mlsanityData to 7 Oct 2026

Towards Segment Anything Model (SAM) for Medical Image Segmentation: A Survey

arXiv 2305.03678 ↗First posted 5 May 2023eess.IV cs.CVcited by 21

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Abstract (arXiv)

Due to the flexibility of prompting, foundation models have become the dominant force in the domains of natural language processing and image generation. With the recent introduction of the Segment Anything Model (SAM), the prompt-driven paradigm has entered the realm of image segmentation, bringing with a range of previously unexplored capabilities. However, it remains unclear whether it can be applicable to medical image segmentation due to the significant differences between natural images and medical images.In this work, we summarize recent efforts to extend the success of SAM to medical image segmentation tasks, including both empirical benchmarking and methodological adaptations, and discuss potential future directions for SAM in medical image segmentation. Although directly applying SAM to medical image segmentation cannot obtain satisfying performance on multi-modal and multi-target medical datasets, many insights are drawn to guide future research to develop foundation models for medical image analysis. To facilitate future research, we maintain an active repository that contains up-to-date paper list and open-source project summary at https://github.com/YichiZhang98/SAM4MIS.

Key facts. Cited by 21 papers in the map (data through 7 Oct 2026). Builds on 38 of its 70 references that are in the map. First posted on arXiv 5 May 2023.

Builds on

38 of 70 references.

References · 38

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  3. 2020Language Models are Few-Shot Learnerscited by 32,199
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  5. 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
  6. 2023GPT-4 Technical Reportcited by 18,132
  7. 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,084
  8. 2023Segment Anythingcited by 8,158
  9. 2021Masked Autoencoders Are Scalable Vision Learnerscited by 7,339
  10. 2021Zero-Shot Text-to-Image Generationcited by 4,276
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  12. 2016V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentationcited by 2,284
26 more
  1. 2020Fourier Features Let Networks Learn High Frequency Functions in Low Dimensional Domainscited by 2,170
  2. 2017A Survey on Deep Learning in Medical Image Analysiscited by 1,182
  3. 2023Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentationcited by 485
  4. 2023Segment Anything Model for Medical Image Analysis: an Experimental Studycited by 291
  5. 2023Customized Segment Anything Model for Medical Image Segmentationcited by 277
  6. 2019Embracing Imperfect Datasets: A Review of Deep Learning Solutions for Medical Image Segmentationcited by 258
  7. 2020AbdomenCT-1K: Is Abdominal Organ Segmentation A Solved Problem?cited by 222
  8. 2023Large-scale Multi-Modal Pre-trained Models: A Comprehensive Surveycited by 153
  9. 2023Segment Anything Is Not Always Perfect: An Investigation of SAM on Different Real-world Applicationscited by 121
  10. 2023SAM on Medical Images: A Comprehensive Study on Three Prompt Modescited by 81
  11. 2023SAM Struggles in Concealed Scenes -- Empirical Study on Segment Anythingcited by 75
  12. 2022Learning with Limited Annotations: A Survey on Deep Semi-Supervised Learning for Medical Image Segmentationcited by 74
  13. 2022CycleMix: A Holistic Strategy for Medical Image Segmentation from Scribble Supervisioncited by 64
  14. 2022Scribble-Supervised Medical Image Segmentation via Dual-Branch Network and Dynamically Mixed Pseudo Labels Supervisioncited by 64
  15. 2023Polyp-SAM: Transfer SAM for Polyp Segmentationcited by 64
  16. 2023SAM.MD: Zero-shot medical image segmentation capabilities of the Segment Anything Modelcited by 61
  17. 2023Can SAM Segment Polyps?cited by 59
  18. 2023Input Augmentation with SAM: Boosting Medical Image Segmentation with Segmentation Foundation Modelcited by 56
  19. 2023When SAM Meets Medical Images: An Investigation of Segment Anything Model (SAM) on Multi-phase Liver Tumor Segmentationcited by 52
  20. 2023SkinSAM: Empowering Skin Cancer Segmentation with Segment Anything Modelcited by 32
  21. 2023SAMM (Segment Any Medical Model): A 3D Slicer Integration to SAMcited by 31
  22. 2020Bridging 2D and 3D Segmentation Networks for Computation Efficient Volumetric Medical Image Segmentation: An Empirical Study of 2.5D Solutionscited by 30
  23. 2023SAM vs BET: A Comparative Study for Brain Extraction and Segmentation of Magnetic Resonance Images using Deep Learningcited by 24
  24. 2023SAM Meets Robotic Surgery: An Empirical Study in Robustness Perspectivecited by 24
  25. 2023GazeSAM: What You See is What You Segmentcited by 19
  26. 2023Towards General Purpose Medical AI: Continual Learning Medical Foundation Modelcited by 14

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2023: 6; 2024: 4; 2025: 9; 2026: 2.

21 papers.

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  1. 2023Multimodal Foundation Models: From Specialists to General-Purpose Assistantscited by 247
  2. 2023A Survey on Segment Anything Model (SAM): Vision Foundation Model Meets Prompt Engineeringcited by 45
  3. 2024How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Modelcited by 32
  4. 2023Evaluating General Purpose Vision Foundation Models for Medical Image Analysis: An Experimental Study of DINOv2 on Radiology Benchmarkscited by 30
  5. 2024Foundation Models for Biomedical Image Segmentation: A Surveycited by 28
  6. 2025SAM2 for Image and Video Segmentation: A Comprehensive Surveycited by 13
  7. 2025No time to train! Training-Free Reference-Based Instance Segmentationcited by 9
  8. 2025SAMed-2: Selective Memory Enhanced Medical Segment Anything Modelcited by 8
  9. 2023Assessing Test-time Variability for Interactive 3D Medical Image Segmentation with Diverse Point Promptscited by 5
  10. 2024Segment Anything for Videos: A Systematic Surveycited by 5
  11. 2025Few-Shot Adaptation of Training-Free Foundation Model for 3D Medical Image Segmentationcited by 5
  12. 2025Prompt Engineering in Segment Anything Model: Methodologies, Applications, and Emerging Challengescited by 3
9 more
  1. 2023MedLSAM: Localize and Segment Anything Model for 3D CT Imagescited by 1
  2. 2024Segment Anything for comprehensive analysis of grapevine cluster architecture and berry propertiescited by 1
  3. 2025SynthFM: Training Modality-agnostic Foundation Models for Medical Image Segmentation without Real Medical Datacited by 1
  4. 2023AdLER: Adversarial Training with Label Error Rectification for One-Shot Medical Image Segmentationcited by 0
  5. 2025SARTM: Segment Any RGB Thermal Model with Language aided Distillationcited by 0
  6. 2025AutoMiSeg: Automatic Medical Image Segmentation via Test-Time Adaptation of Foundation Modelscited by 0
  7. 2025Semantic Segmentation of iPS Cells: Case Study on Model Complexity in Biomedical Imagingcited by 0
  8. 2026Enhancing MedSAM with a Lightweight Box Predictor for Medical Image Segmentationcited by 0
  9. 2026NeuroRefiner: Morphology-Aware Multi-Agent Refinement for 3D Fluorescence Microscopy Neuron Segmentationcited by 0