Automatic Polyp Segmentation via Multi-scale Subtraction Network
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Abstract (arXiv)
More than 90% of colorectal cancer is gradually transformed from colorectal polyps. In clinical practice, precise polyp segmentation provides important information in the early detection of colorectal cancer. Therefore, automatic polyp segmentation techniques are of great importance for both patients and doctors. Most existing methods are based on U-shape structure and use element-wise addition or concatenation to fuse different level features progressively in decoder. However, both the two operations easily generate plenty of redundant information, which will weaken the complementarity between different level features, resulting in inaccurate localization and blurred edges of polyps. To address this challenge, we propose a multi-scale subtraction network (MSNet) to segment polyp from colonoscopy image. Specifically, we first design a subtraction unit (SU) to produce the difference features between adjacent levels in encoder. Then, we pyramidally equip the SUs at different levels with varying receptive fields, thereby obtaining rich multi-scale difference information. In addition, we build a training-free network "LossNet" to comprehensively supervise the polyp-aware features from bottom layer to top layer, which drives the MSNet to capture the detailed and structural cues simultaneously. Extensive experiments on five benchmark datasets demonstrate that our MSNet performs favorably against most state-of-the-art methods under different evaluation metrics. Furthermore, MSNet runs at a real-time speed of ~70fps when processing a 352 × 352 image. The source code will be publicly available at urlhttps://github.com/Xiaoqi-Zhao-DLUT/MSNet. keywordsColorectal Cancer and Automatic Polyp Segmentation and Subtraction and LossNet.
Key facts. Cited by 77 papers in the map (data through 7 Oct 2026). Builds on 17 of its 28 references that are in the map. First posted on arXiv 11 Aug 2021.
Builds on
17 of 28 references.
References · 17
- 2015Deep Residual Learning for Image Recognitioncited by 51,809
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
- 2016Feature Pyramid Networks for Object Detectioncited by 5,021
- 2014Fully Convolutional Networks for Semantic Segmentationcited by 4,845
- 2017Squeeze-and-Excitation Networkscited by 4,763
- 2016DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFscited by 3,239
- 2016Perceptual Losses for Real-Time Style Transfer and Super-Resolutioncited by 2,678
- 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,518
- 2019Kvasir-SEG: A Segmented Polyp Datasetcited by 588
- 2017Structure-measure: A New Way to Evaluate Foreground Mapscited by 480
- 2020PraNet: Parallel Reverse Attention Network for Polyp Segmentationcited by 460
- 2018Enhanced-alignment Measure for Binary Foreground Map Evaluationcited by 370
5 more
- 2016A Benchmark for Endoluminal Scene Segmentation of Colonoscopy Imagescited by 220
- 2019ResUNet++: An Advanced Architecture for Medical Image Segmentationcited by 211
- 2019F3Net: Fusion, Feedback and Focus for Salient Object Detectioncited by 176
- 2021Progressively Normalized Self-Attention Network for Video Polyp Segmentationcited by 75
- 2018Polyp Segmentation in Colonoscopy Images Using Fully Convolutional Networkcited by 33
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Citing papers per year: 2021: 2; 2022: 12; 2023: 18; 2024: 28; 2025: 12; 2026: 5.
77 papers.
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- 2021Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformerscited by 159
- 2022Zoom In and Out: A Mixed-scale Triplet Network for Camouflaged Object Detectioncited by 145
- 2022Video Polyp Segmentation: A Deep Learning Perspectivecited by 81
- 2022Deep Gradient Learning for Efficient Camouflaged Object Detectioncited by 65
- 2023Can SAM Segment Polyps?cited by 59
- 2021CAVER: Cross-Modal View-Mixed Transformer for Bi-Modal Salient Object Detectioncited by 47
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentationcited by 34
- 2023MEGANet: Multi-Scale Edge-Guided Attention Network for Weak Boundary Polyp Segmentationcited by 28
- 2024Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attentioncited by 26
- 2023Polyp-SAM++: Can A Text Guided SAM Perform Better for Polyp Segmentation?cited by 22
- 2024SAM-COD: SAM-guided Unified Framework for Weakly-Supervised Camouflaged Object Detectioncited by 22
- 2023WeakPolyp: You Only Look Bounding Box for Polyp Segmentationcited by 21
38 more
- 2024Spider: A Unified Framework for Context-dependent Concept Segmentationcited by 18
- 2023Towards Diverse Binary Segmentation via A Simple yet General Gated Networkcited by 17
- 2023M2SNet: Multi-scale in Multi-scale Subtraction Network for Medical Image Segmentationcited by 13
- 2024Frontiers in Intelligent Colonoscopycited by 13
- 2022Joint Learning of Salient Object Detection, Depth Estimation and Contour Extractioncited by 12
- 2022Promoting Saliency From Depth: Deep Unsupervised RGB-D Saliency Detectioncited by 12
- 2023A Survey on Deep Learning for Polyp Segmentation: Techniques, Challenges and Future Trendscited by 12
- 2024ASPS: Augmented Segment Anything Model for Polyp Segmentationcited by 12
- 2022BoxPolyp:Boost Generalized Polyp Segmentation Using Extra Coarse Bounding Box Annotationscited by 10
- 2024Concealed Object Segmentation with Hierarchical Coherence Modelingcited by 10
- 2024Polyp SAM 2: Advancing Zero shot Polyp Segmentation in Colorectal Cancer Detectioncited by 8
- 2024Inspiring the Next Generation of Segment Anything Models: Comprehensively Evaluate SAM and SAM 2 with Diverse Prompts Towards Context-Dependent Concepts under Different Scenescited by 8
- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentationcited by 7
- 2024CGCOD: Class-Guided Camouflaged Object Detectioncited by 7
- 2026TP-Seg: Task-Prototype Framework for Unified Medical Lesion Segmentationcited by 7
- 2022DilatedSegNet: A Deep Dilated Segmentation Network for Polyp Segmentationcited by 6
- 2023Meta-Polyp: a baseline for efficient Polyp segmentationcited by 6
- 2024Self-Prompting Polyp Segmentation in Colonoscopy using Hybrid Yolo-SAM 2 Modelcited by 6
- 2022Trichomonas Vaginalis Segmentation in Microscope Imagescited by 5
- 2023M^2UNet: MetaFormer Multi-scale Upsampling Network for Polyp Segmentationcited by 5
- 2024Colorectal Polyp Segmentation in the Deep Learning Era: A Comprehensive Surveycited by 5
- 2024Polyp-DAM: Polyp segmentation via depth anything modelcited by 5
- 2024MonoBox: Tightness-free Box-supervised Polyp Segmentation using Monotonicity Constraintcited by 5
- 2023Edge-aware Feature Aggregation Network for Polyp Segmentationcited by 4
- 2024Multi-scale Information Sharing and Selection Network with Boundary Attention for Polyp Segmentationcited by 3
- 2024Mamba Capsule Routing Towards Part-Whole Relational Camouflaged Object Detectioncited by 3
- 2025UniMRSeg: Unified Modality-Relax Segmentation via Hierarchical Self-Supervised Compensationcited by 3
- 2022LAPFormer: A Light and Accurate Polyp Segmentation Transformercited by 2
- 2023Multi-level feature fusion network combining attention mechanisms for polyp segmentationcited by 2
- 2023IBoxCLA: Towards Robust Box-supervised Segmentation of Polyp via Improved Box-dice and Contrastive Latent-anchorscited by 2
- 2023Contrastive Learning-Based Spectral Knowledge Distillation for Multi-Modality and Missing Modality Scenarios in Semantic Segmentationcited by 2
- 2024Glass Segmentation with Multi Scales and Primary Prediction Guidingcited by 2
- 2024SAM-EG: Segment Anything Model with Egde Guidance framework for efficient Polyp Segmentationcited by 2
- 2024PSTNet: Enhanced Polyp Segmentation with Multi-scale Alignment and Frequency Domain Integrationcited by 2
- 2025Residual-SwinCA-Net: A Channel-Aware Integrated Residual CNN-Swin Transformer for Malignant Lesion Segmentation in BUSIcited by 2
- 2025From SAM to DINOv2: Towards Distilling Foundation Models to Lightweight Baselines for Generalized Polyp Segmentationcited by 2
- 2022Online pseudo labeling for polyp segmentation with momentum networkscited by 1
- 2023Scale-aware Super-resolution Network with Dual Affinity Learning for Lesion Segmentation from Medical Imagescited by 1
50 most cited of 77 All 77 (JSON)
- 2026Induce to Empower: Improving Lightweight Baselines via Foundation Model Induction for Generalized Polyp Segmentation19 Jul 2026
- 2026Beyond Pixel Overlap: A Framework for Decomposing Segmentation Evaluation Metrics1 Jul 2026
- 2026Sharpening Lightweight Models for Generalized Polyp Segmentation: A Boundary Guided Distillation from Foundation Models20 Apr 2026
- 2026ASGNet: Adaptive Spectrum Guidance Network for Automatic Polyp Segmentation16 Apr 2026
- 2026TP-Seg: Task-Prototype Framework for Unified Medical Lesion Segmentation1 Apr 2026
- 2025From SAM to DINOv2: Towards Distilling Foundation Models to Lightweight Baselines for Generalized Polyp Segmentation10 Dec 2025
- 2025Residual-SwinCA-Net: A Channel-Aware Integrated Residual CNN-Swin Transformer for Malignant Lesion Segmentation in BUSI9 Dec 2025
- 2025MSRNet: A Multi-Scale Recursive Network for Camouflaged Object Detection16 Nov 2025
- 2025UniMRSeg: Unified Modality-Relax Segmentation via Hierarchical Self-Supervised Compensation19 Sep 2025
- 2025Power Battery Detection11 Aug 2025
- 2025The Power of Certainty: How Confident Models Lead to Better Segmentation14 Jul 2025
- 2025CL-Polyp: A Contrastive Learning-Enhanced Network for Accurate Polyp Segmentation9 Jul 2025
38 more
- 2025MEGANet-W: A Wavelet-Driven Edge-Guided Attention Framework for Weak Boundary Polyp Detection3 Jul 2025
- 2025Mamba Guided Boundary Prior Matters: A New Perspective for Generalized Polyp Segmentation2 Jul 2025
- 2025BiSeg-SAM: Weakly-Supervised Post-Processing Framework for Boosting Binary Segmentation in Segment Anything Models2 Apr 2025
- 2025TransGUNet: Transformer Meets Graph-based Skip Connection for Medical Image Segmentation14 Feb 2025
- 2025Frequency Domain Enhanced U-Net for Low-Frequency Information-Rich Image Segmentation in Surgical and Deep-Sea Exploration Robots6 Feb 2025
- 2024CGCOD: Class-Guided Camouflaged Object Detection25 Dec 2024
- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation11 Dec 2024
- 2024Inspiring the Next Generation of Segment Anything Models: Comprehensively Evaluate SAM and SAM 2 with Diverse Prompts Towards Context-Dependent Concepts under Different Scenes2 Dec 2024
- 2024DPE-Net: Dual-Parallel Encoder Based Network for Semantic Segmentation of Polyps1 Dec 2024
- 2024Frontiers in Intelligent Colonoscopy22 Oct 2024
- 2024Mamba Capsule Routing Towards Part-Whole Relational Camouflaged Object Detection5 Oct 2024
- 2024Polyp-SES: Automatic Polyp Segmentation with Self-Enriched Semantic Model2 Oct 2024
- 2024MixPolyp: Integrating Mask, Box and Scribble Supervision for Enhanced Polyp Segmentation25 Sep 2024
- 2024Self-Prompting Polyp Segmentation in Colonoscopy using Hybrid Yolo-SAM 2 Model14 Sep 2024
- 2024PSTNet: Enhanced Polyp Segmentation with Multi-scale Alignment and Frequency Domain Integration13 Sep 2024
- 2024Transformer-Enhanced Iterative Feedback Mechanism for Polyp Segmentation25 Aug 2024
- 2024SAM-COD: SAM-guided Unified Framework for Weakly-Supervised Camouflaged Object Detection20 Aug 2024
- 2024Polyp SAM 2: Advancing Zero shot Polyp Segmentation in Colorectal Cancer Detection12 Aug 2024
- 2024ASPS: Augmented Segment Anything Model for Polyp Segmentation30 Jun 2024
- 2024SAM-EG: Segment Anything Model with Egde Guidance framework for efficient Polyp Segmentation21 Jun 2024
- 2024Multi-scale Information Sharing and Selection Network with Boundary Attention for Polyp Segmentation18 May 2024
- 2024Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attention10 May 2024
- 2024ODC-SA Net: Orthogonal Direction Enhancement and Scale Aware Network for Polyp Segmentation10 May 2024
- 2024Spider: A Unified Framework for Context-dependent Concept Segmentation2 May 2024
- 2024DmADs-Net: Dense multiscale attention and depth-supervised network for medical image segmentation1 May 2024
- 2024MonoBox: Tightness-free Box-supervised Polyp Segmentation using Monotonicity Constraint1 Apr 2024
- 2024Medical Visual Prompting (MVP): A Unified Framework for Versatile and High-Quality Medical Image Segmentation1 Apr 2024
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentation20 Mar 2024
- 2024A Spatial-Temporal Progressive Fusion Network for Breast Lesion Segmentation in Ultrasound Videos18 Mar 2024
- 2024Glass Segmentation with Multi Scales and Primary Prediction Guiding13 Feb 2024
- 2024Polyp-DAM: Polyp segmentation via depth anything model3 Feb 2024
- 2024Concealed Object Segmentation with Hierarchical Coherence Modeling22 Jan 2024
- 2024Colorectal Polyp Segmentation in the Deep Learning Era: A Comprehensive Survey22 Jan 2024
- 2023KDAS: Knowledge Distillation via Attention Supervision Framework for Polyp Segmentation13 Dec 2023
- 2023Contrastive Learning-Based Spectral Knowledge Distillation for Multi-Modality and Missing Modality Scenarios in Semantic Segmentation4 Dec 2023
- 2023A Survey on Deep Learning for Polyp Segmentation: Techniques, Challenges and Future Trends30 Nov 2023
- 2023IBoxCLA: Towards Robust Box-supervised Segmentation of Polyp via Improved Box-dice and Contrastive Latent-anchors11 Oct 2023
- 2023Edge-aware Feature Aggregation Network for Polyp Segmentation19 Sep 2023
50 newest of 77 All 77 (JSON)
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentationcited by 34
- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentationcited by 7
- 2024Mamba Capsule Routing Towards Part-Whole Relational Camouflaged Object Detectioncited by 3
- 2025Mamba Guided Boundary Prior Matters: A New Perspective for Generalized Polyp Segmentationcited by 1
- 2025Mamba Guided Boundary Prior Matters: A New Perspective for Generalized Polyp Segmentation2 Jul 2025
- 2024SAM-Mamba: Mamba Guided SAM Architecture for Generalized Zero-Shot Polyp Segmentation11 Dec 2024
- 2024Mamba Capsule Routing Towards Part-Whole Relational Camouflaged Object Detection5 Oct 2024
- 2024H-vmunet: High-order Vision Mamba UNet for Medical Image Segmentation20 Mar 2024
- 2021Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformerscited by 159
- 2022Zoom In and Out: A Mixed-scale Triplet Network for Camouflaged Object Detectioncited by 145
- 2022Video Polyp Segmentation: A Deep Learning Perspectivecited by 81
- 2022Deep Gradient Learning for Efficient Camouflaged Object Detectioncited by 65
- 2023Can SAM Segment Polyps?cited by 59
- 2021CAVER: Cross-Modal View-Mixed Transformer for Bi-Modal Salient Object Detectioncited by 47
- 2023MEGANet: Multi-Scale Edge-Guided Attention Network for Weak Boundary Polyp Segmentationcited by 28
- 2024Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attentioncited by 26
- 2023Polyp-SAM++: Can A Text Guided SAM Perform Better for Polyp Segmentation?cited by 22
- 2024SAM-COD: SAM-guided Unified Framework for Weakly-Supervised Camouflaged Object Detectioncited by 22
- 2023WeakPolyp: You Only Look Bounding Box for Polyp Segmentationcited by 21
- 2024Spider: A Unified Framework for Context-dependent Concept Segmentationcited by 18
12 most cited of 73 All 73 (JSON)
- 2026Induce to Empower: Improving Lightweight Baselines via Foundation Model Induction for Generalized Polyp Segmentation19 Jul 2026
- 2026Beyond Pixel Overlap: A Framework for Decomposing Segmentation Evaluation Metrics1 Jul 2026
- 2026Sharpening Lightweight Models for Generalized Polyp Segmentation: A Boundary Guided Distillation from Foundation Models20 Apr 2026
- 2026ASGNet: Adaptive Spectrum Guidance Network for Automatic Polyp Segmentation16 Apr 2026
- 2026TP-Seg: Task-Prototype Framework for Unified Medical Lesion Segmentation1 Apr 2026
- 2025From SAM to DINOv2: Towards Distilling Foundation Models to Lightweight Baselines for Generalized Polyp Segmentation10 Dec 2025
- 2025Residual-SwinCA-Net: A Channel-Aware Integrated Residual CNN-Swin Transformer for Malignant Lesion Segmentation in BUSI9 Dec 2025
- 2025MSRNet: A Multi-Scale Recursive Network for Camouflaged Object Detection16 Nov 2025
- 2025UniMRSeg: Unified Modality-Relax Segmentation via Hierarchical Self-Supervised Compensation19 Sep 2025
- 2025Power Battery Detection11 Aug 2025
- 2025The Power of Certainty: How Confident Models Lead to Better Segmentation14 Jul 2025
- 2025CL-Polyp: A Contrastive Learning-Enhanced Network for Accurate Polyp Segmentation9 Jul 2025
12 newest of 73 All 73 (JSON)