotation-Free Medical Visual Reasoning via Agentic Reinforcement Learning9 Apr 2026
- 2026MedLoc-R1: Performance-Aware Curriculum Reward Scheduling for GRPO-Based Medical Visual Grounding30 Mar 2026
- 2026Incentivizing Cardiologist-Like Reasoning in MLLMs for Interpretable Echocardiographic Diagnosis13 Jan 2026
- 2026ReasonAny: Incorporating Reasoning Capability to Any Model via Simple and Effective Model Merging9 Jan 2026
- 2025Proactive Reasoning-with-Retrieval Framework for Medical Multimodal Large Language Models21 Oct 2025
- 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMs11 Oct 2025
- 2025AdaThink-Med: Optimizing Inference-Time Compute for Medical Reasoning via Uncertainty Quantification29 Sep 2025
- 2025Bridging the Gap in Ophthalmic AI: MM-Retinal-Reason Dataset and OphthaReason Model toward Dynamic Multimodal Reasoning22 Aug 2025
- 2025Adaptive Reinforcement for Open-ended Medical Reasoning via Semantic-Guided Reward Collapse Mitigation18 Aug 2025
- 2025CX-Mind: A Pioneering Multimodal Large Language Model for Interleaved Reasoning in Chest X-ray via Curriculum-Guided Reinforcement Learning31 Jul 2025
- 2025A global log for medical AIcited by 0
- 2026A Vision for Multisensory Intelligence: Sensing, Science, and Synergycited by 0
- 2026A Vision for Multisensory Intelligence: Sensing, Science, and Synergy8 Jan 2026
- 2025A global log for medical AI5 Oct 2025
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- 2025Toward Effective Reinforcement Learning Fine-Tuning for Medical VQA in Vision-Language Models
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