XVertNet: Unsupervised Contrast Enhancement of Vertebral Structures with Dynamic Self-Tuning Guidance and Multi-Stage Analysis

Chest X-rays remain the primary diagnostic tool in emergency medicine, yet their limited ability to capture fine anatomical details can result in missed or delayed diagnoses. To address this, we introduce XVertNet, a novel deep-learning framework designed to enhance vertebral structure visualization in X-ray images significantly. Our framework introduces two key innovations: (1) An unsupervised learning architecture that eliminates reliance on manually labeled training data a persistent bottleneck in medical imaging, and (2) a dynamic self-tuned internal guidance mechanism featuring an adaptive feedback loop for real-time image optimization. Extensive validation across four major public datasets revealed that XVertNet outperforms state-of-the-art enhancement methods, as demonstrated by improvements in entropy scores, Tenengrad criterion values, the local phase coherence sharpness index (LPC-SI), and thetone mapped image quality index (TMQI). Furthermore, clinical validation conducted with two board-certified radiologists confirmed that the enhanced images enabled more sensitive detection of subtle vertebral fractures and degenerative changes. The unsupervised nature of XVertNet facilitates immediate clinical deployment without requiring additional training overhead. This innovation represents a transformative advancement in emergency radiology, providing a scalable and time-efficient solution to enhance diagnostic accuracy in high-pressure clinical environments.