VILA-M3: Enhancing Vision-Language Models with Medical Expert Knowledge
On the map: Multimodal LLMs / vision-language models → Medical vision-language models
Abstract (arXiv)
Generalist vision language models (VLMs) have made significant strides in computer vision, but they fall short in specialized fields like healthcare, where expert knowledge is essential. In traditional computer vision tasks, creative or approximate answers may be acceptable, but in healthcare, precision is paramount.Current large multimodal models like Gemini and GPT-4o are insufficient for medical tasks due to their reliance on memorized internet knowledge rather than the nuanced expertise required in healthcare. VLMs are usually trained in three stages: vision pre-training, vision-language pre-training, and instruction fine-tuning (IFT). IFT has been typically applied using a mixture of generic and healthcare data. In contrast, we propose that for medical VLMs, a fourth stage of specialized IFT is necessary, which focuses on medical data and includes information from domain expert models. Domain expert models developed for medical use are crucial because they are specifically trained for certain clinical tasks, e.g. to detect tumors and classify abnormalities through segmentation and classification, which learn fine-grained features of medical data-features that are often too intricate for a VLM to capture effectively especially in radiology. This paper introduces a new framework, VILA-M3, for medical VLMs that utilizes domain knowledge via expert models. Through our experiments, we show an improved state-of-the-art (SOTA) performance with an average improvement of ~9% over the prior SOTA model Med-Gemini and ~6% over models trained on the specific tasks. Our approach emphasizes the importance of domain expertise in creating precise, reliable VLMs for medical applications.
Key facts. Cited by 50 papers in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 45 of its 62 references that are in the map. First posted on arXiv 19 Nov 2024.
Builds on
45 of 62 references.
Closest ancestors · 7
Same direction, newest first
- 2024MC-CoT: A Modular Collaborative CoT Framework for Zero-shot Medical-VQA with LLM and MLLM Integration6 Oct
- 2024MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine6 Aug
- 2024D-Rax: Domain-specific Radiologic assistant leveraging multi-modal data and eXpert model predictions2 Jul
- 2024MMedAgent: Learning to Use Medical Tools with Multi-modal Agent2 Jul
- 2024Vision-Language Models for Medical Report Generation and Visual Question Answering: A Review4 Mar
- 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLM14 Feb
- 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day1 Jun
Other references · 38
- 2017Attention Is All You Needcited by 59,932
- 2023GPT-4 Technical Reportcited by 18,132
- 2024The Llama 3 Herd of Modelscited by 14,192
- 2023Llama 2: Open Foundation and Fine-Tuned Chat Modelscited by 12,865
- 2023Visual Instruction Tuningcited by 7,792
- 2020Scaling Laws for Neural Language Modelscited by 6,411
- 2024GPT-4o System Cardcited by 4,467
- 2022Flamingo: a Visual Language Model for Few-Shot Learningcited by 4,337
- 2021Finetuned Language Models Are Zero-Shot Learnerscited by 3,747
- 2015VQA: Visual Question Answeringcited by 2,489
- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
- 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
26 more
- 2017ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseasescited by 969
- 2024Large Language Model based Multi-Agents: A Survey of Progress and Challengescited by 752
- 2024Yi: Open Foundation Models by 01.AIcited by 706
- 2023VILA: On Pre-training for Visual Language Modelscited by 686
- 2019MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographscited by 590
- 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
- 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
- 2023Med-Flamingo: a Multimodal Medical Few-shot Learnercited by 387
- 20183D MRI brain tumor segmentation using autoencoder regularizationcited by 324
- 2023MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoningcited by 311
- 2024Capabilities of Gemini Models in Medicinecited by 231
- 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 215
- 2024Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agentscited by 210
- 2023Towards Generalist Foundation Model for Radiology by Leveraging Web-scale 2D&3D Medical Datacited by 176
- 2021TorchXRayVision: A library of chest X-ray datasets and modelscited by 131
- 2024GREEN: Generative Radiology Report Evaluation and Error Notationcited by 124
- 2023Dynamic Graph Enhanced Contrastive Learning for Chest X-ray Report Generationcited by 114
- 2024BiomedParse: a biomedical foundation model for image parsing of everything everywhere all at oncecited by 107
- 2024Advancing Multimodal Medical Capabilities of Geminicited by 88
- 2017NegBio: a high-performance tool for negation and uncertainty detection in radiology reportscited by 79
- 2024Vision-Flan: Scaling Human-Labeled Tasks in Visual Instruction Tuningcited by 73
- 2024Detecting and Evaluating Medical Hallucinations in Large Vision Language Modelscited by 57
- 2024MEDCO: Medical Education Copilots Based on A Multi-Agent Frameworkcited by 33
- 2021A Systematic Collection of Medical Image Datasets for Deep Learningcited by 29
- 2024Open-ended VQA benchmarking of Vision-Language models by exploiting Classification datasets and their semantic hierarchycited by 26
- 2024DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledgecited by 24
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Citing papers per year: 2024: 2; 2025: 21; 2026: 27.
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- 2026Counterfactual Anatomy-guided Spatial-Temporal Decoding for Annotation-Free Hallucination Mitigation in Medical VLMs18 Aug 2026
- 2026Text Over Image: Auditing Multimodal Robustness in Synthetic Medical Image Detection24 Jun 2026
- 2026Unified Multimodal Model for Brain MRI Imputation and Understanding15 Jun 2026
- 2026MedVol-R1: Reward-Driven Evidence Grounding for Volumetric Reasoning Segmentation26 May 2026
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- 2026MedLVR: Latent Visual Reasoning for Reliable Medical Visual Question Answering10 Apr 2026
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- 2025MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoning31 May 2025
- 2025EndoBench: A Comprehensive Evaluation of Multi-Modal Large Language Models for Endoscopy Analysis29 May 2025
- 2025MORALISE: A Structured Benchmark for Moral Alignment in Visual Language Models20 May 2025
- 2025Med3DVLM: An Efficient Vision-Language Model for 3D Medical Image Analysis25 Mar 2025
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- 2025Med3DVLM: An Efficient Vision-Language Model for 3D Medical Image Analysiscited by 44
- 2025DeepMMSearch-R1: Empowering Multimodal LLMs in Multimodal Web Searchcited by 41
- 2025Object Detection with Multimodal Large Vision-Language Models: An In-depth Reviewcited by 14
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12 most cited of 25 All 25 (JSON)
- 2026Not All Attention Heads Contribute to Critical Visual Token Selection: Head-Aware Pruning Matters More26 Aug 2026
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- 2026Unified Multimodal Model for Brain MRI Imputation and Understanding15 Jun 2026
- 2026MedScribe: Clinically Grounded CT Reporting through Agentic Workflows3 May 2026
- 2026VLMs Need Words: Vision Language Models Ignore Visual Detail In Favor of Semantic Anchors2 Apr 2026
- 2026MedObvious: Exposing the Medical Moravec's Paradox in VLMs via Clinical Triage24 Mar 2026
- 2026Logit-Level Uncertainty Quantification in Vision-Language Models for Histopathology Image Analysis3 Mar 2026
- 2026LUMEN: Longitudinal Multi-Modal Radiology Model for Prognosis and Diagnosis24 Feb 2026
- 2026Grounding-Driven Attack: Improving Encoder-based Adversarial Transferability against Large Vision-Language Models10 Feb 2026
- 2026MedMO: Grounding and Understanding Multimodal Large Language Model for Medical Images6 Feb 2026
- 2026XAI-CLIP: ROI-Guided Perturbation Framework for Explainable Medical Image Segmentation in Multimodal Vision-Language Models1 Feb 2026
- 2026On the Adversarial Robustness of Large Vision-Language Models under Visual Token Compression29 Jan 2026
12 newest of 25 All 25 (JSON)
- 2025Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoningcited by 217
- 2025MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoningcited by 37
- 2025Med-CMR: A Fine-Grained Benchmark Integrating Visual Evidence and Clinical Logic for Medical Complex Multimodal Reasoningcited by 14
- 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMscited by 12
- 2026MEDVISTAGYM: A Scalable Training Environment for Thinking with Medical Images via Tool-Integrated Reinforcement Learningcited by 4
- 2026Lost in Volume: The CT-SpatialVQA Benchmark for Evaluating Semantic-Spatial Understanding of 3D Medical Vision-Language Modelscited by 4
- 2026MedLVR: Latent Visual Reasoning for Reliable Medical Visual Question Answeringcited by 1
- 2026NV-Reason-CT: 3D Visual Language Model for CT Analysiscited by 0
- 2026NV-Reason-CT: 3D Visual Language Model for CT Analysis23 Sep 2026
- 2026Lost in Volume: The CT-SpatialVQA Benchmark for Evaluating Semantic-Spatial Understanding of 3D Medical Vision-Language Models9 May 2026
- 2026MedLVR: Latent Visual Reasoning for Reliable Medical Visual Question Answering10 Apr 2026
- 2026MEDVISTAGYM: A Scalable Training Environment for Thinking with Medical Images via Tool-Integrated Reinforcement Learning12 Jan 2026
- 2025Med-CMR: A Fine-Grained Benchmark Integrating Visual Evidence and Clinical Logic for Medical Complex Multimodal Reasoning30 Nov 2025
- 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMs11 Oct 2025
- 2025Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning8 Jun 2025
- 2025MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoning31 May 2025
- 2025RadAgents: Multimodal Agentic Reasoning for Chest X-ray Interpretation with Radiologist-like Workflowscited by 8
- 2026MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learningcited by 6
- 2026Multi-Modal Multi-Agent Reinforcement Learning for Radiology Report Generationcited by 1
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- 2026Agentic LLM Workflow for MR Spectroscopy Volume-of-Interest Placements in Brain Tumors9 Mar 2026
- 2026Multi-Modal Multi-Agent Reinforcement Learning for Radiology Report Generation17 Feb 2026
- 2026MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learning3 Feb 2026
- 2025RadAgents: Multimodal Agentic Reasoning for Chest X-ray Interpretation with Radiologist-like Workflows24 Sep 2025
- 2026MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolutioncited by 12
- 2024Towards Interactive Global Geolocation Assistantcited by 11
- 2025MoMA: A Mixture-of-Multimodal-Agents Architecture for Enhancing Clinical Prediction Modellingcited by 7
- 2025A DeepSeek-Powered AI System for Automated Chest Radiograph Interpretation in Clinical Practicecited by 2
- 2025A-IDE : Agent-Integrated Denoising Expertscited by 1
- 2025SpineBench: A Clinically Salient, Level-Aware Benchmark Powered by the SpineMed-450k Corpuscited by 1
- 2025Multi-Sequence Parotid Gland Lesion Segmentation via Expert Text-Guided Segment Anything Modelcited by 0
- 2025Learning What Helps: Task-Aligned Context Selection for Vision Taskscited by 0
- 2026Logi-PAR: Logic-Infused Patient Activity Recognition via Differentiable Rulecited by 0
- 2026EchoAgent: Towards Reliable Echocardiography Interpretation with "Eyes","Hands" and "Minds"cited by 0
- 2026ReXSonoVQA: A Video QA Benchmark for Procedure-Centric Ultrasound Understandingcited by 0
- 2026MedVol-R1: Reward-Driven Evidence Grounding for Volumetric Reasoning Segmentationcited by 0
12 most cited of 13 All 13 (JSON)
- 2026Text Over Image: Auditing Multimodal Robustness in Synthetic Medical Image Detection24 Jun 2026
- 2026MedVol-R1: Reward-Driven Evidence Grounding for Volumetric Reasoning Segmentation26 May 2026
- 2026MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolution29 Apr 2026
- 2026ReXSonoVQA: A Video QA Benchmark for Procedure-Centric Ultrasound Understanding13 Apr 2026
- 2026EchoAgent: Towards Reliable Echocardiography Interpretation with "Eyes","Hands" and "Minds"7 Apr 2026
- 2026Logi-PAR: Logic-Infused Patient Activity Recognition via Differentiable Rule5 Mar 2026
- 2025A DeepSeek-Powered AI System for Automated Chest Radiograph Interpretation in Clinical Practice23 Dec 2025
- 2025Learning What Helps: Task-Aligned Context Selection for Vision Tasks29 Nov 2025
- 2025SpineBench: A Clinically Salient, Level-Aware Benchmark Powered by the SpineMed-450k Corpus3 Oct 2025
- 2025Multi-Sequence Parotid Gland Lesion Segmentation via Expert Text-Guided Segment Anything Model13 Aug 2025
- 2025MoMA: A Mixture-of-Multimodal-Agents Architecture for Enhancing Clinical Prediction Modelling7 Aug 2025
- 2025A-IDE : Agent-Integrated Denoising Experts21 Mar 2025
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