COTCAgent: Preventive Consultation via Probabilistic Chain-of-Thought Completion
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Sequential diagnosis requires ranking diseases from a sparse intake under a public budget of follow-up questions, which is diagnostic triage with missing findings rather than screening of people who have no symptoms. Because laboratory series arrive irregularly and histories remain incomplete, the ranking must be updated as new facts arrive, yet most pipelines are limited by unnamed numeric trends, unverifiable free-form chain of thought, and a negative bias from treating unasked findings as absent. To solve these, we propose COTCAgent, a sparse-intake consultation agent built on Chain-of-Thought Completion (COTC), which couples three modules on one shared ternary evidence log. The Temporal-Statistics Adapter (TSA) turns time series into typed predicates with named statistics, while the COTC module scores diseases with a learnable knowledge-base energy in which unknown findings add zero energy, after which bounded probabilistic completion selects unknown findings under the question budget and writes each answer back as present, absent, or unknown. Edge strengths and an absence scale are trained with listwise ranking under a sparse curriculum, so that the same energy chooses the next finding by a surrogate entropy reduction. Experiments on DDXPlus and MIMIC-IV show that these modules improve ranking under a matched question budget, with information-gain completion above asking nothing or at random and above protocol-matched askers and a local LLM, thereby providing a foundation for future calibrated scoring and prospective preventive consultation.
Key facts. No citing papers in the map yet (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 26 of its 53 references that are in the map. First posted on arXiv 14 May 2026.
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26 of 53 references.
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Other references · 24
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- 2024Large Language Models for Disease Diagnosis: A Scoping Reviewcited by 51
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