mlsanityData to 7 Oct 2026

MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents

arXiv 2501.14654 ↗First posted 24 Jan 2025cs.LG cs.AI cs.MAcited by 56

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

Recent large language models (LLMs) have demonstrated significant advancements, particularly in their ability to serve as agents thereby surpassing their traditional role as chatbots. These agents can leverage their planning and tool utilization capabilities to address tasks specified at a high level. However, a standardized dataset to benchmark the agent capabilities of LLMs in medical applications is currently lacking, making the evaluation of LLMs on complex tasks in interactive healthcare environments challenging. To address this gap, we introduce MedAgentBench, a broad evaluation suite designed to assess the agent capabilities of large language models within medical records contexts. MedAgentBench encompasses 300 patient-specific clinically-derived tasks from 10 categories written by human physicians, realistic profiles of 100 patients with over 700,000 data elements, a FHIR-compliant interactive environment, and an accompanying codebase. The environment uses the standard APIs and communication infrastructure used in modern EMR systems, so it can be easily migrated into live EMR systems. MedAgentBench presents an unsaturated agent-oriented benchmark that current state-of-the-art LLMs exhibit some ability to succeed at. The best model (Claude 3.5 Sonnet v2) achieves a success rate of 69.67%. However, there is still substantial space for improvement which gives the community a next direction to optimize. Furthermore, there is significant variation in performance across task categories. MedAgentBench establishes this and is publicly available at https://github.com/stanfordmlgroup/MedAgentBench , offering a valuable framework for model developers to track progress and drive continuous improvements in the agent capabilities of large language models within the medical domain.

Key facts. Cited by 56 papers in the map (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 11 of its 29 references that are in the map. First posted on arXiv 24 Jan 2025.

Builds on

11 of 29 references.

Closest ancestors · 2

Same direction, newest first

  1. 2024MMedAgent: Learning to Use Medical Tools with Multi-modal Agent2 Jul
  2. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments13 May

Other references · 9

  1. 2023Gorilla: Large Language Model Connected with Massive APIscited by 1,302
  2. 2024τ-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domainscited by 1,280
  3. 2023AgentBench: Evaluating LLMs as Agentscited by 1,211
  4. 2024AgentBoard: An Analytical Evaluation Board of Multi-turn LLM Agentscited by 319
  5. 2024Meta-Prompting: Enhancing Language Models with Task-Agnostic Scaffoldingcited by 115
  6. 2024Many-Shot In-Context Learning in Multimodal Foundation Modelscited by 64
  7. 2024AutoBencher: Towards Declarative Benchmark Constructioncited by 40
  8. 2024Superhuman performance of a large language model on the reasoning tasks of a physiciancited by 28
  9. 2020A new paradigm for accelerating clinical data science at Stanford Medicinecited by 16

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2025: 10; 2026: 46.

56 papers.

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  1. 2026A Survey of Agentic Reasoning for Large Language Models: Towards Recursively Self-Improving and Collective Agentscited by 47
  2. 2026HealthBench Professional: Evaluating Large Language Models on Real Clinician Chatscited by 22
  3. 2025FHIR-AgentBench: Benchmarking LLM Agents for Realistic Interoperable EHR Question Answeringcited by 20
  4. 2025GTM: Simulating the World of Tools for AI Agentscited by 12
  5. 2025Aegis: Taxonomy and Optimizations for Overcoming Agent-Environment Failures in LLM Agentscited by 9
  6. 2026HealthAdminBench: Evaluating Computer-Use Agents on Healthcare Administration Taskscited by 9
  7. 2026Agentic Environment Engineering for Large Language Models: A Survey of Environment Modeling, Synthesis, Evaluation, and Applicationcited by 8
  8. 2026ToolFailBench: Diagnosing Tool-Use Failures in LLM Agentscited by 8
  9. 2025MTBBench: A Multimodal Sequential Clinical Decision-Making Benchmark in Oncologycited by 6
  10. 2025EHR-MCP: Real-world Evaluation of Clinical Information Retrieval by Large Language Models via Model Context Protocolcited by 5
  11. 2026NeuroClaw Technical Reportcited by 4
  12. 2026SP-Mind: An Autonomous Reasoning Agent for Spatial Proteomics Analysiscited by 4
38 more
  1. 2025Generalist Foundation Models Are Not Clinical Enough for Hospital Operationscited by 3
  2. 2026AutoMedBench: Towards Medical AutoResearch with Agentic AI Modelscited by 3
  3. 2026MedCUA-Bench: A Screenshot-Only Benchmark for Clinical Computer-Use Agentscited by 3
  4. 2026Measuring Epistemic Resilience of LLMs Under Misleading Medical Contextcited by 3
  5. 2025Enhancing Clinical Decision-Making: Integrating Multi-Agent Systems with Ethical AI Governancecited by 2
  6. 2026R-LAM: Reproducibility-Constrained Large Action Models for Scientific Workflow Automationcited by 2
  7. 2026Can LLM Agents Generate Real-World Evidence? Evaluating Observational Studies in Medical Databasescited by 2
  8. 2026CodeClinic: Evaluating Automation of Coding Skills for Clinical Reasoning Agentscited by 2
  9. 2026AgentFairBench: Do LLM Agents Discriminate When They Act?cited by 2
  10. 2025One Patient, Many Contexts: Scaling Medical AI with Contextual Intelligencecited by 1
  11. 2025From Conversation to Query Execution: Benchmarking User and Tool Interactions for EHR Database Agentscited by 1
  12. 2025MedInsightBench: Evaluating Medical Analytics Agents Through Multi-Step Insight Discovery in Multimodal Medical Datacited by 1
  13. 2026Agentic AI in Healthcare & Medicine: A Seven-Dimensional Taxonomy for Empirical Evaluation of LLM-based Agentscited by 1
  14. 2026MedExAgent: Training LLM Agents to Ask, Examine, and Diagnose in Noisy Clinical Environmentscited by 1
  15. 2026AgentBeats: Agentifying Agent Assessment for Openness, Standardization, and Reproducibilitycited by 1
  16. 2026Teaching LLMs to Recommend and Defer in Underrepresented Epilepsy Carecited by 1
  17. 2026EviDx: Evidence-Aware Active Diagnosis with Scaffolded LLM Agentscited by 1
  18. 2026MedCache: Efficient and Temporally Valid Memory for Longitudinal Clinical Agentscited by 1
  19. 2026Harbor Adapters and Harbor-Index: Infrastructure and a Curated Meta-Dataset for Large-Scale Agentic Evaluationcited by 1
  20. 2026H-AdminSim: A Multi-Agent Simulator for Realistic Hospital Administrative Workflows with FHIR Integrationcited by 0
  21. 2026Doctorina MedBench: A Dialogue-Based Benchmark and Evaluation Framework for Agent-Based Medical AIcited by 0
  22. 2026ESL-Bench: An Event-Driven Synthetic Longitudinal Benchmark for Health Agentscited by 0
  23. 2026BioMedArena: An Open-source Toolkit for Building and Evaluating Biomedical Deep Research Agentscited by 0
  24. 2026MedMeta: A Benchmark for LLMs in Synthesizing Meta-Analysis Conclusion from Medical Studiescited by 0
  25. 2026ClinQueryAgent: A Conversational Agent for Population Health Managementcited by 0
  26. 2026MDIA: A Multi-Agent Diagnostic Intelligence Pipeline on HealthBench Professionalcited by 0
  27. 2026Generalistic or Specific Embeddings, Which is Better? An Empirical Study on Search for Clinical Coding in Non-English Languagescited by 0
  28. 2026Learning to Construct Practical Agentic Systemscited by 0
  29. 2026How Do Tool-Augmented LLM Agents Perform on Real-World Energy Analytics Tasks?cited by 0
  30. 2026MedEvoEval: Evaluating Continual Evolution of Doctor Agents through Simulated Clinical Episodescited by 0
  31. 2026Reinforcement Learning for Evidence-Seeking Diagnostic Reasoning with Large Language Modelscited by 0
  32. 2026Cura 1T: Specialized Model for Agentic Healthcarecited by 0
  33. 2026MedDDC-Eval: Diagnosis-Decoupled Evaluation of Multi-Turn Medical Consultation Agentscited by 0
  34. 2026PatientAgentBench: A Benchmark Framework for Evaluating Patient-Facing Health AI Agentscited by 0
  35. 2026ELICITED: EHR-grounded Longitudinal Interactive Conversations for Information-seeking Triage Evaluation and Decision-makingcited by 0
  36. 2026BaT: Towards Self-Evolving Medical Research Agent with Stage Rubricscited by 0
  37. 2026CDEG: Learning Decision-Critical Evidence for Long-Horizon Diagnostic Agentscited by 0
  38. 2026BALMS: Benchmarking Agentic LLMs for Longitudinal Mental Health Sensingcited by 0

50 most cited of 56 All 56 (JSON)

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  1. 2026PhysicianBench: Evaluating LLM Agents in Real-World EHR Environments
  2. 2025MedAgentBoard: Benchmarking Multi-Agent Collaboration with Conventional Methods for Diverse Medical Tasks
  3. 2025MedBench v4: A Robust and Scalable Benchmark for Evaluating Chinese Medical Language Models, Multimodal Models, and Intelligent Agents
  4. 2026HealthAgentBench: A Unified Benchmark Suite of Realistic Agentic Healthcare Environments for Challenging Frontier AI Agents
  5. 2025A Survey of LLM-based Agents in Medicine: How far are we from Baymax?
  6. 2026AgentRx: A Benchmark Study of LLM Agents for Multimodal Clinical Prediction Tasks
  7. 2025OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries
  8. 2025MedBrowseComp: Benchmarking Medical Deep Research and Computer Use