Diffuse2Seg: Diffusion Models Can Segment Anything Without Supervision
On the map: Diffusion models → Medical imaging and segmentation
Abstract (arXiv)
Open-world entity segmentation aims to predict masks for arbitrary objects across domains and at multiple granularities, from parts to whole objects. In this setting, SAM sets a strong standard: trained on SA-1B, comprising 11M images and over 1B carefully annotated masks, it achieves remarkable zero-shot performance. Collecting such labels is expensive and time-consuming, however, which limits how far this recipe can scale. Text-to-image diffusion models offer a way around this. Their intermediate features transfer well across perception tasks, and since object structure emerges as the model denoises a noise sample into an image conditioned on a text prompt, that structure is already encoded in these representations. They can therefore be exploited for open-world entity segmentation without retraining or supervision. Building on this observation, we introduce Diffuse2Seg, which repurposes generative diffusion models for automatic mask generation by propagating a grid of point prompts through their self-attention representations in an edge-preserving manner. Diffuse2Seg produces multi-granular instance masks and outperforms prior state-of-the-art label generators by 4.3-7.1 p.p. in AR_1000 across five domains. Training an instance segmentation model on these generated masks advances detector-free open-world segmentation by 7.4 and 7.7 p.p. on "things" and "stuff+things" datasets and surpasses the detector-based UnSAM on "stuff+things" by 2.1 p.p. in AR_1000. Finally, we show that a model trained on Diffuse2Seg labels provides a strong initialization for semi-supervised learning, outperforming its fully supervised counterpart with already 5k labeled images.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models. Builds on 56 of its 60 references that are in the map. First posted on arXiv 6 Sep 2026.
Builds on
56 of 60 references.
Closest ancestors · 10
Same direction, newest first
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- 2025Seg4Diff: Unveiling Open-Vocabulary Segmentation in Text-to-Image Diffusion Transformers22 Sep
- 2025TRACE: Your Diffusion Model is Secretly an Instance Edge Detector11 Mar
- 2024Unsupervised Segmentation by Diffusing, Walking and Cutting6 Dec
- 2024Repurposing Stable Diffusion Attention for Training-Free Unsupervised Interactive Segmentation15 Nov
- 2024iSeg: An Iterative Refinement-based Framework for Training-free Segmentation5 Sep
- 2024EmerDiff: Emerging Pixel-level Semantic Knowledge in Diffusion Models22 Jan
- 2023Diffuse, Attend, and Segment: Unsupervised Zero-Shot Segmentation using Stable Diffusion23 Aug
Other references · 46
- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 30,186
- 2021High-Resolution Image Synthesis with Latent Diffusion Modelscited by 18,863
- 2014Microsoft COCO: Common Objects in Contextcited by 17,608
- 2020A Simple Framework for Contrastive Learning of Visual Representationscited by 12,049
- 2023Segment Anythingcited by 8,234
- 2023DINOv2: Learning Robust Visual Features without Supervisioncited by 7,974
- 2021Masked Autoencoders Are Scalable Vision Learnerscited by 7,403
- 2021Emerging Properties in Self-Supervised Vision Transformerscited by 6,968
- 2023SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesiscited by 4,356
- 2024Scaling Rectified Flow Transformers for High-Resolution Image Synthesiscited by 4,181
- 2020Unsupervised Learning of Visual Features by Contrasting Cluster Assignmentscited by 2,857
- 2021BEiT: BERT Pre-Training of Image Transformerscited by 2,375
34 more
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- 2022Self-Supervised Transformers for Unsupervised Object Discovery using Normalized Cutcited by 167
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- 2022High-Quality Entity Segmentationcited by 93
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- 2022Unsupervised Object Localization: Observing the Background to Discover Objectscited by 66
- 2025Your ViT is Secretly an Image Segmentation Modelcited by 63
- 2025ConceptAttention: Diffusion Transformers Learn Highly Interpretable Featurescited by 52
- 2024CleanDIFT: Diffusion Features without Noisecited by 44
- 2026Image Generators are Generalist Vision Learnerscited by 43
- 2024DiffCut: Catalyzing Zero-Shot Semantic Segmentation with Diffusion Features and Recursive Normalized Cutcited by 26
- 2024Not All Diffusion Model Activations Have Been Evaluated as Discriminative Featurescited by 25
- 2023MOST: Multiple Object localization with Self-supervised Transformers for object discoverycited by 17
- 2024CuVLER: Enhanced Unsupervised Object Discoveries through Exhaustive Self-Supervised Transformerscited by 16
- 2026Video Generation Models are General-Purpose Vision Learnerscited by 14
- 2025Attention (as Discrete-Time Markov) Chainscited by 11
- 2024HASSOD: Hierarchical Adaptive Self-Supervised Object Detectioncited by 10
- 2024ProMerge: Prompt and Merge for Unsupervised Instance Segmentationcited by 10
- 2023Deciphering 'What' and 'Where' Visual Pathways from Spectral Clustering of Layer-Distributed Neural Representationscited by 9
- 2024SOHES: Self-supervised Open-world Hierarchical Entity Segmentationcited by 6
- 2024CutS3D: Cutting Semantics in 3D for 2D Unsupervised Instance Segmentationcited by 6
- 2025unMORE: Unsupervised Multi-Object Segmentation via Center-Boundary Reasoningcited by 4
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- 2025M2N2V2: Multi-Modal Unsupervised and Training-free Interactive Segmentationcited by 1
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