End-to-End Knowledge-Routed Relational Dialogue System for Automatic Diagnosis
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Abstract (arXiv)
Beyond current conversational chatbots or task-oriented dialogue systems that have attracted increasing attention, we move forward to develop a dialogue system for automatic medical diagnosis that converses with patients to collect additional symptoms beyond their self-reports and automatically makes a diagnosis. Besides the challenges for conversational dialogue systems (e.g. topic transition coherency and question understanding), automatic medical diagnosis further poses more critical requirements for the dialogue rationality in the context of medical knowledge and symptom-disease relations. Existing dialogue systems (Madotto, Wu, and Fung 2018; Wei et al. 2018; Li et al. 2017) mostly rely on data-driven learning and cannot be able to encode extra expert knowledge graph. In this work, we propose an End-to-End Knowledge-routed Relational Dialogue System (KR-DS) that seamlessly incorporates rich medical knowledge graph into the topic transition in dialogue management, and makes it cooperative with natural language understanding and natural language generation. A novel Knowledge-routed Deep Q-network (KR-DQN) is introduced to manage topic transitions, which integrates a relational refinement branch for encoding relations among different symptoms and symptom-disease pairs, and a knowledge-routed graph branch for topic decision-making. Extensive experiments on a public medical dialogue dataset show our KR-DS significantly beats state-of-the-art methods (by more than 8% in diagnosis accuracy). We further show the superiority of our KR-DS on a newly collected medical dialogue system dataset, which is more challenging retaining original self-reports and conversational data between patients and doctors.
Key facts. Cited by 70 papers in the map (data through 14 Oct 2026). First posted on arXiv 30 Jan 2019.
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Citing papers per year: 2021: 14; 2022: 16; 2023: 16; 2024: 10; 2025: 6; 2026: 8.
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- 2023HuatuoGPT, towards Taming Language Model to Be a Doctorcited by 214
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- 2022DDXPlus: A New Dataset For Automatic Medical Diagnosiscited by 88
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- 2021More but Correct: Generating Diversified and Entity-revised Medical Responsecited by 31
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50 most cited of 70 All 70 (JSON)
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- 2026Aligning Medical Conversational AI through Online Reinforcement Learning with Information-Theoretic Rewards25 Jan 2026
- 2025MIMIC-SR-ICD11: A Dataset for Narrative-Based Diagnosis7 Nov 2025
- 2025Inflated Excellence or True Performance? Rethinking Medical Diagnostic Benchmarks with Dynamic Evaluation10 Oct 2025
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- 2025DDO: Dual-Decision Optimization for LLM-Based Medical Consultation via Multi-Agent Collaboration24 May 2025
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- 2025Feedback-Aware Monte Carlo Tree Search for Efficient Information Seeking in Goal-Oriented Conversations25 Jan 2025
- 2024Building a Chinese Medical Dialogue System: Integrating Large-scale Corpora and Novel Models27 Sep 2024
- 2024Synthetic Patient-Physician Dialogue Generation from Clinical Notes Using LLM12 Aug 2024
- 2024CoD, Towards an Interpretable Medical Agent using Chain of Diagnosis18 Jul 2024
- 2024Towards Knowledge-Infused Automated Disease Diagnosis Assistant18 May 2024
- 2024Medical Dialogue: A Survey of Categories, Methods, Evaluation and Challenges17 May 2024
- 2024Multi-Review Fusion-in-Context22 Mar 2024
- 2024Uncertainty of Thoughts: Uncertainty-Aware Planning Enhances Information Seeking in Large Language Models5 Feb 2024
- 2024Beyond Direct Diagnosis: LLM-based Multi-Specialist Agent Consultation for Automatic Diagnosis29 Jan 2024
- 2024NLICE: Synthetic Medical Record Generation for Effective Primary Healthcare Differential Diagnosis24 Jan 2024
- 2024Medical Dialogue Generation via Intuitive-then-Analytical Differential Diagnosis12 Jan 2024
- 2023Benchmarking and Analyzing In-context Learning, Fine-tuning and Supervised Learning for Biomedical Knowledge Curation: a focused study on chemical entities of biological interest20 Dec 2023
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- 2023Experience and Evidence are the eyes of an excellent summarizer! Towards Knowledge Infused Multi-modal Clinical Conversation Summarization27 Sep 2023
- 2023Foundation Metrics for Evaluating Effectiveness of Healthcare Conversations Powered by Generative AI21 Sep 2023
- 2023MDDial: A Multi-turn Differential Diagnosis Dialogue Dataset with Reliability Evaluation16 Aug 2023
- 2023A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction30 Jul 2023
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- 2023CoAD: Automatic Diagnosis through Symptom and Disease Collaborative Generation17 Jul 2023
- 2023MidMed: Towards Mixed-Type Dialogues for Medical Consultation5 Jun 2023
- 2023Medical Dialogue Generation via Dual Flow Modeling29 May 2023
- 2023KNSE: A Knowledge-aware Natural Language Inference Framework for Dialogue Symptom Status Recognition26 May 2023
- 2023HuatuoGPT, towards Taming Language Model to Be a Doctor24 May 2023
- 2023LLM-empowered Chatbots for Psychiatrist and Patient Simulation: Application and Evaluation23 May 2023
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- 2022On Transforming Reinforcement Learning by Transformer: The Development Trajectory29 Dec 2022
- 2022CDialog: A Multi-turn Covid-19 Conversation Dataset for Entity-Aware Dialog Generation16 Nov 2022
- 2022Terminology-aware Medical Dialogue Generation27 Oct 2022
- 2022TransAlign: Fully Automatic and Effective Entity Alignment for Knowledge Graphs16 Oct 2022
- 2022Towards Trustworthy Automatic Diagnosis Systems by Emulating Doctors' Reasoning with Deep Reinforcement Learning13 Oct 2022
- 2022CorefDiffs: Co-referential and Differential Knowledge Flow in Document Grounded Conversations5 Oct 2022
- 2022Scalable Online Disease Diagnosis via Multi-Model-Fused Actor-Critic Reinforcement Learning8 Jun 2022
- 2022NeuralSympCheck: A Symptom Checking and Disease Diagnostic Neural Model with Logic Regularization2 Jun 2022
- 2022DDXPlus: A New Dataset For Automatic Medical Diagnosis18 May 2022
- 2022DxFormer: A Decoupled Automatic Diagnostic System Based on Decoder-Encoder Transformer with Dense Symptom Representations8 May 2022
50 newest of 70 All 70 (JSON)
- 2024Uncertainty of Thoughts: Uncertainty-Aware Planning Enhances Information Seeking in Large Language Modelscited by 39
- 2023Large Language Models Perform Diagnostic Reasoningcited by 18
- 2025Inflated Excellence or True Performance? Rethinking Medical Diagnostic Benchmarks with Dynamic Evaluationcited by 5
- 2025DDO: Dual-Decision Optimization for LLM-Based Medical Consultation via Multi-Agent Collaborationcited by 2
- 2026COTCAgent: Preventive Consultation via Probabilistic Chain-of-Thought Completioncited by 0
- 2026COTCAgent: Preventive Consultation via Probabilistic Chain-of-Thought Completion14 May 2026
- 2025Inflated Excellence or True Performance? Rethinking Medical Diagnostic Benchmarks with Dynamic Evaluation10 Oct 2025
- 2025DDO: Dual-Decision Optimization for LLM-Based Medical Consultation via Multi-Agent Collaboration24 May 2025
- 2024Uncertainty of Thoughts: Uncertainty-Aware Planning Enhances Information Seeking in Large Language Models5 Feb 2024
- 2023Large Language Models Perform Diagnostic Reasoning18 Jul 2023
- 2023HuatuoGPT, towards Taming Language Model to Be a Doctorcited by 214
- 2023HuatuoGPT, towards Taming Language Model to Be a Doctor24 May 2023
- 2023A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethicscited by 163
- 2022DDXPlus: A New Dataset For Automatic Medical Diagnosiscited by 88
- 2021Pre-trained Language Models in Biomedical Domain: A Systematic Surveycited by 87
- 2022A Benchmark for Automatic Medical Consultation System: Frameworks, Tasks and Datasetscited by 45
- 2024CoD, Towards an Interpretable Medical Agent using Chain of Diagnosiscited by 43
- 2022On Transforming Reinforcement Learning by Transformer: The Development Trajectorycited by 36
- 2023LLM-empowered Chatbots for Psychiatrist and Patient Simulation: Application and Evaluationcited by 34
- 2023Foundation Metrics for Evaluating Effectiveness of Healthcare Conversations Powered by Generative AIcited by 32
- 2021A Benchmark and Comprehensive Survey on Knowledge Graph Entity Alignment via Representation Learningcited by 31
- 2021More but Correct: Generating Diversified and Entity-revised Medical Responsecited by 31
- 2021Semi-Supervised Variational Reasoning for Medical Dialogue Generationcited by 30
- 2023Variational Information Pursuit for Interpretable Predictionscited by 25
12 most cited of 62 All 62 (JSON)
- 2026DocTalkBN: A Novel Dataset of Expert Telemedicine Conversations in Bengali27 Aug 2026
- 2026Beyond Information Seeking: Severity-Aware Question Supervision for Proactive Medical Dialogue25 Aug 2026
- 2026From Triage to Discharge: A Survey of NLP Tasks, Methods, and Open Challenges in the Emergency Department23 Aug 2026
- 2026Synthesis and Evaluation of Long-term History-aware Medical Dialogue19 May 2026
- 2026EMSDialog: Synthetic Multi-person Emergency Medical Service Dialogue Generation from Electronic Patient Care Reports via Multi-LLM Agents8 Apr 2026
- 2026MIND: Unified Inquiry and Diagnosis RL with Criteria Grounded Clinical Supports for Psychiatric Consultation4 Mar 2026
- 2026Aligning Medical Conversational AI through Online Reinforcement Learning with Information-Theoretic Rewards25 Jan 2026
- 2025MIMIC-SR-ICD11: A Dataset for Narrative-Based Diagnosis7 Nov 2025
- 2025Enhancing Medical Dialogue Generation through Knowledge Refinement and Dynamic Prompt Adjustment12 Jun 2025
- 2025Feedback-Aware Monte Carlo Tree Search for Efficient Information Seeking in Goal-Oriented Conversations25 Jan 2025
- 2024Building a Chinese Medical Dialogue System: Integrating Large-scale Corpora and Novel Models27 Sep 2024
- 2024Synthetic Patient-Physician Dialogue Generation from Clinical Notes Using LLM12 Aug 2024
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