mlsanityData to 7 Oct 2026

VILA-M3: Enhancing Vision-Language Models with Medical Expert Knowledge

arXiv 2411.12915 ↗First posted 19 Nov 2024cs.CVcited by 50

On the map: Multimodal LLMs / vision-language models → Medical vision-language models

Abstract (arXiv)

Generalist vision language models (VLMs) have made significant strides in computer vision, but they fall short in specialized fields like healthcare, where expert knowledge is essential. In traditional computer vision tasks, creative or approximate answers may be acceptable, but in healthcare, precision is paramount.Current large multimodal models like Gemini and GPT-4o are insufficient for medical tasks due to their reliance on memorized internet knowledge rather than the nuanced expertise required in healthcare. VLMs are usually trained in three stages: vision pre-training, vision-language pre-training, and instruction fine-tuning (IFT). IFT has been typically applied using a mixture of generic and healthcare data. In contrast, we propose that for medical VLMs, a fourth stage of specialized IFT is necessary, which focuses on medical data and includes information from domain expert models. Domain expert models developed for medical use are crucial because they are specifically trained for certain clinical tasks, e.g. to detect tumors and classify abnormalities through segmentation and classification, which learn fine-grained features of medical data-features that are often too intricate for a VLM to capture effectively especially in radiology. This paper introduces a new framework, VILA-M3, for medical VLMs that utilizes domain knowledge via expert models. Through our experiments, we show an improved state-of-the-art (SOTA) performance with an average improvement of ~9% over the prior SOTA model Med-Gemini and ~6% over models trained on the specific tasks. Our approach emphasizes the importance of domain expertise in creating precise, reliable VLMs for medical applications.

Key facts. Cited by 50 papers in the map (data through 7 Oct 2026). Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models. Builds on 45 of its 62 references that are in the map. First posted on arXiv 19 Nov 2024.

Builds on

45 of 62 references.

Closest ancestors · 7

Same direction, newest first

  1. 2024MC-CoT: A Modular Collaborative CoT Framework for Zero-shot Medical-VQA with LLM and MLLM Integration6 Oct
  2. 2024MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine6 Aug
  3. 2024D-Rax: Domain-specific Radiologic assistant leveraging multi-modal data and eXpert model predictions2 Jul
  4. 2024MMedAgent: Learning to Use Medical Tools with Multi-modal Agent2 Jul
  5. 2024Vision-Language Models for Medical Report Generation and Visual Question Answering: A Review4 Mar
  6. 2024OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLM14 Feb
  7. 2023LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day1 Jun

Other references · 38

  1. 2017Attention Is All You Needcited by 59,932
  2. 2023GPT-4 Technical Reportcited by 18,132
  3. 2024The Llama 3 Herd of Modelscited by 14,192
  4. 2023Llama 2: Open Foundation and Fine-Tuned Chat Modelscited by 12,865
  5. 2023Visual Instruction Tuningcited by 7,792
  6. 2020Scaling Laws for Neural Language Modelscited by 6,411
  7. 2024GPT-4o System Cardcited by 4,467
  8. 2022Flamingo: a Visual Language Model for Few-Shot Learningcited by 4,337
  9. 2021Finetuned Language Models Are Zero-Shot Learnerscited by 3,747
  10. 2015VQA: Visual Question Answeringcited by 2,489
  11. 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
  12. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
26 more
  1. 2017ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseasescited by 969
  2. 2024Large Language Model based Multi-Agents: A Survey of Progress and Challengescited by 752
  3. 2024Yi: Open Foundation Models by 01.AIcited by 706
  4. 2023VILA: On Pre-training for Visual Language Modelscited by 686
  5. 2019MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographscited by 590
  6. 2020PathVQA: 30000+ Questions for Medical Visual Question Answeringcited by 467
  7. 2021SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answeringcited by 444
  8. 2023Med-Flamingo: a Multimodal Medical Few-shot Learnercited by 387
  9. 20183D MRI brain tumor segmentation using autoencoder regularizationcited by 324
  10. 2023MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoningcited by 311
  11. 2024Capabilities of Gemini Models in Medicinecited by 231
  12. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 215
  13. 2024Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agentscited by 210
  14. 2023Towards Generalist Foundation Model for Radiology by Leveraging Web-scale 2D&3D Medical Datacited by 176
  15. 2021TorchXRayVision: A library of chest X-ray datasets and modelscited by 131
  16. 2024GREEN: Generative Radiology Report Evaluation and Error Notationcited by 124
  17. 2023Dynamic Graph Enhanced Contrastive Learning for Chest X-ray Report Generationcited by 114
  18. 2024BiomedParse: a biomedical foundation model for image parsing of everything everywhere all at oncecited by 107
  19. 2024Advancing Multimodal Medical Capabilities of Geminicited by 88
  20. 2017NegBio: a high-performance tool for negation and uncertainty detection in radiology reportscited by 79
  21. 2024Vision-Flan: Scaling Human-Labeled Tasks in Visual Instruction Tuningcited by 73
  22. 2024Detecting and Evaluating Medical Hallucinations in Large Vision Language Modelscited by 57
  23. 2024MEDCO: Medical Education Copilots Based on A Multi-Agent Frameworkcited by 33
  24. 2021A Systematic Collection of Medical Image Datasets for Deep Learningcited by 29
  25. 2024Open-ended VQA benchmarking of Vision-Language models by exploiting Classification datasets and their semantic hierarchycited by 26
  26. 2024DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledgecited by 24

Built on by

Cited by year (2026 to 7 Oct)

Citing papers per year: 2024: 2; 2025: 21; 2026: 27.

50 papers.

Sort:

By area:

  1. 2025Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoningcited by 217
  2. 2024NVILA: Efficient Frontier Visual Language Modelscited by 206
  3. 2025HealthGPT: A Medical Large Vision-Language Model for Unifying Comprehension and Generation via Heterogeneous Knowledge Adaptationcited by 112
  4. 2025Med3DVLM: An Efficient Vision-Language Model for 3D Medical Image Analysiscited by 44
  5. 2025DeepMMSearch-R1: Empowering Multimodal LLMs in Multimodal Web Searchcited by 41
  6. 2025MMedAgent-RL: Optimizing Multi-Agent Collaboration for Multimodal Medical Reasoningcited by 37
  7. 2025Object Detection with Multimodal Large Vision-Language Models: An In-depth Reviewcited by 14
  8. 2025Med-CMR: A Fine-Grained Benchmark Integrating Visual Evidence and Clinical Logic for Medical Complex Multimodal Reasoningcited by 14
  9. 2025EndoBench: A Comprehensive Evaluation of Multi-Modal Large Language Models for Endoscopy Analysiscited by 13
  10. 2025Think Twice to See More: Iterative Visual Reasoning in Medical VLMscited by 12
  11. 2026MedMO: Grounding and Understanding Multimodal Large Language Model for Medical Imagescited by 12
  12. 2026VLMs Need Words: Vision Language Models Ignore Visual Detail In Favor of Semantic Anchorscited by 12
38 more
  1. 2026MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolutioncited by 12
  2. 2024Towards Interactive Global Geolocation Assistantcited by 11
  3. 2025MORALISE: A Structured Benchmark for Moral Alignment in Visual Language Modelscited by 10
  4. 2025Taming Vision-Language Models for Medical Image Analysis: A Comprehensive Reviewcited by 9
  5. 2025RadAgents: Multimodal Agentic Reasoning for Chest X-ray Interpretation with Radiologist-like Workflowscited by 8
  6. 2025MoMA: A Mixture-of-Multimodal-Agents Architecture for Enhancing Clinical Prediction Modellingcited by 7
  7. 2026MedSAM-Agent: Empowering Interactive Medical Image Segmentation with Multi-turn Agentic Reinforcement Learningcited by 6
  8. 2025Visual Alignment of Medical Vision-Language Models for Grounded Radiology Report Generationcited by 5
  9. 2026MedGround: Bridging the Evidence Gap in Medical Vision-Language Models with Verified Grounding Datacited by 5
  10. 2026On the Adversarial Robustness of Large Vision-Language Models under Visual Token Compressioncited by 5
  11. 2026MEDVISTAGYM: A Scalable Training Environment for Thinking with Medical Images via Tool-Integrated Reinforcement Learningcited by 4
  12. 2026Lost in Volume: The CT-SpatialVQA Benchmark for Evaluating Semantic-Spatial Understanding of 3D Medical Vision-Language Modelscited by 4
  13. 2025Can Generalist Vision Language Models (VLMs) Rival Specialist Medical VLMs? Benchmarking and Strategic Insightscited by 3
  14. 2025Multimodal LLM With Hierarchical Mixture-of-Experts for VQA on 3D Brain MRIcited by 2
  15. 2025A DeepSeek-Powered AI System for Automated Chest Radiograph Interpretation in Clinical Practicecited by 2
  16. 2026MedObvious: Exposing the Medical Moravec's Paradox in VLMs via Clinical Triagecited by 2
  17. 2025A-IDE : Agent-Integrated Denoising Expertscited by 1
  18. 2025SpineBench: A Clinically Salient, Level-Aware Benchmark Powered by the SpineMed-450k Corpuscited by 1
  19. 2026CURE: Curriculum-guided Multi-task Training for Reliable Anatomy Grounded Report Generationcited by 1
  20. 2026Grounding-Driven Attack: Improving Encoder-based Adversarial Transferability against Large Vision-Language Modelscited by 1
  21. 2026LUMEN: Longitudinal Multi-Modal Radiology Model for Prognosis and Diagnosiscited by 1
  22. 2026Multi-Modal Multi-Agent Reinforcement Learning for Radiology Report Generationcited by 1
  23. 2026MedLVR: Latent Visual Reasoning for Reliable Medical Visual Question Answeringcited by 1
  24. 2026MedScribe: Clinically Grounded CT Reporting through Agentic Workflowscited by 1
  25. 2026Not All Attention Heads Contribute to Critical Visual Token Selection: Head-Aware Pruning Matters Morecited by 1
  26. 2025Multi-Sequence Parotid Gland Lesion Segmentation via Expert Text-Guided Segment Anything Modelcited by 0
  27. 2025Learning What Helps: Task-Aligned Context Selection for Vision Taskscited by 0
  28. 2026XAI-CLIP: ROI-Guided Perturbation Framework for Explainable Medical Image Segmentation in Multimodal Vision-Language Modelscited by 0
  29. 2026Logit-Level Uncertainty Quantification in Vision-Language Models for Histopathology Image Analysiscited by 0
  30. 2026Logi-PAR: Logic-Infused Patient Activity Recognition via Differentiable Rulecited by 0
  31. 2026Agentic LLM Workflow for MR Spectroscopy Volume-of-Interest Placements in Brain Tumorscited by 0
  32. 2026EchoAgent: Towards Reliable Echocardiography Interpretation with "Eyes","Hands" and "Minds"cited by 0
  33. 2026ReXSonoVQA: A Video QA Benchmark for Procedure-Centric Ultrasound Understandingcited by 0
  34. 2026MedVol-R1: Reward-Driven Evidence Grounding for Volumetric Reasoning Segmentationcited by 0
  35. 2026Unified Multimodal Model for Brain MRI Imputation and Understandingcited by 0
  36. 2026Text Over Image: Auditing Multimodal Robustness in Synthetic Medical Image Detectioncited by 0
  37. 2026Counterfactual Anatomy-guided Spatial-Temporal Decoding for Annotation-Free Hallucination Mitigation in Medical VLMscited by 0
  38. 2026NV-Reason-CT: 3D Visual Language Model for CT Analysiscited by 0

Similar, not cited

Close in wording, no citation either way

  1. 2024Can LLMs' Tuning Methods Work in Medical Multimodal Domain?
  2. 2022Medical Image Understanding with Pretrained Vision Language Models: A Comprehensive Study
  3. 2025Vision Language Models in Medicine
  4. 2025How Far Have Medical Vision-Language Models Come? A Comprehensive Benchmarking Study
  5. 2025Medical Knowledge Intervention Prompt Tuning for Medical Image Classification
  6. 2024Med-MoE: Mixture of Domain-Specific Experts for Lightweight Medical Vision-Language Models
  7. 2025Uncertainty-Driven Expert Control: Enhancing the Reliability of Medical Vision-Language Models
  8. 2024Specialized curricula for training vision-language models in retinal image analysis