Semi-Supervised Variational Reasoning for Medical Dialogue Generation
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Abstract (arXiv)
Medical dialogue generation aims to provide automatic and accurate responses to assist physicians to obtain diagnosis and treatment suggestions in an efficient manner. In medical dialogues two key characteristics are relevant for response generation: patient states (such as symptoms, medication) and physician actions (such as diagnosis, treatments). In medical scenarios large-scale human annotations are usually not available, due to the high costs and privacy requirements. Hence, current approaches to medical dialogue generation typically do not explicitly account for patient states and physician actions, and focus on implicit representation instead. We propose an end-to-end variational reasoning approach to medical dialogue generation. To be able to deal with a limited amount of labeled data, we introduce both patient state and physician action as latent variables with categorical priors for explicit patient state tracking and physician policy learning, respectively. We propose a variational Bayesian generative approach to approximate posterior distributions over patient states and physician actions. We use an efficient stochastic gradient variational Bayes estimator to optimize the derived evidence lower bound, where a 2-stage collapsed inference method is proposed to reduce the bias during model training. A physician policy network composed of an action-classifier and two reasoning detectors is proposed for augmented reasoning ability. We conduct experiments on three datasets collected from medical platforms. Our experimental results show that the proposed method outperforms state-of-the-art baselines in terms of objective and subjective evaluation metrics. Our experiments also indicate that our proposed semi-supervised reasoning method achieves a comparable performance as state-of-the-art fully supervised learning baselines for physician policy learning.
Key facts. Cited by 30 papers in the map (data through 7 Oct 2026). Builds on 44 of its 68 references that are in the map. First posted on arXiv 13 May 2021.
Builds on
44 of 68 references.
References · 44
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Citing papers per year: 2021: 4; 2022: 6; 2023: 5; 2024: 7; 2025: 5; 2026: 3.
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- 2024MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoningcited by 145
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Surveycited by 87
- 2022A Benchmark for Automatic Medical Consultation System: Frameworks, Tasks and Datasetscited by 45
- 2022Transfer Learning with Synthetic Corpora for Spatial Role Labeling and Reasoningcited by 32
- 2023A Review on Explainable Artificial Intelligence for Healthcare: Why, How, and When?cited by 24
- 2024DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledgecited by 24
- 2021ReMeDi: Resources for Multi-domain, Multi-service, Medical Dialoguescited by 20
- 2021Natural Language Processing for Smart Healthcarecited by 14
- 2023MidMed: Towards Mixed-Type Dialogues for Medical Consultationcited by 13
- 2021Efficient Symptom Inquiring and Diagnosis via Adaptive Alignment of Reinforcement Learning and Classificationcited by 12
- 2022DialMed: A Dataset for Dialogue-based Medication Recommendationcited by 12
- 2025Doctor-R1: Mastering Clinical Inquiry with Experiential Agentic Reinforcement Learningcited by 11
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- 2022CDialog: A Multi-turn Covid-19 Conversation Dataset for Entity-Aware Dialog Generationcited by 5
- 2024MedKP: Medical Dialogue with Knowledge Enhancement and Clinical Pathway Encodingcited by 5
- 2024Medical Dialogue: A Survey of Categories, Methods, Evaluation and Challengescited by 5
- 2022Advancing Semi-Supervised Task Oriented Dialog Systems by JSA Learning of Discrete Latent Variable Modelscited by 3
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applicationscited by 3
- 2023Matching-based Term Semantics Pre-training for Spoken Patient Query Understandingcited by 2
- 2024Medical Dialogue Generation via Intuitive-then-Analytical Differential Diagnosiscited by 2
- 2024ZALM3: Zero-Shot Enhancement of Vision-Language Alignment via In-Context Information in Multi-Turn Multimodal Medical Dialoguecited by 2
- 2024The Potential of LLMs in Medical Education: Generating Questions and Answers for Qualification Examscited by 2
- 2026EMSDialog: Synthetic Multi-person Emergency Medical Service Dialogue Generation from Electronic Patient Care Reports via Multi-LLM Agentscited by 2
- 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contextscited by 1
- 2025Enhancing Medical Dialogue Generation through Knowledge Refinement and Dynamic Prompt Adjustmentcited by 1
- 2025Fine-Tuning DialoGPT on Common Diseases in Rural Nepal for Medical Conversationscited by 0
- 2026SynDocDis: A Metadata-Driven Framework for Generating Synthetic Physician Discussions Using Large Language Modelscited by 0
- 2026Dial HEALTHDIAL for Advice: A Multilingual and Multi-Parallel Spoken Dialogue Dataset for Knowledge-Grounded Information Seekingcited by 0
- 2026Dial HEALTHDIAL for Advice: A Multilingual and Multi-Parallel Spoken Dialogue Dataset for Knowledge-Grounded Information Seeking28 May 2026
- 2026EMSDialog: Synthetic Multi-person Emergency Medical Service Dialogue Generation from Electronic Patient Care Reports via Multi-LLM Agents8 Apr 2026
- 2026SynDocDis: A Metadata-Driven Framework for Generating Synthetic Physician Discussions Using Large Language Models16 Mar 2026
- 2025Fine-Tuning DialoGPT on Common Diseases in Rural Nepal for Medical Conversations1 Nov 2025
- 2025Doctor-R1: Mastering Clinical Inquiry with Experiential Agentic Reinforcement Learning5 Oct 2025
- 2025Enhancing Medical Dialogue Generation through Knowledge Refinement and Dynamic Prompt Adjustment12 Jun 2025
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applications7 May 2025
- 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contexts5 May 2025
- 2024The Potential of LLMs in Medical Education: Generating Questions and Answers for Qualification Exams31 Oct 2024
- 2024ZALM3: Zero-Shot Enhancement of Vision-Language Alignment via In-Context Information in Multi-Turn Multimodal Medical Dialogue26 Sep 2024
- 2024MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoning3 Jun 2024
- 2024DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledge21 May 2024
18 more
- 2024Medical Dialogue: A Survey of Categories, Methods, Evaluation and Challenges17 May 2024
- 2024MedKP: Medical Dialogue with Knowledge Enhancement and Clinical Pathway Encoding11 Mar 2024
- 2024Medical Dialogue Generation via Intuitive-then-Analytical Differential Diagnosis12 Jan 2024
- 2023MidMed: Towards Mixed-Type Dialogues for Medical Consultation5 Jun 2023
- 2023Medical Dialogue Generation via Dual Flow Modeling29 May 2023
- 2023PlugMed: Improving Specificity in Patient-Centered Medical Dialogue Generation using In-Context Learning19 May 2023
- 2023A Review on Explainable Artificial Intelligence for Healthcare: Why, How, and When?10 Apr 2023
- 2023Matching-based Term Semantics Pre-training for Spoken Patient Query Understanding2 Mar 2023
- 2022CDialog: A Multi-turn Covid-19 Conversation Dataset for Entity-Aware Dialog Generation16 Nov 2022
- 2022Transfer Learning with Synthetic Corpora for Spatial Role Labeling and Reasoning30 Oct 2022
- 2022Advancing Semi-Supervised Task Oriented Dialog Systems by JSA Learning of Discrete Latent Variable Models25 Jul 2022
- 2022Medical Dialogue Response Generation with Pivotal Information Recalling17 Jun 2022
- 2022A Benchmark for Automatic Medical Consultation System: Frameworks, Tasks and Datasets19 Apr 2022
- 2022DialMed: A Dataset for Dialogue-based Medication Recommendation22 Feb 2022
- 2021Efficient Symptom Inquiring and Diagnosis via Adaptive Alignment of Reinforcement Learning and Classification1 Dec 2021
- 2021Natural Language Processing for Smart Healthcare19 Oct 2021
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Survey11 Oct 2021
- 2021ReMeDi: Resources for Multi-domain, Multi-service, Medical Dialogues1 Sep 2021
- 2024MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoningcited by 145
- 2022Transfer Learning with Synthetic Corpora for Spatial Role Labeling and Reasoningcited by 32
- 2024DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledgecited by 24
- 2024MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoning3 Jun 2024
- 2024DrHouse: An LLM-empowered Diagnostic Reasoning System through Harnessing Outcomes from Sensor Data and Expert Knowledge21 May 2024
- 2022Transfer Learning with Synthetic Corpora for Spatial Role Labeling and Reasoning30 Oct 2022
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Surveycited by 87
- 2022A Benchmark for Automatic Medical Consultation System: Frameworks, Tasks and Datasetscited by 45
- 2023A Review on Explainable Artificial Intelligence for Healthcare: Why, How, and When?cited by 24
- 2021ReMeDi: Resources for Multi-domain, Multi-service, Medical Dialoguescited by 20
- 2021Natural Language Processing for Smart Healthcarecited by 14
- 2023MidMed: Towards Mixed-Type Dialogues for Medical Consultationcited by 13
- 2021Efficient Symptom Inquiring and Diagnosis via Adaptive Alignment of Reinforcement Learning and Classificationcited by 12
- 2022DialMed: A Dataset for Dialogue-based Medication Recommendationcited by 12
- 2023Medical Dialogue Generation via Dual Flow Modelingcited by 10
- 2022Medical Dialogue Response Generation with Pivotal Information Recallingcited by 9
- 2023PlugMed: Improving Specificity in Patient-Centered Medical Dialogue Generation using In-Context Learningcited by 8
- 2022CDialog: A Multi-turn Covid-19 Conversation Dataset for Entity-Aware Dialog Generationcited by 5
12 most cited of 25 All 25 (JSON)
- 2026Dial HEALTHDIAL for Advice: A Multilingual and Multi-Parallel Spoken Dialogue Dataset for Knowledge-Grounded Information Seeking28 May 2026
- 2026EMSDialog: Synthetic Multi-person Emergency Medical Service Dialogue Generation from Electronic Patient Care Reports via Multi-LLM Agents8 Apr 2026
- 2026SynDocDis: A Metadata-Driven Framework for Generating Synthetic Physician Discussions Using Large Language Models16 Mar 2026
- 2025Fine-Tuning DialoGPT on Common Diseases in Rural Nepal for Medical Conversations1 Nov 2025
- 2025Enhancing Medical Dialogue Generation through Knowledge Refinement and Dynamic Prompt Adjustment12 Jun 2025
- 2025Natural Language Generation in Healthcare: A Review of Methods and Applications7 May 2025
- 2025A Typology of Synthetic Datasets for Dialogue Processing in Clinical Contexts5 May 2025
- 2024The Potential of LLMs in Medical Education: Generating Questions and Answers for Qualification Exams31 Oct 2024
- 2024Medical Dialogue: A Survey of Categories, Methods, Evaluation and Challenges17 May 2024
- 2024MedKP: Medical Dialogue with Knowledge Enhancement and Clinical Pathway Encoding11 Mar 2024
- 2024Medical Dialogue Generation via Intuitive-then-Analytical Differential Diagnosis12 Jan 2024
- 2023MidMed: Towards Mixed-Type Dialogues for Medical Consultation5 Jun 2023
12 newest of 25 All 25 (JSON)