Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Experts
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Abstract (arXiv)
As large language models (LLMs) are increasingly used in clinical settings, it is critical to evaluate their reliability under realistic variation in clinical text. We study this question in clinical triage, comparing LLMs to practicing physicians under text perturbations that preserve the underlying clinical setting. We introduce a benchmark of over 6,000 clinical scenarios, 7,000 physician annotations, and 225,000 model responses. Using this benchmark, we make two key observations. First, LLMs are more likely than physicians to recommend unnecessary care at baseline, and this tendency increases under perturbed inputs. Further, we find that LLM recommendations are more sensitive to gender and tone perturbations than human recommendations. Together, these results demonstrate that LLMs can vary under clinically irrelevant textual changes, highlighting the need for deployment-oriented evaluations grounded in expert physician behavior.
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References · 12
- 2022Large Language Models Encode Clinical Knowledgecited by 1,830
- 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,356
- 2019Bias in Bios: A Case Study of Semantic Representation Bias in a High-Stakes Settingcited by 349
- 2023Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarizationcited by 246
- 2023"Kelly is a Warm Person, Joseph is a Role Model": Gender Biases in LLM-Generated Reference Letterscited by 199
- 2025Medical Large Language Model Benchmarks Should Prioritize Construct Validitycited by 38
- 2023Vision-Language Models Performing Zero-Shot Tasks Exhibit Gender-based Disparitiescited by 31
- 2024Evaluating LLM -- Generated Multimodal Diagnosis from Medical Images and Symptom Analysiscited by 24
- 2023An investigation into the impact of deep learning model choice on sex and race bias in cardiac MR segmentationcited by 8
- 2025LLM Sensitivity Evaluation Framework for Clinical Diagnosiscited by 7
- 2025How Individual Traits and Language Styles Shape Preferences In Open-ended User-LLM Interaction: A Preliminary Studycited by 7
- 2025RadOnc-GPT: An Autonomous LLM Agent for Real-Time Patient Outcomes Labeling at Scalecited by 5
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