MultiResUNet : Rethinking the U-Net Architecture for Multimodal Biomedical Image Segmentation
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Abstract (arXiv)
In recent years Deep Learning has brought about a breakthrough in Medical Image Segmentation. U-Net is the most prominent deep network in this regard, which has been the most popular architecture in the medical imaging community. Despite outstanding overall performance in segmenting multimodal medical images, from extensive experimentations on challenging datasets, we found out that the classical U-Net architecture seems to be lacking in certain aspects. Therefore, we propose some modifications to improve upon the already state-of-the-art U-Net model. Hence, following the modifications we develop a novel architecture MultiResUNet as the potential successor to the successful U-Net architecture. We have compared our proposed architecture MultiResUNet with the classical U-Net on a vast repertoire of multimodal medical images. Albeit slight improvements in the cases of ideal images, a remarkable gain in performance has been attained for challenging images. We have evaluated our model on five different datasets, each with their own unique challenges, and have obtained a relative improvement in performance of 10.15%, 5.07%, 2.63%, 1.41%, and 0.62% respectively.
Key facts. Cited by 195 papers in the map (data through 7 Oct 2026). First posted on arXiv 11 Feb 2019.
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Citing papers per year: 2021: 39; 2022: 34; 2023: 46; 2024: 38; 2025: 22; 2026: 16.
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- 2021UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformercited by 197
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- 2024Rotate to Scan: UNet-like Mamba with Triplet SSM Module for Medical Image Segmentationcited by 12
- 2024Integrating Mamba Sequence Model and Hierarchical Upsampling Network for Accurate Semantic Segmentation of Multiple Sclerosis Legioncited by 8
- 2025InceptionMamba: Efficient Multi-Stage Feature Enhancement with Selective State Space Model for Microscopic Medical Image Segmentationcited by 0
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- 2024Rotate to Scan: UNet-like Mamba with Triplet SSM Module for Medical Image Segmentation26 Mar 2024
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- 2023A Unified Framework for U-Net Design and Analysiscited by 27
- 2022Swinv2-Imagen: Hierarchical Vision Transformer Diffusion Models for Text-to-Image Generationcited by 7
- 2026Unsupervised Anatomical Feature Learning via Diffusion Models: Enhanced Medical Image Segmentation with Denoising Diffusion Probabilistic Modelscited by 0
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- 2023A Unified Framework for U-Net Design and Analysis31 May 2023
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- 2021UCTransNet: Rethinking the Skip Connections in U-Net from a Channel-wise Perspective with Transformercited by 197
- 2022Medical Image Segmentation Review: The success of U-Netcited by 190
- 2022Attention Attention Everywhere: Monocular Depth Prediction with Skip Attentioncited by 92
- 2021TransMed: Transformers Advance Multi-modal Medical Image Classificationcited by 85
- 2021Knowledge distillation from multi-modal to mono-modal segmentation networkscited by 68
- 2021MSRF-Net: A Multi-Scale Residual Fusion Network for Biomedical Image Segmentationcited by 53
- 2021A Comprehensive Study on Colorectal Polyp Segmentation with ResUNet++, Conditional Random Field and Test-Time Augmentationcited by 41
- 2021FANet: A Feedback Attention Network for Improved Biomedical Image Segmentationcited by 36
- 2022ColonFormer: An Efficient Transformer based Method for Colon Polyp Segmentationcited by 28
- 2022Assessing generalisability of deep learning-based polyp detection and segmentation methods through a computer vision challengecited by 27
- 2023ACC-UNet: A Completely Convolutional UNet model for the 2020scited by 26
- 2023Source-Free Domain Adaptive Fundus Image Segmentation with Class-Balanced Mean Teachercited by 21
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- 2026Initialization and Stopping Tolerance in CPU Dermoscopic Segmentation22 Sep 2026
- 2026Multiple Myeloma Lesion Segmentation on Whole-Body Diffusion-Weighted Imaging via Efficient Anatomical Anticipation and Multimodal Confirmation5 Sep 2026
- 2026GET: Generative Embedding Translation for Medical Image Segmentation23 Aug 2026
- 2026Decoupling Language Guidance from Backbones for Text-Guided Medical Segmentation10 Jul 2026
- 2026APRIL-MedSeg: A Modular Medical Image Segmentation Toolbox Embracing Modern Paradigms29 Jun 2026
- 2026FSS-Net: Frequency-Spatial Synergy Network with Wavelet Attention for Carotid Artery Ultrasound Segmentation9 Jun 2026
- 2026Multi-Dataset Cross-Domain Knowledge Distillation for Unified Medical Image Segmentation, Classification, and Detection2 May 2026
- 2026PBE-UNet: A light weight Progressive Boundary-Enhanced U-Net with Scale-Aware Aggregation for Ultrasound Image Segmentation15 Apr 2026
- 2026XAttnRes: Cross-Stage Attention Residuals for Medical Image Segmentation28 Mar 2026
- 2026SegMate: Asymmetric Attention-Based Lightweight Architecture for Efficient Multi-Organ Segmentation27 Feb 2026
- 2026Decoder-Free Supervoxel GNN for Accurate Brain-Tumor Localization in Multi-Modal MRI20 Jan 2026
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