mlsanityData to 14 Oct 2026

Multi-instrument Music Synthesis with Spectrogram Diffusion

arXiv 2206.05408 ↗First posted 11 Jun 2022cs.SD cs.LG eess.AScited by 42

On the map: Diffusion models → Audio, speech and music

Abstract (arXiv)

An ideal music synthesizer should be both interactive and expressive, generating high-fidelity audio in realtime for arbitrary combinations of instruments and notes. Recent neural synthesizers have exhibited a tradeoff between domain-specific models that offer detailed control of only specific instruments, or raw waveform models that can train on any music but with minimal control and slow generation. In this work, we focus on a middle ground of neural synthesizers that can generate audio from MIDI sequences with arbitrary combinations of instruments in realtime. This enables training on a wide range of transcription datasets with a single model, which in turn offers note-level control of composition and instrumentation across a wide range of instruments. We use a simple two-stage process: MIDI to spectrograms with an encoder-decoder Transformer, then spectrograms to audio with a generative adversarial network (GAN) spectrogram inverter. We compare training the decoder as an autoregressive model and as a Denoising Diffusion Probabilistic Model (DDPM) and find that the DDPM approach is superior both qualitatively and as measured by audio reconstruction and Fr'echet distance metrics. Given the interactivity and generality of this approach, we find this to be a promising first step towards interactive and expressive neural synthesis for arbitrary combinations of instruments and notes.

Key facts. Cited by 42 papers in the map (data through 14 Oct 2026). Placed in Audio, speech and music, one of 14 directions in Diffusion models. Builds on 64 of its 76 references that are in the map. First posted on arXiv 11 Jun 2022.

Builds on

64 of 76 references.

Closest ancestors · 8

Same direction, newest first

  1. 2021Diffusion-Based Voice Conversion with Fast Maximum Likelihood Sampling Scheme28 Sep
  2. 2021CRASH: Raw Audio Score-based Generative Modeling for Controllable High-resolution Drum Sound Synthesis14 Jun
  3. 2021DiffSVC: A Diffusion Probabilistic Model for Singing Voice Conversion28 May
  4. 2021Grad-TTS: A Diffusion Probabilistic Model for Text-to-Speech13 May
  5. 2021NU-Wave: A Diffusion Probabilistic Model for Neural Audio Upsampling6 Apr
  6. 2021Diff-TTS: A Denoising Diffusion Model for Text-to-Speech3 Apr
  7. 2021Symbolic Music Generation with Diffusion Models30 Mar
  8. 2020DiffWave: A Versatile Diffusion Model for Audio Synthesis21 Sep

Other references · 56

  1. 2017Attention Is All You Needcited by 60,361
  2. 2014Adam: A Method for Stochastic Optimizationcited by 37,240
  3. 2020Denoising Diffusion Probabilistic Modelscited by 21,076
  4. 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,713
  5. 2019Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformercited by 14,599
  6. 2022Hierarchical Text-Conditional Image Generation with CLIP Latentscited by 6,585
  7. 2022Photorealistic Text-to-Image Diffusion Models with Deep Language Understandingcited by 6,355
  8. 2017Neural Discrete Representation Learningcited by 4,712
  9. 2022Flamingo: a Visual Language Model for Few-Shot Learningcited by 4,386
  10. 2021Improved Denoising Diffusion Probabilistic Modelscited by 3,761
  11. 2017FiLM: Visual Reasoning with a General Conditioning Layercited by 2,333
  12. 2016WaveNet: A Generative Model for Raw Audiocited by 1,722
38 more
  1. 2021Variational Diffusion Modelscited by 1,153
  2. 2015Fast and Accurate Deep Network Learning by Exponential Linear Units (ELUs)cited by 1,070
  3. 2018Adafactor: Adaptive Learning Rates with Sublinear Memory Costcited by 905
  4. 2017Natural TTS Synthesis by Conditioning WaveNet on Mel Spectrogram Predictionscited by 804
  5. 2021SoundStream: An End-to-End Neural Audio Codeccited by 771
  6. 2016CNN Architectures for Large-Scale Audio Classificationcited by 704
  7. 2020WaveGrad: Estimating Gradients for Waveform Generationcited by 622
  8. 2020Jukebox: A Generative Model for Musiccited by 542
  9. 2017Tacotron: Towards End-to-End Speech Synthesiscited by 490
  10. 2019MelGAN: Generative Adversarial Networks for Conditional Waveform Synthesiscited by 354
  11. 2018WaveGlow: A Flow-based Generative Network for Speech Synthesiscited by 309
  12. 2017Neural Audio Synthesis of Musical Notes with WaveNet Autoencoderscited by 225
  13. 2018Adversarial Audio Synthesiscited by 225
  14. 2018Efficient Neural Audio Synthesiscited by 219
  15. 2018Enabling Factorized Piano Music Modeling and Generation with the MAESTRO Datasetcited by 217
  16. 2022Scaling Up Models and Data with textttt5x and textttseqiocited by 187
  17. 2020DDSP: Differentiable Digital Signal Processingcited by 178
  18. 2022It's Raw! Audio Generation with State-Space Modelscited by 171
  19. 2019GANSynth: Adversarial Neural Audio Synthesiscited by 116
  20. 2016SampleRNN: An Unconditional End-to-End Neural Audio Generation Modelcited by 110
  21. 2019Cutting Music Source Separation Some Slakh: A Dataset to Study the Impact of Training Data Quality and Quantitycited by 86
  22. 2020Towards Learning a Universal Non-Semantic Representation of Speechcited by 84
  23. 2021RAVE: A variational autoencoder for fast and high-quality neural audio synthesiscited by 73
  24. 2021MT3: Multi-Task Multitrack Music Transcriptioncited by 71
  25. 2016Creating A Multi-track Classical Musical Performance Dataset for Multimodal Music Analysis: Challenges, Insights, and Applicationscited by 61
  26. 2022General-purpose, long-context autoregressive modeling with Perceiver ARcited by 60
  27. 2016Learning Features of Music from Scratchcited by 58
  28. 2021Sequence-to-Sequence Piano Transcription with Transformerscited by 48
  29. 2020A Spectral Energy Distance for Parallel Speech Synthesiscited by 42
  30. 2020Wave-Tacotron: Spectrogram-free end-to-end text-to-speech synthesiscited by 38
  31. 2021Chunked Autoregressive GAN for Conditional Waveform Synthesiscited by 38
  32. 2020SEANet: A Multi-modal Speech Enhancement Networkcited by 37
  33. 2021MIDI-DDSP: Detailed Control of Musical Performance via Hierarchical Modelingcited by 32
  34. 2018SING: Symbol-to-Instrument Neural Generatorcited by 23
  35. 2018A Universal Music Translation Networkcited by 22
  36. 2019Simultaneous Separation and Transcription of Mixtures with Multiple Polyphonic and Percussive Instrumentscited by 18
  37. 2021Catch-A-Waveform: Learning to Generate Audio from a Single Short Examplecited by 15
  38. 2018Neural Music Synthesis for Flexible Timbre Controlcited by 14

50 most cited of 56 All 56 (JSON)

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Cited by year (2026 to 14 Oct)

Citing papers per year: 2022: 2; 2023: 14; 2024: 14; 2025: 6; 2026: 6.

42 papers.

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  1. 2023MusicLM: Generating Music From Textcited by 448
  2. 2024Fast Timing-Conditioned Latent Audio Diffusioncited by 181
  3. 2024DITTO: Diffusion Inference-Time T-Optimization for Music Generationcited by 73
  4. 2023Multi-Source Diffusion Models for Simultaneous Music Generation and Separationcited by 63
  5. 2022Solving Audio Inverse Problems with a Diffusion Modelcited by 62
  6. 2023SingSong: Generating musical accompaniments from singingcited by 55
  7. 2024Foundation Models for Music: A Surveycited by 37
  8. 2023StemGen: A music generation model that listenscited by 32
  9. 2023Exploring Diffusion Models for Unsupervised Video Anomaly Detectioncited by 23
  10. 2023Attributing Image Generative Models using Latent Fingerprintscited by 20
  11. 2023Long-Term Rhythmic Video Soundtrackercited by 17
  12. 2023Discrete Diffusion Probabilistic Models for Symbolic Music Generationcited by 16
30 more
  1. 2023EDMSound: Spectrogram Based Diffusion Models for Efficient and High-Quality Audio Synthesiscited by 15
  2. 2022DiffRoll: Diffusion-based Generative Music Transcription with Unsupervised Pretraining Capabilitycited by 13
  3. 2023LongDanceDiff: Long-term Dance Generation with Conditional Diffusion Modelcited by 12
  4. 2024DExter: Learning and Controlling Performance Expression with Diffusion Modelscited by 11
  5. 2024Combining audio control and style transfer using latent diffusioncited by 10
  6. 2023Timbre transfer using image-to-image denoising diffusion implicit modelscited by 7
  7. 2025Unified Cross-modal Translation of Score Images, Symbolic Music, and Performance Audiocited by 6
  8. 2023AudioSlots: A slot-centric generative model for audio separationcited by 5
  9. 2023Performance Conditioning for Diffusion-Based Multi-Instrument Music Synthesiscited by 5
  10. 2024Expressive Acoustic Guitar Sound Synthesis with an Instrument-Specific Input Representation and Diffusion Outpaintingcited by 5
  11. 2024A Survey of Deep Learning Audio Generation Methodscited by 5
  12. 2024Improving Diffusion Models's Data-Corruption Resistance using Scheduled Pseudo-Huber Losscited by 4
  13. 2025A Survey on Music Generation from Single-Modal, Cross-Modal, and Multi-Modal Perspectivescited by 4
  14. 2025WaveletDiff: Multilevel Wavelet Diffusion For Time Series Generationcited by 3
  15. 2024MR-MT3: Memory Retaining Multi-Track Music Transcription to Mitigate Instrument Leakagecited by 2
  16. 2024Why Perturbing Symbolic Music is Necessary: Fitting the Distribution of Never-used Notes through a Joint Probabilistic Diffusion Modelcited by 2
  17. 2025Pianist Transformer: Towards Expressive Piano Performance Rendering via Scalable Self-Supervised Pre-Trainingcited by 2
  18. 2023Distribution Preserving Source Separation With Time Frequency Predictive Modelscited by 1
  19. 2024ViolinDiff: Enhancing Expressive Violin Synthesis with Pitch Bend Conditioningcited by 1
  20. 2025GuitarFlow: Realistic Electric Guitar Synthesis From Tablatures via Flow Matching and Style Transfercited by 1
  21. 2026Drum Synthesis from Expressive Drum Grids via Neural Audio Codecscited by 1
  22. 2024Integrating Text-to-Music Models with Language Models: Composing Long Structured Music Piecescited by 0
  23. 2024Annotation-Free MIDI-to-Audio Synthesis via Concatenative Synthesis and Generative Refinementcited by 0
  24. 2024Interpreting Graphic Notation with MusicLDM: An AI Improvisation of Cornelius Cardew's Treatisecited by 0
  25. 2025TinyMusician: On-Device Music Generation with Knowledge Distillation and Mixed Precision Quantizationcited by 0
  26. 2026Fusing Memory and Attention: A study on LSTM, Transformer and Hybrid Architectures for Symbolic Music Generationcited by 0
  27. 2026Seconds-Aligned PCA-DAC Latent Diffusion for Symbolic-to-Audio Drum Renderingcited by 0
  28. 2026Optimality of FSQ Tokens for Continuous Diffusion for Categorical Data with Application to Text-to-Speechcited by 0
  29. 2026Adapting Diffusion-Based Music Synthesis to Speech and Singing Voice Conversioncited by 0
  30. 2026Synthesis and editing of multi-instrument audio mixtures using scalar-quantised latents with MIDI Span conditioningcited by 0

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  1. 2026Anysynth:Zero-Shot Instrument Cloning via In-Context Learning and Asymmetric Hierarchical Guidance
  2. 2026Pitch-class Steering for Diffusion-based Music Generation via Latent-space Probes
  3. 2026VIOLET: High-Fidelity Violin Synthesis with Techniques and Dynamics
  4. 2024WaveTransfer: A Flexible End-to-end Multi-instrument Timbre Transfer with Diffusion
  5. 2023Controllable Music Production with Diffusion Models and Guidance Gradients
  6. 2024Editing Music with Melody and Text: Using ControlNet for Diffusion Transformer
  7. 2026MuScriptor: An Open Model for Multi-Instrument Music Transcription
  8. 2024Diff-A-Riff: Musical Accompaniment Co-creation via Latent Diffusion Models