mlsanityData to 14 Oct 2026

Same Patient, Different Order: Action-Level Reliability of Clinical LLM Agents Under Repeated Runs

arXiv 2609.13582 ↗First posted 11 Sep 2026cs.CL cs.AI cs.LGcited by 0

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

A clinical agent benchmark can report the same verdict on identical inputs while the agent files a materially different order on each run. Such agents order tests, request medications and place referrals, yet benchmarks typically score one run per task and rarely ask whether identical inputs produce identical actions; MedAgentBench, the benchmark we use, scores a single attempt and says so. To measure this gap we introduce "same-input rerun", which replays a task with every input held fixed and compares the orders rather than the score, with six reliability metrics, and apply it to 1000 MedAgentBench runs across 50 tasks from its five write-capable families, two open-weight models below ten billion parameters quantised to four bits, and two temperatures. The study establishes that action-level divergence exists and can pass unrecorded by the score, not that any rate generalises. Under the 8B model at temperature 0.7, all 43 ordering groups emit a different set of orders across five identical runs, 26 emit the order on some runs and not others, and 28 record a different coded value, dose or analyte. In 22 of those 43 the benchmark reports the same failing verdict for materially different behaviour, as it does for all 10 divergent groups of the 4B model at 0.7. Orders also reach different endpoints across runs, one of which the record server rejects while the agent is told it succeeded. These findings motivate repeated-run evaluation, action-level stability reporting and execution-faithful environment feedback in clinical-agent benchmarks.

Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 15 of its 26 references that are in the map. First posted on arXiv 11 Sep 2026.

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15 of 26 references.

Closest ancestors · 3

Same direction, newest first

  1. 2026PhysicianBench: Evaluating LLM Agents in Real-World EHR Environments4 May
  2. 2025MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents24 Jan
  3. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments13 May

Other references · 12

  1. 2024τ-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domainscited by 1,402
  2. 2024Non-Determinism of "Deterministic" LLM Settingscited by 92
  3. 2024Quantifying Variance in Evaluation Benchmarkscited by 54
  4. 2025Understanding and Mitigating Numerical Sources of Nondeterminism in LLM Inferencecited by 53
  5. 2026ReliabilityBench: Evaluating LLM Agent Reliability Under Production-Like Stress Conditionscited by 36
  6. 2025Do Repetitions Matter? Strengthening Reliability in LLM Evaluationscited by 14
  7. 2025Stochasticity in Agentic Evaluations: Quantifying Inconsistency with Intraclass Correlationcited by 11
  8. 2026JudgeSense: A Benchmark for Prompt Sensitivity in LLM-as-a-Judge Systemscited by 10
  9. 2025ReasonBENCH: Benchmarking the (In)Stability of LLM Reasoningcited by 9
  10. 2026How Consistent Are LLM Agents? Measuring Behavioral Reproducibility in Multi-Step Tool-Calling Pipelinescited by 5
  11. 2026AgentFairBench: Do LLM Agents Discriminate When They Act?cited by 3
  12. 2026RISED: A Pre-Deployment Evaluation Framework for High-Stakes AI Decision-Support Systems, with Application to Healthcarecited by 1

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