Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)
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Cited by 36 in Diffusion models, but placed by its own abstract, which didn’t fit.
Abstract (arXiv)
Given the potential X-ray radiation risk to the patient, low-dose CT has attracted a considerable interest in the medical imaging field. The current main stream low-dose CT methods include vendor-specific sinogram domain filtration and iterative reconstruction, but they need to access original raw data whose formats are not transparent to most users. Due to the difficulty of modeling the statistical characteristics in the image domain, the existing methods for directly processing reconstructed images cannot eliminate image noise very well while keeping structural details. Inspired by the idea of deep learning, here we combine the autoencoder, the deconvolution network, and shortcut connections into the residual encoder-decoder convolutional neural network (RED-CNN) for low-dose CT imaging. After patch-based training, the proposed RED-CNN achieves a competitive performance relative to the-state-of-art methods in both simulated and clinical cases. Especially, our method has been favorably evaluated in terms of noise suppression, structural preservation and lesion detection.
Key facts. Cited by 224 papers in the map (data through 7 Oct 2026). First posted on arXiv 1 Feb 2017.
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Citing papers per year: 2021: 41; 2022: 35; 2023: 39; 2024: 35; 2025: 44; 2026: 30.
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- 2022Conversion Between CT and MRI Images Using Diffusion and Score-Matching Modelscited by 69
- 2023CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalizationcited by 51
- 2022CTformer: Convolution-free Token2Token Dilated Vision Transformer for Low-dose CT Denoisingcited by 46
- 2024Restore-RWKV: Efficient and Effective Medical Image Restoration with RWKVcited by 36
- 2024Fast-DDPM: Fast Denoising Diffusion Probabilistic Models for Medical Image-to-Image Generationcited by 33
- 2022Self-Supervised Coordinate Projection Network for Sparse-View Computed Tomographycited by 31
- 2021Eformer: Edge Enhancement based Transformer for Medical Image Denoisingcited by 30
- 2024All-In-One Medical Image Restoration via Task-Adaptive Routingcited by 30
- 2022Generative Modeling in Sinogram Domain for Sparse-view CT Reconstructioncited by 27
- 2022Online Deep Equilibrium Learning for Regularization by Denoisingcited by 22
- 2021TED-net: Convolution-free T2T Vision Transformer-based Encoder-decoder Dilation network for Low-dose CT Denoisingcited by 21
- 2023Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoisingcited by 21
38 more
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- 2021SGD-Net: Efficient Model-Based Deep Learning with Theoretical Guaranteescited by 18
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- 2022Sparse-view Cone Beam CT Reconstruction using Data-consistent Supervised and Adversarial Learning from Scarce Training Datacited by 17
- 2021Uncertainty-Guided Progressive GANs for Medical Image Translationcited by 16
- 2022Patch-Based Denoising Diffusion Probabilistic Model for Sparse-View CT Reconstructioncited by 16
- 2021Cycle-free CycleGAN using Invertible Generator for Unsupervised Low-Dose CT Denoisingcited by 15
- 2021Multi-domain Integrative Swin Transformer network for Sparse-View Tomographic Reconstructioncited by 15
- 2023ASCON: Anatomy-aware Supervised Contrastive Learning Framework for Low-dose CT Denoisingcited by 15
- 2022Physics-/Model-Based and Data-Driven Methods for Low-Dose Computed Tomography: A surveycited by 14
- 2022Hypernetwork-based Personalized Federated Learning for Multi-Institutional CT Imagingcited by 14
- 2023Learning to Distill Global Representation for Sparse-View CTcited by 14
- 2021Chest X-Ray Bone Suppression for Improving Classification of Tuberculosis-Consistent Findingscited by 13
- 2022Low-Dose CT Denoising via Sinogram Inner-Structure Transformercited by 13
- 20223D Segmentation Guided Style-based Generative Adversarial Networks for PET Synthesiscited by 13
- 2022Near-Exact Recovery for Tomographic Inverse Problems via Deep Learningcited by 13
- 2021Fourier Image Transformercited by 12
- 2021DuDoTrans: Dual-Domain Transformer Provides More Attention for Sinogram Restoration in Sparse-View CT Reconstructioncited by 12
- 2023LIT-Former: Linking In-plane and Through-plane Transformers for Simultaneous CT Image Denoising and Deblurringcited by 12
- 2022Robust Split Federated Learning for U-shaped Medical Image Networkscited by 11
- 2024DenoMamba: A fused state-space model for low-dose CT denoisingcited by 11
- 2025Noise-Inspired Diffusion Model for Generalizable Low-Dose CT Reconstructioncited by 11
- 2023Prior Mismatch and Adaptation in PnP-ADMM with a Nonconvex Convergence Analysiscited by 10
- 2022Ultra Low-Parameter Denoising: Trainable Bilateral Filter Layers in Computed Tomographycited by 9
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- 2021Improving Generalizability in Limited-Angle CT Reconstruction with Sinogram Extrapolationcited by 8
- 2023Block Coordinate Plug-and-Play Methods for Blind Inverse Problemscited by 8
- 2023Diffusion Prior Regularized Iterative Reconstruction for Low-dose CTcited by 8
- 2021Lesion-Inspired Denoising Network: Connecting Medical Image Denoising and Lesion Detectioncited by 7
- 2021Inverse Aerodynamic Design of Gas Turbine Blades using Probabilistic Machine Learningcited by 7
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- 2025Lightweight Medical Image Restoration via Integrating Reliable Lesion-Semantic Driven Priorcited by 7
- 2025CTLformer: A Hybrid Denoising Model Combining Convolutional Layers and Self-Attention for Enhanced CT Image Reconstructioncited by 7
50 most cited of 224 All 224 (JSON)
- 2026GenDiff: A Dose and Anatomy Aware Diffusion Model with Structural Prior Refinement for Low-Dose CT Reconstruction and Generalization11 Jul 2026
- 2026ProSAC-CT: Progressive Spectral-Anatomical Co-Guided Multi-Stage Diffusion Model for Low-Dose CT Denoising2 Jul 2026
- 2026DeVAR: Low-Dose CT Denoising via Visual Autoregressive Modeling26 Jun 2026
- 2026Enabling self-supervised learned primal dual with Noise2Inverse25 Jun 2026
- 2026Multilevel Stochastic Plug-and-Play for Sparse-View CT Reconstruction23 Jun 2026
- 2026NGPS: Structure-Preserving Self-Supervised Denoising via Neighbor-Guided Patch Sampling22 Jun 2026
- 2026Deep Slice Interpolation for Reducing Through-Plane Anisotropy and Noise in Head CT8 Jun 2026
- 2026AutoMedBench: Towards Medical AutoResearch with Agentic AI Models1 Jun 2026
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- 2026Generative Drifting for Conditional Medical Image Generation21 Apr 2026
- 2026Rethinking Cross-Dose PET Denoising: Mitigating Averaging Effects via Residual Noise Learning18 Apr 2026
- 2026RelativeFlow: Taming Medical Image Denoising Learning with Noisy Reference16 Apr 2026
38 more
- 2026Brain MR Image Synthesis with 3D Multi-Contrast Self-Attention GAN31 Mar 2026
- 2026CARE: Training-Free Controllable Restoration for Medical Images via Dual-Latent Steering26 Mar 2026
- 2026TAFG-MAN: Timestep-Adaptive Frequency-Gated Latent Diffusion for Efficient and High-Quality Low-Dose CT Image Denoising21 Mar 2026
- 2026Projection Guided Personalized Federated Learning for Low Dose CT Denoising12 Mar 2026
- 2026MAP-Diff: Multi-Anchor Guided Diffusion for Progressive 3D Whole-Body Low-Dose PET Denoising2 Mar 2026
- 2026SCOUT: Fast Spectral CT Imaging in Ultra LOw-data Regimes via PseUdo-label GeneraTion28 Feb 2026
- 2026PatchDenoiser: Parameter-efficient multi-scale patch learning and fusion denoiser for Low-dose CT imaging25 Feb 2026
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- 2026Prior-guided Hierarchical Instance-pixel Contrastive Learning for Ultrasound Speckle Noise Suppression14 Feb 2026
- 2026PLOT-CT: Pre-log Voronoi Decomposition Assisted Generation for Low-dose CT Reconstruction12 Feb 2026
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- 2026Deep learning Based Correction Algorithms for 3D Medical Reconstruction in Computed Tomography and Macroscopic Imaging30 Jan 2026
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- 20263D Wavelet-Based Structural Priors for Controlled Diffusion in Whole-Body Low-Dose PET Denoising11 Jan 2026
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- 2025Neural Discrete Representation Learning for Sparse-View CBCT Reconstruction: From Algorithm Design to Prospective Multicenter Clinical Evaluation30 Nov 2025
- 2025Prompting Lipschitz-constrained network for multiple-in-one sparse-view CT reconstruction25 Nov 2025
- 2025D-PerceptCT: Deep Perceptual Enhancement for Low-Dose CT Images18 Nov 2025
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- 2025Learnable Total Variation with Lambda Mapping for Low-Dose CT Denoising13 Nov 2025
- 2025Task-Adaptive Low-Dose CT Reconstruction10 Nov 2025
- 2025Adversarial and Score-Based CT Denoising: CycleGAN vs Noise2Score6 Nov 2025
- 2025Toward Better Optimization of Low-Dose CT Enhancement: A Critical Analysis of Loss Functions and Image Quality Assessment Metrics1 Nov 2025
- 2025MORE: Multi-Organ Medical Image REconstruction Dataset30 Oct 2025
- 2025Cyclic Self-Supervised Diffusion for Ultra Low-field to High-field MRI Synthesis15 Oct 2025
- 2025A Denoising Framework for Real-World Ultra-Low-Dose Lung CT Images Based on an Image Purification Strategy8 Oct 2025
- 2025Extendable Generalization Self-Supervised Diffusion for Low-Dose CT Reconstruction28 Sep 2025
- 2025MAN: Latent Diffusion Enhanced Multistage Anti-Noise Network for Efficient and High-Quality Low-Dose CT Image Denoising28 Sep 2025
- 2025Perceptual Influence: Improving the Perceptual Loss Design for Low-Dose CT Enhancement27 Sep 2025
- 2025Cross-Distribution Diffusion Priors-Driven Iterative Reconstruction for Sparse-View CT16 Sep 2025
- 2025Hybrid Swin Attention Networks for Simultaneously Low-Dose PET and CT Denoising8 Sep 2025
- 2025Systematic Review and Meta-analysis of AI-driven MRI Motion Artifact Detection and Correction5 Sep 2025
- 2025Federated Learning for Large Models in Medical Imaging: A Comprehensive Review28 Aug 2025
- 2025FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoising24 Aug 2025
50 newest of 224 All 224 (JSON)
- 2023CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalizationcited by 51
- 2024Fast-DDPM: Fast Denoising Diffusion Probabilistic Models for Medical Image-to-Image Generationcited by 33
- 2022Generative Modeling in Sinogram Domain for Sparse-view CT Reconstructioncited by 27
- 2023Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoisingcited by 21
- 2022Patch-Based Denoising Diffusion Probabilistic Model for Sparse-View CT Reconstructioncited by 16
- 2025Noise-Inspired Diffusion Model for Generalizable Low-Dose CT Reconstructioncited by 11
- 2023Diffusion Prior Regularized Iterative Reconstruction for Low-dose CTcited by 8
- 2023Parallel Diffusion Model-based Sparse-view Cone-beam Breast CTcited by 7
- 2024MedDiff-FM: A Diffusion-based Foundation Model for Versatile Medical Image Applicationscited by 7
- 2023Two-and-a-half Order Score-based Model for Solving 3D Ill-posed Inverse Problemscited by 5
- 2023Energy-Guided Diffusion Model for CBCT-to-CT Synthesiscited by 4
- 2023PPFM: Image denoising in photon-counting CT using single-step posterior sampling Poisson flow generative modelscited by 4
12 most cited of 36 All 36 (JSON)
- 2026GenDiff: A Dose and Anatomy Aware Diffusion Model with Structural Prior Refinement for Low-Dose CT Reconstruction and Generalization11 Jul 2026
- 2026ProSAC-CT: Progressive Spectral-Anatomical Co-Guided Multi-Stage Diffusion Model for Low-Dose CT Denoising2 Jul 2026
- 2026RelativeFlow: Taming Medical Image Denoising Learning with Noisy Reference16 Apr 2026
- 2026TAFG-MAN: Timestep-Adaptive Frequency-Gated Latent Diffusion for Efficient and High-Quality Low-Dose CT Image Denoising21 Mar 2026
- 2026MAP-Diff: Multi-Anchor Guided Diffusion for Progressive 3D Whole-Body Low-Dose PET Denoising2 Mar 2026
- 2026A Unified Framework for Multimodal Image Reconstruction and Synthesis using Denoising Diffusion Models9 Feb 2026
- 2026FSP-Diff: Full-Spectrum Prior-Enhanced DualDomain Latent Diffusion for Ultra-Low-Dose Spectral CT Reconstruction8 Feb 2026
- 2025MAN: Latent Diffusion Enhanced Multistage Anti-Noise Network for Efficient and High-Quality Low-Dose CT Image Denoising28 Sep 2025
- 2025Cross-Distribution Diffusion Priors-Driven Iterative Reconstruction for Sparse-View CT16 Sep 2025
- 2025FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoising24 Aug 2025
- 2025FD-DiT: Frequency Domain-Directed Diffusion Transformer for Low-Dose CT Reconstruction30 Jun 2025
- 2025Noise-Inspired Diffusion Model for Generalizable Low-Dose CT Reconstruction27 Jun 2025
12 newest of 36 All 36 (JSON)
- 2022Conversion Between CT and MRI Images Using Diffusion and Score-Matching Modelscited by 69
- 2022CTformer: Convolution-free Token2Token Dilated Vision Transformer for Low-dose CT Denoisingcited by 46
- 2024Restore-RWKV: Efficient and Effective Medical Image Restoration with RWKVcited by 36
- 2022Self-Supervised Coordinate Projection Network for Sparse-View Computed Tomographycited by 31
- 2021Eformer: Edge Enhancement based Transformer for Medical Image Denoisingcited by 30
- 2024All-In-One Medical Image Restoration via Task-Adaptive Routingcited by 30
- 2022Online Deep Equilibrium Learning for Regularization by Denoisingcited by 22
- 2021TED-net: Convolution-free T2T Vision Transformer-based Encoder-decoder Dilation network for Low-dose CT Denoisingcited by 21
- 2022UncertaINR: Uncertainty Quantification of End-to-End Implicit Neural Representations for Computed Tomographycited by 19
- 2021SGD-Net: Efficient Model-Based Deep Learning with Theoretical Guaranteescited by 18
- 2023IQAGPT: Image Quality Assessment with Vision-language and ChatGPT Modelscited by 18
- 2022Sparse-view Cone Beam CT Reconstruction using Data-consistent Supervised and Adversarial Learning from Scarce Training Datacited by 17
12 most cited of 185 All 185 (JSON)
- 2026DeVAR: Low-Dose CT Denoising via Visual Autoregressive Modeling26 Jun 2026
- 2026Enabling self-supervised learned primal dual with Noise2Inverse25 Jun 2026
- 2026Multilevel Stochastic Plug-and-Play for Sparse-View CT Reconstruction23 Jun 2026
- 2026NGPS: Structure-Preserving Self-Supervised Denoising via Neighbor-Guided Patch Sampling22 Jun 2026
- 2026Deep Slice Interpolation for Reducing Through-Plane Anisotropy and Noise in Head CT8 Jun 2026
- 2026Conservative AI for Safety-Sensitive Medical Image Restoration: Residual-Bounded CT-CTA Enhancement for Intracranial Aneurysm-Relevant Signal Recovery15 May 2026
- 2026Generative Drifting for Conditional Medical Image Generation21 Apr 2026
- 2026Rethinking Cross-Dose PET Denoising: Mitigating Averaging Effects via Residual Noise Learning18 Apr 2026
- 2026Brain MR Image Synthesis with 3D Multi-Contrast Self-Attention GAN31 Mar 2026
- 2026CARE: Training-Free Controllable Restoration for Medical Images via Dual-Latent Steering26 Mar 2026
- 2026Projection Guided Personalized Federated Learning for Low Dose CT Denoising12 Mar 2026
- 2026SCOUT: Fast Spectral CT Imaging in Ultra LOw-data Regimes via PseUdo-label GeneraTion28 Feb 2026
12 newest of 185 All 185 (JSON)