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Generating (Factual?) Narrative Summaries of RCTs: Experiments with Neural Multi-Document Summarization

arXiv 2008.11293 ↗First posted 25 Aug 2020cs.CLcited by 52

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Abstract (arXiv)

We consider the problem of automatically generating a narrative biomedical evidence summary from multiple trial reports. We evaluate modern neural models for abstractive summarization of relevant article abstracts from systematic reviews previously conducted by members of the Cochrane collaboration, using the authors conclusions section of the review abstract as our target. We enlist medical professionals to evaluate generated summaries, and we find that modern summarization systems yield consistently fluent and relevant synopses, but that they are not always factual. We propose new approaches that capitalize on domain-specific models to inform summarization, e.g., by explicitly demarcating snippets of inputs that convey key findings, and emphasizing the reports of large and high-quality trials. We find that these strategies modestly improve the factual accuracy of generated summaries. Finally, we propose a new method for automatically evaluating the factuality of generated narrative evidence syntheses using models that infer the directionality of reported findings.

Key facts. Cited by 52 papers in the map (data through 7 Oct 2026). First posted on arXiv 25 Aug 2020.

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Citing papers per year: 2021: 3; 2022: 9; 2023: 16; 2024: 13; 2025: 9; 2026: 2.

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  1. 2023A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethicscited by 162
  2. 2022SciFact-Open: Towards open-domain scientific claim verificationcited by 94
  3. 2021Pre-trained Language Models in Biomedical Domain: A Systematic Surveycited by 87
  4. 2021MS2: Multi-Document Summarization of Medical Studiescited by 80
  5. 2023MentaLLaMA: Interpretable Mental Health Analysis on Social Media with Large Language Modelscited by 63
  6. 2023Towards Interpretable Mental Health Analysis with Large Language Modelscited by 53
  7. 2024Detection and Measurement of Syntactic Templates in Generated Textcited by 44
  8. 2024Towards Evaluating and Building Versatile Large Language Models for Medicinecited by 38
  9. 2024SciRIFF: A Resource to Enhance Language Model Instruction-Following over Scientific Literaturecited by 37
  10. 2022Evaluating Factuality in Text Simplificationcited by 34
  11. 2024A Preliminary Study of o1 in Medicine: Are We Closer to an AI Doctor?cited by 33
  12. 2024CHIME: LLM-Assisted Hierarchical Organization of Scientific Studies for Literature Review Supportcited by 28
38 more
  1. 2022Retrieval augmentation of large language models for lay language generationcited by 21
  2. 2024Closing the gap between open-source and commercial large language models for medical evidence summarizationcited by 21
  3. 2022Open Domain Multi-document Summarization: A Comprehensive Study of Model Brittleness under Retrievalcited by 20
  4. 2022Readability Controllable Biomedical Document Summarizationcited by 19
  5. 2023Appraising the Potential Uses and Harms of LLMs for Medical Systematic Reviewscited by 18
  6. 2023Automated Metrics for Medical Multi-Document Summarization Disagree with Human Evaluationscited by 18
  7. 2023LongDocFACTScore: Evaluating the Factuality of Long Document Abstractive Summarisationcited by 16
  8. 2023Investigating Hallucinations in Pruned Large Language Models for Abstractive Summarizationcited by 16
  9. 2025Multimodal Large Language Models for Medicine: A Comprehensive Surveycited by 16
  10. 2023APPLS: Evaluating Evaluation Metrics for Plain Language Summarizationcited by 15
  11. 2023Walking a Tightrope -- Evaluating Large Language Models in High-Risk Domainscited by 15
  12. 2024Accelerating Clinical Evidence Synthesis with Large Language Modelscited by 15
  13. 2022A Survey on Medical Document Summarizationcited by 14
  14. 2022Self-Repetition in Abstractive Neural Summarizerscited by 13
  15. 2024Exploring the Efficacy of Large Language Models in Summarizing Mental Health Counseling Sessions: A Benchmark Studycited by 13
  16. 2023Do Multi-Document Summarization Models Synthesize?cited by 11
  17. 2025A foundation model for human-AI collaboration in medical literature miningcited by 11
  18. 2024Panacea: A foundation model for clinical trial search, summarization, design, and recruitmentcited by 10
  19. 2025HypER: Literature-grounded Hypothesis Generation and Distillation with Provenancecited by 10
  20. 2021What Would it Take to get Biomedical QA Systems into Practice?cited by 7
  21. 2023Automatically Summarizing Evidence from Clinical Trials: A Prototype Highlighting Current Challengescited by 7
  22. 2025Can Large Language Models Match the Conclusions of Systematic Reviews?cited by 7
  23. 2025LLMs Do Not See Age: Assessing Demographic Bias in Automated Systematic Review Synthesiscited by 5
  24. 2024Measuring Risk of Bias in Biomedical Reports: The RoBBR Benchmarkcited by 4
  25. 2023A Survey for Biomedical Text Summarization: From Pre-trained to Large Language Modelscited by 3
  26. 2023ODSum: New Benchmarks for Open Domain Multi-Document Summarizationcited by 3
  27. 2023LitSumm: Large language models for literature summarisation of non-coding RNAscited by 3
  28. 2023Leveraging Generative AI for Clinical Evidence Summarization Needs to Ensure Trustworthinesscited by 3
  29. 2024Contextualizing Generated Citation Textscited by 3
  30. 2024Aspect-oriented Consumer Health Answer Summarizationcited by 3
  31. 2024Evaluation of Large Language Models for Summarization Tasks in the Medical Domain: A Narrative Reviewcited by 3
  32. 2025ROBoto2: An Interactive System and Dataset for LLM-assisted Clinical Trial Risk of Bias Assessmentcited by 3
  33. 2026STABLEVAL: Disagreement-Aware and Stable Evaluation of AI Systemscited by 3
  34. 2022LED down the rabbit hole: exploring the potential of global attention for biomedical multi-document summarisationcited by 2
  35. 2023CSMeD: Bridging the Dataset Gap in Automated Citation Screening for Systematic Literature Reviewscited by 2
  36. 2025Are LLM-generated plain language summaries truly understandable? A large-scale crowdsourced evaluationcited by 2
  37. 2026This Treatment Works, Right? Evaluating LLM Sensitivity to Patient Question Framing in Medical QAcited by 2
  38. 2022Predicting Intervention Approval in Clinical Trials through Multi-Document Summarizationcited by 0

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