Advancing the State-of-the-Art for ECG Analysis through Structured State Space Models
On the map: State-space sequence models (S4, Mamba) → Physiological signal modeling
Abstract (arXiv)
The field of deep-learning-based ECG analysis has been largely dominated by convolutional architectures. This work explores the prospects of applying the recently introduced structured state space models (SSMs) as a particularly promising approach due to its ability to capture long-term dependencies in time series. We demonstrate that this approach leads to significant improvements over the current state-of-the-art for ECG classification, which we trace back to individual pathologies. Furthermore, the model's ability to capture long-term dependencies allows to shed light on long-standing questions in the literature such as the optimal sampling rate or window size to train classification models. Interestingly, we find no evidence for using data sampled at 500Hz as opposed to 100Hz and no advantages from extending the model's input size beyond 3s. Based on this very promising first assessment, SSMs could develop into a new modeling paradigm for ECG analysis.
Key facts. Cited by 9 papers in the map (data through 7 Oct 2026). Placed in Physiological signal modeling, one of 10 directions in State-space sequence models (S4, Mamba). Builds on 8 of its 21 references that are in the map. First posted on arXiv 14 Nov 2022.
Builds on
8 of 21 references.
References · 8
- 2021Efficiently Modeling Long Sequences with Structured State Spacescited by 2,424
- 2021Combining Recurrent, Convolutional, and Continuous-time Models with Linear State-Space Layerscited by 607
- 2020HiPPO: Recurrent Memory with Optimal Polynomial Projectionscited by 600
- 2022On the Parameterization and Initialization of Diagonal State Space Modelscited by 418
- 2022Diffusion-based Time Series Imputation and Forecasting with Structured State Space Modelscited by 195
- 2019Automatic diagnosis of the 12-lead ECG using a deep neural networkcited by 164
- 2020Deep Learning for ECG Analysis: Benchmarks and Insights from PTB-XLcited by 158
- 2021Self-supervised representation learning from 12-lead ECG datacited by 80
Built on by
Citing papers per year: 2023: 3; 2024: 0; 2025: 3; 2026: 3.
9 papers.
- 2023Diffusion-based Conditional ECG Generation with Structured State Space Modelscited by 35
- 2023Explaining Deep Learning for ECG Analysis: Building Blocks for Auditing and Knowledge Discoverycited by 15
- 2023Towards quantitative precision for ECG analysis: Leveraging state space models, self-supervision and patient metadatacited by 15
- 2025BenchECG and xECG: a benchmark and baseline for ECG foundation modelscited by 8
- 2025EchoingECG: An Electrocardiogram Cross-Modal Model for Echocardiogram Taskscited by 4
- 2026Pretraining on Sleep Data Improves non-Sleep Biosignal Taskscited by 1
- 2025Challenges and Limitations of Generative AI in Synthesizing Wearable Sensor Datacited by 0
- 2026A Simple State Space Model Excels at Multivariate Time Series Classificationcited by 0
- 2026Interpretable Stress Detection from ECG Signals Using Motif-Based Anomaly Analysiscited by 0
- 2026Interpretable Stress Detection from ECG Signals Using Motif-Based Anomaly Analysis27 Aug 2026
- 2026A Simple State Space Model Excels at Multivariate Time Series Classification7 May 2026
- 2026Pretraining on Sleep Data Improves non-Sleep Biosignal Tasks4 May 2026
- 2025EchoingECG: An Electrocardiogram Cross-Modal Model for Echocardiogram Tasks30 Sep 2025
- 2025BenchECG and xECG: a benchmark and baseline for ECG foundation models12 Sep 2025
- 2025Challenges and Limitations of Generative AI in Synthesizing Wearable Sensor Data20 May 2025
- 2023Towards quantitative precision for ECG analysis: Leveraging state space models, self-supervision and patient metadata29 Aug 2023
- 2023Explaining Deep Learning for ECG Analysis: Building Blocks for Auditing and Knowledge Discovery26 May 2023
- 2023Diffusion-based Conditional ECG Generation with Structured State Space Models19 Jan 2023
Similar, not cited
Close in wording, no citation either way
- 2026SL-S4Wave: Self-Supervised Learning of Physiological Waveforms with Structured State Space Models
- 2026Pretraining Strategies and Scaling for ECG Foundation Models: A Systematic Study
- 2025Multi-Window Temporal Analysis for Enhanced Arrhythmia Classification: Leveraging Long-Range Dependencies in Electrocardiogram Signals
- 2024SSSD-ECG-nle: New Label Embeddings with Structured State-Space Models for ECG generation
- 2026MedMamba: Recasting Mamba for Medical Time Series Classification
- 2026DR-net-Mamba: Selective State-Space Modeling for Long-Range ECG Time-Series Denoising
- 2025ECG-Mamba-V2: Architectural Refinements to a Bidirectional State Space Model for Multi-Label 12-Lead ECG Classification
- 2024ECGMamba: Towards Efficient ECG Classification with BiSSM