Self-supervised representation learning from 12-lead ECG data
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Abstract (arXiv)
Clinical 12-lead electrocardiography (ECG) is one of the most widely encountered kinds of biosignals. Despite the increased availability of public ECG datasets, label scarcity remains a central challenge in the field. Self-supervised learning represents a promising way to alleviate this issue. In this work, we put forward the first comprehensive assessment of self-supervised representation learning from clinical 12-lead ECG data. To this end, we adapt state-of-the-art self-supervised methods based on instance discrimination and latent forecasting to the ECG domain. In a first step, we learn contrastive representations and evaluate their quality based on linear evaluation performance on a recently established, comprehensive, clinical ECG classification task. In a second step, we analyze the impact of self-supervised pretraining on finetuned ECG classifiers as compared to purely supervised performance. For the best-performing method, an adaptation of contrastive predictive coding, we find a linear evaluation performance only 0.5% below supervised performance. For the finetuned models, we find improvements in downstream performance of roughly 1% compared to supervised performance, label efficiency, as well as robustness against physiological noise. This work clearly establishes the feasibility of extracting discriminative representations from ECG data via self-supervised learning and the numerous advantages when finetuning such representations on downstream tasks as compared to purely supervised training. As first comprehensive assessment of its kind in the ECG domain carried out exclusively on publicly available datasets, we hope to establish a first step towards reproducible progress in the rapidly evolving field of representation learning for biosignals.
Key facts. Cited by 80 papers in the map (data through 7 Oct 2026). Builds on 22 of its 40 references that are in the map. First posted on arXiv 23 Mar 2021.
Builds on
22 of 40 references.
References · 22
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- 2019Automatic diagnosis of the 12-lead ECG using a deep neural networkcited by 164
- 2020Deep Learning for ECG Analysis: Benchmarks and Insights from PTB-XLcited by 158
- 2020Uncovering the structure of clinical EEG signals with self-supervised learningcited by 109
- 2020Self-supervised ECG Representation Learning for Emotion Recognitioncited by 99
- 2020Subject-Aware Contrastive Learning for Biosignalscited by 75
- 2020A Framework For Contrastive Self-Supervised Learning And Designing A New Approachcited by 51
- 2019Self-supervised representation learning from electroencephalography signalscited by 24
- 2019Opportunities and Challenges of Deep Learning Methods for Electrocardiogram Data: A Systematic Reviewcited by 11
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Citing papers per year: 2021: 3; 2022: 12; 2023: 19; 2024: 16; 2025: 11; 2026: 19.
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- 2023Large-scale Training of Foundation Models for Wearable Biosignalscited by 89
- 2024Guiding Masked Representation Learning to Capture Spatio-Temporal Relationship of Electrocardiogramcited by 84
- 2023Frozen Language Model Helps ECG Zero-Shot Learningcited by 62
- 2022Lead-agnostic Self-supervised Learning for Local and Global Representations of Electrocardiogramcited by 38
- 20213KG: Contrastive Learning of 12-Lead Electrocardiograms using Physiologically-Inspired Augmentationscited by 36
- 2021Intra-Inter Subject Self-supervised Learning for Multivariate Cardiac Signalscited by 35
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- 2023ETP: Learning Transferable ECG Representations via ECG-Text Pre-trainingcited by 28
- 2024ECG Semantic Integrator (ESI): A Foundation ECG Model Pretrained with LLM-Enhanced Cardiological Textcited by 25
- 2024Learning General Representation of 12-Lead Electrocardiogram with a Joint-Embedding Predictive Architecturecited by 17
- 2023Explaining Deep Learning for ECG Analysis: Building Blocks for Auditing and Knowledge Discoverycited by 15
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- 2023In-Distribution and Out-of-Distribution Self-supervised ECG Representation Learning for Arrhythmia Detectioncited by 7
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- 2023Using explainable AI to investigate electrocardiogram changes during healthy aging -- from expert features to raw signalscited by 7
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- 2022MedalCare-XL: 16,900 healthy and pathological 12 lead ECGs obtained through electrophysiological simulationscited by 6
- 2022A Domain Generalization Approach for Out-Of-Distribution 12-lead ECG Classification with Convolutional Neural Networkscited by 5
- 2024Automated Contrastive Learning Strategy Search for Time Seriescited by 5
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- 2023Deep Metric Learning for the Hemodynamics Inference with Electrocardiogram Signalscited by 4
- 2023IncepSE: Leveraging InceptionTime's performance with Squeeze and Excitation mechanism in ECG analysiscited by 4
- 2021Computer Vision Self-supervised Learning Methods on Time Seriescited by 3
- 2022Multimodality Multi-Lead ECG Arrhythmia Classification using Self-Supervised Learningcited by 3
- 2022Pretraining ECG Data with Adversarial Masking Improves Model Generalizability for Data-Scarce Taskscited by 3
- 2025TolerantECG: A Foundation Model for Imperfect Electrocardiogramcited by 3
- 2025Self-DANA: A Resource-Efficient Channel-Adaptive Self-Supervised Approach for ECG Foundation Modelscited by 3
- 2022LEAVES: Learning Views for Time-Series Biobehavioral Data in Contrastive Learningcited by 2
- 2022Classification and Self-Supervised Regression of Arrhythmic ECG Signals Using Convolutional Neural Networkscited by 2
- 2023Which Augmentation Should I Use? An Empirical Investigation of Augmentations for Self-Supervised Phonocardiogram Representation Learningcited by 2
- 2024Modally Reduced Representation Learning of Multi-Lead ECG Signals through Simultaneous Alignment and Reconstructioncited by 2
- 2024HeartBERT: A Self-Supervised ECG Embedding Model for Efficient and Effective Medical Signal Analysiscited by 2
- 2025A Systematic Review of ECG Arrhythmia Classification: Adherence to Standards, Fair Evaluation, and Embedded Feasibilitycited by 2
- 2025A Unified AI Approach for Continuous Monitoring of Human Health and Diseases from Intensive Care Unit to Home with Physiological Foundation Models (UNIPHY+)cited by 2
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- 2024Estimating ECG Intervals from Lead-I Alone: External Validation of Supervised Modelscited by 1
50 most cited of 80 All 80 (JSON)
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- 2026A Hybrid CNN--State-Space--Attention Backbone with Joint-Embedding Predictive Pretraining for 12-Lead ECG Classification24 Sep 2026
- 2026TRACE: Tractable Routing Autoencoder for Clinical ECG20 Sep 2026
- 2026Same path, different: a mechanistic comparison of looped and stacked transformer encoders on 12-lead ECG14 Sep 2026
- 2026Leveraging Cardiac Imaging to Improve ECG-Based Detection of Chagas Disease in Resource-Constrained Settings8 Sep 2026
- 2026Beat-Synchronous Tokenization for ECG Transformers31 Aug 2026
- 2026Foundation models for movement data: Are they ready for prime-time?13 Aug 2026
- 2026The Impact of Temporal Context Length and Encoding Strategies on Self-Supervised ECG Representation Learning13 Aug 2026
- 2026FOUND-AF: Benchmarking ECG Foundation Models for Atrial Fibrillation Detection4 Aug 2026
- 2026ECG-InterpBench: Benchmarking the Interpretability of ECG Foundation Models with Matched-Scale Sparse Autoencoders29 Jul 2026
- 2026CADENCE: A Cardiac Atom Dictionary for Interpretable Neural Concept Extraction from ECG Foundation Models28 Jul 2026
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- 2026Information-theoretic Multimodal Representation Learning for Electrocardiogram Signals26 May 2026
- 2026ECG-NAT: A Self-supervised Neighborhood Attention Transformer for Multi-lead Electrocardiogram Classification13 May 2026
- 2026Beyond Patient Invariance: Learning Cardiac Dynamics via Action-Conditioned JEPAs24 Apr 2026
- 2026Bit-Identical Medical Deep Learning via Structured Orthogonal Initialization30 Mar 2026
- 2026Position: Evaluation of ECG Representations Must Be Fixed19 Feb 2026
- 2025CLEF: Clinically-Guided Contrastive Learning for Electrocardiogram Foundation Models1 Dec 2025
- 2025A Unified AI Approach for Continuous Monitoring of Human Health and Diseases from Intensive Care Unit to Home with Physiological Foundation Models (UNIPHY+)19 Sep 2025
- 2025Domain Knowledge is Power: Leveraging Physiological Priors for Self Supervised Representation Learning in Electrocardiography9 Sep 2025
- 2025ECG-Soup: Harnessing Multi-Layer Synergy for ECG Foundation Models27 Aug 2025
- 2025Learning ECG Representations via Poly-Window Contrastive Learning21 Aug 2025
- 2025TolerantECG: A Foundation Model for Imperfect Electrocardiogram14 Jul 2025
- 2025Self-DANA: A Resource-Efficient Channel-Adaptive Self-Supervised Approach for ECG Foundation Models3 Jul 2025
- 2025Towards Hardware Supported Domain Generalization in DNN-Based Edge Computing Devices for Health Monitoring12 Mar 2025
- 2025A Systematic Review of ECG Arrhythmia Classification: Adherence to Standards, Fair Evaluation, and Embedded Feasibility10 Mar 2025
- 2025Conditional Electrocardiogram Generation Using Hierarchical Variational Autoencoders3 Mar 2025
- 2025FADE: Forecasting for Anomaly Detection on ECG11 Feb 2025
- 2024Wearable Accelerometer Foundation Models for Health via Knowledge Distillation15 Dec 2024
- 2024Toward Foundation Model for Multivariate Wearable Sensing of Physiological Signals12 Dec 2024
- 2024Self-Supervised Learning with Probabilistic Density Labeling for Rainfall Probability Estimation8 Dec 2024
- 2024AnyECG: Foundational Models for Multitask Cardiac Analysis in Real-World Settings17 Nov 2024
- 2024HeartBERT: A Self-Supervised ECG Embedding Model for Efficient and Effective Medical Signal Analysis8 Nov 2024
- 2024Considerations for Distribution Shift Robustness of Diagnostic Models in Healthcare25 Oct 2024
- 2024Learning General Representation of 12-Lead Electrocardiogram with a Joint-Embedding Predictive Architecture11 Oct 2024
- 2024Self-Supervised Pre-Training with Joint-Embedding Predictive Architecture Boosts ECG Classification Performance2 Oct 2024
- 2024Estimating ECG Intervals from Lead-I Alone: External Validation of Supervised Models12 Aug 2024
- 2024Guidelines for Augmentation Selection in Contrastive Learning for Time Series Classification12 Jul 2024
- 2024Efficient Multi-View Fusion and Flexible Adaptation to View Missing in Cardiovascular System Signals13 Jun 2024
- 2024Unlocking Telemetry Potential: Self-Supervised Learning for Continuous Clinical Electrocardiogram Monitoring7 Jun 2024
- 2024ECG Semantic Integrator (ESI): A Foundation ECG Model Pretrained with LLM-Enhanced Cardiological Text26 May 2024
- 2024Modally Reduced Representation Learning of Multi-Lead ECG Signals through Simultaneous Alignment and Reconstruction24 May 2024
- 2024Automated Contrastive Learning Strategy Search for Time Series19 Mar 2024
- 2024Guiding Masked Representation Learning to Capture Spatio-Temporal Relationship of Electrocardiogram2 Feb 2024
- 2023Prospects for AI-Enhanced ECG as a Unified Screening Tool for Cardiac and Non-Cardiac Conditions -- An Explorative Study in Emergency Care18 Dec 2023
- 2023Large-scale Training of Foundation Models for Wearable Biosignals8 Dec 2023
- 2023Which Augmentation Should I Use? An Empirical Investigation of Augmentations for Self-Supervised Phonocardiogram Representation Learning1 Dec 2023
- 2023IncepSE: Leveraging InceptionTime's performance with Squeeze and Excitation mechanism in ECG analysis16 Nov 2023
50 newest of 80 All 80 (JSON)
- 2023Large Models for Time Series and Spatio-Temporal Data: A Survey and Outlookcited by 109
- 2023Large-scale Training of Foundation Models for Wearable Biosignalscited by 89
- 2024Guiding Masked Representation Learning to Capture Spatio-Temporal Relationship of Electrocardiogramcited by 84
- 2023Frozen Language Model Helps ECG Zero-Shot Learningcited by 62
- 2022Lead-agnostic Self-supervised Learning for Local and Global Representations of Electrocardiogramcited by 38
- 20213KG: Contrastive Learning of 12-Lead Electrocardiograms using Physiologically-Inspired Augmentationscited by 36
- 2021Intra-Inter Subject Self-supervised Learning for Multivariate Cardiac Signalscited by 35
- 2024Toward Foundation Model for Multivariate Wearable Sensing of Physiological Signalscited by 29
- 2023ETP: Learning Transferable ECG Representations via ECG-Text Pre-trainingcited by 28
- 2024ECG Semantic Integrator (ESI): A Foundation ECG Model Pretrained with LLM-Enhanced Cardiological Textcited by 25
- 2024Learning General Representation of 12-Lead Electrocardiogram with a Joint-Embedding Predictive Architecturecited by 17
- 2023Explaining Deep Learning for ECG Analysis: Building Blocks for Auditing and Knowledge Discoverycited by 15
12 most cited of 78 All 78 (JSON)
- 2026Revitalizing Medical Time Series with Vision-Informed Retrieval: A Vision-Language Perspective28 Sep 2026
- 2026BeatGraph: Self-Supervised Heartbeat Graphs for Infant ECG Representations from the Home Environment25 Sep 2026
- 2026A Hybrid CNN--State-Space--Attention Backbone with Joint-Embedding Predictive Pretraining for 12-Lead ECG Classification24 Sep 2026
- 2026TRACE: Tractable Routing Autoencoder for Clinical ECG20 Sep 2026
- 2026Same path, different: a mechanistic comparison of looped and stacked transformer encoders on 12-lead ECG14 Sep 2026
- 2026Leveraging Cardiac Imaging to Improve ECG-Based Detection of Chagas Disease in Resource-Constrained Settings8 Sep 2026
- 2026Beat-Synchronous Tokenization for ECG Transformers31 Aug 2026
- 2026Foundation models for movement data: Are they ready for prime-time?13 Aug 2026
- 2026The Impact of Temporal Context Length and Encoding Strategies on Self-Supervised ECG Representation Learning13 Aug 2026
- 2026FOUND-AF: Benchmarking ECG Foundation Models for Atrial Fibrillation Detection4 Aug 2026
- 2026ECG-InterpBench: Benchmarking the Interpretability of ECG Foundation Models with Matched-Scale Sparse Autoencoders29 Jul 2026
- 2026CADENCE: A Cardiac Atom Dictionary for Interpretable Neural Concept Extraction from ECG Foundation Models28 Jul 2026
12 newest of 78 All 78 (JSON)