Leveraging Large Language Model as Simulated Patients for Clinical Education
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Abstract (arXiv)
Simulated Patients (SPs) play a crucial role in clinical medical education by providing realistic scenarios for student practice. However, the high cost of training and hiring qualified SPs, along with the heavy workload and potential risks they face in consistently portraying actual patients, limit students' access to this type of clinical training. Consequently, the integration of computer program-based simulated patients has emerged as a valuable educational tool in recent years. With the rapid development of Large Language Models (LLMs), their exceptional capabilities in conversational artificial intelligence and role-playing have been demonstrated, making them a feasible option for implementing Virtual Simulated Patient (VSP). In this paper, we present an integrated model-agnostic framework called CureFun that harnesses the potential of LLMs in clinical medical education. This framework facilitates natural conversations between students and simulated patients, evaluates their dialogue, and provides suggestions to enhance students' clinical inquiry skills. Through comprehensive evaluations, our approach demonstrates more authentic and professional SP-scenario dialogue flows compared to other LLM-based chatbots, thus proving its proficiency in simulating patients. Additionally, leveraging CureFun's evaluation ability, we assess several medical LLMs and discuss the possibilities and limitations of using LLMs as virtual doctors from the perspective of their diagnostic abilities.
Key facts. Cited by 20 papers in the map (data through 7 Oct 2026). Builds on 32 of its 72 references that are in the map. First posted on arXiv 13 Apr 2024.
Builds on
32 of 72 references.
References · 32
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Citing papers per year: 2024: 8; 2025: 7; 2026: 5.
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- 2025PatientSim: A Persona-Driven Simulator for Realistic Doctor-Patient Interactionscited by 30
- 2024Towards a Client-Centered Assessment of LLM Therapists by Client Simulationcited by 23
- 2024Evaluating Large Language Models with Psychometricscited by 22
- 2025AnnaAgent: Dynamic Evolution Agent System with Multi-Session Memory for Realistic Seeker Simulationcited by 21
- 2025Scaffolding Empathy: Training Counselors with Simulated Patients and Utterance-level Performance Visualizationscited by 14
- 2024Depression Diagnosis Dialogue Simulation: Self-improving Psychiatrist with Tertiary Memorycited by 13
- 2024The Imperative of Conversation Analysis in the Era of LLMs: A Survey of Tasks, Techniques, and Trendscited by 11
- 2025Adaptive-VP: A Framework for LLM-Based Virtual Patients that Adapts to Trainees' Dialogue to Facilitate Nurse Communication Trainingcited by 9
- 2024PIORS: Personalized Intelligent Outpatient Reception based on Large Language Model with Multi-Agents Medical Scenario Simulationcited by 8
- 2025Modeling Challenging Patient Interactions: LLMs for Medical Communication Trainingcited by 7
- 2024When LLMs Learn to be Students: The SOEI Framework for Modeling and Evaluating Virtual Student Agents in Educational Interactioncited by 4
- 2024MedDiT: A Knowledge-Controlled Diffusion Transformer Framework for Dynamic Medical Image Generation in Virtual Simulated Patientcited by 2
8 more
- 2025Human or LLM as Standardized Patients? A Comparative Study for Medical Educationcited by 1
- 2026Evaluating Role-Consistency in LLMs for Counselor Trainingcited by 1
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counselingcited by 0
- 2025GAP: Graph-Assisted Prompts for Dialogue-based Medication Recommendationcited by 0
- 2026Beyond Prompt: Fine-grained Simulation of Cognitively Impaired Standardized Patients via Stochastic Steeringcited by 0
- 2026Persona Non Grata: LLM Persona-Driven Generations in MCQA are Unstable in Distinct Dimensionscited by 0
- 2026PAST: Prompt-Adaptive Sampling Termination for Efficient Diffusion Modelcited by 0
- 2026Item-Mean Surrogates: Why Richer Persona Data Fail to Improve LLMs as Human Surrogatescited by 0
- 2026Item-Mean Surrogates: Why Richer Persona Data Fail to Improve LLMs as Human Surrogates29 Aug 2026
- 2026PAST: Prompt-Adaptive Sampling Termination for Efficient Diffusion Model7 Aug 2026
- 2026Persona Non Grata: LLM Persona-Driven Generations in MCQA are Unstable in Distinct Dimensions1 Jul 2026
- 2026Beyond Prompt: Fine-grained Simulation of Cognitively Impaired Standardized Patients via Stochastic Steering14 Apr 2026
- 2026Evaluating Role-Consistency in LLMs for Counselor Training13 Jan 2026
- 2025Human or LLM as Standardized Patients? A Comparative Study for Medical Education12 Nov 2025
- 2025AnnaAgent: Dynamic Evolution Agent System with Multi-Session Memory for Realistic Seeker Simulation31 May 2025
- 2025Adaptive-VP: A Framework for LLM-Based Virtual Patients that Adapts to Trainees' Dialogue to Facilitate Nurse Communication Training31 May 2025
- 2025PatientSim: A Persona-Driven Simulator for Realistic Doctor-Patient Interactions23 May 2025
- 2025GAP: Graph-Assisted Prompts for Dialogue-based Medication Recommendation19 May 2025
- 2025Modeling Challenging Patient Interactions: LLMs for Medical Communication Training28 Mar 2025
- 2025Scaffolding Empathy: Training Counselors with Simulated Patients and Utterance-level Performance Visualizations25 Feb 2025
8 more
- 2024PIORS: Personalized Intelligent Outpatient Reception based on Large Language Model with Multi-Agents Medical Scenario Simulation21 Nov 2024
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counseling29 Oct 2024
- 2024When LLMs Learn to be Students: The SOEI Framework for Modeling and Evaluating Virtual Student Agents in Educational Interaction21 Oct 2024
- 2024The Imperative of Conversation Analysis in the Era of LLMs: A Survey of Tasks, Techniques, and Trends21 Sep 2024
- 2024Depression Diagnosis Dialogue Simulation: Self-improving Psychiatrist with Tertiary Memory20 Sep 2024
- 2024MedDiT: A Knowledge-Controlled Diffusion Transformer Framework for Dynamic Medical Image Generation in Virtual Simulated Patient22 Aug 2024
- 2024Evaluating Large Language Models with Psychometrics25 Jun 2024
- 2024Towards a Client-Centered Assessment of LLM Therapists by Client Simulation18 Jun 2024
- 2025AnnaAgent: Dynamic Evolution Agent System with Multi-Session Memory for Realistic Seeker Simulationcited by 21
- 2024When LLMs Learn to be Students: The SOEI Framework for Modeling and Evaluating Virtual Student Agents in Educational Interactioncited by 4
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counselingcited by 0
- 2025AnnaAgent: Dynamic Evolution Agent System with Multi-Session Memory for Realistic Seeker Simulation31 May 2025
- 2024An LLM-based Simulation Framework for Embodied Conversational Agents in Psychological Counseling29 Oct 2024
- 2024When LLMs Learn to be Students: The SOEI Framework for Modeling and Evaluating Virtual Student Agents in Educational Interaction21 Oct 2024
- 2025PatientSim: A Persona-Driven Simulator for Realistic Doctor-Patient Interactionscited by 30
- 2024Towards a Client-Centered Assessment of LLM Therapists by Client Simulationcited by 23
- 2024Evaluating Large Language Models with Psychometricscited by 22
- 2025Scaffolding Empathy: Training Counselors with Simulated Patients and Utterance-level Performance Visualizationscited by 14
- 2024The Imperative of Conversation Analysis in the Era of LLMs: A Survey of Tasks, Techniques, and Trendscited by 11
- 2025Adaptive-VP: A Framework for LLM-Based Virtual Patients that Adapts to Trainees' Dialogue to Facilitate Nurse Communication Trainingcited by 9
- 2024PIORS: Personalized Intelligent Outpatient Reception based on Large Language Model with Multi-Agents Medical Scenario Simulationcited by 8
- 2025Modeling Challenging Patient Interactions: LLMs for Medical Communication Trainingcited by 7
- 2025Human or LLM as Standardized Patients? A Comparative Study for Medical Educationcited by 1
- 2026Evaluating Role-Consistency in LLMs for Counselor Trainingcited by 1
- 2025GAP: Graph-Assisted Prompts for Dialogue-based Medication Recommendationcited by 0
- 2026Beyond Prompt: Fine-grained Simulation of Cognitively Impaired Standardized Patients via Stochastic Steeringcited by 0
12 most cited of 14 All 14 (JSON)
- 2026Item-Mean Surrogates: Why Richer Persona Data Fail to Improve LLMs as Human Surrogates29 Aug 2026
- 2026Persona Non Grata: LLM Persona-Driven Generations in MCQA are Unstable in Distinct Dimensions1 Jul 2026
- 2026Beyond Prompt: Fine-grained Simulation of Cognitively Impaired Standardized Patients via Stochastic Steering14 Apr 2026
- 2026Evaluating Role-Consistency in LLMs for Counselor Training13 Jan 2026
- 2025Human or LLM as Standardized Patients? A Comparative Study for Medical Education12 Nov 2025
- 2025Adaptive-VP: A Framework for LLM-Based Virtual Patients that Adapts to Trainees' Dialogue to Facilitate Nurse Communication Training31 May 2025
- 2025PatientSim: A Persona-Driven Simulator for Realistic Doctor-Patient Interactions23 May 2025
- 2025GAP: Graph-Assisted Prompts for Dialogue-based Medication Recommendation19 May 2025
- 2025Modeling Challenging Patient Interactions: LLMs for Medical Communication Training28 Mar 2025
- 2025Scaffolding Empathy: Training Counselors with Simulated Patients and Utterance-level Performance Visualizations25 Feb 2025
- 2024PIORS: Personalized Intelligent Outpatient Reception based on Large Language Model with Multi-Agents Medical Scenario Simulation21 Nov 2024
- 2024The Imperative of Conversation Analysis in the Era of LLMs: A Survey of Tasks, Techniques, and Trends21 Sep 2024
12 newest of 14 All 14 (JSON)