mlsanityData to 7 Oct 2026

PhysicianBench: Evaluating LLM Agents in Real-World EHR Environments

arXiv 2605.02240 ↗First posted 4 May 2026cs.AIcited by 19

On the map: LLM agents and tool use → Medical and scientific domain agents

Abstract (arXiv)

We introduce PhysicianBench, a benchmark for evaluating LLM agents on physician tasks grounded in real clinical setting within electronic health record (EHR) environments. Existing medical agent benchmarks primarily focus on static knowledge recall, single-step atomic actions, or action intent without verifiable execution against the environment. As a result, they fail to capture the long-horizon, composite workflows that characterize real clinical systems. PhysicianBench comprises 100 long-horizon tasks adapted from real consultation cases between primary care and subspecialty physicians, with each task independently reviewed by a separate panel of physicians. Tasks are instantiated in an EHR environment with real patient records and accessed through the same standard APIs used by commercial EHR vendors. Tasks span 21 specialties (e.g., cardiology, endocrinology, oncology, psychiatry) and diverse workflow types (e.g., diagnosis interpretation, medication prescribing, treatment planning), requiring an average of 27 tool calls per task. Solving each task requires retrieving data across encounters, reasoning over heterogeneous clinical information, executing consequential clinical actions, and producing clinical documentation. Each task is decomposed into structured checkpoints (670 in total across the benchmark) capturing distinct stages of completion graded by task-specific scripts with execution-grounded verification. Across 13 proprietary and open-source LLM agents, the best-performing model achieves only 46% success rate (pass@1), while open-source models reach at most 19%, revealing a substantial gap between current agent capabilities and the demands of real-world clinical workflows. PhysicianBench provides a realistic and execution-grounded benchmark for measuring progress toward autonomous clinical agents.

Key facts. Cited by 19 papers in the map (data through 7 Oct 2026). Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use. Builds on 22 of its 35 references that are in the map. First posted on arXiv 4 May 2026.

Builds on

22 of 35 references.

Closest ancestors · 2

Same direction, newest first

  1. 2025FHIR-AgentBench: Benchmarking LLM Agents for Realistic Interoperable EHR Question Answering12 Sep
  2. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments13 May

Other references · 20

  1. 2022ReAct: Synergizing Reasoning and Acting in Language Modelscited by 8,355
  2. 2021Evaluating Large Language Models Trained on Codecited by 8,053
  3. 2023SWE-bench: Can Language Models Resolve Real-World GitHub Issues?cited by 3,193
  4. 2023WebArena: A Realistic Web Environment for Building Autonomous Agentscited by 1,908
  5. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  6. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  7. 2024τ-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domainscited by 1,280
  8. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  9. 2023AgentBench: Evaluating LLMs as Agentscited by 1,211
  10. 2026DeepSeek-V4: Towards Highly Efficient Million-Token Context Intelligencecited by 877
  11. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 525
  12. 2025HealthBench: Evaluating Large Language Models Towards Improved Human Healthcited by 385
8 more
  1. 2024TheAgentCompany: Benchmarking LLM Agents on Consequential Real World Taskscited by 306
  2. 2025MCP-Bench: Benchmarking Tool-Using LLM Agents with Complex Real-World Tasks via MCP Serverscited by 101
  3. 2024EHRAgent: Code Empowers Large Language Models for Few-shot Complex Tabular Reasoning on Electronic Health Recordscited by 75
  4. 2025The Tool Decathlon: Benchmarking Language Agents for Diverse, Realistic, and Long-Horizon Task Executioncited by 73
  5. 2026HealthBench Professional: Evaluating Large Language Models on Real Clinician Chatscited by 22
  6. 2020A new paradigm for accelerating clinical data science at Stanford Medicinecited by 16
  7. 2025AI-based Clinical Decision Support for Primary Care: A Real-World Studycited by 10
  8. 2026AgentEHR: Advancing Autonomous Clinical Decision-Making via Retrospective Summarizationcited by 4

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2026: 19.

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  1. 2026HealthAgentBench: A Unified Benchmark Suite of Realistic Agentic Healthcare Environments for Challenging Frontier AI Agentscited by 6
  2. 2026RadThinking: A Dataset for Longitudinal Clinical Reasoning in Radiologycited by 4
  3. 2026AutoMedBench: Towards Medical AutoResearch with Agentic AI Modelscited by 3
  4. 2026ContinualSkillBench: Can LLM Agents Truly Evolve Their Capabilities?cited by 2
  5. 2026The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomycited by 1
  6. 2026CliniCARE-Bench: Clinical Calibrated Audit of Medical Reasoning in EHRcited by 1
  7. 2026MDIA: A Multi-Agent Diagnostic Intelligence Pipeline on HealthBench Professionalcited by 0
  8. 2026Generalistic or Specific Embeddings, Which is Better? An Empirical Study on Search for Clinical Coding in Non-English Languagescited by 0
  9. 2026Cura 1T: Specialized Model for Agentic Healthcarecited by 0
  10. 2026MedDDC-Eval: Diagnosis-Decoupled Evaluation of Multi-Turn Medical Consultation Agentscited by 0
  11. 2026GPAgentBench-2K: Benchmarking Large Language Model Agents in Complex Clinical Action Spacecited by 0
  12. 2026Toward Workflow-Aware Benchmarking for Healthcare NLP Agentscited by 0
7 more
  1. 2026Untangling the Mechanisms of Misleading Context in Medical Question Answeringcited by 0
  2. 2026Finishing the Task Is Not Enough: Evaluating Agent Resilience and Considerate Participation under Accumulating Challengecited by 0
  3. 2026Same Patient, Different Order: Action-Level Reliability of Clinical LLM Agents Under Repeated Runscited by 0
  4. 2026A primer on evaluation methods for large language models in healthcarecited by 0
  5. 2026Synthetic Hospital: An Open, Verifiable, Physician-Validated Longitudinal EHR Benchmarkcited by 0
  6. 2026MammoClaw: Towards Skill-Evolving Agent Harness for Breast Cancer Mammography Analysiscited by 0
  7. 2026KlinikeBench: Evaluating Language Models Beyond Diagnostic Accuracycited by 0

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  1. 2025MedAgentBench: A Realistic Virtual EHR Environment to Benchmark Medical LLM Agents
  2. 2026Are LLMs Ready to Assist Physicians? PhysAssistBench for Interactive Doctor-Patient-EHR Assistance
  3. 2026LongMedBench: Benchmarking Medical Agents for Long-Horizon Clinical Decision-Making
  4. 2026HealthAdminBench: Evaluating Computer-Use Agents on Healthcare Administration Tasks
  5. 2026PatientAgentBench: A Benchmark Framework for Evaluating Patient-Facing Health AI Agents
  6. 2025OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries
  7. 2026EHR-Complex: Benchmarking Medical Agents for Complex Clinical Reasoning
  8. 2026MedConsultBench: A Full-Cycle, Fine-Grained, Process-Aware Benchmark for Medical Consultation Agents