mlsanityData to 7 Oct 2026

Shallow Robustness, Deep Vulnerabilities: Multi-Turn Evaluation of Medical LLMs

arXiv 2510.12255 ↗First posted 14 Oct 2025cs.CL cs.AIcited by 7

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Abstract (arXiv)

Large language models (LLMs) are rapidly transitioning into medical clinical use, yet their reliability under realistic, multi-turn interactions remains poorly understood. Existing evaluation frameworks typically assess single-turn question answering under idealized conditions, overlooking the complexities of medical consultations where conflicting input, misleading context, and authority influence are common. We introduce MedQA-Followup, a framework for systematically evaluating multi-turn robustness in medical question answering. Our approach distinguishes between shallow robustness (resisting misleading initial context) and deep robustness (maintaining accuracy when answers are challenged across turns), while also introducing an indirect-direct axis that separates contextual framing (indirect) from explicit suggestion (direct). Using controlled interventions on the MedQA dataset, we evaluate five state-of-the-art LLMs and find that while models perform reasonably well under shallow perturbations, they exhibit severe vulnerabilities in multi-turn settings, with accuracy dropping from 91.2% to as low as 13.5% for Claude Sonnet 4. Counterintuitively, indirect, context-based interventions are often more harmful than direct suggestions, yielding larger accuracy drops across models and exposing a significant vulnerability for clinical deployment. Further compounding analyses reveal model differences, with some showing additional performance drops under repeated interventions while others partially recovering or even improving. These findings highlight multi-turn robustness as a critical but underexplored dimension for safe and reliable deployment of medical LLMs.

Key facts. Cited by 7 papers in the map (data through 7 Oct 2026). Builds on 11 of its 15 references that are in the map. First posted on arXiv 14 Oct 2025.

Builds on

11 of 15 references.

References · 11

  1. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  2. 2025MedGemma Technical Reportcited by 398
  3. 2023Towards Expert-Level Medical Question Answering with Large Language Modelscited by 382
  4. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 215
  5. 2023Large language models in healthcare and medical domain: A reviewcited by 126
  6. 2024MedExpQA: Multilingual Benchmarking of Large Language Models for Medical Question Answeringcited by 43
  7. 2024Addressing cognitive bias in medical language modelscited by 34
  8. 2025How Is LLM Reasoning Distracted by Irrelevant Context? An Analysis Using a Controlled Benchmarkcited by 26
  9. 2023Exploring the Robustness of Large Language Models for Solving Programming Problemscited by 16
  10. 2024Ensuring Safety and Trust: Analyzing the Risks of Large Language Models in Medicinecited by 7
  11. 2025Enhancing Clinical Multiple-Choice Questions Benchmarks with Knowledge Graph Guided Distractor Generationcited by 1

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7 papers.