mlsanityData to 14 Oct 2026

Bottom-up Domain-specific Superintelligence: A Reliable Knowledge Graph is What We Need

arXiv 2507.13966 ↗First posted 18 Jul 2025cs.CL cs.AIcited by 13

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Language models traditionally used for cross-domain generalization have recently demonstrated task-specific reasoning. However, their top-down training approach on general corpora is insufficient for acquiring abstractions needed for deep domain expertise. This may require a bottom-up approach that acquires expertise by learning to compose simple domain concepts into more complex ones. A knowledge graph (KG) provides this compositional structure, where domain primitives are represented as head-relation-tail edges and their paths encode higher-level concepts. We present a task generation pipeline that synthesizes tasks directly from KG primitives, enabling models to acquire and compose them for reasoning. We fine-tune language models on the resultant KG-grounded curriculum to demonstrate domain-specific superintelligence. While broadly applicable, we validate our approach in medicine, where reliable KGs exist. Using a medical KG, we curate 24,000 reasoning tasks paired with thinking traces derived from diverse medical primitives. We fine-tune the QwQ-32B model on this curriculum to obtain QwQ-Med-3 that takes a step towards medical superintelligence. We also introduce ICD-Bench, an evaluation suite to quantify reasoning abilities across 15 medical domains. Our experiments demonstrate that QwQ-Med-3 significantly outperforms state-of-the-art reasoning models on ICD-Bench categories. Further analysis reveals that QwQ-Med-3 utilizes acquired primitives to widen the performance gap on the hardest tasks of ICD-Bench. Finally, evaluation on medical question-answer benchmarks shows that QwQ-Med-3 transfers acquired expertise to enhance the base model's performance. While the industry's approach to artificial general intelligence (AGI) emphasizes broad expertise, we envision a future in which AGI emerges from the composable interaction of efficient domain-specific superintelligent agents.

Key facts. Cited by 13 papers in the map (data through 14 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 63 of its 101 references that are in the map. First posted on arXiv 18 Jul 2025.

Builds on

63 of 101 references.

Closest ancestors · 4

Same direction, newest first

  1. 2025Med-PRM: Medical Reasoning Models with Stepwise, Guideline-verified Process Rewards13 Jun
  2. 2025Toward Scientific Reasoning in LLMs: Training from Expert Discussions via Reinforcement Learning26 May
  3. 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs25 Dec
  4. 2024Small Language Models Learn Enhanced Reasoning Skills from Medical Textbooks30 Mar

Other references · 59

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  33. 2022A Survey of Knowledge Graph Reasoning on Graph Types: Static, Dynamic, and Multimodalcited by 106
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  38. 2020Efficient Probabilistic Logic Reasoning with Graph Neural Networkscited by 50

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  1. 2025Knowledge or Reasoning? A Close Look at How LLMs Think Across Domains
  2. 2025Disentangling Reasoning and Knowledge in Medical Large Language Models
  3. 2025Brittleness and Promise: Knowledge Graph Based Reward Modeling for Diagnostic Reasoning
  4. 2026Surgical Alignment in Knowledge Graph Training for Clinical Diagnosis with Large Language Models
  5. 2025MedRule-KG: A Knowledge-Graph--Steered Scaffold for Reliable Mathematical and Biomedical Reasoning
  6. 2025Chiron-o1: Igniting Multimodal Large Language Models towards Generalizable Medical Reasoning via Mentor-Intern Collaborative Search
  7. 2025MedicalAgentsBench for Complex Medical Reasoning: Comparing Internalized Reasoning Models versus Externalized Agent-based Frameworks
  8. 2025MedS3: Towards Medical Slow Thinking with Self-Evolved Soft Dual-sided Process Supervision