Bottom-up Domain-specific Superintelligence: A Reliable Knowledge Graph is What We Need
On the map: LLM reasoning → Clinical and biomedical applications
Abstract (arXiv)
Language models traditionally used for cross-domain generalization have recently demonstrated task-specific reasoning. However, their top-down training approach on general corpora is insufficient for acquiring abstractions needed for deep domain expertise. This may require a bottom-up approach that acquires expertise by learning to compose simple domain concepts into more complex ones. A knowledge graph (KG) provides this compositional structure, where domain primitives are represented as head-relation-tail edges and their paths encode higher-level concepts. We present a task generation pipeline that synthesizes tasks directly from KG primitives, enabling models to acquire and compose them for reasoning. We fine-tune language models on the resultant KG-grounded curriculum to demonstrate domain-specific superintelligence. While broadly applicable, we validate our approach in medicine, where reliable KGs exist. Using a medical KG, we curate 24,000 reasoning tasks paired with thinking traces derived from diverse medical primitives. We fine-tune the QwQ-32B model on this curriculum to obtain QwQ-Med-3 that takes a step towards medical superintelligence. We also introduce ICD-Bench, an evaluation suite to quantify reasoning abilities across 15 medical domains. Our experiments demonstrate that QwQ-Med-3 significantly outperforms state-of-the-art reasoning models on ICD-Bench categories. Further analysis reveals that QwQ-Med-3 utilizes acquired primitives to widen the performance gap on the hardest tasks of ICD-Bench. Finally, evaluation on medical question-answer benchmarks shows that QwQ-Med-3 transfers acquired expertise to enhance the base model's performance. While the industry's approach to artificial general intelligence (AGI) emphasizes broad expertise, we envision a future in which AGI emerges from the composable interaction of efficient domain-specific superintelligent agents.
Key facts. Cited by 13 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 63 of its 101 references that are in the map. First posted on arXiv 18 Jul 2025.
Builds on
63 of 101 references.
Closest ancestors · 4
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Other references · 59
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Citing papers per year: 2025: 4; 2026: 9.
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- 2026An Alternative Trajectory for Generative AIcited by 1
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- 2026Co-Evolving Structured Knowledge and Reasoning in Language Models26 Aug 2026
- 2026Knowledge Graph-Driven Expert-Level Reasoning for Neuroscience24 May 2026
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- 2026MMKG-RDS: Reasoning Data Synthesis via Deep Mining of Multimodal Knowledge Graphs27 Feb 2026
- 2026Knowledge Graphs are Implicit Reward Models: Path-Derived Signals Enable Compositional Reasoning21 Jan 2026
- 2025Structured In-context Environment Scaling for Large Language Model Reasoning27 Sep 2025
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