LLMEval-Med: A Real-world Clinical Benchmark for Medical LLMs with Physician Validation
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Abstract (arXiv)
Evaluating large language models (LLMs) in medicine is crucial because medical applications require high accuracy with little room for error. Current medical benchmarks have three main types: medical exam-based, comprehensive medical, and specialized assessments. However, these benchmarks have limitations in question design (mostly multiple-choice), data sources (often not derived from real clinical scenarios), and evaluation methods (poor assessment of complex reasoning). To address these issues, we present LLMEval-Med, a new benchmark covering five core medical areas, including 2,996 questions created from real-world electronic health records and expert-designed clinical scenarios. We also design an automated evaluation pipeline, incorporating expert-developed checklists into our LLM-as-Judge framework. Furthermore, our methodology validates machine scoring through human-machine agreement analysis, dynamically refining checklists and prompts based on expert feedback to ensure reliability. We evaluate 13 LLMs across three categories (specialized medical models, open-source models, and closed-source models) on LLMEval-Med, providing valuable insights for the safe and effective deployment of LLMs in medical domains. The dataset is released in https://github.com/llmeval/LLMEval-Med.
Key facts. Cited by 34 papers in the map (data through 14 Oct 2026). Builds on 12 of its 40 references that are in the map. First posted on arXiv 4 Jun 2025.
Builds on
12 of 40 references.
References · 12
- 2023Judging LLM-as-a-Judge with MT-Bench and Chatbot Arenacited by 8,626
- 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,288
- 2024HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMscited by 265
- 2020MedDialog: Two Large-scale Medical Dialogue Datasetscited by 161
- 2021CBLUE: A Chinese Biomedical Language Understanding Evaluation Benchmarkcited by 101
- 2023DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultationcited by 90
- 2024MedCalc-Bench: Evaluating Large Language Models for Medical Calculationscited by 70
- 2023PromptCBLUE: A Chinese Prompt Tuning Benchmark for the Medical Domaincited by 40
- 2021MedNLI Is Not Immune: Natural Language Inference Artifacts in the Clinical Domaincited by 17
- 2024WorldMedQA-V: a multilingual, multimodal medical examination dataset for multimodal language models evaluationcited by 11
- 2023MedGPTEval: A Dataset and Benchmark to Evaluate Responses of Large Language Models in Medicinecited by 7
- 2023Exploring the Landscape of Natural Language Processing Researchcited by 7
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Citing papers per year: 2025: 7; 2026: 27.
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- 2025Breaking the Exploration Bottleneck: Rubric-Scaffolded Reinforcement Learning for General LLM Reasoningcited by 63
- 2026HealthBench Professional: Evaluating Large Language Models on Real Clinician Chatscited by 26
- 2026EvoRubric: Self-Evolving Rubric-Driven RL for Open-Ended Generationcited by 11
- 2026Rubric Dropout: A Simple Way to Mitigate Reward Hacking in Rubric-as-Reward RLcited by 9
- 2026CriPO: Enhancing Rubric-based RL via Self-Distillationcited by 5
- 2025From Feedback to Checklists: Grounded Evaluation of AI-Generated Clinical Notescited by 4
- 2025Beyond Classification Accuracy: Neural-MedBench and the Need for Deeper Reasoning Benchmarkscited by 3
- 2026Experience is the Best Teacher: Motivating Effective Exploration in Reinforcement Learning for LLMscited by 3
- 2025EH-Benchmark Ophthalmic Hallucination Benchmark and Agent-Driven Top-Down Traceable Reasoning Workflowcited by 2
- 2025LLMEval-Fair: A Large-Scale Longitudinal Study on Robust and Fair Evaluation of Large Language Modelscited by 2
- 2026Quark Medical Alignment: A Holistic Multi-Dimensional Alignment and Collaborative Optimization Paradigmcited by 2
- 2026EHRBench: An Automated and Reliable EHR-based Benchmark for Clinical Decision Making with LLMscited by 2
22 more
- 2026Evaluating Large Language Model Raters for German Open-Response Clinical Questions: A Physician-Annotated Benchmark Study of Agreement, Evaluator Bias, and Abstentioncited by 2
- 2026DecoEvo: Score-Decoupled Co-Evolution of Solver and Rubric-Generator Skills in Text Spacecited by 2
- 2026SERPO: Self-Evolving Rubric Policy Optimization for Open-Ended Test-Time Reinforcement Learningcited by 2
- 2026RISE-RL: Rubric-Informed Selective Exploration for Open-Ended Reinforcement Learningcited by 2
- 2025Can LLMs Threaten Human Survival? Benchmarking Potential Existential Threats from LLMs via Prefix Completioncited by 1
- 2026MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounterscited by 1
- 2025MedGEN-Bench: A Contextually Entangled Benchmark for Open-ended Multimodal Medical Generationcited by 0
- 2026Who Does What? Archetypes of Roles Assigned to LLMs During Human-AI Decision-Makingcited by 0
- 2026ClinConsensus: A Physician-Calibrated Benchmark for Evaluating Clinical Rubric Coverage in Chinese Medical LLMscited by 0
- 2026Leveraging Computerized Adaptive Testing for Cost-effective Evaluation of Large Language Models in Medical Benchmarkingcited by 0
- 2026DepthCharge: A Domain-Agnostic Framework for Measuring Depth-Dependent Knowledge in Large Language Modelscited by 0
- 2026AcuityBench: Evaluating Clinical Acuity Identification and Uncertainty Alignmentcited by 0
- 2026TreeProbe : A Tibetan Medicine Benchmark for Cultural Bias in LLMscited by 0
- 2026RESPClinBench: Benchmarking Multimodal Clinical Decision-Making and Longitudinal Disease Management in Respiratory Specialty Carecited by 0
- 2026A Source-Grounded Framework for Constructing and Evaluating Progressive Multimodal Diagnostic Dialogues from Clinical Case Reportscited by 0
- 2026SUP-MIMIC: A Multi-Task Clinical Diagnosis Benchmark for Evaluating LLMs' Robustness to Contradictory Evidencecited by 0
- 2026PetQA: Benchmarking Veterinary Knowledge and Clinical Reasoningcited by 0
- 2026DischargeBench: Pre-Deployment Evaluation of LLM Discharge Educators through Persona-Grounded Patient Simulationcited by 0
- 2026AnesTRACE: Benchmarking Intraoperative Anesthesia from Multimodal Perception to Multi-step Decision-Makingcited by 0
- 2026PreSO: Privileged Representation Isolation for On-Policy Self-Distillationcited by 0
- 2026RELAY: Selective Self-Distillation with Adaptive Hand-off for Rubric-Based Reinforcement Learningcited by 0
- 2026CoCA: Criterion-Aware Credit Assignment for Rubric-Based Reinforcement Learningcited by 0
- 2026CoCA: Criterion-Aware Credit Assignment for Rubric-Based Reinforcement Learning13 Oct 2026
- 2026RELAY: Selective Self-Distillation with Adaptive Hand-off for Rubric-Based Reinforcement Learning13 Oct 2026
- 2026PreSO: Privileged Representation Isolation for On-Policy Self-Distillation27 Sep 2026
- 2026AnesTRACE: Benchmarking Intraoperative Anesthesia from Multimodal Perception to Multi-step Decision-Making26 Sep 2026
- 2026PetQA: Benchmarking Veterinary Knowledge and Clinical Reasoning4 Sep 2026
- 2026SUP-MIMIC: A Multi-Task Clinical Diagnosis Benchmark for Evaluating LLMs' Robustness to Contradictory Evidence30 Aug 2026
- 2026A Source-Grounded Framework for Constructing and Evaluating Progressive Multimodal Diagnostic Dialogues from Clinical Case Reports24 Aug 2026
- 2026Rubric Dropout: A Simple Way to Mitigate Reward Hacking in Rubric-as-Reward RL12 Aug 2026
- 2026RISE-RL: Rubric-Informed Selective Exploration for Open-Ended Reinforcement Learning10 Aug 2026
- 2026RESPClinBench: Benchmarking Multimodal Clinical Decision-Making and Longitudinal Disease Management in Respiratory Specialty Care5 Aug 2026
- 2026TreeProbe : A Tibetan Medicine Benchmark for Cultural Bias in LLMs1 Aug 2026
- 2026SERPO: Self-Evolving Rubric Policy Optimization for Open-Ended Test-Time Reinforcement Learning29 Jul 2026
22 more
- 2026DecoEvo: Score-Decoupled Co-Evolution of Solver and Rubric-Generator Skills in Text Space28 Jul 2026
- 2026DischargeBench: Pre-Deployment Evaluation of LLM Discharge Educators through Persona-Grounded Patient Simulation22 Jul 2026
- 2026CriPO: Enhancing Rubric-based RL via Self-Distillation20 Jul 2026
- 2026MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounters9 Jul 2026
- 2026Evaluating Large Language Model Raters for German Open-Response Clinical Questions: A Physician-Annotated Benchmark Study of Agreement, Evaluator Bias, and Abstention1 Jul 2026
- 2026EHRBench: An Automated and Reliable EHR-based Benchmark for Clinical Decision Making with LLMs28 May 2026
- 2026EvoRubric: Self-Evolving Rubric-Driven RL for Open-Ended Generation28 May 2026
- 2026AcuityBench: Evaluating Clinical Acuity Identification and Uncertainty Alignment12 May 2026
- 2026HealthBench Professional: Evaluating Large Language Models on Real Clinician Chats30 Apr 2026
- 2026Experience is the Best Teacher: Motivating Effective Exploration in Reinforcement Learning for LLMs20 Mar 2026
- 2026DepthCharge: A Domain-Agnostic Framework for Measuring Depth-Dependent Knowledge in Large Language Models5 Mar 2026
- 2026ClinConsensus: A Physician-Calibrated Benchmark for Evaluating Clinical Rubric Coverage in Chinese Medical LLMs2 Mar 2026
- 2026Leveraging Computerized Adaptive Testing for Cost-effective Evaluation of Large Language Models in Medical Benchmarking28 Feb 2026
- 2026Who Does What? Archetypes of Roles Assigned to LLMs During Human-AI Decision-Making12 Feb 2026
- 2026Quark Medical Alignment: A Holistic Multi-Dimensional Alignment and Collaborative Optimization Paradigm12 Feb 2026
- 2025Can LLMs Threaten Human Survival? Benchmarking Potential Existential Threats from LLMs via Prefix Completion24 Nov 2025
- 2025MedGEN-Bench: A Contextually Entangled Benchmark for Open-ended Multimodal Medical Generation17 Nov 2025
- 2025Beyond Classification Accuracy: Neural-MedBench and the Need for Deeper Reasoning Benchmarks26 Sep 2025
- 2025Breaking the Exploration Bottleneck: Rubric-Scaffolded Reinforcement Learning for General LLM Reasoning23 Aug 2025
- 2025LLMEval-Fair: A Large-Scale Longitudinal Study on Robust and Fair Evaluation of Large Language Models7 Aug 2025
- 2025EH-Benchmark Ophthalmic Hallucination Benchmark and Agent-Driven Top-Down Traceable Reasoning Workflow24 Jul 2025
- 2025From Feedback to Checklists: Grounded Evaluation of AI-Generated Clinical Notes23 Jul 2025
- 2025Breaking the Exploration Bottleneck: Rubric-Scaffolded Reinforcement Learning for General LLM Reasoningcited by 63
- 2025Beyond Classification Accuracy: Neural-MedBench and the Need for Deeper Reasoning Benchmarkscited by 3
- 2026Experience is the Best Teacher: Motivating Effective Exploration in Reinforcement Learning for LLMscited by 3
- 2025EH-Benchmark Ophthalmic Hallucination Benchmark and Agent-Driven Top-Down Traceable Reasoning Workflowcited by 2
- 2026PetQA: Benchmarking Veterinary Knowledge and Clinical Reasoningcited by 0
- 2026RELAY: Selective Self-Distillation with Adaptive Hand-off for Rubric-Based Reinforcement Learningcited by 0
- 2026RELAY: Selective Self-Distillation with Adaptive Hand-off for Rubric-Based Reinforcement Learning13 Oct 2026
- 2026PetQA: Benchmarking Veterinary Knowledge and Clinical Reasoning4 Sep 2026
- 2026Experience is the Best Teacher: Motivating Effective Exploration in Reinforcement Learning for LLMs20 Mar 2026
- 2025Beyond Classification Accuracy: Neural-MedBench and the Need for Deeper Reasoning Benchmarks26 Sep 2025
- 2025Breaking the Exploration Bottleneck: Rubric-Scaffolded Reinforcement Learning for General LLM Reasoning23 Aug 2025
- 2025EH-Benchmark Ophthalmic Hallucination Benchmark and Agent-Driven Top-Down Traceable Reasoning Workflow24 Jul 2025
- 2026Rubric Dropout: A Simple Way to Mitigate Reward Hacking in Rubric-as-Reward RLcited by 9
- 2026Quark Medical Alignment: A Holistic Multi-Dimensional Alignment and Collaborative Optimization Paradigmcited by 2
- 2026RISE-RL: Rubric-Informed Selective Exploration for Open-Ended Reinforcement Learningcited by 2
- 2026Rubric Dropout: A Simple Way to Mitigate Reward Hacking in Rubric-as-Reward RL12 Aug 2026
- 2026RISE-RL: Rubric-Informed Selective Exploration for Open-Ended Reinforcement Learning10 Aug 2026
- 2026Quark Medical Alignment: A Holistic Multi-Dimensional Alignment and Collaborative Optimization Paradigm12 Feb 2026
- 2026HealthBench Professional: Evaluating Large Language Models on Real Clinician Chatscited by 26
- 2025From Feedback to Checklists: Grounded Evaluation of AI-Generated Clinical Notescited by 4
- 2025LLMEval-Fair: A Large-Scale Longitudinal Study on Robust and Fair Evaluation of Large Language Modelscited by 2
- 2026EHRBench: An Automated and Reliable EHR-based Benchmark for Clinical Decision Making with LLMscited by 2
- 2026Evaluating Large Language Model Raters for German Open-Response Clinical Questions: A Physician-Annotated Benchmark Study of Agreement, Evaluator Bias, and Abstentioncited by 2
- 2026DecoEvo: Score-Decoupled Co-Evolution of Solver and Rubric-Generator Skills in Text Spacecited by 2
- 2026MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounterscited by 1
- 2026Who Does What? Archetypes of Roles Assigned to LLMs During Human-AI Decision-Makingcited by 0
- 2026ClinConsensus: A Physician-Calibrated Benchmark for Evaluating Clinical Rubric Coverage in Chinese Medical LLMscited by 0
- 2026Leveraging Computerized Adaptive Testing for Cost-effective Evaluation of Large Language Models in Medical Benchmarkingcited by 0
- 2026DepthCharge: A Domain-Agnostic Framework for Measuring Depth-Dependent Knowledge in Large Language Modelscited by 0
- 2026AcuityBench: Evaluating Clinical Acuity Identification and Uncertainty Alignmentcited by 0
12 most cited of 18 All 18 (JSON)
- 2026AnesTRACE: Benchmarking Intraoperative Anesthesia from Multimodal Perception to Multi-step Decision-Making26 Sep 2026
- 2026SUP-MIMIC: A Multi-Task Clinical Diagnosis Benchmark for Evaluating LLMs' Robustness to Contradictory Evidence30 Aug 2026
- 2026A Source-Grounded Framework for Constructing and Evaluating Progressive Multimodal Diagnostic Dialogues from Clinical Case Reports24 Aug 2026
- 2026RESPClinBench: Benchmarking Multimodal Clinical Decision-Making and Longitudinal Disease Management in Respiratory Specialty Care5 Aug 2026
- 2026TreeProbe : A Tibetan Medicine Benchmark for Cultural Bias in LLMs1 Aug 2026
- 2026DecoEvo: Score-Decoupled Co-Evolution of Solver and Rubric-Generator Skills in Text Space28 Jul 2026
- 2026DischargeBench: Pre-Deployment Evaluation of LLM Discharge Educators through Persona-Grounded Patient Simulation22 Jul 2026
- 2026MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounters9 Jul 2026
- 2026Evaluating Large Language Model Raters for German Open-Response Clinical Questions: A Physician-Annotated Benchmark Study of Agreement, Evaluator Bias, and Abstention1 Jul 2026
- 2026EHRBench: An Automated and Reliable EHR-based Benchmark for Clinical Decision Making with LLMs28 May 2026
- 2026AcuityBench: Evaluating Clinical Acuity Identification and Uncertainty Alignment12 May 2026
- 2026HealthBench Professional: Evaluating Large Language Models on Real Clinician Chats30 Apr 2026
12 newest of 18 All 18 (JSON)