What Makes Transfer Learning Work For Medical Images: Feature Reuse & Other Factors
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Abstract (arXiv)
Transfer learning is a standard technique to transfer knowledge from one domain to another. For applications in medical imaging, transfer from ImageNet has become the de-facto approach, despite differences in the tasks and image characteristics between the domains. However, it is unclear what factors determine whether - and to what extent - transfer learning to the medical domain is useful. The long-standing assumption that features from the source domain get reused has recently been called into question. Through a series of experiments on several medical image benchmark datasets, we explore the relationship between transfer learning, data size, the capacity and inductive bias of the model, as well as the distance between the source and target domain. Our findings suggest that transfer learning is beneficial in most cases, and we characterize the important role feature reuse plays in its success.
Key facts. Cited by 61 papers in the map (data through 7 Oct 2026). Builds on 32 of its 47 references that are in the map. First posted on arXiv 2 Mar 2022.
Builds on
32 of 47 references.
References · 32
- 2015Deep Residual Learning for Image Recognitioncited by 51,809
- 2014Adam: A Method for Stochastic Optimizationcited by 36,960
- 2019PyTorch: An Imperative Style, High-Performance Deep Learning Librarycited by 20,160
- 2021Swin Transformer: Hierarchical Vision Transformer using Shifted Windowscited by 12,082
- 2021Emerging Properties in Self-Supervised Vision Transformerscited by 6,893
- 2015Rethinking the Inception Architecture for Computer Visioncited by 5,451
- 2020Training data-efficient image transformers & distillation through attentioncited by 4,560
- 2015Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classificationcited by 3,590
- 2013Rich feature hierarchies for accurate object detection and semantic segmentationcited by 2,160
- 2019Similarity of Neural Network Representations Revisitedcited by 1,695
- 2018ImageNet-trained CNNs are biased towards texture; increasing shape bias improves accuracy and robustnesscited by 1,430
- 2019CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparisoncited by 1,410
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- 2014How transferable are features in deep neural networks?cited by 1,216
- 2021Do Vision Transformers See Like Convolutional Neural Networks?cited by 671
- 2018Do Better ImageNet Models Transfer Better?cited by 560
- 2017Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)cited by 549
- 2018Rotation Equivariant CNNs for Digital Pathologycited by 420
- 2018Rethinking ImageNet Pre-trainingcited by 376
- 2019Transfusion: Understanding Transfer Learning for Medical Imagingcited by 366
- 2020What is being transferred in transfer learning?cited by 365
- 2019Rapid Learning or Feature Reuse? Towards Understanding the Effectiveness of MAMLcited by 359
- 2017Are GANs Created Equal? A Large-Scale Studycited by 267
- 2020Do Wide and Deep Networks Learn the Same Things? Uncovering How Neural Network Representations Vary with Width and Depthcited by 241
- 2018Pros and Cons of GAN Evaluation Measurescited by 224
- 2019BCN20000: Dermoscopic Lesions in the Wildcited by 224
- 2017Convolutional Neural Networks for Medical Image Analysis: Full Training or Fine Tuning?cited by 220
- 2021Revisiting ResNets: Improved Training and Scaling Strategiescited by 158
- 2019Are All Layers Created Equal?cited by 94
- 2021Is it Time to Replace CNNs with Transformers for Medical Images?cited by 60
- 2020A scoping review of transfer learning research on medical image analysis using ImageNetcited by 54
- 2021Supervised Transfer Learning at Scale for Medical Imagingcited by 38
- 2018Domain Adaptive Transfer Learning with Specialist Modelscited by 31
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Citing papers per year: 2022: 6; 2023: 22; 2024: 16; 2025: 12; 2026: 5.
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- 2024Self-supervised learning improves robustness of deep learning lung tumor segmentation to CT imaging differences14 May 2024
- 2024Scaling Laws for Galaxy Images3 Apr 2024
- 2024To Supervise or Not to Supervise: Understanding and Addressing the Key Challenges of Point Cloud Transfer Learning26 Mar 2024
- 2024Multi-Scale Texture Loss for CT denoising with GANs25 Mar 2024
- 2024FissionFusion: Fast Geometric Generation and Hierarchical Souping for Medical Image Analysis20 Mar 2024
- 2024MedMerge: Merging Models for Effective Transfer Learning to Medical Imaging Tasks18 Mar 2024
- 2024RadCLIP: Enhancing Radiologic Image Analysis through Contrastive Language-Image Pre-training15 Mar 2024
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- 2024Part-aware Prompted Segment Anything Model for Adaptive Segmentation8 Mar 2024
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- 2024Analysis of the Two-Step Heterogeneous Transfer Learning for Laryngeal Blood Vessel Classification: Issue and Improvement29 Feb 2024
- 2024BarlowTwins-CXR : Enhancing Chest X-Ray abnormality localization in heterogeneous data with cross-domain self-supervised learning9 Feb 2024
- 2024B-Cos Aligned Transformers Learn Human-Interpretable Features16 Jan 2024
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- 2023Bridging Generalization Gaps in High Content Imaging Through Online Self-Supervised Domain Adaptation21 Nov 2023
- 2023Shifting to Machine Supervision: Annotation-Efficient Semi and Self-Supervised Learning for Automatic Medical Image Segmentation and Classification17 Nov 2023
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- 2023Assessing Test-time Variability for Interactive 3D Medical Image Segmentation with Diverse Point Prompts13 Nov 2023
- 2023Promise:Prompt-driven 3D Medical Image Segmentation Using Pretrained Image Foundation Models30 Oct 2023
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- 2023Progressive Feature Adjustment for Semi-supervised Learning from Pretrained Models9 Sep 2023
- 2023Generalized Cross-domain Multi-label Few-shot Learning for Chest X-rays8 Sep 2023
- 2023How Can We Tame the Long-Tail of Chest X-ray Datasets?8 Sep 2023
- 2023Enhancing Medical Image Segmentation: Optimizing Cross-Entropy Weights and Post-Processing with Autoencoders21 Aug 2023
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- 2023The Performance of Transferability Metrics does not Translate to Medical Tasks14 Aug 2023
- 2023AViT: Adapting Vision Transformers for Small Skin Lesion Segmentation Datasets26 Jul 2023
- 2023DAGrid: Directed Accumulator Grid5 Jun 2023
- 2023Training Transitive and Commutative Multimodal Transformers with LoReTTa23 May 2023
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- 2023Are Natural Domain Foundation Models Useful for Medical Image Classification?cited by 44
- 2022PatchDropout: Economizing Vision Transformers Using Patch Dropoutcited by 28
- 2023Promise:Prompt-driven 3D Medical Image Segmentation Using Pretrained Image Foundation Modelscited by 18
- 2023Rotation-Agnostic Image Representation Learning for Digital Pathologycited by 15
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- 2025Understanding the Learning Dynamics of LoRA: A Gradient Flow Perspective on Low-Rank Adaptation in Matrix Factorizationcited by 13
- 2025Towards Scalable Language-Image Pre-training for 3D Medical Imagingcited by 13
- 2024Source Matters: Source Dataset Impact on Model Robustness in Medical Imagingcited by 10
- 2022Metadata-guided Consistency Learning for High Content Imagescited by 8
- 2023DPA-P2PNet: Deformable Proposal-aware P2PNet for Accurate Point-based Cell Detectioncited by 8
- 2023Generalizing Across Domains in Diabetic Retinopathy via Variational Autoencoderscited by 8
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- 2026Benchmarking transferability of SSL pretraining to same and different modality segmentation tasks18 May 2026
- 2026Vision Transformer-Conditioned UNet for Domain-Adaptive Semantic Segmentation12 May 2026
- 2026Tumor-aware augmentation with task-guided attention analysis improves rectal cancer segmentation from magnetic resonance images6 May 2026
- 2026Are Natural-Domain Foundation Models Effective for Accelerated Cardiac MRI Reconstruction?24 Apr 2026
- 2026GloCTM: Cross-Lingual Topic Modeling via a Global Context Space17 Jan 2026
- 2025Weakly Supervised Tuberculosis Localization in Chest X-rays through Knowledge Distillation11 Dec 2025
- 2025Segmentation of Ischemic Stroke Lesions using Transfer Learning on Multi-sequence MRI10 Nov 2025
- 2025Rethinking Convergence in Deep Learning: The Predictive-Corrective Paradigm for Anatomy-Informed Brain MRI Segmentation17 Oct 2025
- 2025Intuitions of Machine Learning Researchers about Transfer Learning for Medical Image Classification1 Oct 2025
- 2025Towards Scalable Language-Image Pre-training for 3D Medical Imaging28 May 2025
- 2025Advancements in Medical Image Classification through Fine-Tuning Natural Domain Foundation Models26 May 2025
- 2025Self-Supervision Enhances Instance-based Multiple Instance Learning Methods in Digital Pathology: A Benchmark Study2 May 2025
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