Self-Prompting Large Vision Models for Few-Shot Medical Image Segmentation
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Abstract (arXiv)
Recent advancements in large foundation models have shown promising potential in the medical industry due to their flexible prompting capability. One such model, the Segment Anything Model (SAM), a prompt-driven segmentation model, has shown remarkable performance improvements, surpassing state-of-the-art approaches in medical image segmentation. However, existing methods primarily rely on tuning strategies that require extensive data or prior prompts tailored to the specific task, making it particularly challenging when only a limited number of data samples are available. In this paper, we propose a novel perspective on self-prompting in medical vision applications. Specifically, we harness the embedding space of SAM to prompt itself through a simple yet effective linear pixel-wise classifier. By preserving the encoding capabilities of the large model, the contextual information from its decoder, and leveraging its interactive promptability, we achieve competitive results on multiple datasets (i.e. improvement of more than 15% compared to fine-tuning the mask decoder using a few images).
Key facts. Cited by 35 papers in the map (data through 14 Oct 2026). Builds on 18 of its 30 references that are in the map. First posted on arXiv 15 Aug 2023.
Builds on
18 of 30 references.
References · 18
- 2018BERT: Pre-training of Deep Bidirectional Transformers for Language Understandingcited by 40,399
- 2020An Image is Worth 16x16 Words: Transformers for Image Recognition at Scalecited by 30,186
- 2015U-Net: Convolutional Networks for Biomedical Image Segmentationcited by 19,713
- 2021LoRA: Low-Rank Adaptation of Large Language Modelscited by 14,380
- 2023Segment Anythingcited by 8,234
- 2021Zero-Shot Text-to-Image Generationcited by 4,288
- 2019Kvasir-SEG: A Segmented Polyp Datasetcited by 589
- 2017Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)cited by 549
- 2023Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentationcited by 490
- 2023Customized Segment Anything Model for Medical Image Segmentationcited by 280
- 2023Segment Anything Model (SAM) for Digital Pathology: Assess Zero-shot Segmentation on Whole Slide Imagingcited by 161
- 2023Segment Anything Is Not Always Perfect: An Investigation of SAM on Different Real-world Applicationscited by 121
6 more
- 2023Can SAM Segment Polyps?cited by 59
- 2023When SAM Meets Medical Images: An Investigation of Segment Anything Model (SAM) on Multi-phase Liver Tumor Segmentationcited by 52
- 2020Few-shot Medical Image Segmentation using a Global Correlation Network with Discriminative Embeddingcited by 48
- 2020Semi-supervised few-shot learning for medical image segmentationcited by 34
- 2023FoPro-KD: Fourier Prompted Effective Knowledge Distillation for Long-Tailed Medical Image Recognitioncited by 10
- 2021MetaMedSeg: Volumetric Meta-learning for Few-Shot Organ Segmentationcited by 6
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Citing papers per year: 2023: 2; 2024: 16; 2025: 13; 2026: 4.
35 papers.
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- 2023MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentationcited by 82
- 2024Surgical-DINO: Adapter Learning of Foundation Models for Depth Estimation in Endoscopic Surgerycited by 52
- 2024EndoDAC: Efficient Adapting Foundation Model for Self-Supervised Depth Estimation from Any Endoscopic Cameracited by 43
- 2024MedCLIP-SAMv2: Towards Universal Text-Driven Medical Image Segmentationcited by 39
- 2024How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Modelcited by 32
- 2024CAT-SAM: Conditional Tuning for Few-Shot Adaptation of Segment Anything Modelcited by 27
- 2024Biomedical SAM 2: Segment Anything in Biomedical Images and Videoscited by 14
- 2024De-LightSAM: Modality-Decoupled Lightweight SAM for Generalizable Medical Segmentationcited by 11
- 2024SAM-based instance segmentation models for the automation of structural damage detectioncited by 10
- 2024MapSAM: Adapting Segment Anything Model for Automated Feature Detection in Historical Mapscited by 7
- 2024Sam2Rad: A Segmentation Model for Medical Images with Learnable Promptscited by 6
- 2024Automating MedSAM by Learning Prompts with Weak Few-Shot Supervisioncited by 5
23 more
- 2024Systematic Evaluation and Guidelines for Segment Anything Model in Surgical Video Analysiscited by 5
- 2025TextSAM-EUS: Text Prompt Learning for SAM to Accurately Segment Pancreatic Tumor in Endoscopic Ultrasoundcited by 5
- 2025PGP-SAM: Prototype-Guided Prompt Learning for Efficient Few-Shot Medical Image Segmentationcited by 4
- 2024Auto-Generating Weak Labels for Real & Synthetic Data to Improve Label-Scarce Medical Image Segmentationcited by 3
- 2024CycleSAM: Few-Shot Surgical Scene Segmentation with Cycle- and Scene-Consistent Feature Matchingcited by 3
- 2025Prompt-Tuning SAM: From Generalist to Specialist with only 2048 Parameters and 16 Training Imagescited by 3
- 2025Prompt Engineering in Segment Anything Model: Methodologies, Applications, and Emerging Challengescited by 3
- 2023SqueezeSAM: User friendly mobile interactive segmentationcited by 2
- 2025CodeSCM: Causal Analysis for Multi-Modal Code Generationcited by 2
- 2025SurgiSAM2: Fine-tuning a foundational model for surgical video anatomy segmentation and detectioncited by 2
- 2025Prompt learning with bounding box constraints for medical image segmentationcited by 2
- 2025Supervise Less, See More: Training-free Nuclear Instance Segmentation with Prototype-Guided Promptingcited by 2
- 2025Proxy Prompt: Endowing SAM and SAM 2 with Auto-Interactive-Prompt for Medical Segmentationcited by 1
- 2025MapSAM2: Adapting SAM2 for Automatic Segmentation of Historical Map Images and Time Seriescited by 1
- 2025MedSapiens: Taking a Pose to Rethink Medical Imaging Landmark Detectioncited by 1
- 2026Focus on Background: Exploring SAM's Potential in Few-shot Medical Image Segmentation with Background-centric Promptingcited by 1
- 2026Mask to Concept: Auto-Promptable SAM3 via Efficient Test-Time Concept Embedding Search for Few-Shot Annotationcited by 1
- 2024Towards Full-parameter and Parameter-efficient Self-learning For Endoscopic Camera Depth Estimationcited by 0
- 2024A versatile machine learning workflow for high-throughput analysis of supported metal catalyst particlescited by 0
- 2025MedSAM-CA: A CNN-Augmented ViT with Attention-Enhanced Multi-Scale Fusion for Medical Image Segmentationcited by 0
- 2025PPBoost: Progressive Prompt Boosting for Text-Driven Medical Image Segmentationcited by 0
- 2026Learning from Noisy Prompts: Saliency-Guided Prompt Distillation for Robust Segmentation with SAMcited by 0
- 2026SetPlanner: A Lightweight Plug-in Point-Set Planner for Frozen SAMcited by 0
- 2026SetPlanner: A Lightweight Plug-in Point-Set Planner for Frozen SAM16 Sep 2026
- 2026Mask to Concept: Auto-Promptable SAM3 via Efficient Test-Time Concept Embedding Search for Few-Shot Annotation25 Jun 2026
- 2026Learning from Noisy Prompts: Saliency-Guided Prompt Distillation for Robust Segmentation with SAM25 Apr 2026
- 2026Focus on Background: Exploring SAM's Potential in Few-shot Medical Image Segmentation with Background-centric Prompting22 Mar 2026
- 2025PPBoost: Progressive Prompt Boosting for Text-Driven Medical Image Segmentation26 Nov 2025
- 2025Supervise Less, See More: Training-free Nuclear Instance Segmentation with Prototype-Guided Prompting25 Nov 2025
- 2025MedSapiens: Taking a Pose to Rethink Medical Imaging Landmark Detection6 Nov 2025
- 2025MapSAM2: Adapting SAM2 for Automatic Segmentation of Historical Map Images and Time Series31 Oct 2025
- 2025TextSAM-EUS: Text Prompt Learning for SAM to Accurately Segment Pancreatic Tumor in Endoscopic Ultrasound24 Jul 2025
- 2025Prompt Engineering in Segment Anything Model: Methodologies, Applications, and Emerging Challenges13 Jul 2025
- 2025Prompt learning with bounding box constraints for medical image segmentation3 Jul 2025
- 2025MedSAM-CA: A CNN-Augmented ViT with Attention-Enhanced Multi-Scale Fusion for Medical Image Segmentation30 Jun 2025
23 more
- 2025Prompt-Tuning SAM: From Generalist to Specialist with only 2048 Parameters and 16 Training Images23 Apr 2025
- 2025SurgiSAM2: Fine-tuning a foundational model for surgical video anatomy segmentation and detection5 Mar 2025
- 2025CodeSCM: Causal Analysis for Multi-Modal Code Generation7 Feb 2025
- 2025Proxy Prompt: Endowing SAM and SAM 2 with Auto-Interactive-Prompt for Medical Segmentation5 Feb 2025
- 2025PGP-SAM: Prototype-Guided Prompt Learning for Efficient Few-Shot Medical Image Segmentation12 Jan 2025
- 2024Systematic Evaluation and Guidelines for Segment Anything Model in Surgical Video Analysis31 Dec 2024
- 2024MapSAM: Adapting Segment Anything Model for Automated Feature Detection in Historical Maps11 Nov 2024
- 2024A versatile machine learning workflow for high-throughput analysis of supported metal catalyst particles2 Oct 2024
- 2024Towards Full-parameter and Parameter-efficient Self-learning For Endoscopic Camera Depth Estimation1 Oct 2024
- 2024Automating MedSAM by Learning Prompts with Weak Few-Shot Supervision30 Sep 2024
- 2024MedCLIP-SAMv2: Towards Universal Text-Driven Medical Image Segmentation28 Sep 2024
- 2024Sam2Rad: A Segmentation Model for Medical Images with Learnable Prompts10 Sep 2024
- 2024Biomedical SAM 2: Segment Anything in Biomedical Images and Videos6 Aug 2024
- 2024De-LightSAM: Modality-Decoupled Lightweight SAM for Generalizable Medical Segmentation19 Jul 2024
- 2024CycleSAM: Few-Shot Surgical Scene Segmentation with Cycle- and Scene-Consistent Feature Matching9 Jul 2024
- 2024EndoDAC: Efficient Adapting Foundation Model for Self-Supervised Depth Estimation from Any Endoscopic Camera14 May 2024
- 2024Auto-Generating Weak Labels for Real & Synthetic Data to Improve Label-Scarce Medical Image Segmentation25 Apr 2024
- 2024How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Model15 Apr 2024
- 2024CAT-SAM: Conditional Tuning for Few-Shot Adaptation of Segment Anything Model6 Feb 2024
- 2024SAM-based instance segmentation models for the automation of structural damage detection27 Jan 2024
- 2024Surgical-DINO: Adapter Learning of Foundation Models for Depth Estimation in Endoscopic Surgery11 Jan 2024
- 2023SqueezeSAM: User friendly mobile interactive segmentation11 Dec 2023
- 2023MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentation16 Sep 2023
- 2023MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentationcited by 82
- 2024Surgical-DINO: Adapter Learning of Foundation Models for Depth Estimation in Endoscopic Surgerycited by 52
- 2024EndoDAC: Efficient Adapting Foundation Model for Self-Supervised Depth Estimation from Any Endoscopic Cameracited by 43
- 2024MedCLIP-SAMv2: Towards Universal Text-Driven Medical Image Segmentationcited by 39
- 2024How to build the best medical image segmentation algorithm using foundation models: a comprehensive empirical study with Segment Anything Modelcited by 32
- 2024CAT-SAM: Conditional Tuning for Few-Shot Adaptation of Segment Anything Modelcited by 27
- 2024Biomedical SAM 2: Segment Anything in Biomedical Images and Videoscited by 14
- 2024De-LightSAM: Modality-Decoupled Lightweight SAM for Generalizable Medical Segmentationcited by 11
- 2024SAM-based instance segmentation models for the automation of structural damage detectioncited by 10
- 2024MapSAM: Adapting Segment Anything Model for Automated Feature Detection in Historical Mapscited by 7
- 2024Sam2Rad: A Segmentation Model for Medical Images with Learnable Promptscited by 6
- 2024Automating MedSAM by Learning Prompts with Weak Few-Shot Supervisioncited by 5
12 most cited of 35 All 35 (JSON)
- 2026SetPlanner: A Lightweight Plug-in Point-Set Planner for Frozen SAM16 Sep 2026
- 2026Mask to Concept: Auto-Promptable SAM3 via Efficient Test-Time Concept Embedding Search for Few-Shot Annotation25 Jun 2026
- 2026Learning from Noisy Prompts: Saliency-Guided Prompt Distillation for Robust Segmentation with SAM25 Apr 2026
- 2026Focus on Background: Exploring SAM's Potential in Few-shot Medical Image Segmentation with Background-centric Prompting22 Mar 2026
- 2025PPBoost: Progressive Prompt Boosting for Text-Driven Medical Image Segmentation26 Nov 2025
- 2025Supervise Less, See More: Training-free Nuclear Instance Segmentation with Prototype-Guided Prompting25 Nov 2025
- 2025MedSapiens: Taking a Pose to Rethink Medical Imaging Landmark Detection6 Nov 2025
- 2025MapSAM2: Adapting SAM2 for Automatic Segmentation of Historical Map Images and Time Series31 Oct 2025
- 2025TextSAM-EUS: Text Prompt Learning for SAM to Accurately Segment Pancreatic Tumor in Endoscopic Ultrasound24 Jul 2025
- 2025Prompt Engineering in Segment Anything Model: Methodologies, Applications, and Emerging Challenges13 Jul 2025
- 2025Prompt learning with bounding box constraints for medical image segmentation3 Jul 2025
- 2025MedSAM-CA: A CNN-Augmented ViT with Attention-Enhanced Multi-Scale Fusion for Medical Image Segmentation30 Jun 2025
12 newest of 35 All 35 (JSON)