Denoising Diffusion Semantic Segmentation with Mask Prior Modeling
On the map: Diffusion models → Medical imaging and segmentation
Abstract (arXiv)
The evolution of semantic segmentation has long been dominated by learning more discriminative image representations for classifying each pixel. Despite the prominent advancements, the priors of segmentation masks themselves, e.g., geometric and semantic constraints, are still under-explored. In this paper, we propose to ameliorate the semantic segmentation quality of existing discriminative approaches with a mask prior modeled by a recently-developed denoising diffusion generative model. Beginning with a unified architecture that adapts diffusion models for mask prior modeling, we focus this work on a specific instantiation with discrete diffusion and identify a variety of key design choices for its successful application. Our exploratory analysis revealed several important findings, including: (1) a simple integration of diffusion models into semantic segmentation is not sufficient, and a poorly-designed diffusion process might lead to degradation in segmentation performance; (2) during the training, the object to which noise is added is more important than the type of noise; (3) during the inference, the strict diffusion denoising scheme may not be essential and can be relaxed to a simpler scheme that even works better. We evaluate the proposed prior modeling with several off-the-shelf segmentors, and our experimental results on ADE20K and Cityscapes demonstrate that our approach could achieve competitively quantitative performance and more appealing visual quality.
Key facts. Cited by 15 papers in the map (data through 7 Oct 2026). Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models. Builds on 78 of its 89 references that are in the map. First posted on arXiv 2 Jun 2023.
Builds on
78 of 89 references.
Closest ancestors · 7
Same direction, newest first
- 2023MedSegDiff-V2: Diffusion based Medical Image Segmentation with Transformer19 Jan
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- 2022MedSegDiff: Medical Image Segmentation with Diffusion Probabilistic Model1 Nov
- 2021Diffusion Models for Implicit Image Segmentation Ensembles6 Dec
- 2021Label-Efficient Semantic Segmentation with Diffusion Models6 Dec
- 2021SegDiff: Image Segmentation with Diffusion Probabilistic Models1 Dec
Other references · 71
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Citing papers per year: 2023: 7; 2024: 5; 2025: 1; 2026: 2.
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