Synthetic Data in Healthcare
Not on the map. Why?
Abstract (arXiv)
Synthetic data are becoming a critical tool for building artificially intelligent systems. Simulators provide a way of generating data systematically and at scale. These data can then be used either exclusively, or in conjunction with real data, for training and testing systems. Synthetic data are particularly attractive in cases where the availability of ``real'' training examples might be a bottleneck. While the volume of data in healthcare is growing exponentially, creating datasets for novel tasks and/or that reflect a diverse set of conditions and causal relationships is not trivial. Furthermore, these data are highly sensitive and often patient specific. Recent research has begun to illustrate the potential for synthetic data in many areas of medicine, but no systematic review of the literature exists. In this paper, we present the cases for physical and statistical simulations for creating data and the proposed applications in healthcare and medicine. We discuss that while synthetics can promote privacy, equity, safety and continual and causal learning, they also run the risk of introducing flaws, blind spots and propagating or exaggerating biases.
Key facts. Cited by 8 papers in the map (data through 7 Oct 2026). Builds on 44 of its 110 references that are in the map. First posted on arXiv 6 Apr 2023.
Builds on
44 of 110 references.
References · 44
- 2020Denoising Diffusion Probabilistic Modelscited by 20,851
- 2021Diffusion Models Beat GANs on Image Synthesiscited by 8,185
- 2015Deep Unsupervised Learning using Nonequilibrium Thermodynamicscited by 7,005
- 2018A Style-Based Generator Architecture for Generative Adversarial Networkscited by 5,986
- 2022Generative Adversarial Networkscited by 5,603
- 2013Auto-Encoding Variational Bayescited by 3,980
- 2016Equality of Opportunity in Supervised Learningcited by 2,000
- 2018Glow: Generative Flow with Invertible 1x1 Convolutionscited by 1,539
- 2018Model Cards for Model Reportingcited by 1,068
- 2020Domain-Specific Language Model Pretraining for Biomedical Natural Language Processingcited by 996
- 2016Semantics derived automatically from language corpora contain human-like biasescited by 894
- 2020COVID-Net: A Tailored Deep Convolutional Neural Network Design for Detection of COVID-19 Cases from Chest X-Ray Imagescited by 264
32 more
- 2018GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classificationcited by 242
- 2015Doctor AI: Predicting Clinical Events via Recurrent Neural Networkscited by 205
- 2018Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networkscited by 146
- 2019Data augmentation using learned transformations for one-shot medical image segmentationcited by 138
- 2020Deep Learning for Medical Anomaly Detection -- A Surveycited by 127
- 2021DECAF: Generating Fair Synthetic Data Using Causally-Aware Generative Networkscited by 109
- 2018Translating and Segmenting Multimodal Medical Volumes with Cycle- and Shape-Consistency Generative Adversarial Networkcited by 97
- 2022DataPerf: Benchmarks for Data-Centric AI Developmentcited by 89
- 2019Bias Correction of Learned Generative Models using Likelihood-Free Importance Weightingcited by 70
- 2018A Review of Challenges and Opportunities in Machine Learning for Healthcited by 67
- 2021CovidGAN: Data Augmentation Using Auxiliary Classifier GAN for Improved Covid-19 Detectioncited by 64
- 2021Iterative Methods for Private Synthetic Data: Unifying Framework and New Methodscited by 58
- 2017Unsupervised Reverse Domain Adaptation for Synthetic Medical Images via Adversarial Trainingcited by 57
- 2021Camera Measurement of Physiological Vital Signscited by 49
- 2022A Multifaceted Benchmarking of Synthetic Electronic Health Record Generation Modelscited by 43
- 2017Boosting Deep Learning Risk Prediction with Generative Adversarial Networks for Electronic Health Recordscited by 36
- 2019DermGAN: Synthetic Generation of Clinical Skin Images with Pathologycited by 33
- 2020SimGANs: Simulator-Based Generative Adversarial Networks for ECG Synthesis to Improve Deep ECG Classificationcited by 32
- 2022SCAMPS: Synthetics for Camera Measurement of Physiological Signalscited by 28
- 2016Identifying Unknown Unknowns in the Open World: Representations and Policies for Guided Explorationcited by 26
- 2019Characterizing Bias in Classifiers using Generative Modelscited by 23
- 2021CausalCity: Complex Simulations with Agency for Causal Discovery and Reasoningcited by 23
- 2020Endo-Sim2Real: Consistency learning-based domain adaptation for instrument segmentationcited by 20
- 2020Unnatural Language Processing: Bridging the Gap Between Synthetic and Natural Language Datacited by 16
- 2020Advancing Non-Contact Vital Sign Measurement using Synthetic Avatarscited by 15
- 2020XCAT-GAN for Synthesizing 3D Consistent Labeled Cardiac MR Images on Anatomically Variable XCAT Phantomscited by 11
- 2022Virtual Histological Staining of Label-Free Total Absorption Photoacoustic Remote Sensing (TA-PARS)cited by 10
- 2019Visual Physics: Discovering Physical Laws from Videoscited by 9
- 2020Hide-and-Seek Privacy Challengecited by 8
- 2022Decouple-and-Sample: Protecting sensitive information in task agnostic data releasecited by 4
- 2015Model Validation for Vision Systems via Graphics Simulationcited by 3
- 2022MIME: Minority Inclusion for Majority Group Enhancement of AI Performancecited by 2
Built on by
Citing papers per year: 2023: 3; 2024: 0; 2025: 3; 2026: 2.
8 papers.
- 2023A Unified Framework for Generative Data Augmentation: A Comprehensive Surveycited by 4
- 2025Generating Clinically Realistic EHR Data via a Hierarchy- and Semantics-Guided Transformercited by 4
- 2025Beyond Real Data: Synthetic Data through the Lens of Regularizationcited by 2
- 2023Should ChatGPT and Bard Share Revenue with Their Data Providers? A New Business Model for the AI Eracited by 1
- 2023F?D: On understanding the role of deep feature spaces on face generation evaluationcited by 1
- 2025Leveraging Generative AI Through Prompt Engineering and Rigorous Validation to Create Comprehensive Synthetic Datasets for AI Training in Healthcarecited by 1
- 2026From Statistical Fidelity to Clinical Consistency: Scalable Generation and Auditing of Synthetic Patient Trajectoriescited by 1
- 2026Enhancing Facial Expression Recognition in Head-Mounted Displays with Synthetic Datacited by 0
- 2026Enhancing Facial Expression Recognition in Head-Mounted Displays with Synthetic Data5 Jul 2026
- 2026From Statistical Fidelity to Clinical Consistency: Scalable Generation and Auditing of Synthetic Patient Trajectories6 Mar 2026
- 2025Beyond Real Data: Synthetic Data through the Lens of Regularization9 Oct 2025
- 2025Leveraging Generative AI Through Prompt Engineering and Rigorous Validation to Create Comprehensive Synthetic Datasets for AI Training in Healthcare29 Apr 2025
- 2025Generating Clinically Realistic EHR Data via a Hierarchy- and Semantics-Guided Transformer28 Feb 2025
- 2023A Unified Framework for Generative Data Augmentation: A Comprehensive Survey30 Sep 2023
- 2023F?D: On understanding the role of deep feature spaces on face generation evaluation31 May 2023
- 2023Should ChatGPT and Bard Share Revenue with Their Data Providers? A New Business Model for the AI Era4 May 2023