DEEPMED: Building a Medical DeepResearch Agent via Multi-hop Med-Search Data and Turn-Controlled Agentic Training & Inference
On the map: LLM reasoning → Clinical and biomedical applications
also in 1 more
Abstract (arXiv)
Medical reasoning models remain constrained by parametric knowledge and are thus susceptible to forgetting and hallucinations. DeepResearch (DR) models ground outputs in verifiable evidence from tools and perform strongly in general domains, but their direct transfer to medical field yields relatively limited gains. We attribute this to two gaps: task characteristic and tool-use scaling. Medical questions require evidence interpretation in a knowledge-intensive clinical context; while general DR models can retrieve information, they often lack clinical-context reasoning and thus "find it but fail to use it," leaving performance limited by medical abilities. Moreover, in medical scenarios, blindly scaling tool-call can inject noisy context, derailing sensitive medical reasoning and prompting repetitive evidence-seeking along incorrect paths. Therefore, we propose DeepMed. For data, we deploy a multi-hop med-search QA synthesis method supporting the model to apply the DR paradigm in medical contexts. For training, we introduce a difficulty-aware turn-penalty to suppress excessive tool-call growth. For inference, we bring a monitor to help validate hypotheses within a controlled number of steps and avoid context rot. Overall, on seven medical benchmarks, DeepMed improves its base model by 9.79% on average and outperforms larger medical reasoning and DR models.
Key facts. Cited by 6 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 21 of its 31 references that are in the map. First posted on arXiv 26 Jan 2026.
Builds on
21 of 31 references.
Closest ancestors · 5
Same direction, newest first
- 2025Med-U1: Incentivizing Unified Medical Reasoning in LLMs via Large-scale Reinforcement Learning14 Jun
- 2025Beyond Distillation: Pushing the Limits of Medical LLM Reasoning with Minimalist Rule-Based RL23 May
- 2025MedReason: Eliciting Factual Medical Reasoning Steps in LLMs via Knowledge Graphs1 Apr
- 2025A Retrieval-Augmented Knowledge Mining Method with Deep Thinking LLMs for Biomedical Research and Clinical Support29 Mar
- 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec
Other references · 16
- 2024DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Modelscited by 9,379
- 2022ReAct: Synergizing Reasoning and Acting in Language Modelscited by 8,695
- 2024HybridFlow: A Flexible and Efficient RLHF Frameworkcited by 2,057
- 2024MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmarkcited by 1,848
- 2025Search-R1: Training LLMs to Reason and Leverage Search Engines with Reinforcement Learningcited by 1,444
- 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
- 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,288
- 2025BrowseComp: A Simple Yet Challenging Benchmark for Browsing Agentscited by 647
- 2025GLM-4.5: Agentic, Reasoning, and Coding (ARC) Foundation Modelscited by 467
- 2024Benchmarking Retrieval-Augmented Generation for Medicinecited by 331
- 2025MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilotcited by 83
- 2025Deep Research: A Survey of Autonomous Research Agentscited by 66
4 more
- 2025DeepDive: Advancing Deep Search Agents with Knowledge Graphs and Multi-Turn RLcited by 55
- 2025MedBrowseComp: Benchmarking Medical Deep Research and Computer Usecited by 30
- 2025MedResearcher-R1: Expert-Level Medical Deep Researcher via A Knowledge-Informed Trajectory Synthesis Frameworkcited by 22
- 2025REPAIR: Robust Editing via Progressive Adaptive Intervention and Reintegrationcited by 3
Built on by
Citing papers per year: 2026: 6.
6 papers.
- 2026ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoningcited by 4
- 2026The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomycited by 2
- 2026TheraAgent: Multi-Agent Framework with Self-Evolving Memory and Evidence-Calibrated Reasoning for PET Theranosticscited by 1
- 2026SLAT: Segment-Level Adaptive Trimming for Efficient CoT Reasoningcited by 1
- 2026Learning from Medical Entity Trees: An Entity-Centric Medical Data Engineering Framework for MLLMscited by 0
- 2026Explicit Trajectory Diversity for RL-Based Post-Training of LLM Agentscited by 0
- 2026Explicit Trajectory Diversity for RL-Based Post-Training of LLM Agents30 Sep 2026
- 2026The Path to Self-Evolving Clinical Systems: Scaling Medical Agents from Assistance to Autonomy13 Jul 2026
- 2026SLAT: Segment-Level Adaptive Trimming for Efficient CoT Reasoning29 May 2026
- 2026ClinSeekAgent: Automating Multimodal Evidence Seeking for Agentic Clinical Reasoning19 May 2026
- 2026Learning from Medical Entity Trees: An Entity-Centric Medical Data Engineering Framework for MLLMs28 Apr 2026
- 2026TheraAgent: Multi-Agent Framework with Self-Evolving Memory and Evidence-Calibrated Reasoning for PET Theranostics14 Mar 2026
Similar, not cited
Close in wording, no citation either way
- 2026DEEPMED Search: An Open-Source Agentic Platform for Medical Deep Research with Introspective Verification
- 2026DeepER-Med: Advancing Deep Evidence-Based Research in Medicine Through Agentic AI
- 2026QuarkMedSearch: A Long-Horizon Deep Search Agent for Exploring Medical Intelligence
- 2026A Multi-Agent Framework for Medical AI: Leveraging Fine-Tuned GPT, LLaMA, and DeepSeek R1 for Evidence-Based and Bias-Aware Clinical Query Processing
- 2025End-to-End Agentic RAG System Training for Traceable Diagnostic Reasoning
- 2026From Given to Gathered Evidence: Agentic Learning for Longitudinal Medical Reasoning
- 2025Reasoning LLMs in the Medical Domain: A Literature Survey
- 2026Scaling Medical Reasoning Verification via Tool-Integrated Reinforcement Learning