mlsanityData to 7 Oct 2026

Citrus: Leveraging Expert Cognitive Pathways in a Medical Language Model for Advanced Medical Decision Support

arXiv 2502.18274 ↗First posted 25 Feb 2025cs.AI cs.CLcited by 16

On the map: LLM reasoning → Clinical and biomedical applications

Abstract (arXiv)

Large language models (LLMs), particularly those with reasoning capabilities, have rapidly advanced in recent years, demonstrating significant potential across a wide range of applications. However, their deployment in healthcare, especially in disease reasoning tasks, is hindered by the challenge of acquiring expert-level cognitive data. In this paper, we introduce Citrus, a medical language model that bridges the gap between clinical expertise and AI reasoning by emulating the cognitive processes of medical experts. The model is trained on a large corpus of simulated expert disease reasoning data, synthesized using a novel approach that accurately captures the decision-making pathways of clinicians. This approach enables Citrus to better simulate the complex reasoning processes involved in diagnosing and treating medical conditions. To further address the lack of publicly available datasets for medical reasoning tasks, we release the last-stage training data, including a custom-built medical diagnostic dialogue dataset. This open-source contribution aims to support further research and development in the field. Evaluations using authoritative benchmarks such as MedQA, covering tasks in medical reasoning and language understanding, show that Citrus achieves superior performance compared to other models of similar size. These results highlight Citrus potential to significantly enhance medical decision support systems, providing a more accurate and efficient tool for clinical decision-making.

Key facts. Cited by 16 papers in the map (data through 7 Oct 2026). Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning. Builds on 56 of its 86 references that are in the map. First posted on arXiv 25 Feb 2025.

Builds on

56 of 86 references.

Closest ancestors · 4

Same direction, newest first

  1. 2025O1 Replication Journey -- Part 3: Inference-time Scaling for Medical Reasoning11 Jan
  2. 2024MedCoT: Medical Chain of Thought via Hierarchical Expert18 Dec
  3. 2023MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning16 Nov
  4. 2022Can large language models reason about medical questions?17 Jul

Other references · 52

  1. 2023GPT-4 Technical Reportcited by 18,132
  2. 2024The Llama 3 Herd of Modelscited by 14,192
  3. 2022Chain-of-Thought Prompting Elicits Reasoning in Large Language Modelscited by 12,302
  4. 2020Measuring Massive Multitask Language Understandingcited by 7,768
  5. 2025DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learningcited by 6,146
  6. 2024Qwen2.5 Technical Reportcited by 4,713
  7. 2019BioBERT: a pre-trained biomedical language representation model for biomedical text miningcited by 1,935
  8. 2022Large Language Models Encode Clinical Knowledgecited by 1,807
  9. 2024MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmarkcited by 1,758
  10. 2020What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Examscited by 1,324
  11. 2019PubMedQA: A Dataset for Biomedical Research Question Answeringcited by 1,271
  12. 2023WizardLM: Empowering large pre-trained language models to follow complex instructionscited by 1,116
38 more
  1. 2019Publicly Available Clinical BERT Embeddingscited by 995
  2. 2024SimPO: Simple Preference Optimization with a Reference-Free Rewardcited by 951
  3. 2022Towards Reasoning in Large Language Models: A Surveycited by 593
  4. 2022MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answeringcited by 525
  5. 2024StarCoder 2 and The Stack v2: The Next Generationcited by 484
  6. 2023Scaling Relationship on Learning Mathematical Reasoning with Large Language Modelscited by 417
  7. 2023ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledgecited by 324
  8. 2023Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicinecited by 319
  9. 2024Large Language Models for Mathematical Reasoning: Progresses and Challengescited by 283
  10. 2023MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Datacited by 282
  11. 2022Reasoning with Language Model Prompting: A Surveycited by 251
  12. 2024Capabilities of Gemini Models in Medicinecited by 231
  13. 2024AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environmentscited by 215
  14. 2024Agent Hospital: A Simulacrum of Hospital with Evolvable Medical Agentscited by 210
  15. 2024HuatuoGPT-Vision, Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scalecited by 194
  16. 2024RedPajama: an Open Dataset for Training Large Language Modelscited by 178
  17. 2023HuaTuo: Tuning LLaMA Model with Chinese Medical Knowledgecited by 161
  18. 2023A Study of Generative Large Language Model for Medical Research and Healthcarecited by 160
  19. 2024O1 Replication Journey: A Strategic Progress Report -- Part 1cited by 140
  20. 2023DoctorGLM: Fine-tuning your Chinese Doctor is not a Herculean Taskcited by 130
  21. 2023DeID-GPT: Zero-shot Medical Text De-Identification by GPT-4cited by 128
  22. 2023A Survey of Large Language Models in Medicine: Progress, Application, and Challengecited by 123
  23. 2023Zhongjing: Enhancing the Chinese Medical Capabilities of Large Language Model through Expert Feedback and Real-world Multi-turn Dialoguecited by 118
  24. 2024Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questionscited by 106
  25. 2023DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultationcited by 89
  26. 2023Efficient Online Data Mixing For Language Model Pre-Trainingcited by 77
  27. 2023MathPile: A Billion-Token-Scale Pretraining Corpus for Mathcited by 67
  28. 2024MAP-Neo: Highly Capable and Transparent Bilingual Large Language Model Seriescited by 67
  29. 2024Med42 -- Evaluating Fine-Tuning Strategies for Medical LLMs: Full-Parameter vs. Parameter-Efficient Approachescited by 51
  30. 2024CoD, Towards an Interpretable Medical Agent using Chain of Diagnosiscited by 43
  31. 2025Baichuan-M1: Pushing the Medical Capability of Large Language Modelscited by 41
  32. 2024Apollo: A Lightweight Multilingual Medical LLM towards Democratizing Medical AI to 6B Peoplecited by 38
  33. 2025Llamba: Scaling Distilled Recurrent Models for Efficient Language Processingcited by 35
  34. 2024Large Language Models in Mental Health Care: a Scoping Reviewcited by 34
  35. 2024A Preliminary Study of o1 in Medicine: Are We Closer to an AI Doctor?cited by 33
  36. 2023Qilin-Med: Multi-stage Knowledge Injection Advanced Medical Large Language Modelcited by 24
  37. 2024Efficiently Democratizing Medical LLMs for 50 Languages via a Mixture of Language Family Expertscited by 17
  38. 2023ChineseWebText: Large-scale High-quality Chinese Web Text Extracted with Effective Evaluation Modelcited by 16

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Cited by year (2026 to 7 Oct)

Citing papers per year: 2025: 8; 2026: 8.

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  1. 2025Towards Reasoning Era: A Survey of Long Chain-of-Thought for Reasoning Large Language Modelscited by 381
  2. 2025Fleming-R1: Toward Expert-Level Medical Reasoning via Reinforcement Learningcited by 9
  3. 2025Citrus-V: Advancing Medical Foundation Models with Unified Medical Image Grounding for Clinical Reasoningcited by 8
  4. 2026Medical Reasoning with Large Language Models: A Survey and MR-Benchcited by 4
  5. 2025MedKGEval: A Knowledge Graph-Based Multi-Turn Evaluation Framework for Open-Ended Patient Interactions with Clinical LLMscited by 3
  6. 2026ClinFusion: A Vision-Centric Multimodal LLM System for Holistic Medical Understandingcited by 2
  7. 2025AnesSuite: A Comprehensive Benchmark and Dataset Suite for Anesthesiology Reasoning in LLMscited by 1
  8. 2025DDO: Dual-Decision Optimization for LLM-Based Medical Consultation via Multi-Agent Collaborationcited by 1
  9. 2025MedCoAct: Confidence-Aware Multi-Agent Collaboration for Complete Clinical Decisioncited by 1
  10. 2025Overview of CHIP 2025 Shared Task 2: Discharge Medication Recommendation for Metabolic Diseases Based on Chinese Electronic Health Recordscited by 1
  11. 2026MLB: A Scenario-Driven Benchmark for Evaluating Large Language Models in Clinical Applicationscited by 1
  12. 2026MIND: Unified Inquiry and Diagnosis RL with Criteria Grounded Clinical Supports for Psychiatric Consultationcited by 1
4 more
  1. 2026A Human-Centric Pipeline for Aligning Large Language Models with Chinese Medical Ethicscited by 0
  2. 2026HiMed: Incentivizing Hindi Reasoning in Medical LLMscited by 0
  3. 2026MedPixel: A Unified Pixel-Language Model for Medical Reasoning and Segmentationcited by 0
  4. 2026SAM Meets VLM: Parameter-Decoupled Full-Parameter Training for Unified Medical Reasoning and Segmentationcited by 0

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  1. 2024Critique of Impure Reason: Unveiling the reasoning behaviour of medical Large Language Models
  2. 2026Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning
  3. 2025Medical Reasoning in the Era of LLMs: A Systematic Review of Enhancement Techniques and Applications
  4. 2025Automating Expert-Level Medical Reasoning Evaluation of Large Language Models
  5. 2025Chiron-o1: Igniting Multimodal Large Language Models towards Generalizable Medical Reasoning via Mentor-Intern Collaborative Search
  6. 2025Reasoning LLMs in the Medical Domain: A Literature Survey
  7. 2026Uncertainty Reasoning with Large Language Models for Explainable Disease Diagnosis
  8. 2026Med-CoReasoner: Reducing Language Disparities in Medical Reasoning via Language-Informed Co-Reasoning