mlsanityData to 7 Oct 2026

MISSFormer: An Effective Medical Image Segmentation Transformer

arXiv 2109.07162 ↗First posted 15 Sep 2021cs.CVcited by 103

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Abstract (arXiv)

The CNN-based methods have achieved impressive results in medical image segmentation, but they failed to capture the long-range dependencies due to the inherent locality of the convolution operation. Transformer-based methods are recently popular in vision tasks because of their capacity for long-range dependencies and promising performance. However, it lacks in modeling local context. In this paper, taking medical image segmentation as an example, we present MISSFormer, an effective and powerful Medical Image Segmentation tranSFormer. MISSFormer is a hierarchical encoder-decoder network with two appealing designs: 1) A feed-forward network is redesigned with the proposed Enhanced Transformer Block, which enhances the long-range dependencies and supplements the local context, making the feature more discriminative. 2) We proposed Enhanced Transformer Context Bridge, different from previous methods of modeling only global information, the proposed context bridge with the enhanced transformer block extracts the long-range dependencies and local context of multi-scale features generated by our hierarchical transformer encoder. Driven by these two designs, the MISSFormer shows a solid capacity to capture more discriminative dependencies and context in medical image segmentation. The experiments on multi-organ and cardiac segmentation tasks demonstrate the superiority, effectiveness and robustness of our MISSFormer, the experimental results of MISSFormer trained from scratch even outperform state-of-the-art methods pre-trained on ImageNet. The core designs can be generalized to other visual segmentation tasks. The code has been released on Github: https://github.com/ZhifangDeng/MISSFormer

Key facts. Cited by 103 papers in the map (data through 7 Oct 2026). Builds on 36 of its 39 references that are in the map. First posted on arXiv 15 Sep 2021.

Builds on

36 of 39 references.

References · 36

  1. 2017Attention Is All You Needcited by 59,932
  2. 2015Deep Residual Learning for Image Recognitioncited by 51,809
  3. 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 29,915
  4. 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,604
  5. 2021Swin Transformer: Hierarchical Vision Transformer using Shifted Windowscited by 12,082
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  10. 2016DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFscited by 3,239
  11. 2021SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformerscited by 2,923
  12. 2016Pyramid Scene Parsing Networkcited by 2,472
24 more
  1. 2016V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentationcited by 2,284
  2. 2021Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutionscited by 1,960
  3. 2021TransUNet: Transformers Make Strong Encoders for Medical Image Segmentationcited by 1,552
  4. 2018UNet++: A Nested U-Net Architecture for Medical Image Segmentationcited by 1,518
  5. 20163D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotationcited by 1,471
  6. 2020Rethinking Semantic Segmentation from a Sequence-to-Sequence Perspective with Transformerscited by 1,368
  7. 2021Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentationcited by 1,218
  8. 2021UNETR: Transformers for 3D Medical Image Segmentationcited by 954
  9. 2021Uformer: A General U-Shaped Transformer for Image Restorationcited by 864
  10. 2021PVT v2: Improved Baselines with Pyramid Vision Transformercited by 749
  11. 2021Twins: Revisiting the Design of Spatial Attention in Vision Transformerscited by 565
  12. 2021LeViT: a Vision Transformer in ConvNet's Clothing for Faster Inferencecited by 475
  13. 2020PraNet: Parallel Reverse Attention Network for Polyp Segmentationcited by 460
  14. 2021Conditional Positional Encodings for Vision Transformerscited by 402
  15. 2020UNet 3+: A Full-Scale Connected UNet for Medical Image Segmentationcited by 331
  16. 2021TransBTS: Multimodal Brain Tumor Segmentation Using Transformercited by 265
  17. 2021LocalViT: Analyzing Locality in Vision Transformerscited by 228
  18. 2021CoTr: Efficiently Bridging CNN and Transformer for 3D Medical Image Segmentationcited by 227
  19. 2019CE-Net: Context Encoder Network for 2D Medical Image Segmentationcited by 219
  20. 2020How Much Position Information Do Convolutional Neural Networks Encode?cited by 171
  21. 2018Reverse Attention for Salient Object Detectioncited by 113
  22. 2019Multi-scale self-guided attention for medical image segmentationcited by 84
  23. 2019ET-Net: A Generic Edge-aTtention Guidance Network for Medical Image Segmentationcited by 38
  24. 2021Rethinking Skip Connection with Layer Normalization in Transformers and ResNetscited by 22

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2022: 25; 2023: 26; 2024: 22; 2025: 17; 2026: 13.

103 papers.

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  1. 2022Transformers in Medical Imaging: A Surveycited by 245
  2. 2022Medical Image Segmentation Review: The success of U-Netcited by 190
  3. 2022UNETR++: Delving into Efficient and Accurate 3D Medical Image Segmentationcited by 112
  4. 2024EMCAD: Efficient Multi-scale Convolutional Attention Decoding for Medical Image Segmentationcited by 64
  5. 2024Unleashing the Potential of SAM for Medical Adaptation via Hierarchical Decodingcited by 48
  6. 2022Transformers in Medical Image Analysis: A Reviewcited by 41
  7. 2022D-Former: A U-shaped Dilated Transformer for 3D Medical Image Segmentationcited by 35
  8. 2023Multi-scale Hierarchical Vision Transformer with Cascaded Attention Decoding for Medical Image Segmentationcited by 34
  9. 2023SAM3D: Segment Anything Model in Volumetric Medical Imagescited by 34
  10. 2023Loss Functions in the Era of Semantic Segmentation: A Survey and Outlookcited by 33
  11. 2022Transforming medical imaging with Transformers? A comparative review of key properties, current progresses, and future perspectivescited by 32
  12. 2022HUMUS-Net: Hybrid unrolled multi-scale network architecture for accelerated MRI reconstructioncited by 30
38 more
  1. 2022DAE-Former: Dual Attention-guided Efficient Transformer for Medical Image Segmentationcited by 27
  2. 2023Ladder Fine-tuning approach for SAM integrating complementary networkcited by 25
  3. 2025Primus: Enforcing Attention Usage for 3D Medical Image Segmentationcited by 22
  4. 2023G-CASCADE: Efficient Cascaded Graph Convolutional Decoding for 2D Medical Image Segmentationcited by 21
  5. 2022HistoSeg : Quick attention with multi-loss function for multi-structure segmentation in digital histology imagescited by 17
  6. 2023Transformers in Healthcare: A Surveycited by 17
  7. 2022PHTrans: Parallelly Aggregating Global and Local Representations for Medical Image Segmentationcited by 16
  8. 2022A survey on attention mechanisms for medical applications: are we moving towards better algorithms?cited by 15
  9. 2022BATFormer: Towards Boundary-Aware Lightweight Transformer for Efficient Medical Image Segmentationcited by 14
  10. 2024SegStitch: Multidimensional Transformer for Robust and Efficient Medical Imaging Segmentationcited by 13
  11. 2025MedSegFactory: Text-Guided Generation of Medical Image-Mask Pairscited by 13
  12. 2022Optimizing Vision Transformers for Medical Image Segmentationcited by 12
  13. 2023DermoSegDiff: A Boundary-aware Segmentation Diffusion Model for Skin Lesion Delineationcited by 12
  14. 2023MIST: Medical Image Segmentation Transformer with Convolutional Attention Mixing (CAM) Decodercited by 12
  15. 2023Adapting Pre-trained Vision Transformers from 2D to 3D through Weight Inflation Improves Medical Image Segmentationcited by 11
  16. 2024BEFUnet: A Hybrid CNN-Transformer Architecture for Precise Medical Image Segmentationcited by 11
  17. 2024CC-SAM: SAM with Cross-feature Attention and Context for Ultrasound Image Segmentationcited by 11
  18. 2022Dynamic Linear Transformer for 3D Biomedical Image Segmentationcited by 10
  19. 2022ConvFormer: Combining CNN and Transformer for Medical Image Segmentationcited by 10
  20. 2023Learning with Explicit Shape Priors for Medical Image Segmentationcited by 10
  21. 2022The Lighter The Better: Rethinking Transformers in Medical Image Segmentation Through Adaptive Pruningcited by 9
  22. 2023Rethinking Boundary Detection in Deep Learning Models for Medical Image Segmentationcited by 9
  23. 2023Attention Mechanisms in Medical Image Segmentation: A Surveycited by 9
  24. 2023ConvFormer: Plug-and-Play CNN-Style Transformers for Improving Medical Image Segmentationcited by 9
  25. 2024D-Net: Dynamic Large Kernel with Dynamic Feature Fusion for Volumetric Medical Image Segmentationcited by 9
  26. 2026EEO-TFV: Escape-Explore Optimizer for Web-Scale Time-Series Forecasting and Vision Analysiscited by 9
  27. 2023Dilated-UNet: A Fast and Accurate Medical Image Segmentation Approach using a Dilated Transformer and U-Net Architecturecited by 8
  28. 2023Channel prior convolutional attention for medical image segmentationcited by 8
  29. 2024BRAU-Net++: U-Shaped Hybrid CNN-Transformer Network for Medical Image Segmentationcited by 7
  30. 2024MSVM-UNet: Multi-Scale Vision Mamba UNet for Medical Image Segmentationcited by 7
  31. 2022UNet-2022: Exploring Dynamics in Non-isomorphic Architecturecited by 6
  32. 2023SA2-Net: Scale-aware Attention Network for Microscopic Image Segmentationcited by 6
  33. 2024Self Pre-training with Topology- and Spatiality-aware Masked Autoencoders for 3D Medical Image Segmentationcited by 6
  34. 2022Transformer based Generative Adversarial Network for Liver Segmentationcited by 5
  35. 2024HemoSet: The First Blood Segmentation Dataset for Automation of Hemostasis Managementcited by 4
  36. 2024MedVisionLlama: Leveraging Pre-Trained Large Language Model Layers to Enhance Medical Image Segmentationcited by 4
  37. 2024HResFormer: Hybrid Residual Transformer for Volumetric Medical Image Segmentationcited by 4
  38. 2022APAUNet: Axis Projection Attention UNet for Small Target in 3D Medical Segmentationcited by 3

50 most cited of 103 All 103 (JSON)