mlsanityData to 7 Oct 2026

Depression Diagnosis Dialogue Simulation: Self-improving Psychiatrist with Tertiary Memory

arXiv 2409.15084 ↗First posted 20 Sep 2024cs.CL cs.AI cs.HCcited by 13

On the map: Synthetic data and self-improvement for LLMs → Medical synthetic data and agents

Abstract (arXiv)

Mental health issues, particularly depressive disorders, present significant challenges in contemporary society, necessitating the development of effective automated diagnostic methods. This paper introduces the Agent Mental Clinic (AMC), a self-improving conversational agent system designed to enhance depression diagnosis through simulated dialogues between patient and psychiatrist agents. To enhance the dialogue quality and diagnosis accuracy, we design a psychiatrist agent consisting of a tertiary memory structure, a dialogue control and reflect plugin that acts as ``supervisor'' and a memory sampling module, fully leveraging the skills reflected by the psychiatrist agent, achieving great accuracy on depression risk and suicide risk diagnosis via conversation. Experiment results on datasets collected in real-life scenarios demonstrate that the system, simulating the procedure of training psychiatrists, can be a promising optimization method for aligning LLMs with real-life distribution in specific domains without modifying the weights of LLMs, even when only a few representative labeled cases are available.

Key facts. Cited by 13 papers in the map (data through 7 Oct 2026). Placed in Medical synthetic data and agents, one of 13 directions in Synthetic data and self-improvement for LLMs. Builds on 24 of its 41 references that are in the map. First posted on arXiv 20 Sep 2024.

Builds on

24 of 41 references.

References · 24

  1. 2023Reflexion: Language Agents with Verbal Reinforcement Learningcited by 4,064
  2. 2023AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversationcited by 1,906
  3. 2023The Rise and Potential of Large Language Model Based Agents: A Surveycited by 1,422
  4. 2024Evaluating Very Long-Term Conversational Memory of LLM Agentscited by 800
  5. 2023Character-LLM: A Trainable Agent for Role-Playingcited by 335
  6. 2023ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledgecited by 324
  7. 2024Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agentscited by 210
  8. 2023Prompting and Evaluating Large Language Models for Proactive Dialogues: Clarification, Target-guided, and Non-collaborationcited by 115
  9. 2024Pride and Prejudice: LLM Amplifies Self-Bias in Self-Refinementcited by 111
  10. 2023Understanding the Benefits and Challenges of Using Large Language Model-based Conversational Agents for Mental Well-being Supportcited by 75
  11. 2024Ask-before-Plan: Proactive Language Agents for Real-World Planningcited by 59
  12. 2024Can Large Language Models be Good Emotional Supporter? Mitigating Preference Bias on Emotional Support Conversationcited by 55
12 more
  1. 2024Towards Human-centered Proactive Conversational Agentscited by 48
  2. 2023Knowledge-enhanced Mixed-initiative Dialogue System for Emotional Support Conversationscited by 41
  3. 2022D4: a Chinese Dialogue Dataset for Depression-Diagnosis-Oriented Chatcited by 37
  4. 2023Memory Sandbox: Transparent and Interactive Memory Management for Conversational Agentscited by 36
  5. 2024IBSEN: Director-Actor Agent Collaboration for Controllable and Interactive Drama Script Generationcited by 35
  6. 2024GPTCoach: Towards LLM-Based Physical Activity Coachingcited by 29
  7. 2024Leveraging Large Language Model as Simulated Patients for Clinical Educationcited by 20
  8. 2023LLM-Mini-CEX: Automatic Evaluation of Large Language Model for Diagnostic Conversationcited by 14
  9. 2024DiagESC: Dialogue Synthesis for Integrating Depression Diagnosis into Emotional Support Conversationcited by 6
  10. 2024Towards Reliable and Empathetic Depression-Diagnosis-Oriented Chatscited by 3
  11. 2024WundtGPT: Shaping Large Language Models To Be An Empathetic, Proactive Psychologistcited by 3
  12. 2024Enhancing Depression-Diagnosis-Oriented Chat with Psychological State Trackingcited by 2

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2024: 1; 2025: 6; 2026: 6.

13 papers.

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  1. 2026DS@GT ARC at eRisk 2026: Hybrid Multi-Agent LLM System with Structured Algorithmic Guidance for Conversational Depression Screening
  2. 2023An Integrative Survey on Mental Health Conversational Agents to Bridge Computer Science and Medical Perspectives
  3. 2026LingxiDiagBench: A Multi-Agent Framework for Benchmarking LLMs in Chinese Psychiatric Consultation and Diagnosis
  4. 2025MAGI: Multi-Agent Guided Interview for Psychiatric Assessment
  5. 2026An Agentic LLM-Based Framework for Population-Scale Mental Health Screening
  6. 2026Towards Efficient and Robust Linguistic Emotion Diagnosis for Mental Health via Multi-Agent Instruction Refinement
  7. 2026CPEMH: An Agentic Framework for Prompt-Driven Behavior Evaluation and Assurance in Foundation-Model Systems for Mental Health Screening
  8. 2025Trustworthy AI Psychotherapy: Multi-Agent LLM Workflow for Counseling and Explainable Mental Disorder Diagnosis