mlsanityData to 7 Oct 2026

MedExpQA: Multilingual Benchmarking of Large Language Models for Medical Question Answering

arXiv 2404.05590 ↗First posted 8 Apr 2024cs.CLcited by 43

On the map: Retrieval-augmented generation → Medical and biomedical RAG

Abstract (arXiv)

Large Language Models (LLMs) have the potential of facilitating the development of Artificial Intelligence technology to assist medical experts for interactive decision support, which has been demonstrated by their competitive performances in Medical QA. However, while impressive, the required quality bar for medical applications remains far from being achieved. Currently, LLMs remain challenged by outdated knowledge and by their tendency to generate hallucinated content. Furthermore, most benchmarks to assess medical knowledge lack reference gold explanations which means that it is not possible to evaluate the reasoning of LLMs predictions. Finally, the situation is particularly grim if we consider benchmarking LLMs for languages other than English which remains, as far as we know, a totally neglected topic. In order to address these shortcomings, in this paper we present MedExpQA, the first multilingual benchmark based on medical exams to evaluate LLMs in Medical Question Answering. To the best of our knowledge, MedExpQA includes for the first time reference gold explanations written by medical doctors which can be leveraged to establish various gold-based upper-bounds for comparison with LLMs performance. Comprehensive multilingual experimentation using both the gold reference explanations and Retrieval Augmented Generation (RAG) approaches show that performance of LLMs still has large room for improvement, especially for languages other than English. Furthermore, and despite using state-of-the-art RAG methods, our results also demonstrate the difficulty of obtaining and integrating readily available medical knowledge that may positively impact results on downstream evaluations for Medical Question Answering. So far the benchmark is available in four languages, but we hope that this work may encourage further development to other languages.

Key facts. Cited by 43 papers in the map (data through 7 Oct 2026). Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation. Builds on 25 of its 43 references that are in the map. First posted on arXiv 8 Apr 2024.

Builds on

25 of 43 references.

Closest ancestors · 2

Same direction, newest first

  1. 2024Benchmarking Retrieval-Augmented Generation for Medicine20 Feb
  2. 2023Almanac: Retrieval-Augmented Language Models for Clinical Medicine1 Mar

Other references · 23

  1. 2020Language Models are Few-Shot Learnerscited by 32,199
  2. 2019Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformercited by 14,491
  3. 2023Llama 2: Open Foundation and Fine-Tuned Chat Modelscited by 12,865
  4. 2020Retrieval-Augmented Generation for Knowledge-Intensive NLP Taskscited by 9,160
  5. 2022PaLM: Scaling Language Modeling with Pathwayscited by 5,304
  6. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  7. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  8. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  9. 2023TIES-Merging: Resolving Interference When Merging Modelscited by 795
  10. 2023Language Models are Super Mario: Absorbing Abilities from Homologous Models as a Free Lunchcited by 679
  11. 2023Capabilities of GPT-4 on Medical Challenge Problemscited by 630
  12. 2022BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Miningcited by 531
11 more
  1. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 525
  2. 2023ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledgecited by 324
  3. 2024BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domainscited by 299
  4. 2023MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Datacited by 282
  5. 2023MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrievalcited by 182
  6. 2019HEAD-QA: A Healthcare Dataset for Complex Reasoningcited by 100
  7. 2021SciFive: a text-to-text transformer model for biomedical literaturecited by 99
  8. 2023PMC-LLaMA: Towards Building Open-source Language Models for Medicinecited by 87
  9. 2023ClinicalGPT: Large Language Models Finetuned with Diverse Medical Data and Comprehensive Evaluationcited by 85
  10. 2023Explanatory Argument Extraction of Correct Answers in Resident Medical Examscited by 6
  11. 2023HiTZ@Antidote: Argumentation-driven Explainable Artificial Intelligence for Digital Medicinecited by 5

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2024: 7; 2025: 21; 2026: 15.

43 papers.

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  1. 2024A Systematic Survey and Critical Review on Evaluating Large Language Models: Challenges, Limitations, and Recommendationscited by 84
  2. 2024CaLMQA: Exploring culturally specific long-form question answering across 23 languagescited by 31
  3. 2024ClinicalBench: Can LLMs Beat Traditional ML Models in Clinical Prediction?cited by 31
  4. 2024A Survey of Conversational Searchcited by 22
  5. 2024Efficiently Democratizing Medical LLMs for 50 Languages via a Mixture of Language Family Expertscited by 17
  6. 2025Large language models provide unsafe answers to patient-posed medical questionscited by 17
  7. 2025MedArabiQ: Benchmarking Large Language Models on Arabic Medical Taskscited by 15
  8. 2024CasiMedicos-Arg: A Medical Question Answering Dataset Annotated with Explanatory Argumentative Structurescited by 11
  9. 2025WiCkeD: A Simple Method to Make Multiple Choice Benchmarks More Challengingcited by 10
  10. 2025MAP: Evaluation and Multi-Agent Enhancement of Large Language Models for Inpatient Pathwayscited by 9
  11. 2025LLM Evaluation Based on Aerospace Manufacturing Expertise: Automated Generation and Multi-Model Question Answeringcited by 7
  12. 2025Trustworthy Medical Question Answering: An Evaluation-Centric Surveycited by 7
31 more
  1. 2025Shallow Robustness, Deep Vulnerabilities: Multi-Turn Evaluation of Medical LLMscited by 7
  2. 2025Med-R2: Crafting Trustworthy LLM Physicians via Retrieval and Reasoning of Evidence-Based Medicinecited by 5
  3. 2025Quantifying Uncertainty in Natural Language Explanations of Large Language Models for Question Answeringcited by 3
  4. 2025EyePCR: A Comprehensive Benchmark for Fine-Grained Perception, Knowledge Comprehension and Clinical Reasoning in Ophthalmic Surgerycited by 3
  5. 2025Gradual Code-Switching as Inference-Time Cross-Lingual Representational Alignment for LLMscited by 3
  6. 2026MedAraBench: Large-Scale Arabic Medical Question Answering Dataset and Benchmarkcited by 3
  7. 2026From Conflict to Consensus: Boosting Medical Reasoning via Multi-Round Agentic RAGcited by 3
  8. 2024The #Somos600M Project: Generating NLP resources that represent the diversity of the languages from LATAM, the Caribbean, and Spaincited by 2
  9. 2025From Superficial to Deep: Integrating External Knowledge for Follow-up Question Generation Using Knowledge Graph and LLMcited by 2
  10. 2025Efficient and Reproducible Biomedical Question Answering using Retrieval Augmented Generationcited by 2
  11. 2025La Leaderboard: A Large Language Model Leaderboard for Spanish Varieties and Languages of Spain and Latin Americacited by 2
  12. 2026XProvence: Zero-Cost Multilingual Context Pruning for Retrieval-Augmented Generationcited by 2
  13. 2026Cross-Lingual Empirical Evaluation of Large Language Models for Arabic Medical Taskscited by 2
  14. 2026Legal-DC: Benchmarking Retrieval-Augmented Generation for Legal Documentscited by 2
  15. 2025AnesSuite: A Comprehensive Benchmark and Dataset Suite for Anesthesiology Reasoning in LLMscited by 1
  16. 2025Scene-Aware Vectorized Memory Multi-Agent Framework with Cross-Modal Differentiated Quantization VLMs for Visually Impaired Assistancecited by 1
  17. 2026Can Continual Pre-training Bridge the Performance Gap between General-purpose and Specialized Language Models in the Medical Domain?cited by 1
  18. 2026The Reliability Gap in Benchmark Auditing: Distribution Shift and Scale as Failure Modes of Contamination Detectioncited by 1
  19. 2026Reassessing High-Performing LLMs on Polish Medical Exams: True Competence or Bias-Driven Performance?cited by 1
  20. 2025ClinText-SP and RigoBERTa Clinical: a new set of open resources for Spanish Clinical NLPcited by 0
  21. 2025CRAB: A Benchmark for Evaluating Curation of Retrieval-Augmented LLMs in Biomedicinecited by 0
  22. 2025From Guidelines to Guarantees: A Graph-Based Evaluation Harness for Domain-Specific Evaluation of LLMscited by 0
  23. 2025An Iterative LLM Framework for SIBT utilizing RAG-based Adaptive Weight Optimizationcited by 0
  24. 2025Safer in Translation? Presupposition Robustness in Indic Languagescited by 0
  25. 2026EuropeMedQA Study Protocol: A Multilingual, Multimodal Medical Examination Dataset for Language Model Evaluationcited by 0
  26. 2026Effects of Cross-lingual Evidence in Multilingual Medical Question Answeringcited by 0
  27. 2026Fully Open Meditron: An Auditable Pipeline for Clinical LLMscited by 0
  28. 2026Can I Take Another Dose? Evaluating LLM Decision-Making Under Temporal Uncertainty in OTC Dosing QAcited by 0
  29. 2026Toward Workflow-Aware Benchmarking for Healthcare NLP Agentscited by 0
  30. 2026MMTClinic: Multimodal, Multilingual Time Series Question Answering and Reasoning Benchmark for Clinical Domaincited by 0
  31. 2026Which Medical Questions Deserve Rationales? Perturbation-Sensitive Selection for Robust QAcited by 0

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  1. 2025PersianMedQA: Evaluating Large Language Models on a Persian-English Bilingual Medical Question Answering Benchmark
  2. 2023Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Dataset
  3. 2025Multilingual Medical Reasoning for Question Answering with Large Language Models
  4. 2025Benchmarking the Medical Understanding and Reasoning of Large Language Models in Arabic Healthcare Tasks
  5. 2025MKG-Rank: Enhancing Large Language Models with Knowledge Graph for Multilingual Medical Question Answering
  6. 2024LLM-MedQA: Enhancing Medical Question Answering through Case Studies in Large Language Models
  7. 2023MedBench: A Large-Scale Chinese Benchmark for Evaluating Medical Large Language Models
  8. 2026Medmarks: A Comprehensive Open-Source LLM Benchmark Suite for Medical Tasks