Interpretable machine learning: definitions, methods, and applications
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Abstract (arXiv)
Machine-learning models have demonstrated great success in learning complex patterns that enable them to make predictions about unobserved data. In addition to using models for prediction, the ability to interpret what a model has learned is receiving an increasing amount of attention. However, this increased focus has led to considerable confusion about the notion of interpretability. In particular, it is unclear how the wide array of proposed interpretation methods are related, and what common concepts can be used to evaluate them. We aim to address these concerns by defining interpretability in the context of machine learning and introducing the Predictive, Descriptive, Relevant (PDR) framework for discussing interpretations. The PDR framework provides three overarching desiderata for evaluation: predictive accuracy, descriptive accuracy and relevancy, with relevancy judged relative to a human audience. Moreover, to help manage the deluge of interpretation methods, we introduce a categorization of existing techniques into model-based and post-hoc categories, with sub-groups including sparsity, modularity and simulatability. To demonstrate how practitioners can use the PDR framework to evaluate and understand interpretations, we provide numerous real-world examples. These examples highlight the often under-appreciated role played by human audiences in discussions of interpretability. Finally, based on our framework, we discuss limitations of existing methods and directions for future work. We hope that this work will provide a common vocabulary that will make it easier for both practitioners and researchers to discuss and choose from the full range of interpretation methods.
Key facts. Cited by 303 papers in the map (data through 7 Oct 2026). First posted on arXiv 14 Jan 2019.
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Citing papers per year: 2021: 58; 2022: 66; 2023: 63; 2024: 51; 2025: 35; 2026: 30.
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50 most cited of 303 All 303 (JSON)
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- 2025The Epistemological Consequences of Large Language Models: Rethinking collective intelligence and institutional knowledge22 Dec 2025
- 2024Rethinking Interpretability in the Era of Large Language Models30 Jan 2024
- 2022Towards Human-Compatible XAI: Explaining Data Differentials with Concept Induction over Background Knowledge27 Sep 2022
- 2021Towards Out-Of-Distribution Generalization: A Surveycited by 431
- 2022From Anecdotal Evidence to Quantitative Evaluation Methods: A Systematic Review on Evaluating Explainable AIcited by 299
- 2021Explainable artificial intelligence (XAI) in deep learning-based medical image analysiscited by 147
- 2021Benchmarking and Survey of Explanation Methods for Black Box Modelscited by 136
- 2022Towards Faithful Model Explanation in NLP: A Surveycited by 129
- 2021Teach Me to Explain: A Review of Datasets for Explainable Natural Language Processingcited by 126
- 2021Explainable AI (XAI): A Systematic Meta-Survey of Current Challenges and Future Opportunitiescited by 125
- 2022OpenXAI: Towards a Transparent Evaluation of Model Explanationscited by 125
- 2023Explainable Artificial Intelligence (XAI) 2.0: A Manifesto of Open Challenges and Interdisciplinary Research Directionscited by 123
- 2022A Comprehensive Survey on Trustworthy Graph Neural Networks: Privacy, Robustness, Fairness, and Explainabilitycited by 118
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- 2021A Comprehensive Taxonomy for Explainable Artificial Intelligence: A Systematic Survey of Surveys on Methods and Conceptscited by 90
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- 2026Structural Alignment for Reliable Industrial AI: Bridging Physical Reality, Data, Models, and Human Intent28 Sep 2026
- 2026Null importance: Disentangling relevance for interpretable machine learning16 Sep 2026
- 2026Algorithmic stability via ensembling9 Sep 2026
- 2026Sparse Oblique Rule Boosting for Simpler Additive Rule Ensembles6 Sep 2026
- 2026What is Smoothness?3 Sep 2026
- 2026Explainable Artificial Intelligence (XAI) in Computational Pathology: Definitions, Taxonomy, and Recommendations28 Aug 2026
- 2026Learning Auditable Classifier Models: Source-Disjoint Tree Ensembles16 Aug 2026
- 2026Structure-Guided Spatiotemporal Attention Graph Neural Network for Traffic Flow Prediction14 Aug 2026
- 2026Gaze Behavior in Visual World Experiments Can be Modeled With Off-the-shelf Language-Vision Encoders7 Aug 2026
- 2026ECG-InterpBench: Benchmarking the Interpretability of ECG Foundation Models with Matched-Scale Sparse Autoencoders29 Jul 2026
- 2026Signed Evidence Flow: Conflict-Aware and Stability-Calibrated Data Analysis20 Jun 2026
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