The Blessings of Multiple Causes
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Abstract (arXiv)
Causal inference from observational data often assumes "ignorability," that all confounders are observed. This assumption is standard yet untestable. However, many scientific studies involve multiple causes, different variables whose effects are simultaneously of interest. We propose the deconfounder, an algorithm that combines unsupervised machine learning and predictive model checking to perform causal inference in multiple-cause settings. The deconfounder infers a latent variable as a substitute for unobserved confounders and then uses that substitute to perform causal inference. We develop theory for the deconfounder, and show that it requires weaker assumptions than classical causal inference. We analyze its performance in three types of studies: semi-simulated data around smoking and lung cancer, semi-simulated data around genome-wide association studies, and a real dataset about actors and movie revenue. The deconfounder provides a checkable approach to estimating closer-to-truth causal effects.
Key facts. Cited by 104 papers in the map (data through 14 Oct 2026). First posted on arXiv 17 May 2018.
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Citing papers per year: 2019: 1; 2020: 0; 2021: 28; 2022: 19; 2023: 19; 2024: 14; 2025: 16; 2026: 7.
104 papers.
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- 2019Causal Confusion in Imitation Learningcited by 288
- 2021D'ya like DAGs? A Survey on Structure Learning and Causal Discoverycited by 211
- 2021Desiderata for Representation Learning: A Causal Perspectivecited by 76
- 2022Continuous-Time Modeling of Counterfactual Outcomes Using Neural Controlled Differential Equationscited by 59
- 2023Counterfactual Identifiability of Bijective Causal Modelscited by 43
- 2021Graph Infomax Adversarial Learning for Treatment Effect Estimation with Networked Observational Datacited by 42
- 2022Anticipating Performativity by Predicting from Predictionscited by 37
- 2022Combining Observational and Randomized Data for Estimating Heterogeneous Treatment Effectscited by 32
- 2021Identifiable Generative Models for Missing Not at Random Data Imputationcited by 30
- 2021Sequential Deconfounding for Causal Inference with Unobserved Confounderscited by 24
- 2021Counterfactual Explanations for Arbitrary Regression Modelscited by 22
- 2022Data-Driven Causal Effect Estimation Based on Graphical Causal Modelling: A Surveycited by 19
38 more
- 2022Estimating individual treatment effects under unobserved confounding using binary instrumentscited by 18
- 2023Zero-shot causal learningcited by 17
- 2023Estimating Treatment Effects from Irregular Time Series Observations with Hidden Confounderscited by 17
- 2021The Blessings of Unlabeled Background in Untrimmed Videoscited by 16
- 2021Deconfounding Temporal Autoencoder: Estimating Treatment Effects over Time Using Noisy Proxiescited by 16
- 2021Deconfounded Visual Groundingcited by 16
- 2023CF-GODE: Continuous-Time Causal Inference for Multi-Agent Dynamical Systemscited by 16
- 2024Causal Inference with Generative Artificial Intelligence: Application to Texts as Treatmentscited by 16
- 2023Causal Reasoning in the Presence of Latent Confounders via Neural ADMG Learningcited by 15
- 2023Reliable Off-Policy Learning for Dosage Combinationscited by 15
- 2021NCoRE: Neural Counterfactual Representation Learning for Combinations of Treatmentscited by 14
- 2021Deconfounded Causal Collaborative Filteringcited by 14
- 2022Deep Multi-Modal Structural Equations For Causal Effect Estimation With Unstructured Proxiescited by 13
- 2025Black Box Causal Inference: Effect Estimation via Meta Predictioncited by 13
- 2025Towards Interpretable Deep Generative Models via Causal Representation Learningcited by 13
- 2021Intact-VAE: Estimating Treatment Effects under Unobserved Confoundingcited by 10
- 2023Instrumental Variable Estimation for Causal Inference in Longitudinal Data with Time-Dependent Latent Confounderscited by 10
- 2021Causal Estimation with Functional Confounderscited by 9
- 2021Obtaining Causal Information by Merging Datasets with MAXENTcited by 9
- 2021Causal Inference Despite Limited Global Confounding via Mixture Modelscited by 9
- 2023Why Do Probabilistic Clinical Models Fail To Transport Between Sites?cited by 9
- 2021Causal Effect Variational Autoencoder with Uniform Treatmentcited by 8
- 2025DeCaFlow: A deconfounding causal generative modelcited by 8
- 2022Mitigating Health Disparities in EHR via Deconfoundercited by 7
- 2023Debiasing Recommendation by Learning Identifiable Latent Confounderscited by 7
- 2023Delphic Offline Reinforcement Learning under Nonidentifiable Hidden Confoundingcited by 7
- 2024Causal Contrastive Learning for Counterfactual Regression Over Timecited by 7
- 2022Estimating Social Influence from Observational Datacited by 5
- 2023Scalable Computation of Causal Boundscited by 5
- 2024What is Fair? Defining Fairness in Machine Learning for Healthcited by 5
- 2024Two-way Deconfounder for Off-policy Evaluation in Causal Reinforcement Learningcited by 5
- 2021Towards Principled Causal Effect Estimation by Deep Identifiable Modelscited by 4
- 2021Estimating Causal Effects of Multi-Aspect Online Reviews with Multi-Modal Proxiescited by 4
- 2022Generative multitask learning mitigates target-causing confoundingcited by 4
- 2022Scientometric Review of Artificial Intelligence for Operations & Maintenance of Wind Turbines: The Past, Present and Futurecited by 4
- 2024Self-Distilled Disentangled Learning for Counterfactual Predictioncited by 4
- 2024Causal Inference with Latent Variables: Recent Advances and Future Prospectivescited by 4
- 2021Effects of Multi-Aspect Online Reviews with Unobserved Confounders: Estimation and Implicationcited by 3
50 most cited of 104 All 104 (JSON)
- 2026Linear Regression Beyond Covariance: Latent Slope Spectra from Higher-Order Cumulants13 Oct 2026
- 2026LUCID: Learning Under Confounding for Inference and Discovery in Time Series25 Sep 2026
- 2026Learning Hierarchical Causal Representations of the Effects of Forcings on Temperature in Climate Models25 Sep 2026
- 2026Causal Inference with Unobserved Confounding: A Mixture Learning Perspective19 Sep 2026
- 2026Shrinkage priors for Bayesian Substitute Confounders16 Jun 2026
- 2026Identifiable Deep Latent Variable Models for MNAR Data25 Mar 2026
- 2026Learning Audio-Visual Embeddings with Inferred Latent Interaction Graphs17 Jan 2026
- 2025Transferring Causal Effects using Proxies29 Oct 2025
- 2025A tutorial on discovering and quantifying the effect of latent causal sources of multimodal EHR data15 Oct 2025
- 2025Spatial Deconfounder: Interference-Aware Deconfounding for Spatial Causal Inference9 Oct 2025
- 2025DAG DECORation: Continuous Optimization for Structure Learning under Hidden Confounding2 Oct 2025
- 2025Beyond Correlation: Causal Multi-View Unsupervised Feature Selection Learning17 Sep 2025
38 more
- 2025Causality in the human niche: lessons for machine learning13 Jun 2025
- 2025Deconfounded Warm-Start Thompson Sampling with Applications to Precision Medicine22 May 2025
- 2025Attribution Projection Calculus: A Novel Framework for Causal Inference in Bayesian Networks17 May 2025
- 2025Sequential Treatment Effect Estimation with Unmeasured Confounders14 May 2025
- 2025Towards Interpretable Deep Generative Models via Causal Representation Learning15 Apr 2025
- 2025A Computational Theory for Efficient Mini Agent Evaluation with Causal Guarantees27 Mar 2025
- 2025DeCaFlow: A deconfounding causal generative model19 Mar 2025
- 2025Black Box Causal Inference: Effect Estimation via Meta Prediction7 Mar 2025
- 2025Causal Effect Estimation under Networked Interference without Networked Unconfoundedness Assumption27 Feb 2025
- 2025Individualised Treatment Effects Estimation with Composite Treatments and Composite Outcomes12 Feb 2025
- 2025Falsification of Unconfoundedness by Testing Independence of Causal Mechanisms10 Feb 2025
- 2024Two-way Deconfounder for Off-policy Evaluation in Causal Reinforcement Learning8 Dec 2024
- 2024Leaning Time-Varying Instruments for Identifying Causal Effects in Time-Series Data26 Nov 2024
- 2024Causal Inference with Generative Artificial Intelligence: Application to Texts as Treatments1 Oct 2024
- 2024Deconfounding Multi-Cause Latent Confounders: A Factor-Model Approach to Climate Model Bias Correction22 Aug 2024
- 2024Causal Inference with Complex Treatments: A Survey19 Jul 2024
- 2024Causal Inference with Latent Variables: Recent Advances and Future Prospectives20 Jun 2024
- 2024What is Fair? Defining Fairness in Machine Learning for Health13 Jun 2024
- 2024Estimating Heterogeneous Treatment Effects by Combining Weak Instruments and Observational Data10 Jun 2024
- 2024Self-Distilled Disentangled Learning for Counterfactual Prediction9 Jun 2024
- 2024Causal Contrastive Learning for Counterfactual Regression Over Time1 Jun 2024
- 2024Synthetic Potential Outcomes and Causal Mixture Identifiability29 May 2024
- 2024Automating the Selection of Proxy Variables of Unmeasured Confounders25 May 2024
- 2024A/B testing under Interference with Partial Network Information16 Apr 2024
- 2024Substitute adjustment via recovery of latent variables1 Mar 2024
- 2023Instrumental Variable Estimation for Causal Inference in Longitudinal Data with Time-Dependent Latent Confounders12 Dec 2023
- 2023Why Do Probabilistic Clinical Models Fail To Transport Between Sites?8 Nov 2023
- 2023Estimating treatment effects from single-arm trials via latent-variable modeling6 Nov 2023
- 2023Causal Dynamic Variational Autoencoder for Counterfactual Regression in Longitudinal Data16 Oct 2023
- 2023The Blessings of Multiple Treatments and Outcomes in Treatment Effect Estimation29 Sep 2023
- 2023A Counterfactual Fair Model for Longitudinal Electronic Health Records via Deconfounder22 Aug 2023
- 2023Deep Generative Imputation Model for Missing Not At Random Data16 Aug 2023
- 2023Scalable Computation of Causal Bounds4 Aug 2023
- 2023CF-GODE: Continuous-Time Causal Inference for Multi-Agent Dynamical Systems20 Jun 2023
- 2023Delphic Offline Reinforcement Learning under Nonidentifiable Hidden Confounding1 Jun 2023
- 2023Calibrated and Conformal Propensity Scores for Causal Effect Estimation1 Jun 2023
- 2023Reliable Off-Policy Learning for Dosage Combinations31 May 2023
- 2023Causal Reasoning in the Presence of Latent Confounders via Neural ADMG Learning22 Mar 2023
50 newest of 104 All 104 (JSON)
- 2019Causal Confusion in Imitation Learningcited by 288
- 2023Delphic Offline Reinforcement Learning under Nonidentifiable Hidden Confoundingcited by 7
- 2021D'ya like DAGs? A Survey on Structure Learning and Causal Discoverycited by 211
- 2021Desiderata for Representation Learning: A Causal Perspectivecited by 76
- 2022Continuous-Time Modeling of Counterfactual Outcomes Using Neural Controlled Differential Equationscited by 59
- 2023Counterfactual Identifiability of Bijective Causal Modelscited by 43
- 2021Graph Infomax Adversarial Learning for Treatment Effect Estimation with Networked Observational Datacited by 42
- 2022Anticipating Performativity by Predicting from Predictionscited by 37
- 2022Combining Observational and Randomized Data for Estimating Heterogeneous Treatment Effectscited by 32
- 2021Identifiable Generative Models for Missing Not at Random Data Imputationcited by 30
- 2021Sequential Deconfounding for Causal Inference with Unobserved Confounderscited by 24
- 2021Counterfactual Explanations for Arbitrary Regression Modelscited by 22
- 2022Data-Driven Causal Effect Estimation Based on Graphical Causal Modelling: A Surveycited by 19
- 2022Estimating individual treatment effects under unobserved confounding using binary instrumentscited by 18
12 most cited of 99 All 99 (JSON)
- 2026Linear Regression Beyond Covariance: Latent Slope Spectra from Higher-Order Cumulants13 Oct 2026
- 2026LUCID: Learning Under Confounding for Inference and Discovery in Time Series25 Sep 2026
- 2026Learning Hierarchical Causal Representations of the Effects of Forcings on Temperature in Climate Models25 Sep 2026
- 2026Causal Inference with Unobserved Confounding: A Mixture Learning Perspective19 Sep 2026
- 2026Shrinkage priors for Bayesian Substitute Confounders16 Jun 2026
- 2026Identifiable Deep Latent Variable Models for MNAR Data25 Mar 2026
- 2026Learning Audio-Visual Embeddings with Inferred Latent Interaction Graphs17 Jan 2026
- 2025Transferring Causal Effects using Proxies29 Oct 2025
- 2025A tutorial on discovering and quantifying the effect of latent causal sources of multimodal EHR data15 Oct 2025
- 2025Spatial Deconfounder: Interference-Aware Deconfounding for Spatial Causal Inference9 Oct 2025
- 2025DAG DECORation: Continuous Optimization for Structure Learning under Hidden Confounding2 Oct 2025
- 2025Beyond Correlation: Causal Multi-View Unsupervised Feature Selection Learning17 Sep 2025
12 newest of 99 All 99 (JSON)